Abstract:
:Many behavioral effects of cocaine are attenuated by dopamine (DA) receptor antagonists. Yet, long-term DA antagonist administration enhances neuronal responsiveness to DA in several pathways, including the mesolimbic system. This study compared the effects of short-term versus long-term administration of the DA antagonist, haloperidol, on cocaine place conditioning. In the short-term study, rats were maintained on haloperidol or vehicle for the 10 days of place conditioning. Place conditioning to moderate doses of cocaine (10-15 mg/kg) was attenuated significantly, consistent with the dopaminergic actions of haloperidol and cocaine. In the second study, rats were administered haloperidol after place conditioning which had no effect on the expression of this behavior. Finally, rats were maintained on haloperidol for 30 days prior to and throughout place conditioning and testing which resulted in significant place conditioning at low cocaine doses (2.5-7.5 mg/kg). Because these cocaine doses do not support place conditioning in vehicle-maintained rats, these data suggest that long-term haloperidol administration enhances the sensitivity to these behavioral effects in contrast to the attenuation seen with short-term haloperidol administration. These results have wide-ranging implications for cocaine abuse treatment, particularly among schizophrenic populations.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Kosten TA,DeCaprio JL,Nestler EJdoi
10.1007/s002130050138subject
Has Abstractpub_date
1996-12-01 00:00:00pages
304-12issue
3eissn
0033-3158issn
1432-2072journal_volume
128pub_type
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pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432514
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2005-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00652236
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00181961
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journal_title:Psychopharmacology
pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2004-04-01 00:00:00
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更新日期:2017-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1994-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426726
更新日期:1979-03-22 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-020-05505-z
更新日期:2020-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2015-10-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1996-11-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,评审
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更新日期:2003-09-01 00:00:00