Abstract:
:Suriclone is a new anxiolytic drug belonging to the family of cyclopyrrolones. Although chemically entirely different from the benzodiazepines, it acts as a benzodiazepine agonist with very high affinity for the benzodiazepine receptors. In the present cross-over study, 33 out-patients with a diagnosis of neurotic anxiety were treated with suriclone (mean dose 2 mg/day) and diazepam (25 mg/day) in two 6-week periods. Both drugs had a significant anxiolytic effect, but diazepam appeared to have a better effect within the first 2 weeks of treatment, while no significant difference was seen after treatment, while no significant difference was seen after treatment for 6 weeks. Suriclone and diazepam had a different side effect profile: suriclone produced mainly dizziness, while diazepam caused sedation. This may reflect the fact that suriclone and benzodiazepines bind to distinct sites or different allosteric conformations of the benzodiazepine receptors.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Gerlach J,Christensen JK,Christensen TL,Elley J,Jensen JP,Larsen SBdoi
10.1007/BF00187246subject
Has Abstractpub_date
1987-01-01 00:00:00pages
296-300issue
3eissn
0033-3158issn
1432-2072journal_volume
93pub_type
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