Dietary additives and the acquisition of cocaine self-administration in rats.


:The effects of dietary caffeine and the amount and palatability of food on the acquisition of cocaine (0.2 mg/kg) self-administration were examined. Using an autoshaping procedure, seven groups of 13 rats each were trained to press a lever resulting in a cocaine (0.2 mg/kg infusion under a fixed-ratio 1 (FR 1) schedule. One group had ad libitum access to caffeine- (0.2% w/w) admixed food. Three groups had access to 10 g, 20 g or ad lib food each day. Another three groups had the same three amounts of ground food with powdered saccharin (0.2% w/w) added. During daily 6-h autoshaping sessions, ten infusions were delivered each hour under a random-time 90-s schedule after a brief (15 s) extension of a retractable lever. These were followed by 6-h self-administration sessions, when the lever remained extended and cocaine infusions were available under an FR 1 schedule. The acquisition criterion was self-administration of a mean of 100 infusions over 5 days. Cocaine self-administration was accelerated in the caffeine group compared to the regular chow group. However, by 30 days nearly the same percentage of rats in the caffeine and regular food groups met the acquisition criterion. In the other six groups, as the amount of food increased, the rate of acquisition and percentage of rats per group meeting the acquisition criterion decreased. In the ad lib group, acquisition was further reduced when saccharin was added to food. In summary, dietary caffeine accelerated acquisition and a greater amount and increased palatability of food independently interfered with acquisition of cocaine self-administration in rats.




Carroll ME,Lac ST




Has Abstract


1998-05-01 00:00:00












  • Computational psychopharmacology: a translational and pragmatic approach.

    abstract:RATIONALE:Psychopharmacology needs novel quantitative measures and theoretical approaches based on computational modelling that can be used to help translate behavioural findings from experimental animals to humans, including patients with neuropsychiatric disorders. OBJECTIVES:This brief review exemplifies this appro...


    pub_type: 杂志文章,评审


    authors: Robbins TW,Cardinal RN

    更新日期:2019-08-01 00:00:00

  • Comparison between the effects of propranolol and chlordiazepoxide on timing behaviour in the rat.

    abstract::Ten rats were trained to lever press for food reward on a schedule of differential reinforcement of low rates of response with a 20-s criterion (DRL 20). Ten more were trained on a new schedule of punishment, designed to be comparable to DRL 20 - differential punishment of high rates of response (DPH 20). Under this s...


    pub_type: 杂志文章


    authors: Salmon P,Gray JA

    更新日期:1985-01-01 00:00:00

  • Neonatal domoic acid alters in vivo binding of [11C]yohimbine to α2-adrenoceptors in adult rat brain.

    abstract:RATIONALE:Epilepsy is a debilitating seizure disorder that affects approximately 50 million people. Noradrenaline reduces neuronal excitability, has anticonvulsant effects and is protective against seizure onset. OBJECTIVE:We investigated the role of α2-adrenoceptors in vivo in a neonatal domoic acid (DOM) rat model o...


    pub_type: 杂志文章


    authors: Thomsen MB,Lillethorup TP,Jakobsen S,Nielsen EH,Simonsen M,Wegener G,Landau AM,Tasker RA

    更新日期:2016-10-01 00:00:00

  • Effects of oxytocin on methamphetamine-seeking exacerbated by predator odor pre-exposure in rats.

    abstract:RATIONALE:The endogenous oxytocin system has emerged as an inhibitor of drug-seeking and stress in preclinical models. OBJECTIVES:The goal of this study was to examine whether systemic oxytocin administration attenuated methamphetamine (METH)-seeking in rats pre-exposed to a predator odor threat. METHODS:In Experimen...


    pub_type: 杂志文章


    authors: Ferland CL,Reichel CM,McGinty JF

    更新日期:2016-03-01 00:00:00

  • Sensitization to systemic amphetamine produces an enhanced locomotor response to a subsequent intra-accumbens amphetamine challenge in rats.

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    pub_type: 杂志文章


    authors: Paulson PE,Robinson TE

    更新日期:1991-01-01 00:00:00

  • Abnormal response to methylphenidate across multiple fMRI procedures in cocaine use disorder: feasibility study.

    abstract:RATIONALE:The indirect dopamine agonist methylphenidate remediates cognitive deficits in psychopathology, but the individual characteristics that determine its effects on the brain are not known. OBJECTIVES:We aimed to determine whether targeted dopaminergically modulated traits and individual differences could predic...


    pub_type: 杂志文章,随机对照试验


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    更新日期:2016-07-01 00:00:00

  • Discriminative stimulus effects of a low dose of apomorphine in the rat.

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    pub_type: 杂志文章


    authors: Tang AH,Franklin SR

    更新日期:1987-01-01 00:00:00

  • Post-retrieval extinction training enhances or hinders the extinction of morphine-induced conditioned place preference in rats dependent on the retrieval-extinction interval.

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    pub_type: 杂志文章


    authors: Ma X,Zhang JJ,Yu LC

    更新日期:2012-05-01 00:00:00

  • The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats.

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    pub_type: 杂志文章


    authors: Campbell UC,Lalwani K,Hernandez L,Kinney GG,Conn PJ,Bristow LJ

    更新日期:2004-09-01 00:00:00

  • Association of OPRM1 A118G variant with the relative reinforcing value of nicotine.

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    pub_type: 杂志文章


    authors: Ray R,Jepson C,Patterson F,Strasser A,Rukstalis M,Perkins K,Lynch KG,O'Malley S,Berrettini WH,Lerman C

    更新日期:2006-10-01 00:00:00

  • Role of orexin/hypocretin in conditioned sucrose-seeking in rats.

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    pub_type: 杂志文章


    authors: Cason AM,Aston-Jones G

    更新日期:2013-03-01 00:00:00

  • Rapid development of tolerance to sub-anaesthetic dose of ketamine: an oculomotor study in macaque monkeys.

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    pub_type: 杂志文章


    authors: Pouget P,Wattiez N,Rivaud-Péchoux S,Gaymard B

    更新日期:2010-05-01 00:00:00

  • Effect of social stress during acute nicotine abstinence.

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    pub_type: 杂志文章,随机对照试验


    authors: Wardle MC,Munafò MR,de Wit H

    更新日期:2011-11-01 00:00:00

  • Anxiolytic-like profile in Wistar, but not Sprague-Dawley rats in the social interaction test.

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    pub_type: 杂志文章


    authors: Rex A,Voigt JP,Gustedt C,Beckett S,Fink H

    更新日期:2004-12-01 00:00:00

  • On the selectivity and specificity of the antagonism of apomorphine-induced suppression of exploration by sulpiride.

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    pub_type: 杂志文章


    authors: Ståhle L,Ungerstedt U

    更新日期:1989-01-01 00:00:00

  • Stimuli produced by observing responses make rats' ethanol self-administration more resistant to price increases.

    abstract:RATIONALE:Observing responses bring sensory receptors into contact with environmental stimuli. In the observing-response procedure, periods in which an operant response (e.g. pressing a lever) is reinforced by drug deliveries alternate with periods in which this response is never reinforced (i.e. extinction). These alt...


    pub_type: 杂志文章


    authors: Shahan TA

    更新日期:2003-05-01 00:00:00

  • Facilitation of self-stimulation with high doses of amphetamine in the rat.

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    pub_type: 杂志文章


    authors: Zacharko RM,Wishart TB

    更新日期:1979-08-08 00:00:00

  • The aluminum-induced increase in blood-brain barrier permeability to delta-sleep-inducing peptide occurs throughout the brain and is independent of phosphorus and acetylcholinesterase levels.

    abstract::The effect of aluminum on levels of inorganic phosphorus and acetylcholinesterase in blood and brain and on permeability of the blood-brain barrier (BBB) in different regions of the brain to the neuropeptide delta-sleep-inducing peptide (DSIP) was studied in adult rats. Aluminum (100 mg/kg) significantly increased the...


    pub_type: 杂志文章


    authors: Banks WA,Kastin AJ

    更新日期:1985-01-01 00:00:00

  • Continuous low-level apomorphine administration induces motor abnormalities and hallucinogen-like behaviors.

    abstract::Continuous low-level (0.825 mg/kg/h for 20 h) administration of AP through SC in-dwelling silicone reservoirs in the rat induced behavioral and biochemical changes that were similar to those induced by low levels (0.1 mg/kg) of acutely administered AP (decreased behavioral activity and decreased dopamine metabolism in...


    pub_type: 杂志文章


    authors: Davis RE,Sant WW,Ellison G

    更新日期:1985-01-01 00:00:00

  • Behavioral effects of benzylideneoxymorphone (BOM), a low efficacy µ opioid receptor agonist and a δ opioid receptor antagonist.

    abstract:RATIONALE:Opioids remain the drugs of choice for treating moderate to severe pain, although adverse effects often limit use. Drugs acting concomitantly as agonists at μ opioid receptors and antagonists at δ opioid receptors produce antinociceptive effects with a reduced profile of adverse effects; one such drug, benzyl...


    pub_type: 杂志文章


    authors: Mada S,Gerak LR,Soyer A,Maguire DR,Hu Z,Minervini V,Cunningham CW,France CP

    更新日期:2020-12-01 00:00:00

  • Separate and combined effects of marijuana and alcohol on mood, equilibrium and simulated driving.

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    pub_type: 临床试验,杂志文章


    authors: Liguori A,Gatto CP,Jarrett DB

    更新日期:2002-10-01 00:00:00

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    pub_type: 杂志文章


    authors: Jewett DC,Mosberg HI,Woods JH

    更新日期:1996-10-01 00:00:00

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    pub_type: 杂志文章


    authors: McKee SA,Krishnan-Sarin S,Shi J,Mase T,O'Malley SS

    更新日期:2006-12-01 00:00:00

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    pub_type: 杂志文章


    authors: Ujike H,Akiyama K,Otsuki S

    更新日期:1990-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Freret T,Lelong-Boulouard V,Lecouflet P,Hamidouche K,Dauphin F,Boulouard M

    更新日期:2017-08-01 00:00:00

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    pub_type: 杂志文章


    authors: Lacy RT,Strickland JC,Feinstein MA,Robinson AM,Smith MA

    更新日期:2016-09-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Foulds J,McSorley K,Sneddon J,Feyerabend C,Jarvis MJ,Russell MA

    更新日期:1994-06-01 00:00:00

  • Response sensitization and depression following long-term amphetamine treatment in a self-stimulation paradigm.

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    pub_type: 杂志文章


    authors: Kokkinidis L,Zacharko RM

    更新日期:1980-01-01 00:00:00

  • The DBA/2J strain and prepulse inhibition of startle: a model system to test antipsychotics?

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    pub_type: 杂志文章


    authors: Olivier B,Leahy C,Mullen T,Paylor R,Groppi VE,Sarnyai Z,Brunner D

    更新日期:2001-07-01 00:00:00

  • Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats.

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    pub_type: 杂志文章


    authors: Harun N,Johari IS,Mansor SM,Shoaib M

    更新日期:2020-03-01 00:00:00