Abstract：
:Progabide inhibited male rat sexual behavior at a dose of 200 mg/kg. This dose had only modest effects on ambulatory activity and no effect at all on motor coordination as evaluated by a rotarod test. The GABAA antagonist bicuculline, at a dose of 1 mg/kg, blocked the effects of progabide on sex behavior. In contrast, the GABAB antagonist CGP 35348, at doses of 50 and 100 mg/kg, was ineffective. These doses have previously been shown to block the actions of baclofen on sexual behavior. It was concluded that the GABAA but not the GABAB receptor is important for the inhibitory effects of progabide on that behavior. The actions of progabide on ambulatory activity were not blocked by bicuculline or CGP 35348 at any of the doses used (up to 2 and 200 mg/kg, respectively). Even the combination of both antagonists was ineffective. This suggests that the motor effects of progabide are mediated by either a non-GABAergic receptor or by a subtype of the GABAA or the GABAB receptor that is not sensitive to the antagonists. Present results show that the effects of progabide on motor functions depend on mechanisms different from those involved in its effects on sexual behavior. They further suggest that the GABAA receptor may be important for drug actions on male sexual behavior.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Agmo A,Paredes RG,Sierra L,Garcés Idoi
10.1007/s002130050158subject
Has Abstractpub_date
1997-01-01 00:00:00pages
27-34issue
1eissn
0033-3158issn
1432-2072journal_volume
129pub_type
杂志文章abstract：:The effects of phencyclidine (PCP) on locomotor activity were compared to those of the stereoisomers of N-allylnormetazocine (NAN) after acute administration to rats. PCP produced swaying and falling movements, increased sniffing behavior, and enhanced horizontal locomotor activity. d-NAN also induced swaying, falling...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00310633
更新日期：1986-01-01 00:00:00
abstract：RATIONALE:We have shown that differences in the level of neural activation to stimuli associated with smoking vs. natural rewards, a biomarker related to reward sensitivity, predict treatment outcome. OBJECTIVES:This paper examined whether this biomarker moderates the impact of bupropion or varenicline on smoking cess...
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pub_type： 杂志文章,随机对照试验
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abstract：RATIONALE:During the course of our investigation of antalarmin, a corticotropin-releasing hormone (CRH) antagonist, in rhesus monkeys, we noticed that large, intravenous doses of antalarmin resulted in behavioral changes that resembled intoxication. OBJECTIVES:Antalarmin was evaluated in rhesus monkeys for its reinfor...
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journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
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journal_title：Psychopharmacology
pub_type： 杂志文章,多中心研究,随机对照试验
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journal_title：Psychopharmacology
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2010-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：1980-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1998-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s002130050992
更新日期：1999-05-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-012-2958-8
更新日期：2013-05-01 00:00:00
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doi：10.1007/s00213-008-1238-0
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pub_type： 杂志文章
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更新日期：1979-11-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00432251
更新日期：1982-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：1997-11-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2014-03-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：2009-12-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 已发布勘误
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更新日期：2019-07-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02246414
更新日期：1996-07-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：2013-05-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-014-3444-2
更新日期：2014-07-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427955
更新日期：1983-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：2005-10-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3796-7
更新日期：2015-05-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章,评审
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更新日期：2008-05-01 00:00:00
