当前位置： SCI文献检索 > PSYCHOPHARMACOLOGY期刊下所有文献 > Continuous low-level apomorphine administration induces motor abnormalities and hallucinogen-like behaviors.

Continuous low-level apomorphine administration induces motor abnormalities and hallucinogen-like behaviors.

Abstract：

:Continuous low-level (0.825 mg/kg/h for 20 h) administration of AP through SC in-dwelling silicone reservoirs in the rat induced behavioral and biochemical changes that were similar to those induced by low levels (0.1 mg/kg) of acutely administered AP (decreased behavioral activity and decreased dopamine metabolism in the striatum). With longer periods of continuous AP exposure (40 h or more) the activity-depressing effects of low-level AP diminished. Concurrently a novel behavioral syndrome emerged characterized by limb flicks, body shakes, sudden orienting responses, and motor abnormalities, such as tremors of the jaw muscles, chewing movements, prominent tongue extensions, and body 'tics'. This behavioral syndrome became more apparent following cessation of drug treatment. These novel behavioral changes, which were accompanied by increased behavioral responsiveness to acutely administered AP and amphetamine, were correlated with increased levels of dopamine, homovanillic acid, and 3,4-dihydroxyphenylacetic acid in the striatum but not the nucleus accumbens. This novel behavioral syndrome appears to reflect a rebound increase in dopaminergic mechanisms in striatum following their chronic suppression by low levels of AP.

journal_name

Psychopharmacology (Berl)

journal_title

Psychopharmacology

authors

Davis RE,Sant WW,Ellison G

doi

10.1007/BF00427314

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

1-7

issue

1

eissn

0033-3158

issn

1432-2072

journal_volume

85

pub_type

杂志文章

相关文献

PSYCHOPHARMACOLOGY文献大全
  • Prospective memory impairment in "ecstasy" (MDMA) users.

    abstract：RATIONALE:Considerable research indicates that "ecstasy" users perceive their memory for future intentions (prospective memory) to be impaired. However, only one empirical study to date has directly tested how this capacity is affected by ecstasy use, and this study provided relatively limited information regarding the...

    journal_title：Psychopharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00213-007-0859-z

    authors： Rendell PG,Gray TJ,Henry JD,Tolan A

    更新日期：2007-11-01 00:00:00

  • The interaction between hippocampal GABA-B and cannabinoid receptors upon spatial change and object novelty discrimination memory function.

    abstract：RATIONALE:Previous studies have postulated functional links between GABA and cannabinoid systems in the hippocampus. The aim of the present study was to investigate any possible interaction between these systems in spatial change and object novelty discrimination memory consolidation in the dorsal hippocampus (CA1 regi...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-017-4688-4

    authors： Nasehi M,Alaghmandan-Motlagh N,Ebrahimi-Ghiri M,Nami M,Zarrindast MR

    更新日期：2017-10-01 00:00:00

  • Pressure-sensitive and -insensitive coupling in gamma-aminobutyric acid(A) receptors.

    abstract：RATIONALE:Previous behavioral and biochemical studies suggest that allosteric coupling processes initiated by benzodiazepines, barbiturates and neuroactive steroids can be sub-categorized on the basis of their sensitivities to antagonism by increased atmospheric pressure. However, biochemical evidence supporting this h...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s002130100825

    authors： Davies DL,McCauley LD,Bolger MB,Alkana RL

    更新日期：2001-10-01 00:00:00

  • Beta-2 adrenergic receptors mediate stress-evoked reinstatement of cocaine-induced conditioned place preference and increases in CRF mRNA in the bed nucleus of the stria terminalis in mice.

    abstract：RATIONALE:Understanding the mechanisms responsible for stress-induced relapse is important for guiding treatment strategies aimed at minimizing the contribution of stress to addiction. Evidence suggests that these mechanisms involve interactions between noradrenergic systems and the neuropeptide corticotropin-releasing...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-014-3535-0

    authors： McReynolds JR,Vranjkovic O,Thao M,Baker DA,Makky K,Lim Y,Mantsch JR

    更新日期：2014-10-01 00:00:00

  • Attentional capture by alcohol-related stimuli may be activated involuntarily by top-down search goals.

    abstract：:Previous research has found that the attention of social drinkers is preferentially oriented towards alcohol-related stimuli (attentional capture). This is argued to play a role in escalating craving for alcohol that can result in hazardous drinking. According to incentive theories of drug addiction, the stimuli assoc...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-018-4906-8

    authors： Brown CRH,Duka T,Forster S

    更新日期：2018-07-01 00:00:00

  • Nucleus accumbens dopamine increases sexual motivation in sexually satiated male rats.

    abstract：RATIONALE:The influence of the main dopaminergic brain regions controlling copulation, the medial preoptic area (mPOA) and the nucleus accumbens (NAcc), on male rat sexual behavior expression has not been fully established. OBJECTIVE:This work analyzes the sexual effects of dopamine (DA) receptor activation in the mPO...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-018-5142-y

    authors： Guadarrama-Bazante IL,Rodríguez-Manzo G

    更新日期：2019-04-01 00:00:00

  • Pentagastrin has panic-inducing properties in obsessive compulsive disorder.

    abstract：:The effects of the CCKB-receptor agonist pentagastrin, a synthetic analogue of the cholecystokinin tetrapeptide (CCK-4), were studied in seven patients suffering from obsessive compulsive disorder (OCD) and seven healthy controls. All subjects were challenged with an IV dose of 0.6 micrograms/kg pentagastrin or placeb...

    journal_title：Psychopharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF02247385

    authors： de Leeuw AS,Den Boer JA,Slaap BR,Westenberg HG

    更新日期：1996-08-01 00:00:00

  • 'Waiting impulsivity' in isolation-reared and socially-reared rats: effects of amphetamine.

    abstract：BACKGROUND:Rats reared in social isolation exhibit various cognitive and behavioural abnormalities in adulthood. However, impulsivity following this treatment still remains unclear, especially in response to medications used in attention deficit hyperactivity disorder, such as amphetamine. METHODS:Using an isolation-r...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-017-4579-8

    authors： Liu YP,Wilkinson LS,Robbins TW

    更新日期：2017-05-01 00:00:00

  • Alterations in behavioral flexibility by cannabinoid CB1 receptor agonists and antagonists.

    abstract：RATIONALE:Cannabinoid CB1 receptors are expressed in the prefrontal cortex, but their role in mediating executive functions such as behavioral flexibility is unclear. OBJECTIVE:The present study examined the effect of pharmacological activation or blockade of the cannabinoid CB1 receptors on behavioral flexibility usi...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-006-0421-4

    authors： Hill MN,Froese LM,Morrish AC,Sun JC,Floresco SB

    更新日期：2006-08-01 00:00:00

  • Contribution of the prefrontal cortex and basolateral amygdala to behavioral decision-making under reward/punishment conflict.

    abstract：RATIONALE:Control of reward-seeking behavior under conditions of punishment is an important function for survival. OBJECTIVES AND METHODS:We designed a task in which rats could choose to either press a lever and obtain a food pellet accompanied by a footshock or refrain from pressing the lever to avoid footshock, in r...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-019-05398-7

    authors： Ishikawa J,Sakurai Y,Ishikawa A,Mitsushima D

    更新日期：2020-03-01 00:00:00

  • Studies on the interactions of copper and cannabis.

    abstract：:The action of copper (CuSO4, 5 mg/kg, oral) on selected neuropharmacological actions of cannabis resin (CI, oral) was studied on albino rats and mice. Copper potentiated the barbiturate hypnosis-potentiating activity of CI in albino rats and mice and had no effect on hypothermic activity in albino rats. Single doses o...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00432855

    authors： Singh PP,Das PK

    更新日期：1978-04-11 00:00:00

  • Sources of variation in locomotor activity and stereotypy in rats treated with d-amphetamine.

    abstract：:Rats injected with doses of d-amphetamine 0--5.0 mg/kg were observed continuously in either an enclosed Y-maze or on an elevated Y-shaped platform. Patterns of increased walking and stereotypy were unaffected by the type of apparatus, but rearing remained totally suppressed at all dose levels on the elevated platform....

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00431954

    authors： Mumford L,Teixeira AR,Kumar R

    更新日期：1979-04-25 00:00:00

  • Serotonin uptake by blood platelets of acute schizophrenic patients.

    abstract：:Active uptake of serotonin by blood platelets of acute schizophrenic patients has been compared to that of a control group. Preliminary results presented in this article indicate that the uptake of the schizophrenic patients was about 40% lower than that of controls. Patients were followed over a period of 5 weeks wit...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00496061

    authors： Modai I,Rotman A,Munitz H,Tjano S,Wijsenbeek H

    更新日期：1979-08-08 00:00:00

  • Clozapine and olanzapine, but not haloperidol, reverse cold-induced and lipopolysaccharide-induced cutaneous vasoconstriction.

    abstract：RATIONALE:Reduction of body temperature is used as predictor of psychotropic drug action. The cutaneous circulation functions as a heat-loss component of temperature regulation. Clozapine and olanzapine reverse hyperthermia and sympathetically-mediated cutaneous vasoconstriction induced by MDMA (3,4-methylenedioxymetha...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-004-1850-6

    authors： Blessing WW

    更新日期：2004-10-01 00:00:00

  • Effects of haloperidol in a response-reinstatement model of heroin relapse.

    abstract：:The present study employed an animal model of drug relapse in which previously extinguished heroin self-administration behavior was reinstated following a single reinforced trial. Male albino rats were trained to traverse a straight-alley for a reinforcer consisting of a single IV injection of 0.06 mg/kg diacetylmorph...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF02246658

    authors： Ettenberg A,MacConell LA,Geist TD

    更新日期：1996-04-01 00:00:00

  • Evidence of a role for the 5-HTTLPR genotype in the modulation of motor response to antidepressant treatment.

    abstract：RATIONALE:Serotonergic mechanisms are thought to play an important role in the regulation of mood, motor activity and sleep patterns. Serotonin reuptake is controlled by the serotonin transporter (5-HTT) and by a common functional insertion/deletion polymorphism in the corresponding gene's promoter region (5-HTTLPR). H...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-004-1995-3

    authors： Putzhammer A,Schoeler A,Rohrmeier T,Sand P,Hajak G,Eichhammer P

    更新日期：2005-03-01 00:00:00

  • Chronic treatment with a selective inhibitor of casein kinase I delta/epsilon yields cumulative phase delays in circadian rhythms.

    abstract：INTRODUCTION:Casein kinase I epsilon/delta phosphorylates certain clock-related proteins as part of a complex arrangement of transcriptional/translational feedback loops that comprise the circadian oscillator in mammals. Pharmacologic inhibition leads to a delay of the oscillations with the magnitude of this effect dep...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-010-1860-5

    authors： Sprouse J,Reynolds L,Kleiman R,Tate B,Swanson TA,Pickard GE

    更新日期：2010-07-01 00:00:00

  • Alcohol use and premenstrual symptoms in social drinkers.

    abstract：:The relationship between premenstrual dysphoria and alcohol acquistion and use patterns was studied in 14 women over 35 days on a clinical research ward. A 7-day drug-free baseline was followed by 21 days of alcohol availability and a post-alcohol drug-free period of 7 days. Women could earn alcohol or 50 cents for 30...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF02244221

    authors： Mello NK,Mendelson JH,Lex BW

    更新日期：1990-01-01 00:00:00

  • Serotonin-induced platelet intracellular calcium mobilization in depressed patients.

    abstract：:Serotonin(5-HT)-stimulated intracellular calcium(Ca) mobilization was measured in the platelets of depressed patients to assess 5-HT2 receptor function. The 5-HT-induced Ca response was significantly higher in unmedicated patients with bipolar depression and melancholic major depression than in those with non-melancho...

    journal_title：Psychopharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF02245204

    authors： Kusumi I,Koyama T,Yamashita I

    更新日期：1994-01-01 00:00:00

  • Symmetrical effects of amphetamine and alpha-flupenthixol on conditioned punishment and conditioned reinforcement: contrasts with midazolam.

    abstract：:In a test of conditioned punishment, saline-treated controls showed a moderate bias in responding away from a lever producing a response-contingent auditory conditioned stimulus (CS) that had been paired with mild footshock during training and towards a lever producing a neutral auditory CS. Systemic treatment with th...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s002130050174

    authors： Killcross AS,Everitt BJ,Robins TW

    更新日期：1997-01-01 00:00:00

  • Role of nucleus accumbens μ opioid receptors in the effects of morphine on ERK1/2 phosphorylation.

    abstract：RATIONALE:Despite the critical role attributed to phosphorylated extracellular signal regulated kinase (pERK1/2) in the nucleus accumbens (Acb) in the actions of addictive drugs, the effects of morphine on ERK1/2 phosphorylation in this area are still controversial. OBJECTIVES:In order to investigate further this issu...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-016-4340-8

    authors： Rosas M,Porru S,Fenu S,Ruiu S,Peana AT,Papale A,Brambilla R,Di Chiara G,Acquas E

    更新日期：2016-08-01 00:00:00

  • Higher serotonin transporter occupancy after multiple dose administration of escitalopram compared to citalopram: an [123I]ADAM SPECT study.

    abstract：OBJECTIVES:Previous studies have investigated the occupancy of the serotonin reuptake transporter (SERT) after clinical doses of citalopram and other selective serotonin reuptake inhibitors. In the present study, the occupancies of SERT after multiple doses of escitalopram and citalopram were compared using the radioli...

    journal_title：Psychopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00213-006-0666-y

    authors： Klein N,Sacher J,Geiss-Granadia T,Mossaheb N,Attarbaschi T,Lanzenberger R,Spindelegger C,Holik A,Asenbaum S,Dudczak R,Tauscher J,Kasper S

    更新日期：2007-04-01 00:00:00

  • Post-extinction fluoxetine treatment prevents stress-induced reemergence of extinguished fear.

    abstract：RATIONALE:The post-extinction exposure of rats to a sub-conditioning procedure (SCP; i.e., retraining with a shock intensity that is too weak to induce by itself significant fear conditioning) has been reported to provoke the reemergence of extinguished fear. This phenomenon can be prevented by chronic fluoxetine treat...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-012-2806-x

    authors： Deschaux O,Zheng X,Lavigne J,Nachon O,Cleren C,Moreau JL,Garcia R

    更新日期：2013-01-01 00:00:00

  • Effect of lithium carbonate on memory processes of bipolar affectively ill patients.

    abstract：:The effect of long-term lithium carbonate treatment on parameters of immediate, short-, and long-term memory was examined in a group of bipolar affectively ill patients. The lithium treatment group recalled significantly fewer words across trials on a verbal learning task than a group of bipolar affectively ill patien...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00426919

    authors： Reus VI,Targum SD,Weingartner H,Post RM

    更新日期：1979-05-08 00:00:00

  • Characterisation of olanzapine-induced weight gain and effect of aripiprazole vs olanzapine on body weight and prolactin secretion in female rats.

    abstract：RATIONALE:Atypical antipsychotic drug (APD)-induced weight gain causes non-compliance, increasing the risk of relapse and medical complications. OBJECTIVES:In an animal model, we assessed body weights, food intake, body fat/lean body mass contents and blood serum levels of glucose and lipids in female rats treated wit...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-005-0081-9

    authors： Kalinichev M,Rourke C,Daniels AJ,Grizzle MK,Britt CS,Ignar DM,Jones DN

    更新日期：2005-10-01 00:00:00

  • On the selectivity and specificity of the antagonism of apomorphine-induced suppression of exploration by sulpiride.

    abstract：:Ten behavioural variables were recorded by means of an automatic holeboard apparatus. The behaviour of rats placed for the first time in the apparatus was recorded for 10 min. The suppression of this exploratory behaviour by the dopamine agonist apomorphine (0.01-0.1 mg/kg) was shown to be reversible in a surmountable...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00634456

    authors： Ståhle L,Ungerstedt U

    更新日期：1989-01-01 00:00:00

  • Evidence that d-fenfluramine anorexia is mediated by 5-HT1 receptors.

    abstract：:The effects of eight serotonin (5-HT) receptor antagonists on the anorectic effect of d-fenfluramine (3.0 mg/kg, IP) were examined in a test of sweet mash consumption, using non-deprived male rats. d-Fenfluramine's effect was attenuated by the mixed 5-HT1/5-HT2 receptor antagonists, methiothepin and metergoline; by th...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00442252

    authors： Neill JC,Cooper SJ

    更新日期：1989-01-01 00:00:00

  • The influence of amphetamine on language activation: an fMRI study.

    abstract：RATIONALE:Amphetamine administration has been found to affect the degree of cerebral dominance for motor control in animals. In humans, cerebral dopamine neurotransmission is also correlated to motor dominance. Since language dominance is related to motor dominance, amphetamine might also affect cerebral dominance for ...

    journal_title：Psychopharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00213-005-0176-3

    authors： Sommer IE,Oranje B,Ramsey NF,Klerk FA,Mandl RC,Westenberg HG,Kahn RS

    更新日期：2006-01-01 00:00:00

  • Lack of consistent sex differences in D-amphetamine-induced dopamine release measured with [18F]fallypride PET.

    abstract：RATIONALE:Sex differences in the dopaminergic response to psychostimulants could have implications for drug abuse risk and other psychopathology involving the dopamine system, but human data are limited and mixed. OBJECTIVES:Here, we sought to investigate sex differences in dopamine release after oral D-amphetamine ad...

    journal_title：Psychopharmacology

    pub_type： 杂志文章

    doi：10.1007/s00213-018-5083-5

    authors： Smith CT,Dang LC,Burgess LL,Perkins SF,San Juan MD,Smith DK,Cowan RL,Le NT,Kessler RM,Samanez-Larkin GR,Zald DH

    更新日期：2019-02-01 00:00:00

  • Platelet MAO activity and the 5-HTT gene promoter polymorphism are associated with impulsivity and cognitive style in visual information processing.

    abstract：RATIONALE:Low capacity of the central serotonergic system has been associated with impulsive behaviour. Both low platelet monoamine oxidase (MAO) activity and the short (S) allele of the serotonin transporter gene promoter region polymorphism (5-HTTLPR) are proposed to be markers of less efficient serotonergic function...

    journal_title：Psychopharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00213-007-0867-z

    authors： Paaver M,Nordquist N,Parik J,Harro M,Oreland L,Harro J

    更新日期：2007-11-01 00:00:00