Abstract:
:The effects of an "aggression"-reducing drug, fluprazine, and an "aggression"-enhancing drug, ethanol, were evaluated in mice using the target biting and resident-intruder paradigms. Under baseline conditions there was a high target biting rate immediately after the delivery of a 2.0 mA tail shock, an intermediate target biting rate during a 2-min intershock interval, and a low target biting rate during a 15-s tone stimulus which signaled the shock. During the 10-min resident intruder test sessions, resident males attacked bulbectomized intruders an average of 11.3 times with an average latency to the first attack of 68.3 s. Fluprazine caused a dose-dependent decrease in postshock and intershock interval target biting behavior, increased the latency to the first attack, and decreased the number of attacks in the intruder-evoked aggression paradigm. Ethanol exerted a biphasic effect in both paradigms. A dose of 0.5 g/kg increased and 4.0 g/kg decreased intershock interval target biting behavior. Likewise, ethanol at a dose of 1.0 g/kg increased the number of intruder-evoked attacks and 0.5 g/kg reduced the latency to the first attack whereas 2.0 g/kg ethanol reduced the number of intruder-evoked attacks. These observations are discussed in reference to the specificity with which different drugs and paradigms are able to dissociate offensive versus defensive aggression.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Wagner GC,Carelli RMdoi
10.1007/BF00217061subject
Has Abstractpub_date
1987-01-01 00:00:00pages
193-7issue
2eissn
0033-3158issn
1432-2072journal_volume
91pub_type
杂志文章abstract:RATIONALE:The intake of psychostimulant drugs may induce cognitive dysfunction and negative affective-like states, and is associated with increased activity of stress-responsive systems. The corticotropin-releasing factor (CRF) system mediates neuroendocrine, behavioural and autonomic responses to stressors, and might ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3534-1
更新日期:2014-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVE:Because of the important role of dopamine in neurotransmission, it would be useful to be able to image brain dopamine receptor-mediated signal transduction in animals and humans. Administering the D1-D2 receptor agonist apomorphine may allow us to do this, as the D2-like receptor is reported to ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1073-3
更新日期:2008-05-01 00:00:00
abstract:RATIONALE:The ability of nicotine to induce dependence (result in a withdrawal syndrome) is typically thought to require long-term, daily smoking. Emerging evidence suggests that symptoms of nicotine withdrawal may occur following only a few cigarettes. Whether acute exposure to nicotine can induce dependence in animal...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2814-x
更新日期:2013-01-01 00:00:00
abstract:RATIONALE:The use and misuse of prescription opiates in adolescent populations, and in particular, adolescent female populations, has increased dramatically in the past two decades. Given the significant role that opioids play in neuroendocrine function, exposure to opiates during this critical developmental period cou...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2960-1
更新日期:2013-05-01 00:00:00
abstract::The increasing interest in subjective well-being and quality of life of schizophrenic patients represents a conceptual shift in therapeutic outcome criteria. Symptom reduction alone was the most essential outcome parameter for a long time; with the development of atypical antipsychotics more ambitious success criteria...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-002-1052-z
更新日期:2002-06-01 00:00:00
abstract::The behavioural effects of selective mu-, kappa- and delta-opioid agonists in 5-, 10- and 20-day-old rats were investigated by observational analysis. The predominant response to mu-agonists was behavioural depression. High doses (10 mg/kg IP) of morphine and DAGO (D-Ala2, NMe-Phe4, Glyol5-enkephalin) produced overt s...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00439459
更新日期:1989-01-01 00:00:00
abstract:RATIONALE:Understanding factors contributing to individual differences in vulnerability to opioid addiction is essential for developing more effective preventions and treatments, yet few reliable behavioral predictors of subsequent opioid self-administration have been identified in rodents. Sensitivity to the acute eff...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05532-w
更新日期:2020-08-01 00:00:00
abstract:RATIONALE:Repeated exposure to psychostimulant drugs causes a long-lasting increase in the psychomotor and reinforcing effects of these drugs and an array of neuroadaptations. One such alteration is a hypersensitivity of striatal activity such that a low dose of amphetamine in sensitized animals produces dorsal striata...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1100-4
更新日期:2008-05-01 00:00:00
abstract::Single-dose pharmacokinetics of alprazolam was studied in 42 normal male volunteers (14 Caucasians, 14 American-born Asians, and 14 foreign-born Asians), after both oral and parenteral (IV) administration of a small dose (0.5 mg) of the test drug. Asians manifested significantly higher Cmax, larger AUC, slower CL and ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00216063
更新日期:1988-01-01 00:00:00
abstract:RATIONALE:Orexins A and B have recently been discovered and shown to be derived from preproorexin, primarily expressed in the rat hypothalamus. Orexin-A has been ascribed a number of in vivo functions in the rat after intracerebroventricular (ICV) administration, including hyperphagia, neuroendocrine modulation and, mo...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000550
更新日期:2001-01-01 00:00:00
abstract:RATIONALE:The ultra-short-acting mu opioid agonist analgesic/anesthetic remifentanil (RMF) is extremely rapidly eliminated from blood (half-life in rats, 0.3-0.7 min). This extremely fast elimination is thought to be the main reason why RMF maintains such high rates of responding in animal operant-conditioning models o...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-0180-7
更新日期:2005-12-01 00:00:00
abstract::We examined whether any locus postsynaptic to the GABAergic striatonigral projection might be involved in the enhancement of behavioral response to dopaminergic stimulants induced by chronic treatment with either neuroleptic drugs or stimulants. Rats exposed chronically to either chlorpromazine or cocaine were tested ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00212767
更新日期:1988-01-01 00:00:00
abstract:RATIONALE:Concurrent abuse of cocaine and heroin is a common form of polydrug abuse, but the interactions between the reinforcing effects of cocaine and heroin are poorly understood. Dose-addition analysis is a tool for the quantitative assessment of drug interactions, but this analysis has not been applied to evaluati...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-2133-y
更新日期:2005-06-01 00:00:00
abstract::Neonatal treatment with monoamine reuptake inhibitors results in a constellation of neurobehavioral alterations in adult rats that may model human depression. Since alterations in circadian rhythmicity have been reported in both depressed patients and in animal depression models, the present study examined the effects...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244777
更新日期:1994-06-01 00:00:00
abstract:RATIONALE:Serotonin (5-HT) plays a key role in different aspects of value-based decision-making. A recent framework proposed that tonic 5-HT (together with dopamine, DA) codes future average reward expectations, providing a baseline against which possible choice outcomes are compared to guide decision-making. OBJECTIV...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-4913-9
更新日期:2018-07-01 00:00:00
abstract::Chronic tolerance to ethanol-induced sleep, motor impairment (moving belt test), and hypothermia were examined in two lines of rats that had been selectively bred for their different initial sensitivities to ethanol. In agreement with previous work (Mayer et al. 1982, 1983), the least-affected (LA) rats were found to ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432218
更新日期:1985-01-01 00:00:00
abstract:RATIONALE:Nicotine displays rewarding and aversive effects, and while dopamine has been linked with nicotine's reward, the neurotransmitter(s) involved with aversion remains speculative. The kappa-dynorphinergic system has been associated with negative motivational and affective states, and whether dynorphin (Dyn) cont...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1315-4
更新日期:2009-01-01 00:00:00
abstract:RATIONALE:Carrageenan-induced hyperalgesia is a widely used pain model in rodents. However, characteristics of carrageenan-induced hyperalgesia and effects of analgesic drugs under these conditions are unknown in nonhuman primates. OBJECTIVE:The aims of this study were to develop carrageenan-induced hyperalgesia in rh...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3341-0
更新日期:2014-04-01 00:00:00
abstract:RATIONALE:Treatment of the most widely abused drugs, nicotine and alcohol, is hampered by high rates of relapse. Varenicline tartrate, an α4β2 nicotinic receptor partial agonist, is currently prescribed as a smoking cessation aid. However, there is emerging evidence that it may also modulate alcohol seeking and cogniti...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2213-8
更新日期:2011-07-01 00:00:00
abstract:RATIONALE:Lithium is the most widely prescribed mood stabilizer, but the precise mechanism of lithium is unresolved. OBJECTIVE:We examine the effects of the administration of therapeutically relevant concentrations of lithium on the expression of brain-derived neurotrophic factor (BDNF) and its receptor, Trk B, as wel...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100871
更新日期:2001-10-01 00:00:00
abstract::We investigated the striatal dopamine-2 (D2) receptor occupancy caused by different antipsychotic substances in 18 psychotic patients (16 with schizophrenic and two with schizoaffective disorder according to DSM-IV) with single photon emission computed tomography (SPECT) using 123I-iodobenzamide (IBZM) as tracer subst...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s002130050409
更新日期:1997-10-01 00:00:00
abstract::There were marked strain differences in the duration of the protective effects of diazepam against the convulsant actions of penylenetetrazole and picrotoxin in mice. In no case was significant protection found at 12 h or longer, regardless of whether the incidence of or the latencies to myoclonus or tonic-clonic conv...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431698
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Rats reared in social isolation exhibit various cognitive and behavioural abnormalities in adulthood. However, impulsivity following this treatment still remains unclear, especially in response to medications used in attention deficit hyperactivity disorder, such as amphetamine. METHODS:Using an isolation-r...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4579-8
更新日期:2017-05-01 00:00:00
abstract::Acamprosate (calcium-acetyl homotaurinate) is a new compound used in the treatment of alcohol abuse. Because of the putative link between alcoholism and the endogenous opioid systems in both humans and laboratory animals, we tested in rats the effects of acamprosate on behavioral and neurochemical effects of opioid dr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050730
更新日期:1998-10-01 00:00:00
abstract::Dopamine (DA), injected unilaterally into rat forebrain after pretreatment with a monoamine oxidase inhibitor, equipotently induced locomotor arousal when placed in the nucleus accumbens septi (a limbic site) and contralateral deviation of the head when placed in the corpus striatum (an extrapyramidal target); testing...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244285
更新日期:1991-01-01 00:00:00
abstract::Previous studies indicate that some aspects of endotoxin-induced sickness behavior in rats may be mediated by interleukin-1 stimulated events and can be attenuated by corticosteroids, cyclooxygenase inhibitors and the interleukin-1-receptor antagonist. In the current studies, we replicate and extend these findings in ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050353
更新日期:1997-08-01 00:00:00
abstract::Peripheral administration of the unsulphated cholecystokinin octapeptide (CCK-8us) led to an anxiogenic-like action in the elevated plus-maze model of anxiety in rats. Devazepide and L-365,260 showed potent anxiolytic-like effects at similar doses. The fact that devazepide is 1000 times more potent as a CCK-A receptor...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244646
更新日期:1993-01-01 00:00:00
abstract:RATIONALE:Epidemiological studies of smokers suggest that there is a link between nicotine and depression. Nonetheless, few studies have examined the potential use of nicotinic ligands in the treatment of depression. OBJECTIVES:The goal of this study was to evaluate the effects of SIB-1508Y, a novel subtype-selective ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000531
更新日期:2000-10-01 00:00:00
abstract:RATIONALE:Arcaine is a competitive antagonist of the polyamine binding site at the N-methyl-D-aspartic acid receptor which induces state-dependent recall. However, no study has addressed the involvement of other neurotransmitter/neuromodulators in arcaine-induced state dependency. OBJECTIVES:The current study investig...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2215-6
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND AND RATIONALE:More than two decades ago, Wise proposed his "anhedonia hypothesis" to explain the role of dopamine in motivated behaviors. The hypothesis posits that dopamine mediates the pleasure experienced by reward obtainment. However, some experimental findings have contested this hypothesis and several ...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-006-0521-1
更新日期:2007-04-01 00:00:00