Abstract:
:The effects of acute marijuana intoxication on remote memory and new learning were assessed. To test for the effects of marijuana on remote memory, titles of one-season television shows, aired up to 14 years previously, were used in three tests measuring recognition, temporal judgement and detailed recall of facts from the shows. Marijuana did not affect remote memory in comparison to placebo. The effects of marijuana on the learning of a word list were also tested. Marijuana significantly impaired new learning at the same time that remote memory was unaffected.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Wetzel CD,Janowsky DS,Clopton PLdoi
10.1007/BF00432561subject
Has Abstractpub_date
1982-01-01 00:00:00pages
278-81issue
3eissn
0033-3158issn
1432-2072journal_volume
76pub_type
临床试验,杂志文章,随机对照试验abstract::Tolerance to nicotine occurs in mice after its chronic administration. This tolerance is accompanied by an up-regulation of nicotinic receptors as assessed by the binding of (3H)-nicotine and alpha-(125I)-bungarotoxin (BTX). Past studies (Marks et al. 1983, 1986) have shown that the increase in BTX binding sites is mo...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00212766
更新日期:1988-01-01 00:00:00
abstract::A prospective, placebo-controlled, comparative evaluation was conducted on two widely prescribed, sympatholytic antihypertensive agents with known CNS effects. In order to separately assess these effects in younger and older male hypertensives, patients were assigned to either of two treatment studies based on age. Fo...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02245917
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:The pharmacological profile of escitalopram, the S-(+)-enantiomer of citalopram, was studied and compared with citalopram and the R-(-)-enantiomer, R-citalopram. METHODS:Inhibition of the serotonin transporter (5-HTT) was studied in COS-1 cells expressing the human 5-HTT (h-5-HTT) and in rat brain synaptosom...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1364-z
更新日期:2003-06-01 00:00:00
abstract::Antipsychotic drugs, such as haloperidol and risperidone, are used in long-term treatment of psychiatric patients and thus increase the risk of obesity and other metabolic dysfunctions. Available evidence suggests that these drugs have pro-inflammatory effect, which contributes to the establishment of endocrine distur...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-4079-7
更新日期:2016-05-01 00:00:00
abstract:RATIONALE:Preclinical studies suggest that medications enhancing the brain gamma amino butyric acid (GABA) system attenuate the rewarding effects of stimulants including nicotine. These preclinical studies have not been followed up in systematic human studies. OBJECTIVES:This study was conducted to examine the effects...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-005-0010-y
更新日期:2005-09-01 00:00:00
abstract::NCQ 298 ((S)-3-iodo-N-[(l-ethyl-2-pyrrolidinyl)methyl]-5,6- dimethoxysalicylamide) has an iodine substituent. We have labelled NCQ 298 with 123I and 125I, and used the radioligands as tracers in receptor studies in vitro, in vivo in autoradiography and in SPECT studies on Cynomolgus monkeys. [125I]NCQ 298 bound in vit...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244067
更新日期:1991-01-01 00:00:00
abstract:INTRODUCTION:Alcohol has been shown to increase smoking urges and smoking behavior. However, alcohol's effects on specific components of smoking behavior for nicotine versus non-nicotine factors and potential sex differences in this response have not been investigated. METHODS:Forty-two young male and female non-depen...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-009-1638-9
更新日期:2009-11-01 00:00:00
abstract:RATIONALE:The startle reflex to a sudden intense acoustic pulse stimulus is attenuated if the pulse is shortly preceded by a weak prepulse stimulus. This represents a form of sensory gating, known as prepulse inhibition (PPI), observable across species. PPI is modulated by dopamine and readily disrupted by acute amphet...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2819-5
更新日期:2013-01-01 00:00:00
abstract::Brain 5-hydroxytryptamine (5-HT) was depleted in rats by intraventricular injection with 5,7-dihyroxytryptamine (5,7-DHT) prior to feeding rats a liquid diet containing ethanol. After withdrawal of ethanol, withdrawal reactions were significantly less severe in 5-HT-depleted rats than control rats. Sleeping times afte...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427597
更新日期:1980-01-01 00:00:00
abstract:RATIONALE:Direct activation of the cannabinoid CB1 receptor in the dorsolateral periaqueductal gray (dlPAG) inhibits anxiety- and panic-related behaviours in experimental animals. It has remained unclear, however, whether the local endocannabinoid signalling is recruited as a protective mechanism against aversive stimu...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3793-x
更新日期:2015-05-01 00:00:00
abstract:RATIONALE:Observing responses bring sensory receptors into contact with environmental stimuli. In the observing-response procedure, periods in which an operant response (e.g. pressing a lever) is reinforced by drug deliveries alternate with periods in which this response is never reinforced (i.e. extinction). These alt...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1390-5
更新日期:2003-05-01 00:00:00
abstract::Recently, evidence has emerged showing that the behavioural and hormonal features of fear extinction are altered as a result of reproductive experience in both rats and humans. The current set of experiments sought to determine whether reproductive experience also alters the molecular features of fear extinction. In a...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-4956-y
更新日期:2019-01-01 00:00:00
abstract:RATIONALE:Psychomotor stimulants can induce psychotic states in humans that closely resemble those observed in patients with idiopathic schizophrenia. Attentional and sensorimotor gating impairments are observed in schizophrenic patients using the latent inhibition (LI) and prepulse inhibition (PPI) behavioral assays, ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1254-4
更新日期:2003-09-01 00:00:00
abstract::It has been suggested that reward-related learning may require intact functioning at the dopamine D1 receptor. The present experiment tested this hypothesis by challenging the reward-enhancing effects of the D2 agonist, bromocriptine, with a D1 antagonist, SCH 23390. For comparison, the effects of the D2 antagonist, p...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245944
更新日期:1995-04-01 00:00:00
abstract::The distinctive effects of ethanol on behavior suggest that certain parts of the CNS may be especially sensitive to it. One of the primary candidates is the hippocampal formation. Damage to this structure mimics acute ethanol treatment across a wide variety of behavioral tasks and processes. The possibility of a hippo...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00445554
更新日期:1989-01-01 00:00:00
abstract:INTRODUCTION:Nearly 25% of American adults remain regular smokers. Current smokers may be especially likely to possess characteristics that impair their ability to quit, such as impulsivity. Impulsive individuals may be overly prone to smoke because they are particularly drawn to rewarding stimuli and related cues. The...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-007-0832-x
更新日期:2007-10-01 00:00:00
abstract::The effects of dietary caffeine and the amount and palatability of food on the acquisition of cocaine (0.2 mg/kg) self-administration were examined. Using an autoshaping procedure, seven groups of 13 rats each were trained to press a lever resulting in a cocaine (0.2 mg/kg infusion under a fixed-ratio 1 (FR 1) schedul...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050596
更新日期:1998-05-01 00:00:00
abstract::Many behavioral effects of cocaine are attenuated by dopamine (DA) receptor antagonists. Yet, long-term DA antagonist administration enhances neuronal responsiveness to DA in several pathways, including the mesolimbic system. This study compared the effects of short-term versus long-term administration of the DA antag...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050138
更新日期:1996-12-01 00:00:00
abstract:RATIONALE:Alzheimer disease (AD), a progressive neurodegenerative disorder, is the leading cause of dementia in the elderly. A combination of cholinergic and glutamatergic dysfunction appears to underlie the symptomatology of AD, and thus, treatment strategies should address impairments in both systems. Evidence sugges...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-008-1092-0
更新日期:2008-05-01 00:00:00
abstract:RATIONALE:The indirect dopamine agonist methylphenidate remediates cognitive deficits in psychopathology, but the individual characteristics that determine its effects on the brain are not known. OBJECTIVES:We aimed to determine whether targeted dopaminergically modulated traits and individual differences could predic...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-016-4307-9
更新日期:2016-07-01 00:00:00
abstract::Chronic treatment (2 weeks) with piracetam (500 mg/kg, once daily PO) elevated m-cholinoceptor density in the frontal cortex of aged (18 months) female mice by about 30-40%, but had no effect on m-cholinoceptor density in the frontal cortex of young (4 weeks) mice. The effect of piracetam on m-cholinoceptor density as...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00735884
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Alcoholics report persistent alcohol craving that is heightened by cognitive cues, stressful situations, and abstinence. The role of endogenous cannabinoids in human alcohol craving--though long suspected--remains elusive. MATERIALS AND METHODS:We employed laboratory exposure to stress, alcohol cue, and neu...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1518-3
更新日期:2009-07-01 00:00:00
abstract:RATIONALE:There is a requirement to ensure that UK armed forces are provided with the best possible medical countermeasures to prevent or mitigate the effects of exposure to nerve agents. When pretreatments are under consideration, it is of particular importance to ensure that they do not in themselves give rise to adv...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1324-7
更新日期:2003-03-01 00:00:00
abstract:RATIONALE:Opioids remain the drugs of choice for treating moderate to severe pain, although adverse effects often limit use. Drugs acting concomitantly as agonists at μ opioid receptors and antagonists at δ opioid receptors produce antinociceptive effects with a reduced profile of adverse effects; one such drug, benzyl...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05638-1
更新日期:2020-12-01 00:00:00
abstract::The problem of the advantage of using nortriptyline (NT) plasma level during treatment for endogenous depression has been approached. In an ordinary psychiatric department, 34 patients had their NT level checked the second week of treatment and their dosage subsequently adjusted, if it was outside the recommended ther...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00428027
更新日期:1978-09-15 00:00:00
abstract::The behavioral effects following intrastriatal MPP+, the neurotoxic metabolite of MPTP, were evaluated in mice. Bilateral injections of 10 micrograms MPP+ to mice previously trained in the shuttle box paradigm produced a 66% decrease in striatal dopamine and significant deficits in all measures of conditioned avoidanc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00176480
更新日期:1987-01-01 00:00:00
abstract:RATIONALE:Attention-deficit/hyperactivity disorder (ADHD) is thought to involve hypofunctional catecholamine systems in the striatum, nucleus accumbens, and prefrontal cortex (PFC); however, recent clinical evidence has implicated glutamate dysfunction in the pathophysiology of ADHD. Recent studies show that increased ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3479-4
更新日期:2014-08-01 00:00:00
abstract:RATIONALE:The intake of psychostimulant drugs may induce cognitive dysfunction and negative affective-like states, and is associated with increased activity of stress-responsive systems. The corticotropin-releasing factor (CRF) system mediates neuroendocrine, behavioural and autonomic responses to stressors, and might ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3534-1
更新日期:2014-10-01 00:00:00
abstract::The differential sensitivity of young and elderly healthy adults to the impairment effects of benzodiazepines was assessed by tasks with several levels of difficulty. Using a double-blind procedure, single doses of placebo, alprazolam (0.75 and 1.5 mg) and triazolam (0.25 and 0.5 mg) were ingested orally by 10 young m...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02245796
更新日期:1990-01-01 00:00:00
abstract::Oxytocin plays an important role in the regulation of normal cognitive functions and behaviors, which are disturbed in schizophrenia. Several studies suggest that oxytocinergic function is abnormal in schizophrenia patients. Thus, oxytocin may be involved in the pathophysiology associated with this disorder. This stud...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050811
更新日期:1999-01-01 00:00:00