Abstract:
RATIONALE:3,4-Methylenedioxypyrovalerone (MDPV) is a synthetic cathinone abused for its cocaine-like psychostimulant effects in "bath salts" products. While there are currently no pharmacotherapies for MDPV abuse, rodent studies suggest immunotherapy may offer a feasible treatment option. OBJECTIVES:These studies tested the capacity of active vaccination to reduce the reinforcing effects of MDPV in Sprague-Dawley rats. METHODS:Rats acquired cocaine self-administration (0.32 mg/kg/inf) on an FR1 schedule. Dose-effect functions for cocaine (0.032-1.0 mg/kg/inf) and MDPV (0.001-0.32 mg/kg/inf) were determined under an FR5 schedule. Rats in the vaccine group were immunized during cocaine self-administration. All rats transitioned to a progressive-ratio (PR) schedule to establish breakpoints for cocaine (0.1-1.0 mg/kg/inf) and MDPV (0.01-0.32 mg/kg/inf). Responding was extinguished, and cue-induced and MDPV-primed reinstatement (0.56 mg/kg, IP) were evaluated. RESULTS:No endpoints of cocaine self-administration differed between groups, but the ED50 for MDPV self-administration was significantly lower in control relative to vaccinated rats. Under the PR schedule, MDPV was ~ 2.5-fold more potent in maintaining responding in control than vaccinated rats, but Emax was not different between groups. Vaccination did not reduce MDPV-primed reinstatement, perhaps due to a decrease in antibody titer. CONCLUSIONS:Vaccination did not alter acquisition of cocaine self-administration, demonstrating pharmacological selectivity and suggesting that the vaccine did not affect learning or motivation, while effectively reducing the potency of MDPV as a reinforcer. The protective effects of the vaccine were surmounted by large unit doses of MDPV, suggesting maximal efficacy of drug-conjugate vaccines in substance abuse disorders will likely require concurrent behavior modification therapy.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
McClenahan SJ,Gunnell MG,Owens SM,Fantegrossi WEdoi
10.1007/s00213-020-05558-0subject
Has Abstractpub_date
2020-09-01 00:00:00pages
2613-2620issue
9eissn
0033-3158issn
1432-2072pii
10.1007/s00213-020-05558-0journal_volume
237pub_type
杂志文章abstract:RATIONALE:Decision-making is a complex cognitive process that is mediated, in part, by subregions of the medial prefrontal cortex (PFC). Decision-making is impaired in a number of psychiatric conditions including schizophrenia. Notably, people with schizophrenia exhibit reductions in GABA function in the same PFC areas...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3816-7
更新日期:2015-05-01 00:00:00
abstract::The effects of brofaremine (CGP 11 305A), a short-acting, reversible and selective inhibitor of MAO-A, on sleep, nocturnal penile tumescence (NPT) and hormonal secretion during the night were studied during a long-term trial. Three healthy males underwent sleep-EEG and NPT recordings during consecutive nights (1) unde...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00215489
更新日期:1987-01-01 00:00:00
abstract:RATIONALE:Neuroanatomical evidence suggests that GABAergic deficits and progressive cortical atrophy occur with schizophrenia. OBJECTIVE:To evaluate the hypothesis that neurodevelopmental deficits affect neurodegeneration occurring with schizophrenia, this study examined a novel animal model for schizophrenia-related ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2269-5
更新日期:2011-06-01 00:00:00
abstract::The present study was undertaken to evaluate the effects of single and repeated doses of triazolam (1 mg/kg IP) and desipramine (DMI) (10 mg/kg IP) alone and in combination on certain pharmacologic responses and brain catecholamine levels in rats. The significant findings were: (1) triazolam and DMI given alone and in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427882
更新日期:1980-01-01 00:00:00
abstract:RATIONALE:Diazepam, a benzodiazepine with a relatively rapid onset of clinical effects, has been associated with suicide and other self-aggressive acts. The evidence for this association, however, comes exclusively from retrospective non-experimental studies. Although suggestive, the results of these studies do not sup...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00213-004-1966-8
更新日期:2005-02-01 00:00:00
abstract::Two experiments examined the effect of the benzodiazepine receptor agonist, zolpidem, on palatable fluid intake in water-deprived rats. In the first experiment, pretreatment with 3.0 or 10.0 mg/kg zolpidem IP was found to increase consumption of a novel glucose drink (3% d-glucose and 0.15 sodium saccharine w/v in wat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245521
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Caffeine has a well-established effect on reaction times (RTs) but the neurocognitive mechanisms underlying this are unclear. METHODS:In the present study, 15 female participants performed an oddball task after ingesting caffeine or a placebo, and electroencephalographic data were obtained. Single-trial P3b...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4790-7
更新日期:2018-03-01 00:00:00
abstract::This study examined the role of the strychnine-insensitive glycine binding site of the NMDA receptor in prepulse inhibition (PPI) of the acoustic startle response (ASR) in rats. PPI is an operational measure of gating processes which normally lead to a diminished ASR when a startling stimulus is preceded by a weak pre...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050220
更新日期:1997-03-01 00:00:00
abstract::The ability of mu and kappa opioids to alter the discriminative-stimulus and rate-decreasing effects of the 5-HT1A receptor agonist 8-OH-DPAT was examined in rats trained to discriminate either a low (0.1 mg/kg) or a high (0.3 mg/kg) dose of 8-OH-DPAT from water using a two-lever food-reinforced drug discrimination pr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246263
更新日期:1995-12-01 00:00:00
abstract:INTRODUCTION:Locomotor sensitization, defined as the progressive and enduring enhancement of the motor stimulant effects elicited by repeated exposure to drugs of abuse, is the consequence of drug-induced cellular neuroadaptations that likely contribute to addictive behavior. Neuroadaptations within the dopaminergic sy...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1707-0
更新日期:2010-01-01 00:00:00
abstract::The purpose of this study was to compare the subchronic, low-dose effects of clozapine with those of olanzapine in a learned behavioral task previously shown to distinguish between clozapine and haloperidol with acute and subchronic treatment regimes. Rats were trained to use a single forelimb to press a force-recordi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050363
更新日期:1997-08-01 00:00:00
abstract:RATIONALE:Anxiety and aggression are associated with ethanol self-administration, but these behaviors can serve as either risk factors for or consequences of heavy drinking in rodents and humans. Baseline levels of aggressive-like and anxious-like behavior in non-human primates have not yet been characterized in relati...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4427-2
更新日期:2016-12-01 00:00:00
abstract:RATIONALE:The endogenous oxytocin system has emerged as an inhibitor of drug-seeking and stress in preclinical models. OBJECTIVES:The goal of this study was to examine whether systemic oxytocin administration attenuated methamphetamine (METH)-seeking in rats pre-exposed to a predator odor threat. METHODS:In Experimen...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-4184-7
更新日期:2016-03-01 00:00:00
abstract::The effects of four indirect dopamine agonists, d-amphetamine (0.25-4.0 mg/kg), cocaine (2.5-40.0 mg/kg), GBR 12909 (10.0-30.0 mg/kg), and nomifensine (5.0-20.0 mg/kg), on the behavioral organization of movements in an unconditioned motor paradigm were investigated in rats. The extended scaling hypothesis using the fl...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245696
更新日期:1993-01-01 00:00:00
abstract::The behavioural effects of increasing doses of apomorphine and haloperidol were observed in a group of six marmosets. Behaviour was classified quantitatively into categories: Locomotion, inactivity, checking (small head movements), social interaction and purposeful activities. Statistical analysis revealed that apomor...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431987
更新日期:1979-01-01 00:00:00
abstract:RATIONALE:Cessation of daily caffeine consumption produces a withdrawal syndrome comprised of subjective symptoms and functional impairment. Few controlled studies have examined the physiological effects of caffeine withdrawal. OBJECTIVE:The present study examined the effect of caffeine withdrawal on cerebral blood fl...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130050005
更新日期:2000-01-01 00:00:00
abstract::Evaluation of the efficacy of antidepressant agents needs to take into account factors which increase the "effect size", such as dosage, treatment duration, the use of two-phase trials, and pattern analysis of responders. Although many patients are thought to receive inadequate doses of antidepressants, relatively few...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/BF02246244
更新日期:1992-01-01 00:00:00
abstract:RATIONALE:Acute tryptophan depletion (ATD) is a widely used method to study the role of serotonin (5-HT) in affect and cognition. ATD results in a strong but transient decrease in plasma tryptophan and central 5-HT synthesis and availability. Although its use is widespread, the evidence that the numerous functional eff...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-007-0908-7
更新日期:2007-12-01 00:00:00
abstract::Following the stereotaxic implantation of chronic cannulae for intracerebroventricular (ICV) infusion, rats were given an alcohol preference test to establish their preferred concentration in comparison with water. After alcohol was removed, 15 mg/kg cyanamide was then injected subcutaneously for 4 days in order to ma...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00444688
更新日期:1989-01-01 00:00:00
abstract:RATIONALE:We recently reported that simultaneous exposure to amphetamine and various stressors resulted in reduced hypothalamic-pituitary-adrenal (HPA) and glycemic responses to the stressors. Since this is a new and relevant phenomenon, we wanted to further explore this interaction. OBJECTIVES:This study aims (i) to ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4675-9
更新日期:2017-10-01 00:00:00
abstract::While chronic intermittent administration of stimulants often induces behavioral sensitization in adulthood, stimulant sensitization has rarely been reported prior to weaning [around postnatal day (P) 21]. Consistent pairing of drug administration with the test context often facilitates sensitization in adults, yet yo...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050653
更新日期:1998-07-01 00:00:00
abstract::The effect of electroconvulsive shock (ECS) on the responsiveness to pain (measured by the hot-plate test) and on the characteristics of L-type calcium channels (measured as [3H]nitrendipine binding sites) in the cortex and hippocampus was tested on the Wistar rat. In animals receiving a single ECS, the calcium channe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244133
更新日期:1990-01-01 00:00:00
abstract:RATIONALE:The endocannabinoid system has been implicated in the pathogenesis of major depression (MD) as well as in the mediation of antidepressant drug effects. OBJECTIVES:To analyze CNR1 gene variants in MD and clinical response to citalopram (selective serotonin re-uptake inhibitors [SSRI]). METHODS:The role of CN...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-2995-y
更新日期:2013-06-01 00:00:00
abstract::Shaking movements of the body, similar to that made by a dog when wet ('wet-dog shakes'), occur in rats in response to pharmacological stimuli and in response to stimuli associated with cold and skin irritation. In this study, shaking movements, elicited by a variety of stimuli, were inhibited by central administratio...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00429002
更新日期:1983-01-01 00:00:00
abstract:RATIONALE:Delaying presentation of a drug can decrease its effectiveness as a reinforcer, but the effect of delaying punishment of drug self-administration is unknown. OBJECTIVE:This study examined whether a histamine injection could punish cocaine self-administration in a drug-drug choice, whether delaying histamine ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2501-3
更新日期:2012-04-01 00:00:00
abstract:RATIONALE:Robust intravenous (i.v.) nicotine self-administration (SA) in rats has been reported by several laboratories, including our own, using fixed ratio (FR) schedules of reinforcement. Studies on other drugs of abuse, however, suggest that progressive ratio (PR) schedules may provide additional information not ga...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051153
更新日期:1999-11-01 00:00:00
abstract:RATIONALE:Atypical antipsychotic drug (APD)-induced weight gain causes non-compliance, increasing the risk of relapse and medical complications. OBJECTIVES:In an animal model, we assessed body weights, food intake, body fat/lean body mass contents and blood serum levels of glucose and lipids in female rats treated wit...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-0081-9
更新日期:2005-10-01 00:00:00
abstract::Intravenous self-administration of d-amphetamine (0.25 mg/kg/injection) decreased in a dose-related fashion after injections of the dopaminergic agonists apomorphine and piribedil. The dopaminergic agonists appear to suppress amphetamine intake in the same way as do 'free' amphetamine injections, by extending drug sat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427393
更新日期:1978-07-19 00:00:00
abstract::In an operant learning lever-pressing procedure on an FR10 schedule of milk reinforcement, male Wistar rats were trained to discriminate between saline and 3 mg/kg IP DN-2327, a new anxiolytic which acts on benzodiazepine receptors, 3 mg/kg IP diazepam or 15 mg/kg IP pentylenetetrazol (PTZ). More than 80% appropriate ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02251282
更新日期:1993-01-01 00:00:00
abstract::Four benzodiazepine tranquilizers have been tested, alone or in combination with scopolamine, on the spontaneous locomotor activity of BALB/c mice. Scopolamine-induced locomotor stimulation was enhanced by chlordiazepoxide, diazepam, and medazepam, but not by bromazepam. These effects are similar to those exerted by t...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00433058
更新日期:1980-01-01 00:00:00