Abstract:
RATIONALE:Quetiapine extended release (XR) has been used to treat various psychiatric disorders, including depressive episodes associated with bipolar I and II disorders. Quetiapine XR is the first approved drug in China for the treatment of bipolar disorder. OBJECTIVES:The study evaluated the efficacy and safety of short-term quetiapine XR monotherapy in the treatment of depressive episodes of bipolar I and II disorders. METHODS:This was an 8-week multi-center, randomized, double-blind, placebo-controlled, fixed-dose phase 3 study. The primary endpoint was the mean change of the Montgomery-Åsberg Depression Rating Scale (MADRS) total score. Secondary endpoints included Clinical Global Impressions-Bipolar (CGI-BP) and remission rates. RESULTS:The study recruited 279 adult bipolar I or II patients currently experiencing depression from 11 Chinese provinces. Of these, 139 received quetiapine XR (300 mg/day) and 140 received placebo for 8 weeks. The mean change in the MADRS total score was significantly greater in the quetiapine XR group than in the placebo group (-19.00 ± 7.88 vs. -16.20 ± 9.32; p = 0.004). Adverse events occurred in 96 patients (65.3 %) in the quetiapine XR group and 72 (49.0 %) in the placebo group. The incidence of serious adverse events did not differ significantly between the groups (p = 0.247). CONCLUSIONS:This study, which is the first to evaluate 300 mg/day quetiapine XR monotherapy for depression in Chinese patients with bipolar disorders, found that this drug was superior to the placebo. Quetiapine XR was generally safe and well tolerated (ClinicalTrials.gov number, NCT01256177).
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Li H,Gu N,Zhang H,Wang G,Tan Q,Yang F,Ning Y,Zhang H,Lu Z,Xu X,Shi J,Gao C,Li L,Zhang K,Tian H,Wang X,Li K,Li H,Xu Y,Xie S,Yu Xdoi
10.1007/s00213-016-4215-zsubject
Has Abstractpub_date
2016-04-01 00:00:00pages
1289-97issue
7eissn
0033-3158issn
1432-2072pii
10.1007/s00213-016-4215-zjournal_volume
233pub_type
杂志文章,多中心研究,随机对照试验abstract::In a phase II study the antidepressive effect of citalopram, a selective and potent serotonin reuptake inhibitor, was examined in 20 endogenously and three non-endogenously depressed hospitalized patients. Four endogenously depressed patients dropped out due to deterioration early in the treatment period. The remainin...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00464566
更新日期:1982-01-01 00:00:00
abstract:RATIONALE:Prior research suggests that high levels of acetylcholine (ACh) in the nucleus accumbens (NAc) are associated with aversive states such as morphine withdrawal, but this has not been tested for nicotine withdrawal. OBJECTIVES:The goal was to test the hypothesis that acute nicotine decreases extracellular ACh ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100781
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND:Opioid neurotransmission mediates hedonic value of sweet tastants; their intake may be exaggerated by the consumption of exogenous opioids (e.g., opioid dependence). Sweet Taste Test (STT) is a validated quantitative instrument assessing taste perception and hedonic features of sugar (sucrose) using a random...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2503-1
更新日期:2012-04-01 00:00:00
abstract::Rats were trained to self-administer cocaine in 1-h sessions on a fixed ratio 5 (FR5) schedule of reinforcement. Acquisition was carried out at a unit dose of 0.3 mg/kg and responding was then stabilized at cocaine doses of 0.1, 0.3, and 1.0 mg/kg/infusion. Pretreatments with naltrexone (0.1-10 mg/kg, SC) 20 min prior...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244173
更新日期:1991-01-01 00:00:00
abstract::This study examined the possibility that amphetamine-induced stereotypy and facilitation of memory consolidation are both mediated by amphetamine's stimulation of dopaminergic activity in the caudate nucleus. In the first experiment, rats were given pairings of a tone and a shock followed by SC amphetamine (2 mg/kg). ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427774
更新日期:1984-01-01 00:00:00
abstract:RATIONALE:Drug-paired stimuli elicit drug craving and relapse in addicts and drug-seeking behavior in rats. The functional integrity of the basolateral amygdala (BLA) is necessary for reinstatement of cocaine-seeking behavior elicited by cocaine-conditioned stimuli, but not by cocaine itself. It is unclear, however, wh...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-001-0997-7
更新日期:2002-04-01 00:00:00
abstract::Several behaviors associated with the serotonin syndrome have been reported in rats following administration of the 5-HT1A receptor agonist 8-OH-DPAT. The present investigation approached this phenomenon from an ethopharmacological perspective, and provided a detailed temporal analysis of the behavioral effects of thi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02247363
更新日期:1993-01-01 00:00:00
abstract:RATIONALE:Converging evidence suggests that dopaminergic and serotonergic mechanisms affect distinct aspects of cognitive performance. Experiments using the rodent five-choice reaction time task have established a critical role for dopaminergic mechanisms in the rat medial prefrontal cortex (mPFC), but have yielded onl...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1227-7
更新日期:2003-01-01 00:00:00
abstract::The effects of ibogaine (40 and 80 mg/kg, i.p.), an indole alkaloid proposed for the treatment of drug abuse, were determined in three different groups of rats responding under an FR10 schedule of food, cocaine or heroin reinforcement. Ibogaine (80 mg/kg, i.p.) given 60 min before the start of the session resulted in ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246099
更新日期:1995-02-01 00:00:00
abstract:RATIONALE:Impulsive behaviour is a component of psychiatric disorders such as bipolar disorder, attention deficit hyperactivity disorder (ADHD), or personality disorders. Most experimental studies on impulsive behaviour punish impulsive choices by loss or delay of reward. In the present study, impulsive behaviour was p...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-2163-0
更新日期:2005-07-01 00:00:00
abstract:RATIONALE:The integrity of cortical cholinergic transmission is vital to attentional processing. A growing literature suggests that alterations in attentional processing accompany addictive drug use. This study examined the effects of acute and repeated administration of nicotine on cortical acetylcholine release. OBJ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1260-6
更新日期:2003-02-01 00:00:00
abstract:RATIONALE:The majority of volumetric magnetic resonance imaging (MRI) studies of the hippocampus in patients with bipolar disorder (BD) show no differences in hippocampal volume between patients and healthy controls. Significant variability, however, exists in the medication status of patients included in these studies...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-007-0906-9
更新日期:2007-12-01 00:00:00
abstract:RATIONALE:There is a growing concern over excessive caffeine use and development of caffeine use disorder in children. OBJECTIVES:This study aimed to identify the association between caffeine intake and cognitive functioning in children. METHODS:This study included 11,718 youths aged 9-10 years with cognitive and caf...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05596-8
更新日期:2020-10-01 00:00:00
abstract::7-Hydroxychlorpromazine (7-OHCPZ) has been identified and quantified in CSF from chlorpromazine (CPZ)-treated schizophrenic patients. The level of the metabolite in CSF was similar to that of CPZ. In serum the amount of 7-OHCPZ was about 30% of CPZ. The concentration of 7-OHCPZ in csf was positively and significantly ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432774
更新日期:1982-01-01 00:00:00
abstract::Maternal pup searching behaviour of lactating house mice treated with apomorphine, haloperidol or saline was examined on a running board with a central depression as a nest. Pup searching was elicited by artificial ultrasonic stimuli: a female moved out from the nest either towards a 50 kHz tone (key stimulus) which i...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00174523
更新日期:1988-01-01 00:00:00
abstract:RATIONALE:Morphine and buprenorphine have analgesic and anxiolytic-like properties. While their analgesic effects have been well characterized, their anxiolytic-like properties have not. OBJECTIVES:Effects of acute morphine and buprenorphine on the expression of acoustic fear-potentiated startle (FPS) and naloxone pre...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1112-0
更新日期:2008-06-01 00:00:00
abstract:RATIONALE:Repeated exposure to psychostimulants that either increase dopamine (DA) release or target N-methyl-D-aspartate (NMDA) receptors can induce behavioural sensitisation, a phenomenon that may be important for the processes of addiction and even psychosis. A critical component of behavioural sensitisation is an i...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3689-9
更新日期:2015-02-01 00:00:00
abstract:RATIONALE:Considerable evidence suggests that genetic factors combine with environmental influences to impact on the development of aggressive behavior. A genetic variant that has repeatedly been reported to render individuals more sensitive to the presence of adverse experiences, including stress exposure during fetal...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3484-7
更新日期:2014-08-01 00:00:00
abstract::The effects of dopamine agonists on self-stimulation are a matter of considerable dispute. Apomorphine has variously been reported to inhibit, have no effect on, or to facilitate lever-press self-stimulation. To investigate the possibility that these discrepancies may reflect peculiarities of the lever-press test situ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00433261
更新日期:1980-01-01 00:00:00
abstract:RATIONALE:Neurobiological models of addiction suggest that abnormalities of brain reward circuitry distort salience attribution and inhibitory control processes, which in turn contribute to high relapse rates. OBJECTIVES:The aim of this study is to determine whether impairments of salience attribution and inhibitory c...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1975-8
更新日期:2010-12-01 00:00:00
abstract:RATIONALE:Methamphetamine (METH) is a powerfully addictive stimulant associated with serious health conditions. Accumulating evidence suggests a role of oxidative stress in METH-induced behavioral abnormalities. Sulforaphane (SFN), found in cruciferous vegetables, is a potent antioxidant. It is of interest to determine...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2619-3
更新日期:2012-07-01 00:00:00
abstract::The effect of lithium on serotonin (5-HT)-mediated responses in the brain was assessed by measuring changes in the prolactin (PRL) and growth hormone (GH) responses to L-tryptophan (LTP) in eight normal subjects. On the 4th day of lithium treatment the PRL responses were significantly enhanced, and this enhancement wa...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00179198
更新日期:1986-01-01 00:00:00
abstract::Recent clinical data suggest that buspirone may enhance the efficacy and/or reduce the latency to therapeutic effect of selective serotonin reuptake inhibitors (SSRIs) in unipolar major depressive disorder. The present study, using the mouse forced swimming test, was performed to investigate further the mechanisms inv...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050663
更新日期:1998-07-01 00:00:00
abstract:RATIONALE:Acute alcohol intoxication induces a selective impairment of recognition memory associated with conscious recollection whilst recognition based on familiarity is left intact. OBJECTIVES:We aimed to further elucidate the acute effects of alcohol on recognition memory by assessing three different doses of alco...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-009-1709-y
更新日期:2010-01-01 00:00:00
abstract:RATIONALE:The Scheduled High Alcohol Consumption (SHAC) binge drinking model is a simple, partial murine model with which to investigate some of the neurobiological underpinnings of alcoholism. OBJECTIVES:The SHAC model was used to characterize monoamine and amino acid adaptations produced in the nucleus accumbens (NA...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0641-7
更新日期:2007-03-01 00:00:00
abstract:RATIONALE:Cue-elicited craving and stress responses have been identified as predictors of relapse in drug dependence, but little research exists on the contribution of these factors to marijuana use specifically. OBJECTIVES:The aims of the present study were to evaluate (1) responses to a psychological stressor, (2) r...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2376-3
更新日期:2011-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Footshock stress reliably reinstates heroin seeking in rats, but the time course of the development of this effect following drug withdrawal is not known. Here we studied the effect of intermittent footshock stress on reinstatement of heroin seeking following different withdrawal periods (1-66 ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100748
更新日期:2001-06-01 00:00:00
abstract::The present study assessed the discriminative stimulus effects of the delta-opioid agonist [D-Pen2-D-Pen5]enkephalin (DPDPE) in pigeons. Food-restricted pigeons were trained to discriminate between i.c.v injections of 100 micrograms [D-Pen2-D-Pen5]enkephalin (DPDPE) and saline in a two-key operant procedure; acquisiti...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:
更新日期:1996-10-01 00:00:00
abstract::The present study was conducted to determine whether methadone maintenance alters the pharmacodynamic effects of single doses of cocaine. Twenty-two current users of IV cocaine who were not seeking treatment for their illicit cocaine use participated while living on a research unit. Eleven were maintained on methadone...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02246276
更新日期:1996-01-01 00:00:00
abstract:RATIONALE:Cocaine and opioids are often co-abused. As yet, however, there is no clear evidence that the drugs interact to make the mixture a more effective reinforcer. OBJECTIVE:The present study examined the relative reinforcing potency and maximum effectiveness of the cocaine-opioid combination in monkeys given a ch...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-2131-1
更新日期:2011-05-01 00:00:00