Abstract:
:Two groups of schizophrenic outpatients were treated with perphenazine decanoate (N = 20) and cis(z)-flupentixol decanoate (N = 24) respectively. Every 3 months the dose was gradually reduced until symptoms appeared that were suggestive of a prodromal phase of a psychotic episode. A slightly higher dose was then promptly reinstituted (the minimum effective dose). At each dose level, two blood samples were drawn for determination of serum concentration. The mean minimum effective dose of perphenazine decanoate was 99.3 mg/2 weeks (range 21.6-270.5), while the mean minimum effective dose of cis(z)-flupentixol decanoate was 60 mg/2 weeks (range 20-250). The corresponding mean serum level of perphenazine decanoate was 7.3 nmol/l (range 2.0-18.1) and of cis(z)-flupentixol decanoate 7.8 nmol/l (range 1.2-37.0). There was a significant correlation between the administered doses and the corresponding serum levels for both drugs (r = 0.87, P less than 0.01). A weak positive correlation was found between serum levels at the minimum effective dose and symptom intensity (BPRS total score) (r = 0.53, P less than 0.02) for perphenazine, but not cis(z)-flupentixol. No correlation was found between serum levels and side effects or length of neuroleptic treatment. It is concluded that the serum drug concentrations corresponding to the lowest effective dose are so variable that routine serum level monitoring may be of limited value in the long-term maintenance treatment of schizophrenia.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Kistrup K,Gerlach J,Aaes-Jørgensen T,Larsen NEdoi
10.1007/BF02316862subject
Has Abstractpub_date
1991-01-01 00:00:00pages
42-8issue
1eissn
0033-3158issn
1432-2072journal_volume
105pub_type
杂志文章abstract:RATIONALE:Training in research ethics is crucial for psychiatric investigators. Addressing ethical dimensions of human subjects research requires knowledge about the rules and norms governing research; sensitivity to ethical implications of actions; and skills in ethics problem solving. Investigators in training who ar...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
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更新日期:2003-12-01 00:00:00
abstract::Serotonin receptors of the 5HT2 type were labeled on platelet membranes using tritiated ketanserin. Blood was collected from the umbilical cord of newborns and venous samples were collected from 6-year-old children as well as junior-high and high school students (ages 13 through 18) to determine age-related changes in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245309
更新日期:1992-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00432038
更新日期:1984-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00213-014-3658-3
更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-020-05505-z
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abstract:RATIONALE:The emergence of the consumption of highly potent synthetic cannabinoid receptor agonists (spice drugs) that produce important neurological symptoms has prompted the research on the consequences of acute and chronic use of these new psychoactive substances. Most studies on cannabinoid dependence have been per...
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pub_type: 杂志文章
doi:10.1007/BF00432218
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/s002130000658
更新日期:2001-05-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244870
更新日期:1994-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00178505
更新日期:1986-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF02246154
更新日期:1995-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00213-006-0397-0
更新日期:2006-07-01 00:00:00
abstract:RATIONALE:So-called atypical antipsychotics (AAPs) are associated with varying levels of weight gain and associated metabolic disturbances, which in patients with serious mental illness (SMI) have been linked to non-compliance and poor functional outcomes. Mechanisms underlying AAP-induced metabolic abnormalities are o...
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pub_type: 杂志文章,评审
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更新日期:2016-07-01 00:00:00
abstract:RATIONALE:Research suggests the experimental manipulation of oxytocin facilitates positive interactions, cooperation, and trust. The mechanism by which oxytocin influences social behavior is not well understood. OBJECTIVE:We explored the hypothesis that oxytocin alters how people perceive themselves, which could be on...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2527-6
更新日期:2012-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s002130000602
更新日期:2000-12-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00439459
更新日期:1989-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00433058
更新日期:1980-01-01 00:00:00
abstract::The effects of chronic lithium treatment on methylphenidate-, D1 dopamine receptor agonist (A-77636)-, and tactile stimulation-induced increases in frontal cortical acetylcholine release were studied in the rat using in vivo brain microdialysis. Cortical acetylcholine release in control rats was maximally stimulated b...
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pub_type: 杂志文章
doi:10.1007/BF02249415
更新日期:1996-05-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00429198
更新日期:1981-01-01 00:00:00
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更新日期:2008-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00187263
更新日期:1987-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00213-010-1957-x
更新日期:2010-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-07-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-006-0666-y
更新日期:2007-04-01 00:00:00
abstract::In the rat, the antimuscarinics atropine and scopolamine failed to block the reduction in pentobarbital-induced sleep time produced by either thyrotropin-releasing hormone (TRH) or MK-771 (a TRH analog). Previous reports have indicated that the marked analeptic effect produced by TRH is antagonized by such agents. It ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431749
更新日期:1981-01-01 00:00:00
abstract::Nicotine has been reported to increase or decrease measures of activity in rats, including locomotor activity and rearing. Nicotine dose and repeated exposure to nicotine are known to be important factors in determining the effects on locomotor behavior. Less information has been gathered on rearing and other measures...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244758
更新日期:1994-06-01 00:00:00
abstract:RATIONALE:Available neurochemical probes that lower brain dopamine (DA) levels in man are limited by their tolerability and efficacy. For instance, the acute lowering of brain tyrosine is well tolerated, but only modestly lowers brain DA levels. Modification of tyrosine depletion to robustly lower DA levels would provi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-2977-0
更新日期:2013-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-09-01 00:00:00
abstract::There is little evidence concerning the effects of caffeine in doses typical of one cup of tea. The present study investigated the effect of 60 mg caffeine, consumed in either tea or hot water, on performance on a subset of the CANTAB test battery. Eight males participated in a practice session and four test sessions....
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050746
更新日期:1998-11-01 00:00:00
abstract::The present study was undertaken to evaluate the effects of single and repeated doses of triazolam (1 mg/kg IP) and desipramine (DMI) (10 mg/kg IP) alone and in combination on certain pharmacologic responses and brain catecholamine levels in rats. The significant findings were: (1) triazolam and DMI given alone and in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427882
更新日期:1980-01-01 00:00:00