Abstract:
:Chronic treatment of rats with choline caused a decrease in the hypothermic response to pilocarpine. The action of choline on the muscarinic receptors is consistent with electrophysiological and binding studies, supporting a direct muscarinic action for choline. Administration of direct muscarinic agonists has been shown to cause a decrease in the number of muscarinic receptors. Thus, the long-term use of cholinergic precursors could have some adverse effects on central cholinergic functioning.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Pomara N,Block R,Demetriou S,Fucek F,Stanley M,Gershon Sdoi
10.1007/BF00427955subject
Has Abstractpub_date
1983-01-01 00:00:00pages
129-30issue
2eissn
0033-3158issn
1432-2072journal_volume
80pub_type
杂志文章abstract:RATIONALE:Dopamine (DA) D2-like antagonists block several effects of cocaine, including its locomotor stimulant and interoceptive discriminative-stimulus effects. Because these compounds generally lack selectivity among the D2-like DA receptors, the specific roles of the subtypes remain unclear. OBJECTIVES:DA D2 recep...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1142-y
更新日期:2002-08-01 00:00:00
abstract::The anxiolytic activity of diazepam (DZP) (0.25-1 mg/kg) was investigated in streptozotocin (STZ)-induced diabetic adult Charles Foster albino rats of either sex. Diabetes was induced by injecting STZ IP (50 mg/kg; in citrate buffer, pH 4.5). Experiments were performed 72 h later. The rats were subjected to various an...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050523
更新日期:1998-02-01 00:00:00
abstract::The topography of stereotyped behaviour produced by apomorphine in rats was studied by using either a scoring system, based on observation in a wire cage, or by quantification of horizontal and vertical activities, and of the total distances run in an open field, using an automatic recording system. The latter design ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00172869
更新日期:1986-01-01 00:00:00
abstract::This study demonstrates that the selective delta receptor antagonists ICI 174864 and naltrindole (NTI) attenuate alcohol intake in a dose-dependent manner, without altering water intake, in rats selectively bred for alcohol preference. ICI 174864 had a very limited duration of action, as evidenced by the fact that sup...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246191
更新日期:1995-07-01 00:00:00
abstract::Haloperidol has recently been found to be metabolized to its pyridinium ion (HP+). This conversion of haloperidol to HP+ appears to be similar to the activation of the dopaminergic neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to N-methyl-4-phenyl pyridinium ion (MPP+). MPP+ is responsible for the dam...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246077
更新日期:1995-10-01 00:00:00
abstract:INTRODUCTION:Alcohol has been shown to increase smoking urges and smoking behavior. However, alcohol's effects on specific components of smoking behavior for nicotine versus non-nicotine factors and potential sex differences in this response have not been investigated. METHODS:Forty-two young male and female non-depen...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-009-1638-9
更新日期:2009-11-01 00:00:00
abstract:RATIONALE:Concurrent abuse of cocaine and heroin is a common form of polydrug abuse, but the interactions between the reinforcing effects of cocaine and heroin are poorly understood. Dose-addition analysis is a tool for the quantitative assessment of drug interactions, but this analysis has not been applied to evaluati...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-2133-y
更新日期:2005-06-01 00:00:00
abstract:INTRODUCTION:The objective of this study was to examine age-, hormone-, and sex-dependent differences to the behavioral effects of nicotine using place-conditioning procedures in female rats. METHODS:Animals received nicotine in their initially non-preferred side and saline on alternate days in their initially preferr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1607-3
更新日期:2009-10-01 00:00:00
abstract:INTRODUCTION:The majority of individuals who suffer an episode of depression go on to experience recurrences. We have proposed, based upon the observation that reducing serotonin via acute tryptophan depletion (ATD) is more likely to induce negative mood in recovered depressed individuals than never depressed individua...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-009-1533-4
更新日期:2009-08-01 00:00:00
abstract:RATIONALE:We recently reported that simultaneous exposure to amphetamine and various stressors resulted in reduced hypothalamic-pituitary-adrenal (HPA) and glycemic responses to the stressors. Since this is a new and relevant phenomenon, we wanted to further explore this interaction. OBJECTIVES:This study aims (i) to ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4675-9
更新日期:2017-10-01 00:00:00
abstract:RATIONALE:Neuropeptide Y (NPY) is implicated in the pathophysiology of affective illness. Multiple receptor subtypes (Y1R, Y2R, and Y5R) have been suggested to contribute to NPY's effects on rodent anxiety and depression-related behaviors. OBJECTIVES:To further elucidate the role of Y1R in (1) NPY's anxiolytic-like ef...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-007-0945-2
更新日期:2008-01-01 00:00:00
abstract::Previous research has found that the attention of social drinkers is preferentially oriented towards alcohol-related stimuli (attentional capture). This is argued to play a role in escalating craving for alcohol that can result in hazardous drinking. According to incentive theories of drug addiction, the stimuli assoc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-4906-8
更新日期:2018-07-01 00:00:00
abstract:RATIONALE:Buprenorphine is a partial mu opioid agonist under development as a sublingual (SL) medication for opioid dependence treatment in the United States. Because buprenorphine may be abused, tablets combining buprenorphine with naloxone in a 4:1 ratio have been developed to reduce that risk. Low doses of injected ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130000637
更新日期:2001-03-01 00:00:00
abstract:RATIONALE:Hypersignaling of corticotropin releasing factor (CRF) has been implicated in stress disorders; however, many of its downstream mechanisms of action remain unclear. In vitro, CRF1 receptor activation initiates multiple cell signaling cascades, including protein kinase A (PKA), protein kinase C (PKC), and mito...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3114-9
更新日期:2013-10-01 00:00:00
abstract:RATIONALE:The C57BL/6 is one of the most widely used mouse strains in behavioral, pharmacological, and genetic research but little is known about their response on tests for antidepressant drugs. OBJECTIVES:The behavior of C57BL/6 mice, and mice from other strains, was examined in the tail suspension test (TST), a com...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100687
更新日期:2001-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVE:Drug-associated memories are hypothesized to underlie the high risk of relapse in addiction. Recent studies show that post-retrieval extinction training erases fear memories by reconsolidation blockade. Here, we examine the efficacy of this non-invasive procedure in rats with drug-associated mem...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2545-4
更新日期:2012-05-01 00:00:00
abstract:RATIONALE:Initial sensitivity to drugs of abuse often predicts subsequent use and abuse, but this relationship is not always observed in human studies. Moreover, studies examining the relationship between initial locomotor sensitivity and the rewarding and reinforcing effects of drugs in animal models have also been eq...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-4834-7
更新日期:2018-04-01 00:00:00
abstract:RATIONALE:3,4-Methylenedioxymethamphetamine (MDMA or ecstasy) is a potent and selective serotonin neurotoxin whose use is growing among adolescents. Although cognitive deficits among adult MDMA users are well documented, little is known of the cognitive and brain functional sequelae of MDMA use during adolescence. OBJ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1679-4
更新日期:2004-05-01 00:00:00
abstract::The [14C]-2-deoxyglucose method was used to map the in vivo metabolic response of glucose to savoxepine, a novel tetracyclic cyano-dibenzoxepino-azepine. Savoxepine is reported to have higher affinity for dopamine (DA) receptors in the hippocampus than in the striatum and hence should have dose-dependent, anatomically...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244849
更新日期:1994-03-01 00:00:00
abstract:RATIONALE:Results from clinical studies have shown that topiramate effectively reduces alcohol consumption in a population of heavy-drinking alcohol-dependent humans. OBJECTIVES:We undertook this preclinical study in order to establish topiramate's efficacy in a rodent model and to determine whether topiramate's effic...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1683-4
更新日期:2010-01-01 00:00:00
abstract:RATIONALE:We recently demonstrated that blocking specific nicotinic acetylcholine receptors (nAChRs) abolishes the conditioned reinforcing properties of ethanol-associated cues in rat, suggesting nAChRs as promising pharmacological targets for prevention of cue-induced relapse. OBJECTIVES:The present study investigate...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1957-x
更新日期:2010-10-01 00:00:00
abstract::The effects of the selective 5-HT1A agonists 8-OH-DPAT and flesinoxan and the selective 5-HT2 antagonists ritanserin and ketanserin on immobility time in rats bred for predisposition to catalepsy have been studied. Treatment with 8-OH-DPAT as well as flesinoxan caused a marked dose-dependent decrease in immobility tim...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245460
更新日期:1994-02-01 00:00:00
abstract:RATIONALE:Acute tryptophan depletion (ATD) is a widely used method to study the role of serotonin (5-HT) in affect and cognition. ATD results in a strong but transient decrease in plasma tryptophan and central 5-HT synthesis and availability. Although its use is widespread, the evidence that the numerous functional eff...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-007-0908-7
更新日期:2007-12-01 00:00:00
abstract:RATIONALE:Several halogenated analogs of benztropine (BZT) have previously been characterized as potent DA uptake inhibitors with behavioral profiles that indicate diminished psychomotor stimulant effects relative to cocaine. In a previous study using a fixed-ratio 10 schedule, two chloro-analogs (3'-Cl-BZT and 4'-Cl-B...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000616
更新日期:2001-04-01 00:00:00
abstract::Chronic treatment (2 weeks) with piracetam (500 mg/kg, once daily PO) elevated m-cholinoceptor density in the frontal cortex of aged (18 months) female mice by about 30-40%, but had no effect on m-cholinoceptor density in the frontal cortex of young (4 weeks) mice. The effect of piracetam on m-cholinoceptor density as...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00735884
更新日期:1988-01-01 00:00:00
abstract::The four homoeopathic drugs, Gelsemium, Cannabis Indica, Graphites and Agaricus Muscarius, administered orally in 30th and 200th potencies on white rats, enhanced restraint-induced catalepsy in a similar manner to the two standard drugs pilocarpine and haloperidol (IP injection at 5 mg/kg). All the drugs tested differ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00174371
更新日期:1986-01-01 00:00:00
abstract::Measurements of the amplitude and latency of the P3b component of the event-related potential (ERP), simple reaction time (SRT) and four psychomotor tests (VAS, DSST, DSp and CFF) were made on 12 male subjects (aged 19-24 years) 1.0-1.5 and 4.0-4.5 h after single oral doses of triprolidine (7.5 mg), terfenadine (60 mg...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00451699
更新日期:1989-01-01 00:00:00
abstract:RATIONALE:A substantial body of research suggests that the neuropeptide oxytocin promotes social affiliative behaviors in a wide range of animals including humans. However, its antiaggressive action has not been unequivocally demonstrated in male laboratory rodents. OBJECTIVE:Our primary goal was to examine the putati...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3124-7
更新日期:2013-10-01 00:00:00
abstract::Progabide inhibited male rat sexual behavior at a dose of 200 mg/kg. This dose had only modest effects on ambulatory activity and no effect at all on motor coordination as evaluated by a rotarod test. The GABAA antagonist bicuculline, at a dose of 1 mg/kg, blocked the effects of progabide on sex behavior. In contrast,...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050158
更新日期:1997-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Dopamine (DA) agonists reliably disrupt prepulse inhibition (PPI) of the startle reflex in animals but less so in humans despite cross-species similarities in the neural regulation of PPI. This study examines whether individual variation in baseline PPI may account for the inconsistencies in DA...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-005-0056-x
更新日期:2005-10-01 00:00:00