Abstract:
RATIONALE:Brain waves reflect collective behavior of neurons and provide insight into distributed network processing. Frontal and hippocampal theta oscillations (4-7 Hz) were linked to cognitive tasks and animal studies have suggested an involvement of glutamatergic neurotransmission in integrative frontal-hippocampal processing. Human evidence for such relationships is lacking. METHODS:Here, we studied the associations between glutamate concentrations in the hippocampal region, measured by a 3-T proton magnetic resonance spectroscopy (1H-MRS), and EEG theta activity during an auditory target detection paradigm. RESULTS:A robust relationship between hippocampal glutamate and frontal theta activity during stimulus processing was found. Moreover, frontal theta oscillations were related to response speed. CONCLUSION:The results suggest a functional coupling between the frontal cortex and hippocampal region during stimulus processing and support the idea of the hippocampus as a neural rhythm generator driven by glutamatergic neurotransmission. These preliminary data show, for the first time, a relationship between in vivo measured glutamate and basic cerebral information processing in humans.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Gallinat J,Kunz D,Senkowski D,Kienast T,Seifert F,Schubert F,Heinz Adoi
10.1007/s00213-006-0397-0subject
Has Abstractpub_date
2006-07-01 00:00:00pages
103-11issue
1eissn
0033-3158issn
1432-2072journal_volume
187pub_type
杂志文章abstract:RATIONALE:Both methylphenidate (MPH), a catecholamine reuptake blocker, and guanfacine, an alpha2A agonist, are used to treat attention-deficit hyperactivity disorder (ADHD). Childhood impulsivity, including delay discounting, is associated with increased substance use during adolescence. These effects can be mitigated...
journal_title:Psychopharmacology
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doi:10.1007/s00213-018-5096-0
更新日期:2019-02-01 00:00:00
abstract::Two behaviors related to nonreward (omission of water in an enclosure where the rats were habituated to drink) were studied. The time spent licking the bottles during water omission and the time spent drinking during a subsequent 5-min drinking session (water available) were recorded. The drinking session was performe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00428038
更新日期:1978-09-15 00:00:00
abstract::Two experiments were conducted to assess the acute behavioral effects of triazolam and temazepam in healthy, non-drug abusing men in double-blind, placebo-controlled, crossover trials, where all subjects received all possible doses. These drugs were compared to examine allegations that triazolam produces greater behav...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1993-01-01 00:00:00
abstract:RATIONALE:Acute cocaine administration produces an initial rewarding state followed by a dysphoric/anxiogenic "crash." OBJECTIVE:The objective of this study was to determine whether individual differences in the relative value of cocaine's positive and negative effects would account for variations in subsequent drug s...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-3873-6
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abstract:RATIONALE:Perospirone is a novel second-generation antipsychotic drug with high affinity to dopamine D(2) receptor and short half-life of plasma concentration. There has been no investigation of dopamine D(2) receptor occupancy in patients with schizophrenia and the time course of occupancy by antipsychotics with peros...
journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2010-05-01 00:00:00
abstract::Many behavioral effects of cocaine are attenuated by dopamine (DA) receptor antagonists. Yet, long-term DA antagonist administration enhances neuronal responsiveness to DA in several pathways, including the mesolimbic system. This study compared the effects of short-term versus long-term administration of the DA antag...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050138
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abstract::Lithium pretreatment in rats potentiates the epileptogenic effects of pilocarpine and other cholinergic agonists. In order to determine if this effect of lithium could be reversed by myo-inositol, rats were pretreated with intracerebroventricular (ICV) injections of myoinositol, artificial CSF or L-chiro-inositol. Lit...
journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00217061
更新日期:1987-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050638
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journal_title:Psychopharmacology
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abstract::The concurrent influence of dopaminergic, sigma and muscarinic neurotransmitter systems in mediating cocaine-induced lethality is predicted by previous receptor binding results from our laboratories. The present results demonstrate that pharmacological manipulations of these predicted neurotransmitter systems alter th...
journal_title:Psychopharmacology
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更新日期:1997-02-01 00:00:00
abstract:RATIONALE:Pindolol has been reported to shorten the onset of antidepressant action of selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors (SSRIs) as well as to increase their efficacy. It has been postulated that pindolol enhances the antidepressant effect of SSRIs by blocking somatodendritic 5-HT1A aut...
journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2000-07-01 00:00:00
abstract:RATIONALE:Inattentional blindness (IB) is the inability to detect a salient yet unexpected task irrelevant stimulus in one's visual field when attention is engaged in an ongoing primary task. The present study is the first to examine the impact of both task difficulty and alcohol consumption on IB and primary task perf...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4772-9
更新日期:2018-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2017-05-01 00:00:00
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journal_title:Psychopharmacology
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doi:10.1007/s002130000585
更新日期:2001-02-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:2016-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246951
更新日期:1993-01-01 00:00:00
abstract::The effects of a new alpha-2 adrenoceptor antagonist on erectile function was assessed in 12 normal volunteers (mean age 28.7, range 20-42), using a double blind, placebo controlled design with two doses of drug and three testing sessions. The drug was administered by intravenous infusion and erectile responses to ero...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00179193
更新日期:1986-01-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:2015-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050788
更新日期:1998-12-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1982-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Dopamine (DA) agonists reliably disrupt prepulse inhibition (PPI) of the startle reflex in animals but less so in humans despite cross-species similarities in the neural regulation of PPI. This study examines whether individual variation in baseline PPI may account for the inconsistencies in DA...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-005-0056-x
更新日期:2005-10-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-010-1819-6
更新日期:2010-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVE:Estradiol decline has been associated with depression and anxiety in post-menopausal women. Agomelatine (Ago) is an agonist of the melatonergic MT1/MT2 receptors and an antagonist of the serotonergic 5-HT2c receptors. The present study aimed to evaluate the effects of combining Ago with 17β-estr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05580-2
更新日期:2020-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1995-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:2011-12-01 00:00:00
abstract:RATIONALE:Conditioned behavioral responses to discrete drug-associated cues can be modulated by the environmental context in which those cues are experienced, a process that may facilitate relapse in humans. Rodent models of drug self-administration have been adapted to reveal the capacity of contexts to trigger drug s...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1657-6
更新日期:2009-12-01 00:00:00
abstract::In neuroleptic therapy for psychotic illness, clinical improvement is produced more slowly than is central dopamine blockade, and its time course is highly variable between patients. A theory of neuroleptic-responsive psychotic illness thus requires more than dopamine blockade, though that appears to be the first step...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
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更新日期:1987-01-01 00:00:00