Alcohol attenuates amygdala-frontal connectivity during processing social signals in heavy social drinkers: a preliminary pharmaco-fMRI study.

abstract：RATIONALE:Dopamine (DA) D2-like antagonists block several effects of cocaine, including its locomotor stimulant and interoceptive discriminative-stimulus effects. Because these compounds generally lack selectivity among the D2-like DA receptors, the specific roles of the subtypes remain unclear. OBJECTIVES:DA D2 recep...

journal_title：Psychopharmacology

authors： Chausmer AL,Elmer GI,Rubinstein M,Low MJ,Grandy DK,Katz JL

更新日期：2002-08-01 00:00:00

abstract：OBJECTIVES:The present study investigates the effects of injections of a specific N-methyl-D-aspartic acid (NMDA) antagonist 3-[(R)-2-carboxypiperazin-4-yl]-propyl-1-phophonic acid (CPP) into the prefrontal cortex (PFC) on the extracellular concentrations of dopamine and acetylcholine in the nucleus accumbens (NAc) and...

journal_title：Psychopharmacology

authors： Del Arco A,Segovia G,Mora F

更新日期：2008-12-01 00:00:00

abstract：RATIONALE:Whilst the deleterious effects of alcohol on retrospective remembering have been widely documented, no study has yet objectively determined alcohol's effects on prospective memory (PM)--remembering to do something in the future. OBJECTIVES:With this aim, the present study determined the acute effects of alco...

journal_title：Psychopharmacology

authors： Leitz JR,Morgan CJ,Bisby JA,Rendell PG,Curran HV

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Several different animal models are currently used to research the neurodegenerative movement disorder Parkinson's disease (PD). RESULTS:Models based on the genetic deficits associated with a small percentage of sufferers demonstrate the pathological accumulation of alpha-synuclein characteristic of the dis...

journal_title：Psychopharmacology

authors： Lane E,Dunnett S

更新日期：2008-08-01 00:00:00

abstract：:The effects of 4 weeks of treatment with the selective monoamine oxidase (MAO) inhibiting antidepressant clorgyline and pargyline on the sleep of affectively disordered patients were studied. Both inhibitors resulted in near total suppression of REM sleep, a decrease in total sleep time, and an increase in the percent...

journal_title：Psychopharmacology

authors： Cohen RM,Pickar D,Garnett D,Lipper S,Gillin JC,Murphy DL

更新日期：1982-01-01 00:00:00

abstract：:The current study examined whether stimuli predictive of heroin availability were capable of inducing a relapse of drug-seeking behavior in an operant runway task. Olfactory stimuli (orange and almond food extract) served as discriminative cues about the availability (S+) or unavailability (S-) of heroin reinforcement...

journal_title：Psychopharmacology

authors： McFarland K,Ettenberg A

更新日期：1997-05-01 00:00:00

abstract：RATIONALE:Consumption of alcohol begins during late adolescence in a majority of humans, and the greatest drinking occurs at 18-25 years then decreases with age. OBJECTIVES:The present study measured the differences in ethanol intake in relation to age at the onset of ethanol access among nonhuman primates to control ...

journal_title：Psychopharmacology

authors： Helms CM,Rau A,Shaw J,Stull C,Gonzales SW,Grant KA

更新日期：2014-04-01 00:00:00

abstract：RATIONALE:Neuromedin-U (NmU) is an agonist at NMU1R and NMU2R. The brain distribution of NmU and its receptors, in particular NMU2R, suggests widespread central roles for NmU. In agreement, centrally administered NmU affects feeding behaviour, energy expenditure and pituitary output. Further central nervous system (CNS...

journal_title：Psychopharmacology

authors： Gartlon J,Szekeres P,Pullen M,Sarau HM,Aiyar N,Shabon U,Michalovich D,Steplewski K,Ellis C,Elshourbagy N,Duxon M,Ashmeade TE,Harrison DC,Murdock P,Wilson S,Ennaceur A,Atkins A,Heidbreder C,Hagan JJ,Hunter AJ,Jones

更新日期：2004-12-01 00:00:00

abstract：:Dopamine (DA), injected unilaterally into rat forebrain after pretreatment with a monoamine oxidase inhibitor, equipotently induced locomotor arousal when placed in the nucleus accumbens septi (a limbic site) and contralateral deviation of the head when placed in the corpus striatum (an extrapyramidal target); testing...

journal_title：Psychopharmacology

authors： Campbell A,Yeghiayan S,Baldessarini RJ,Neumeyer JL

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:Pairing rewarding outcomes with audiovisual cues in simulated gambling games increases risky choice in both humans and rats. However, the cognitive mechanism through which this sensory enhancement biases decision-making is unknown. OBJECTIVES:To assess the computational mechanisms that promote risky choice d...

journal_title：Psychopharmacology

authors： Langdon AJ,Hathaway BA,Zorowitz S,Harris CBW,Winstanley CA

更新日期：2019-08-01 00:00:00

abstract：:Intact male and ovariectomized female rats were trained to lever press under a random ratio (RR) schedule of food reinforcement. Effects of different doses of pentobarbital (1-16 mg/kg) and progesterone (10-80 mg/kg) on response output were studied. Low doses of pentobarbital increased responding, high doses decreased...

journal_title：Psychopharmacology

authors： Heinsbroek RP,van Haaren F,Zantvoord F,van de Poll NE

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:We test methods to advance (shift earlier) circadian rhythms without producing misalignment between rhythms and sleep. We previously tested (1) a gradually advancing sleep/dark schedule plus morning bright light and afternoon/evening melatonin and (2) the same sleep schedule with only morning bright light. No...

journal_title：Psychopharmacology

authors： Crowley SJ,Eastman CI

更新日期：2013-02-01 00:00:00

abstract：:Pigeons trained to discriminate between the presence and absence of delta 9-THC (0.56 mg/kg, IM, intramuscularly) were tested with diazepam (5.6-30 mg/kg), administered IG (intragastrically), and were found to generalize the response associated with the THC training to the diazepam treatment only to a limited extent. ...

journal_title：Psychopharmacology

authors： Järbe TU,Hiltunen AJ

更新日期：1988-01-01 00:00:00

abstract：:Experiments were carried out using rats to investigate whether 5-HT1A neural mechanisms are involved in lithium-induced conditioned taste aversion (CTA). We found that the 5-HT1A antagonists p-MPPI and pindolol caused CTA similar to that produced by LiCl. The 5-HT1A agonist 8-OH-DPAT counteracted lithium-induced CTA. ...

journal_title：Psychopharmacology

authors： Wegener G,Smith DF,Rosenberg R

更新日期：1997-09-01 00:00:00

abstract：:A continuing challenge for preclinical research on anxiolytic drugs is to capture the affective dimension that characterizes anxiety and aggression, either in their adaptive forms or when they become of clinical concern. Experimental protocols for the preclinical study of anxiolytic drugs typically involve the suppres...

journal_title：Psychopharmacology

authors： Miczek KA,Weerts EM,Vivian JA,Barros HM

更新日期：1995-09-01 00:00:00

abstract：RATIONALE:Serotonin and especially serotonin 2A (5-HT(2A)) receptor signaling are important in the etiology and treatment of schizophrenia and affective disorders. We previously reported a novel 5-HT(2A) receptor effector, increased transglutaminase (TGase)-catalyzed transamidation, and activation of the small G protei...

journal_title：Psychopharmacology

authors： Dai Y,Dudek NL,Li Q,Muma NA

更新日期：2011-02-01 00:00:00

abstract：INTRODUCTION:The present study was designed to investigate the rewarding effects induced by tramadol and its active metabolite O-desmethyltramadol (M1) under a neuropathic pain-like state. RESULTS:In opioid receptor binding and G protein activation, we confirmed that M1, but not tramadol, showed mu-opioid receptor (MO...

journal_title：Psychopharmacology

authors： Nakamura A,Narita M,Miyoshi K,Shindo K,Okutsu D,Suzuki M,Higashiyama K,Suzuki T

更新日期：2008-10-01 00:00:00

abstract：:The effects of the antiepilepsy drugs methsuximide and mephenytoin were examined in pigeons responding under a fixed-consecutive-number (FCN) schedule with and without an added external discriminative stimulus. On this schedule, food was delivered whenever subjects responded between 8 and 12 times on one response key ...

journal_title：Psychopharmacology

authors： Schlinger H,Wilkenfield J,Poling A

更新日期：1988-01-01 00:00:00

abstract：:Continuous low-level (0.825 mg/kg/h for 20 h) administration of AP through SC in-dwelling silicone reservoirs in the rat induced behavioral and biochemical changes that were similar to those induced by low levels (0.1 mg/kg) of acutely administered AP (decreased behavioral activity and decreased dopamine metabolism in...

journal_title：Psychopharmacology

authors： Davis RE,Sant WW,Ellison G

更新日期：1985-01-01 00:00:00

abstract：:Chronic treatment of rats with choline caused a decrease in the hypothermic response to pilocarpine. The action of choline on the muscarinic receptors is consistent with electrophysiological and binding studies, supporting a direct muscarinic action for choline. Administration of direct muscarinic agonists has been sh...

journal_title：Psychopharmacology

authors： Pomara N,Block R,Demetriou S,Fucek F,Stanley M,Gershon S

更新日期：1983-01-01 00:00:00

abstract：:Chronic tolerance to ethanol-induced sleep, motor impairment (moving belt test), and hypothermia were examined in two lines of rats that had been selectively bred for their different initial sensitivities to ethanol. In agreement with previous work (Mayer et al. 1982, 1983), the least-affected (LA) rats were found to ...

journal_title：Psychopharmacology

authors： Khanna JM,Lê AD,LeBlanc AE,Shah G

更新日期：1985-01-01 00:00:00

abstract：:The effect of diazepam on spatial visualization was studied using a double-blind crossover design. Diazepam 10 mg (or placebo) was given orally to 12 healthy young men at bedtime, followed again by 10 mg (or placebo) the next morning. One hour after the administration of the morning dose, the subjects performed a ment...

journal_title：Psychopharmacology

authors： Taylor J,Hunt E,Coggan P

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:Phytocannabinoids are useful therapeutics for multiple applications including treatments of constipation, malaria, rheumatism, alleviation of intraocular pressure, emesis, anxiety and some neurological and neurodegenerative disorders. Consistent with these medicinal properties, extracted cannabinoids have rec...

journal_title：Psychopharmacology

authors： Deiana S,Watanabe A,Yamasaki Y,Amada N,Arthur M,Fleming S,Woodcock H,Dorward P,Pigliacampo B,Close S,Platt B,Riedel G

更新日期：2012-02-01 00:00:00

abstract：:The effects of naloxone, metenkephalin, and morphine were tested on phencyclidine(PCP)-induced stereotyped behaviors, ataxia, and hyperactivity in the rat. Naloxone (8 mg/kg) significantly decreased stereotypy, ataxia, and hyperactivity across all PCP doses tested (2.0, 4.0, and 6.0 mg/kg). Metenkephalin (40 microgram...

journal_title：Psychopharmacology

authors： Castellani S,Giannini AJ,Adams PM

更新日期：1982-01-01 00:00:00

abstract：:We examined whether any locus postsynaptic to the GABAergic striatonigral projection might be involved in the enhancement of behavioral response to dopaminergic stimulants induced by chronic treatment with either neuroleptic drugs or stimulants. Rats exposed chronically to either chlorpromazine or cocaine were tested ...

journal_title：Psychopharmacology

authors： Bachus SE,Gale K

更新日期：1988-01-01 00:00:00

abstract：:The relationship between premenstrual dysphoria and alcohol acquistion and use patterns was studied in 14 women over 35 days on a clinical research ward. A 7-day drug-free baseline was followed by 21 days of alcohol availability and a post-alcohol drug-free period of 7 days. Women could earn alcohol or 50 cents for 30...

journal_title：Psychopharmacology

authors： Mello NK,Mendelson JH,Lex BW

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Synthetic psychostimulant abuse, including cathinone-derived 3,4-methylenedioxypyrovalerone (MDPV), continues to increase in many countries. Similar to cocaine but with greater potency, MDPV elicits a transient sympathomimetic response by blocking cellular uptake of dopamine (DA) and norepinephrine (NE)-admin...

journal_title：Psychopharmacology

authors： Simmons SJ,Martorana R,Philogene-Khalid H,Tran FH,Gentile TA,Xu X,Su S,Rawls SM,Muschamp JW

更新日期：2017-11-01 00:00:00

abstract：:Abnormal beta-adrenergic receptor (betaAR) density in the brains of suicide victims has been reported, although results of studies are inconsistent. Ethanol modifies betaAR-mediated signal transduction. Moreover abnormal betaAR function has been implicated in alcoholism. BetaAR antagonists, which were used as ligands ...

journal_title：Psychopharmacology

authors： Gurguis GN,Turkka J,Laruelle M,Kleinman J,Linnoila M

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVES:In recent years, there has been growing research interest in using nicotine replacement medications to aid smoking reduction prior to a quit attempt. Gaining a better understanding of how treatments influence smoking reduction may allow for better tailoring of treatments and, ultimately, better cessation out...

journal_title：Psychopharmacology

authors： Lu W,Chappell K,Walters JAE,Jacobson GA,Patel R,Schüz N,Ferguson SG

更新日期：2017-07-01 00:00:00

abstract：:NCQ 298 ((S)-3-iodo-N-[(l-ethyl-2-pyrrolidinyl)methyl]-5,6- dimethoxysalicylamide) has an iodine substituent. We have labelled NCQ 298 with 123I and 125I, and used the radioligands as tracers in receptor studies in vitro, in vivo in autoradiography and in SPECT studies on Cynomolgus monkeys. [125I]NCQ 298 bound in vit...

journal_title：Psychopharmacology

authors： Hall H,Högberg T,Halldin C,Köhler C,Ström P,Ross SB,Larsson SA,Farde L

更新日期：1991-01-01 00:00:00