Abstract:
RATIONALE:Previous research has identified a number of factors that appear to moderate the behavioural response to glucose administration. These include physiological state, dose, types of cognitive tasks used and level of cognitive demand. Another potential moderating factor is the length of the fasting interval prior to a glucose load. OBJECTIVES:Therefore, we aimed to examine the effect of glucose dose and fasting interval on mood and cognitive function. METHODS:The current study utilised a double-blind, placebo-controlled, balanced, six period crossover design to examine potential interactions between length of fasting interval (2 versus 12 hours) and optimal dose for cognition enhancement. RESULTS:Results demonstrated that the higher dose (60 g) increased working memory performance following an overnight fast, whereas the lower dose (25 g) enhanced working memory performance following a 2-h fast. CONCLUSIONS:The data suggest that optimal glucose dosage may differ under different conditions of depleted blood glucose resources. In addition, glucoregulation was observed to be a moderating factor. However, further research is needed to develop a model of the moderating and mediating factors under which glucose facilitation is best achieved.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Owen L,Scholey AB,Finnegan Y,Hu H,Sünram-Lea SIdoi
10.1007/s00213-011-2510-2subject
Has Abstractpub_date
2012-04-01 00:00:00pages
577-89issue
3eissn
0033-3158issn
1432-2072journal_volume
220pub_type
杂志文章,随机对照试验abstract::Naloxone, an opioid receptor antagonist, attenuates a wide range of behavioral effects of d-amphetamine, such as the stimulation of motor activity. To investigate the pharmacological selectivity of the naloxone/amphetamine interaction, we assessed the effects of naloxone (5.0 mg/kg SC) upon motor activity induced in r...
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