Abstract：
:Chronic treatment (2 weeks) with piracetam (500 mg/kg, once daily PO) elevated m-cholinoceptor density in the frontal cortex of aged (18 months) female mice by about 30-40%, but had no effect on m-cholinoceptor density in the frontal cortex of young (4 weeks) mice. The effect of piracetam on m-cholinoceptor density as determined by the specific binding of tritiated QNB was not affected by concomitant daily treatment with either choline (200 mg/kg) or scopolamine (4 mg/kg). It is concluded that the effect of piracetam on m-cholinoceptor density could explain the positive effects which have been reported for combinations of cholinergic precursor treatment with piracetam on memory and other cognitive functions in aged experimental animals and patients and could also represent part of the possible mechanism of action of piracetam alone.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Pilch H,Müller WEdoi
10.1007/BF00735884subject
Has Abstractpub_date
1988-01-01 00:00:00pages
74-8issue
1eissn
0033-3158issn
1432-2072journal_volume
94pub_type
杂志文章abstract：:A continuous intravenous infusion of the opiate receptor antagonist naloxone, at doses ranging from 0.7 to 1.0 micrograms/kg/min (total dose 8.8-13.2 mg), was performed in eight normal subjects during the first 240 min of night sleep. A significant reduction in stage REM and in stage 4 percent duration was observed. P...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00429731
更新日期：1984-01-01 00:00:00
abstract：RATIONALE:Flumazenil, a competitive antagonist of benzodiazepine receptors (BZRs), has been used as a probe to detect effects of putative endogenous ligands for BZRs in anxiety. Flumazenil is renowned for its highly inconsistent behavioral effects. OBJECTIVE:To ascertain effects of flumazenil in the social conflict te...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-003-1583-y
更新日期：2004-01-01 00:00:00
abstract：RATIONALE:Inhibition of glutamatergic N-methyl-D-aspartate (NMDA) receptors following the administration of NMDA receptor antagonists results in psychotic-like behaviour. Whereas it is known that pharmacological manipulation of dopaminergic and serotonergic pathways affect this drug-induced psychosis, a role for noradr...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130000630
更新日期：2001-03-01 00:00:00
abstract：:Twenty-one depressed patients participated in a study that assessed the predictability of amitriptyline (AT) dosage based on plasma drug concentrations after a single dose. In 11 patients maintained on a fixed dose regimen, the 18-h single-dose level was confirmed to be predictive of steady-state levels. The dose for ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00431471
更新日期：1984-01-01 00:00:00
abstract：INTRODUCTION:Alcohol has been shown to increase smoking urges and smoking behavior. However, alcohol's effects on specific components of smoking behavior for nicotine versus non-nicotine factors and potential sex differences in this response have not been investigated. METHODS:Forty-two young male and female non-depen...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-009-1638-9
更新日期：2009-11-01 00:00:00
abstract：BACKGROUND:Alcohol drinking may lead to increased aggression in certain individuals, and both fighting and drinking increase levels of dopamine and serotonin in mesocorticolimbic structures. Assessing the dynamic changes in these neurotransmitters during the course of drinking and fighting has remained challenging. OB...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0637-3
更新日期：2007-04-01 00:00:00
abstract：RATIONALE:Stress, a powerful precipitant of drug seeking during abstinence, may also accelerate the return to pathological patterns of intake after initial instances of drug reuse. OBJECTIVE:To explore the effect of stress on a learning process underlying relapse, this study assessed the effect of yohimbine on reacqui...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-012-2640-1
更新日期：2012-07-01 00:00:00
abstract：RATIONALE:Delta-opioid agonists produce a number of behavioral effects, including convulsions, antinociception, locomotor stimulation, and antidepressant-like effects. The development of these compounds as treatments for depression is limited by their convulsive effects. Therefore, determining how to separate the convu...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-005-0138-9
更新日期：2005-11-01 00:00:00
abstract：:Rats were treated once with doses of haloperidol or of droperidol below and above the acute ID50 vs the dopamine agonist apomorphine; they were later challenged with an acute dose of apomorphine (0.3 mg/kg, SC) and rated for stereotyped behavioral responses. The two neuroleptics were similar in acute anti-apomorphine ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00431801
更新日期：1985-01-01 00:00:00
abstract：RATIONALE:3,4-Methylenedioxypyrovalerone (MDPV) is a synthetic cathinone abused for its cocaine-like psychostimulant effects in "bath salts" products. While there are currently no pharmacotherapies for MDPV abuse, rodent studies suggest immunotherapy may offer a feasible treatment option. OBJECTIVES:These studies test...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-020-05558-0
更新日期：2020-09-01 00:00:00
abstract：RATIONALE:Repeated administration of psychoactive drugs results in a progressive enhancement of the behavioral effects of these compounds, a phenomenon termed sensitization. OBJECTIVE:We tested whether repeated administration of the non-competitive NMDA receptor antagonist dizocilpine (MK-801) induces sensitization of...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130100776
更新日期：2001-07-01 00:00:00
abstract：:The aim of the present study was to evaluate the effects of cholinergic receptor blockade in the rat prefrontal cortex on cognitive processes. The nicotinic antagonists neuronal bungarotoxin and dihydro-beta-erythroidine and the muscarinic antagonist scopolamine were injected into the prelimbic area of the prefrontal ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02246154
更新日期：1995-05-01 00:00:00
abstract：:The effects of intra-amygdala injections of corticotropin-releasing factor (CRF) on memory and exploratory behavior in rats were examined in the present study. Rats with chronically implanted cannulae received intra-amygdala injections of vehicle or CRF at a dose of 0.01, 0.1 or 1.0 micrograms, either immediately afte...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00177566
更新日期：1988-01-01 00:00:00
abstract：RATIONALE:(+/-)-3,4-methylenedioxymethamphet-amine (MDMA; 'ecstasy'), a commonly used recreational drug, has typically been found to be related to poor cognitive function in humans. However, cannabis consumption may not have been adequately controlled for in these studies. OBJECTIVE:The present study was designed to f...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130000591
更新日期：2001-01-01 00:00:00
abstract：:Acute tolerance, defined as a decreasing drug effect relative to drug-plasma levels (DPL) over a period of minutes to a few hours, is pronounced following single doses of diazepam or pentobarbital. Both of these lipid-soluble drugs produce an early peak behavioral impairment and subsequent rapid recovery component tha...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427800
更新日期：1983-01-01 00:00:00
abstract：RATIONALE:Prepulse inhibition (PPI) and locomotor activity have been used to investigate the effects of antipsychotic and stimulant drugs and their underlying dopaminergic mechanisms. Whereas D2-like agonists consistently decreased PPI and increased locomotion in rats in previous studies, we recently reported that thes...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0511-3
更新日期：2007-04-01 00:00:00
abstract：RATIONALE:F17464, a dopamine D3 receptor antagonist with relatively high D3 selectivity (70 fold vs D2 in vitro), exhibits an antipsychotic profile in preclinical studies, and therapeutic efficacy was demonstrated in a randomized placebo-controlled clinical trial in patients with schizophrenia (Bitter et al. Neuropsych...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-019-05387-w
更新日期：2020-02-01 00:00:00
abstract：:Twelve healthy chronic schizophrenic patients were treated with the long-acting oral dopamine (DA) receptor blocker penfluridol (100 mg orally) for 6 weeks. Plasma prolactin (PRL) levels were measured during insulin-tolerance tests (ITT) performed at the end of the drug-free period (7-10 days) and during weeks 1 and 6...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427494
更新日期：1983-01-01 00:00:00
abstract：RATIONALE:Endogenous opioid systems within the mesencephalic periaqueductal gray matter (PAG) appear to be intricately involved in many affective, defensive, submissive, and reflexive responses, and these systems are activated by aversive stimuli. OBJECTIVES:The present experiments evaluated the influence of opioid re...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130051101
更新日期：1999-09-01 00:00:00
abstract：BACKGROUND:The main psychoactive component of cannabis, delta-9-tetrahydrocannabinol (THC), can impair driving performance. Cannabidiol (CBD), a non-intoxicating cannabis component, is thought to mitigate certain adverse effects of THC. It is possible then that cannabis containing equivalent CBD and THC will differenti...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-019-05246-8
更新日期：2019-09-01 00:00:00
abstract：:The effects of the selective 5-HT1A agonists 8-OH-DPAT and flesinoxan and the selective 5-HT2 antagonists ritanserin and ketanserin on immobility time in rats bred for predisposition to catalepsy have been studied. Treatment with 8-OH-DPAT as well as flesinoxan caused a marked dose-dependent decrease in immobility tim...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245460
更新日期：1994-02-01 00:00:00
abstract：RATIONALE:There is a growing concern over excessive caffeine use and development of caffeine use disorder in children. OBJECTIVES:This study aimed to identify the association between caffeine intake and cognitive functioning in children. METHODS:This study included 11,718 youths aged 9-10 years with cognitive and caf...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-020-05596-8
更新日期：2020-10-01 00:00:00
abstract：:Paradoxical sleep (PS) in the rat, cat and mouse is preceded and sometimes followed by a short-lasting intermediate stage (IS) characterized by high amplitude cortical spindles and low frequency theta rhythm. This stage, which is mimicked by an intercollicular transection, is massively extended at the expense of PS by...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245333
更新日期：1994-11-01 00:00:00
abstract：RATIONALE:Serotonergic mechanisms are thought to play an important role in the regulation of mood, motor activity and sleep patterns. Serotonin reuptake is controlled by the serotonin transporter (5-HTT) and by a common functional insertion/deletion polymorphism in the corresponding gene's promoter region (5-HTTLPR). H...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-004-1995-3
更新日期：2005-03-01 00:00:00
abstract：RATIONALE:Although the effects of D: -cycloserine (DCS) and valproic acid (VPA) on the facilitation of the extinction of fear-conditioned memory have been elucidated in animals, these effects have not been clearly confirmed in humans. OBJECTIVE:This study aimed to determine the effect of DCS (100 mg) and VPA (400 mg) ...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-011-2353-x
更新日期：2011-12-01 00:00:00
abstract：RATIONALE:In humans, the retrieval of memories associated with an alcohol-related experience frequently evokes alcohol-seeking behaviour. The reconsolidation hypothesis states that a consolidated memory could again become labile and susceptible to disruption after memory retrieval. OBJECTIVES:The aim of our study was ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-009-1544-1
更新日期：2009-08-01 00:00:00
abstract：:Nine depressed patients were treated with alaproclate, a selective 5-HT uptake inhibitor, for 3 weeks in a dose of 400 mg daily. The pupillary responses to tyramine, phenylephrine, and pilocarpine eye drops were measured on consecutive days before, after 1 week and after 3 weeks of treatment. The tyramine-induced mydr...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427324
更新日期：1985-01-01 00:00:00
abstract：RATIONALE:We test methods to advance (shift earlier) circadian rhythms without producing misalignment between rhythms and sleep. We previously tested (1) a gradually advancing sleep/dark schedule plus morning bright light and afternoon/evening melatonin and (2) the same sleep schedule with only morning bright light. No...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-012-2869-8
更新日期：2013-02-01 00:00:00
abstract：:These experiments examined the neurochemical mechanisms involved in the development and expression of place conditioning produced by heroin. Conditioned place preferences (CPP) lasting up to 8 weeks were obtained with doses of 50-1000 micrograms/kg heroin, using a regimen shown not to produce physical dependence. Nalo...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00442007
更新日期：1989-01-01 00:00:00
abstract：:The metabolism of the tricyclic antidepressants amitriptyline (AMI), imipramine (IMI), chlorimipramine (CMI) and some of their metabolites was studied in vitro in isolated liver microsomes of female Spraque-Dawley rats. Nine metabolites of AMI, seven metabolites of IMI, and 11 metabolites of CMI were quantitatively de...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00178516
更新日期：1986-01-01 00:00:00
