IBZM SPECT imaging of striatal dopamine-2 receptors in psychotic patients treated with the novel antipsychotic substance quetiapine in comparison to clozapine and haloperidol.

abstract：RATIONALE:Considerable evidence suggests that genetic factors combine with environmental influences to impact on the development of aggressive behavior. A genetic variant that has repeatedly been reported to render individuals more sensitive to the presence of adverse experiences, including stress exposure during fetal...

journal_title：Psychopharmacology

authors： Buchmann AF,Zohsel K,Blomeyer D,Hohm E,Hohmann S,Jennen-Steinmetz C,Treutlein J,Becker K,Banaschewski T,Schmidt MH,Esser G,Brandeis D,Poustka L,Zimmermann US,Laucht M

更新日期：2014-08-01 00:00:00

abstract：RATIONALE:Intermittent footshock stress reliably reinstates extinguished alcohol-taking behavior in drug-free rats, but the neurochemical events involved in this effect are not known. OBJECTIVE:We studied here whether two main modulators of stress responses, corticotropin-releasing factor (CRF) and corticosterone, are...

journal_title：Psychopharmacology

authors： Lê AD,Harding S,Juzytsch W,Watchus J,Shalev U,Shaham Y

更新日期：2000-06-01 00:00:00

abstract：RATIONALE:The five-choice serial reaction time task (5-CSRTT) is regularly used to study attention and impulsivity. In the 5-CSRTT, rodents initiate a trial, then after an inter-trial interval (ITI), a light appears in one of five holes. Responding in the lit vs. unlit hole reflects attention (accuracy), while respondi...

journal_title：Psychopharmacology

authors： Cope ZA,Halberstadt AL,van Enkhuizen J,Flynn AD,Breier M,Swerdlow NR,Geyer MA,Young JW

更新日期：2016-10-01 00:00:00

abstract：RATIONALE:Antidepressants (ADs) are slow to produce their therapeutic effect. This long latency promotes the development of new strategies to short their onset of action. Previous reports indicated that 17beta-estradiol (E(2)) promotes the antidepressant-like activity of fluoxetine (FLX) and desipramine (DMI) in the fo...

journal_title：Psychopharmacology

authors： Estrada-Camarena E,Rivera NM,Berlanga C,Fernández-Guasti A

更新日期：2008-12-01 00:00:00

abstract：RATIONALE:The experience of strong traumata leads to the formation of enduring fear memories that may degenerate into post-traumatic stress disorder. One of the most successful treatments for this condition consists of extinction training during which the repeated exposure to trauma-inducing stimuli in a safe environme...

journal_title：Psychopharmacology

authors： Silva BA,Burns AM,Gräff J

更新日期：2019-01-01 00:00:00

abstract：:The place-preference paradigm was evaluated as a measure of morphine's positive reinforcing properties. Previous place-preference studies obtained a morphine place preference of 26%-63%. In order to examine whether differences in procedure may account for this scatter, the present experiment investigated whether there...

journal_title：Psychopharmacology

authors： Blander A,Hunt T,Blair R,Amit Z

更新日期：1984-01-01 00:00:00

abstract：:In mice, quipazine has shown several behavioral effects: It antagonizes hypothermia induced by a high dose of apomorphine without altering climbing or stereotyped behavior; it antagonizes oxotremorine-induced hypothermia without altering tremors or peripheral signs; and it increases the toxicity of yohimbine. These th...

journal_title：Psychopharmacology

authors： Francès H,Lecrubier Y,Puech AJ,Simon P

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:Ketamine, a well-known general dissociative anesthetic agent that is a non-competitive antagonist of the N-methyl-D-aspartate receptor, perturbs the perception of elapsed time and the expectation of upcoming events. OBJECTIVE:The objective of this study was to determine the influence of ketamine on temporal ...

journal_title：Psychopharmacology

authors： Brulé S,Herlin B,Pouget P,Missal M

更新日期：2021-02-01 00:00:00

abstract：:The selective serotonin reuptake inhibitor fluvoxamine interferes with the metabolism of tricyclic antidepressants. The present investigation was set out to characterize these interactions in vitro using rat liver microsomes and in vivo by analysing levels of clomipramine and metabolites in sera of depressed patients ...

journal_title：Psychopharmacology

authors： Härtter S,Arand M,Oesch F,Hiemke C

更新日期：1995-01-01 00:00:00

abstract：RATIONALE:Previous studies have shown that the effect of setting on drug-taking is substance specific in both humans and rats. In particular, we have shown that when the setting of drug self-administration (SA) coincides with the home environment of the rats (resident rats), the rats tend to prefer heroin to cocaine. T...

journal_title：Psychopharmacology

authors： Montanari C,Stendardo E,De Luca MT,Meringolo M,Contu L,Badiani A

更新日期：2015-07-01 00:00:00

abstract：:The existence of cyclical (circadian) variations in lithium toxicity in mice was determined. Mice, standardized to a light-dark cycle, were injected with lithium chloride (940 mg/kg) at one of six times (20:00, 24:00, 4:00, 8:00, 12:00, and 16:00) and subsequently observed for mortality over 28 h. A significant (P les...

journal_title：Psychopharmacology

authors： Hawkins R,Kripke DF,Janowsky DS

更新日期：1978-01-31 00:00:00

abstract：:Three sets of experiments were carried out in a Y water maze in which mice had to swim toward the light or the dark, in two different procedures. The first procedure involved, orientation toward a light source (L procedure), corresponding to natural preference, the latter involved orientation toward the dark (D proced...

journal_title：Psychopharmacology

authors： Castellano C

更新日期：1976-08-17 00:00:00

abstract：INTRODUCTION:Alcohol has been shown to increase smoking urges and smoking behavior. However, alcohol's effects on specific components of smoking behavior for nicotine versus non-nicotine factors and potential sex differences in this response have not been investigated. METHODS:Forty-two young male and female non-depen...

journal_title：Psychopharmacology

authors： King A,McNamara P,Conrad M,Cao D

更新日期：2009-11-01 00:00:00

abstract：RATIONALE:Previous research has identified a number of factors that appear to moderate the behavioural response to glucose administration. These include physiological state, dose, types of cognitive tasks used and level of cognitive demand. Another potential moderating factor is the length of the fasting interval prior...

journal_title：Psychopharmacology

authors： Owen L,Scholey AB,Finnegan Y,Hu H,Sünram-Lea SI

更新日期：2012-04-01 00:00:00

abstract：:Preclinical studies suggest that acoustic startle amplitude is increased during ethanol withdrawal. The current study evaluated the effects of intravenous infusion of the alpha 2-adrenergic antagonist, yohimbine (0.4 mg/kg), the serotonin partial agonist m-chlorophenylpiperazine (mCPP, 0.1 mg/kg), and placebo administ...

journal_title：Psychopharmacology

authors： Krystal JH,Webb E,Grillon C,Cooney N,Casal L,Morgan CA 3rd,Southwick SM,Davis M,Charney DS

更新日期：1997-06-01 00:00:00

abstract：:Two experiments were conducted to test the hypothesis that tolerance to the hypothermic effect of ethanol fails to develop if rats are denied the unconditional stimulus represented by hypothermia. In both experiments, rats were injected with either ethanol (1.9 or 2.5 g/kg) or saline and given microwave hyperthermia (...

journal_title：Psychopharmacology

authors： Hjeresen DL,Reed DR,Woods SC

更新日期：1986-01-01 00:00:00

abstract：:The effects of the selective 5-HT1A agonists 8-OH-DPAT and flesinoxan and the selective 5-HT2 antagonists ritanserin and ketanserin on immobility time in rats bred for predisposition to catalepsy have been studied. Treatment with 8-OH-DPAT as well as flesinoxan caused a marked dose-dependent decrease in immobility tim...

journal_title：Psychopharmacology

authors： Kulikov AV,Kolpakov VG,Maslova GB,Kozintsev I,Popova NK

更新日期：1994-02-01 00:00:00

abstract：:Amphetamine stimulates locomotor activity, in large part by activating central dopaminergic systems. Serotonin shares on overlapping distribution with dopamine and has been shown to modulate dopaminergic function and dopamine-mediated behaviors. The present study examined whether increasing serotonergic function, via ...

journal_title：Psychopharmacology

authors： Sills TL,Greenshaw AJ,Baker GB,Fletcher PJ

更新日期：1999-02-01 00:00:00

abstract：:Fourteen rats were trained to discriminate the effects of gamma-hydroxybutyrate (GHB) (sodium salt, 200 mg/kg) and saline in a two-lever choice task using a fixed ratio 10 schedule of water reinforcement. Intermediate responding, i.e., responding not fully appropriate for either training condition was observed in test...

journal_title：Psychopharmacology

authors： Winter JC

更新日期：1981-01-01 00:00:00

abstract：:To confirm the conclusions from a previous study supporting the usefullness of electropupillogram (E.P.G.) in predicting clinical response, data from three separate studies with hyperkinetic and learning disabled (L.D.) children treated with stimulants were surveyed. Change in extent of pupillary contraction (E.C.) af...

journal_title：Psychopharmacology

authors： Bhatara V,Arnold LE,Knopp W,Smeltzer DJ

更新日期：1978-04-28 00:00:00

abstract：RATIONALE:Heavy ecstasy use in humans has been associated with cognitive impairments and changes in cognitive brain function supposedly due to damage to the serotonin system. There is concern that even a single dose of 3,4-methylenedioxymethamphetamine may be neurotoxic, but very little is known about the consequences ...

journal_title：Psychopharmacology

authors： Jager G,de Win MM,Vervaeke HK,Schilt T,Kahn RS,van den Brink W,van Ree JM,Ramsey NF

更新日期：2007-08-01 00:00:00

abstract：:Progabide inhibited male rat sexual behavior at a dose of 200 mg/kg. This dose had only modest effects on ambulatory activity and no effect at all on motor coordination as evaluated by a rotarod test. The GABAA antagonist bicuculline, at a dose of 1 mg/kg, blocked the effects of progabide on sex behavior. In contrast,...

journal_title：Psychopharmacology

authors： Agmo A,Paredes RG,Sierra L,Garcés I

更新日期：1997-01-01 00:00:00

abstract：:Postsynaptic dopamine-cholecystokinin (CCK) interactions in the nucleus accumbens were studied in two behavioral preparations of DA receptor supersensitivity: chronic-neuroleptic treated and 6-hydroxydopamine (6-OHDA) denervated rats. Subcutaneous (SC) injections of apomorphine (APO; 0.15 mg/kg) in experiment 1 produc...

journal_title：Psychopharmacology

authors： Weiss F,Ettenberg A,Koob GF

更新日期：1989-01-01 00:00:00

abstract：:After initial exposure to 80 mg/kg, pigeons trained on a two-key drug discrimination procedure rapidly learned to discriminate 120 mg/kg ethosuximide from saline. When 40-160 mg/kg doses of ethosuximide were administered during generalization tests, the percentage of responses directed to the ethosuximide-appropriate ...

journal_title：Psychopharmacology

authors： Clark RD,Schlinger H,Poling A

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:In patients, ketamine is a fast-acting antidepressant that can induce long-lasting symptom relief. Similar rapid effects have been reported in rodents, but reports of lasting effects are limited. OBJECTIVES:We sought to extend past findings by examining dose-response curves that overlap with the individual d...

journal_title：Psychopharmacology

authors： Bechtholt-Gompf AJ,Smith KL,John CS,Kang HH,Carlezon WA Jr,Cohen BM,Ongür D

更新日期：2011-06-01 00:00:00

abstract：:The study compares the behavioral profiles induced in rats (N = 118) by the D2-dopaminergic receptor agonist quinpirole (0.03 and 0.5 mg/kg), and the D1-agonist SKF38393 (1.25-40 mg/kg), and both agonists administered together. Locomotion and snout contact frequency were reduced by the low but increased by the high do...

journal_title：Psychopharmacology

authors： Eilam D,Talangbayan H,Canaran G,Szechtman H

更新日期：1992-01-01 00:00:00

abstract：:SCH 39166 is the first selective D1-dopamine receptor antagonist developed for clinical trials in schizophrenia. SCH 39166 was evaluated as a radioligand for PET, labeled with 11C, and as a D1-dopamine receptor antagonist after single oral doses in healthy men. After intravenous injection of [11C]SCH 39166 distributio...

journal_title：Psychopharmacology

authors： Karlsson P,Sedvall G,Halldin C,Swahn CG,Farde L

更新日期：1995-10-01 00:00:00

abstract：:The relationship between nicotine yield as determined by the FTC method and nicotine absorption was examined in 72 smokers in a more rigorous repetition of a previous study of 33 smokers. For this study, 113 smokers evenly distributed across four FTC "tar" yield ranges were recruited, only 72 demonstrated reasonable c...

journal_title：Psychopharmacology

authors： Byrd GD,Davis RA,Caldwell WS,Robinson JH,deBethizy JD

更新日期：1998-10-01 00:00:00

abstract：RATIONALE:Combining neuroleptics with 5-HT1A ligands is thought to improve the preclinical profile of neuroleptics and may be of interest in the development of new compounds that have greater therapeutic potential and/or are better tolerated. OBJECTIVE:To examine 1) the ability of 5-HT1A ligands to alter the effects o...

journal_title：Psychopharmacology

authors： Prinssen EP,Kleven MS,Koek W

更新日期：1999-05-01 00:00:00

abstract：:The present study compared cocaine-induced hyperlocomotion and cocaine i.v. self-administration in DBA/2J and C57BL/6J mice. In the locomotor activity experiment, these strains were tested for hyperlocomotion after i.p. cocaine injection (0-60.0 mg/kg), using a Digiscan Animal Activity Monitoring System. In the cocain...

journal_title：Psychopharmacology

authors： Rocha BA,Odom LA,Barron BA,Ator R,Wild SA,Forster MJ

更新日期：1998-07-01 00:00:00