Abstract:
RATIONALE:Whilst the deleterious effects of alcohol on retrospective remembering have been widely documented, no study has yet objectively determined alcohol's effects on prospective memory (PM)--remembering to do something in the future. OBJECTIVES:With this aim, the present study determined the acute effects of alcohol upon PM using a laboratory measure that simulates the PM tasks in everyday life--'Virtual Week'--both (a) in its standard form with regular, irregular, event-based and time-based PM tasks; and (b) an adapted version which enabled exploration of how future event simulation at encoding impacted upon subsequent PM. METHODS:Forty healthy volunteers were administered 0.6 g/kg ethanol or a matched placebo in a double-blind fashion and completed the two versions of Virtual Week along with prose recall (to tap retrospective memory) and an executive function task. RESULTS:Alcohol acutely produced global impairments across all (regular, irregular, event-based and time-based) PM tasks. It also produced impairments of episodic memory which positively correlated with PM performance of irregular tasks. Future-event simulation tended to enhance PM in the placebo but not in the alcohol group. CONCLUSIONS:These findings on an objective measure of PM suggest that 4-5 units of alcohol will compromise PM abilities in everyday life.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Leitz JR,Morgan CJ,Bisby JA,Rendell PG,Curran HVdoi
10.1007/s00213-009-1546-zsubject
Has Abstractpub_date
2009-08-01 00:00:00pages
379-87issue
3eissn
0033-3158issn
1432-2072journal_volume
205pub_type
杂志文章,随机对照试验abstract::The ventral tegmental area (VTA) evaluates salience of environmental stimuli and provides dopaminergic innervation to many brain areas affected by acute and chronic ethanol exposure. While primarily associated with rewarding and reinforcing stimuli, recent evidence indicates a role for the VTA in aversion as well. Eth...
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