Effect of selective 5-HT1A agonists and 5-HT2 antagonists on inherited catalepsy in rats.

abstract：RATIONALE:(+)-HA-966, a partial agonist at the glycine/NMDA modulatory site, significantly reduced i.v. cocaine self-administration in a fixed-ratio (FR) schedule. Since this effect was observed studying only one dose of cocaine and considering the characteristic bell-shaped curve generated by cocaine in self-administr...

journal_title：Psychopharmacology

authors： Cervo L,Cocco A,Carnovali F

更新日期：2004-04-01 00:00:00

abstract：:The low rate of success for identifying effective treatments for cognitive dysfunction has prompted recent efforts to improve pharmaceutical discovery and development. In particular, investigators have emphasized improving translation from pre-clinical to clinical research. A specific area of focus has been touchscree...

journal_title：Psychopharmacology

authors： Mohler EG,Ding Z,Rueter LE,Chapin D,Young D,Kozak R

更新日期：2015-11-01 00:00:00

abstract：:Mood disorders, despite the widespread availability of monoamine-based antidepressant treatments, are associated with persistently high rates of disability, together with elevated rates of mortality due to suicide, cardiovascular disease, and other causes. The development of more effective treatments has been hindered...

journal_title：Psychopharmacology

authors： Bhattacharya A,Derecki NC,Lovenberg TW,Drevets WC

更新日期：2016-05-01 00:00:00

abstract：:Carbachol, muscarine, eserine and neostigmine injected into the cerebral ventricles of conscious cats evoked emotional behaviour with aggression, autonomic and motor phenomena as well as clonic-tonic convulsions. The main and the most impressive feature of the gross behavioural effects of intraventricular carbachol, m...

journal_title：Psychopharmacology

authors： Beleslin DB,Samardzić R

更新日期：1979-04-11 00:00:00

abstract：RATIONALE:Many previous studies have reported that alcohol and cannabis produce additive psychomotor effects in acute combination, but few have explicitly tested whether chronic exposure to cannabis, in the absence of acute administration, alters the effects of alcohol on psychomotor performance. OBJECTIVES:To test wh...

journal_title：Psychopharmacology

authors： Wright A,Terry P

更新日期：2002-03-01 00:00:00

abstract：:The ability of mu and kappa opioids to alter the discriminative-stimulus and rate-decreasing effects of the 5-HT1A receptor agonist 8-OH-DPAT was examined in rats trained to discriminate either a low (0.1 mg/kg) or a high (0.3 mg/kg) dose of 8-OH-DPAT from water using a two-lever food-reinforced drug discrimination pr...

journal_title：Psychopharmacology

authors： Morgan D,Picker MJ

更新日期：1995-12-01 00:00:00

abstract：RATIONALE:Selective attention deficit, characterised by the inability to differentiate relevant from irrelevant information, is considered to underlie many cognitive deficits of schizophrenia, and appears to be only marginally responsive to treatment with current antipsychotics. OBJECTIVES:We compared the activity of ...

journal_title：Psychopharmacology

authors： Terranova JP,Chabot C,Barnouin MC,Perrault G,Depoortere R,Griebel G,Scatton B

更新日期：2005-08-01 00:00:00

abstract：RATIONALE:The phenomenon of sensitization has been theoretically implicated in mediating various aspects of drug addiction. Recent dose-response studies demonstrated that pretreatment with the putative antiaddictive agent, ibogaine (IBO), and a synthetic iboga alkaloid congener, 18-methoxycoronaridine (18-MC), increase...

journal_title：Psychopharmacology

authors： Szumlinski KK,Balogun MY,Maisonneuve IM,Glick SD

更新日期：2000-08-01 00:00:00

abstract：:There is an increasing prevalence of smokeless tobacco use. However, very little descriptive information is available on the pattern of use. This study examines topographical features of smokeless tobacco use in a male college-age population (N = 56). Subjects were required to use smokeless tobacco ad lib. for a perio...

journal_title：Psychopharmacology

authors： Hatsukami DK,Keenan RM,Anton DJ

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Elevated whole-blood serotonin (5-HT) is a robust biomarker in ~ 30% of patients with autism spectrum disorders, in which repetitive behavior is a core symptom. Furthermore, elevated whole-blood 5-HT has also been described in patients with pediatric obsessive-compulsive disorder. The 5-HT1B receptor is assoc...

journal_title：Psychopharmacology

authors： O'Reilly KC,Connor M,Pierson J,Shuffrey LC,Blakely RD,Ahmari SE,Veenstra-VanderWeele J

更新日期：2021-01-29 00:00:00

abstract：:First, it was confirmed that systemic injection of the neurotoxin 6-hydroxydopamine HBr (30 mg/kg IP) depleted noradrenaline levels in rat heart, but not centrally. Losses averaged 90% of control 1 day after injection, and 50% at 42 days. The same drug and dose was then administered to 50% of a group of rats which had...

journal_title：Psychopharmacology

authors： Salmon P,Stanford C,Gray JA

更新日期：1985-01-01 00:00:00

abstract：RATIONALE:Consistent sex differences are observed in human drug addiction, with females often exceeding males on drug intake. However, there is still a need for animal models for some aspects of addiction such as acquisition of drug self-administration and the subsequent development of drug-seeking. OBJECTIVES:The pre...

journal_title：Psychopharmacology

authors： Swalve N,Smethells JR,Carroll ME

更新日期：2016-03-01 00:00:00

abstract：RATIONALE:Little is known about patterns of opiate use by heroin addicts. OBJECTIVES:To describe opiate use over time among heroin addicts who had access to legally prescribed intravenous heroin and oral opiates. METHODS:Analysis of daily drug administration records of 37 patients enrolled in the Geneva heroin mainte...

journal_title：Psychopharmacology

authors： Perneger TV,Mino A,Giner F,Broers B

更新日期：2000-09-01 00:00:00

abstract：:Progabide inhibited male rat sexual behavior at a dose of 200 mg/kg. This dose had only modest effects on ambulatory activity and no effect at all on motor coordination as evaluated by a rotarod test. The GABAA antagonist bicuculline, at a dose of 1 mg/kg, blocked the effects of progabide on sex behavior. In contrast,...

journal_title：Psychopharmacology

authors： Agmo A,Paredes RG,Sierra L,Garcés I

更新日期：1997-01-01 00:00:00

abstract：:Quantitative receptor autoradiography was used to study the effects of the selective serotonin reuptake inhibitors citalopram and fluoxetine and the tricyclic antidepressant imipramine on the regulation of beta 1-adrenergic receptors in the rat brain. Rats were treated with saline, citalopram (10 mg kg-1), fluoxetine ...

journal_title：Psychopharmacology

authors： Pälvimäki EP,Laakso A,Kuoppamäki M,Syvälahti E,Hietala J

更新日期：1994-08-01 00:00:00

abstract：:Transdermal nicotine has been shown to relieve nicotine withdrawal and to double smoking cessation rates compared to placebo in clinical trials. A 21 or 22 mg/day dose provides a steady state serum nicotine that is less than obtained from smoking. Limited information is available about higher nicotine patch doses. To ...

journal_title：Psychopharmacology

authors： Fredrickson PA,Hurt RD,Lee GM,Wingender L,Croghan IT,Lauger G,Gomez-Dahl L,Offord KP

更新日期：1995-12-01 00:00:00

abstract：RATIONALE:Electronic cigarettes (ECs) are becoming popular alternatives for smokers, but there has been limited study of their abuse liability. OBJECTIVES:The objective of this study was to evaluate the abuse liability of three Vuse Solo ECs, ranging from 14 to 36 mg in nicotine content, relative to high- and low-abus...

journal_title：Psychopharmacology

authors： Stiles MF,Campbell LR,Graff DW,Jones BA,Fant RV,Henningfield JE

更新日期：2017-09-01 00:00:00

abstract：RATIONALE:Cocaine (COC), ethanol (EtOH), and methamphetamine (MA) are widely abused substances and share the ability to induce behavioral stimulation in mice and humans. Understanding the biological basis of behavioral stimulation to COC, EtOH, and MA may provide a greater understanding of drug and alcohol abuse. OBJE...

journal_title：Psychopharmacology

authors： Kamens HM,Phillips TJ

更新日期：2008-02-01 00:00:00

abstract：RATIONALE:Epidemiological studies of smokers suggest that there is a link between nicotine and depression. Nonetheless, few studies have examined the potential use of nicotinic ligands in the treatment of depression. OBJECTIVES:The goal of this study was to evaluate the effects of SIB-1508Y, a novel subtype-selective ...

journal_title：Psychopharmacology

authors： Ferguson SM,Brodkin JD,Lloyd GK,Menzaghi F

更新日期：2000-10-01 00:00:00

abstract：:The release of serotonin (5-HT) at serotonergic nerve terminals is regulated by 5-HT(1B) autoreceptors. Several studies have reported that the effects of selective 5-HT reuptake inhibitors (SSRIs) on extracellular 5-HT are augmented by 5-HT(1B) receptor antagonists, whereas administration of these antagonists alone do...

journal_title：Psychopharmacology

authors： de Groote L,Klompmakers AA,Olivier B,Westenberg HG

更新日期：2003-05-01 00:00:00

abstract：RATIONALE:Major depression is a chronic disabling disorder, often preceded by stress. Despite emerging clinical interest in mechanisms perpetuating episodes of depression and/or establishing increased vulnerability for relapse, little attention has been paid to address these aspects in experimental models. Here, we stu...

journal_title：Psychopharmacology

authors： Elizalde N,García-García AL,Totterdell S,Gendive N,Venzala E,Ramirez MJ,Del Rio J,Tordera RM

更新日期：2010-06-01 00:00:00

abstract：:On the heels of clozapine, we now have a number of newer agents (risperidone, olanzapine, quetiapine, sertindole, and ziprasidone). Are they all the same? What are the differences? How do we best understand them? In this article we review current clinical evidence to compare these issues on four measures of atypicalit...

journal_title：Psychopharmacology

authors： Remington G,Kapur S

更新日期：2000-01-01 00:00:00

abstract：:Recent clinical data suggest that buspirone may enhance the efficacy and/or reduce the latency to therapeutic effect of selective serotonin reuptake inhibitors (SSRIs) in unipolar major depressive disorder. The present study, using the mouse forced swimming test, was performed to investigate further the mechanisms inv...

journal_title：Psychopharmacology

authors： Redrobe JP,Bourin M

更新日期：1998-07-01 00:00:00

abstract：:Patients taking lithium often report difficulties in concentration, memory, learning, and attention and many of these complaints are verified on psychometric testing. Laboratory tests of cognitive functions in healthy volunteers on chronic lithium demonstrate that disruptions in memory-learning processes are apparent ...

journal_title：Psychopharmacology

authors： Weingartner H,Rudorfer MV,Linnoila M

更新日期：1985-01-01 00:00:00

abstract：:The anti-withdrawal effect of clonidine was studied using quasi-morphine abstinence behaviour induced by dipropylacetate (DPA) in naive rats. Clonidine potently suppressed body shakes and locomotor activity (ID50 30 and 40 micrograms/kg IP respectively). Phenoxybenzamine and prazosine did not antagonize the anti-withd...

journal_title：Psychopharmacology

authors： van der Laan JW,Weick G,Hillen FC

更新日期：1983-01-01 00:00:00

abstract：RATIONALE:Cortisol hypersecretion is regarded as important in the pathophysiology of major depression. However, recent studies in community-based samples have been inconclusive. OBJECTIVE:To determine whether acutely depressed, medication-free subjects show an exaggerated release of cortisol in saliva in relation to a...

journal_title：Psychopharmacology

authors： Bhagwagar Z,Hafizi S,Cowen PJ

更新日期：2005-10-01 00:00:00

abstract：:The behavioral effects of repeated methylphenidate (MPH) treatment were assessed in the adult rat. Protein kinase A (PKA) and adenylyl cyclase (basal and DA-stimulated) activity in the dorsal striatum (i.e., caudate-putamen) were measured to determine whether MPH-induced alterations in these enzymes correlate with the...

journal_title：Psychopharmacology

authors： Crawford CA,McDougall SA,Meier TL,Collins RL,Watson JB

更新日期：1998-03-01 00:00:00

abstract：:Rats were maintained on a regimen of restricted access to water. Desipramine (DMI) IP 1 h prior to the access period dose-dependently reduced water intake. Following completion of the dose-response determination for the effect of desipramine or water intake, rats were divided into three groups for repeated administrat...

journal_title：Psychopharmacology

authors： O'Donnell JM,Rider DP,Somani S,Seiden LS

更新日期：1982-01-01 00:00:00

abstract：:An operant task for the measurement of sustained attention or vigilance in rats was characterized. The task requires the animals to respond to the presentation of visual signals (presented for 25, 50, or 500 ms) by operating one lever ("hits") and to the absence of a signal by operating the opposite lever ("correct re...

journal_title：Psychopharmacology

authors： McGaughy J,Sarter M

更新日期：1995-02-01 00:00:00

abstract：:Chlordiazepoxide (5 and 10 mg/kg) and diazepam (2.5 mg/kg) reduced the latency to eat and enhanced feeding response to familiar food in a food-preference test. The increased feeding response resulted from an increased frequency of individual eating episodes (bouts) without significant change in the episode duration. E...

journal_title：Psychopharmacology

authors： Cooper SJ

更新日期：1980-01-01 00:00:00