Abstract:
:Brain 5-hydroxytryptamine (5-HT) was depleted in rats by intraventricular injection with 5,7-dihyroxytryptamine (5,7-DHT) prior to feeding rats a liquid diet containing ethanol. After withdrawal of ethanol, withdrawal reactions were significantly less severe in 5-HT-depleted rats than control rats. Sleeping times after a standard dose of ethanol or pentobarbitone were significantly prolonged in 5-HT-depleted rats. However, metabolic and pharmacodynamic tolerance developed to a similar extent in 5-HT-depleted rats as in control rats. It was concluded that 5-hydroxytryptaminergic neurons are not directly involved in the development of physical dependence on or tolerance to ethanol. Depletion of brain 5-HT by 5,7-DHT appears to result in a non-specific central nervous system depression that potentiates the depressant actions of ethanol and pentobarbitone and antagonises the hyperexcitability of ethanol withdrawal.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Wood JMdoi
10.1007/BF00427597subject
Has Abstractpub_date
1980-01-01 00:00:00pages
67-72issue
1eissn
0033-3158issn
1432-2072journal_volume
67pub_type
杂志文章abstract::Acute and chronic effects of ethosuximide (40, 80, and 120 mg/kg), phenytoin (2.5, 5, and 7.5 mg/kg), clonazepam (0.25, 0.5, and 0.75 mg/kg), and valproic acid (40, 80, and 120 mg/kg) were examined in pigeons performing under a delayed-matching-to-sample procedure. Acute administration of clonazepam or valproic acid p...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00180828
更新日期:1986-01-01 00:00:00
abstract::We examined the possibility that anoxia at birth can alter behavioral sensitization to amphetamine during adulthood. Male rats born either vaginally or by Cesarean section with or without an additional 15-min period of anoxia received five once-daily injections of either d-amphetamine (2.0 mg/kg, i.p.) or vehicle or n...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050419
更新日期:1997-10-01 00:00:00
abstract::Using a conditioned avoidance procedure in rats, the present study examined the ability of 8-OH-DPAT, ritanserin, and prazosin to alter the effects of the dopamine antagonists, raclopride and haloperidol, on avoidance- and on escape responding. The 5-HT1A agonist 8-OH-DPAT (0.16 mg/kg) significantly enhanced the inhib...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050124
更新日期:1996-11-01 00:00:00
abstract::Oral administration of the serotonin (5-HT) precursor L-5-hydroxytryptophan (5-HTP), 200 mg, significantly increased plasma cortisol levels in man. L-5-HTP had no significant effect on the plasma prolactin levels. A borderline effect of 5-HTP on plasma ACTH levels was found. Pretreatment with the 5-HT2/5-HT1c antagoni...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244213
更新日期:1991-01-01 00:00:00
abstract::Paradoxical sleep (PS) in the rat, cat and mouse is preceded and sometimes followed by a short-lasting intermediate stage (IS) characterized by high amplitude cortical spindles and low frequency theta rhythm. This stage, which is mimicked by an intercollicular transection, is massively extended at the expense of PS by...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245333
更新日期:1994-11-01 00:00:00
abstract::The release of serotonin (5-HT) at serotonergic nerve terminals is regulated by 5-HT(1B) autoreceptors. Several studies have reported that the effects of selective 5-HT reuptake inhibitors (SSRIs) on extracellular 5-HT are augmented by 5-HT(1B) receptor antagonists, whereas administration of these antagonists alone do...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1371-0
更新日期:2003-05-01 00:00:00
abstract:RATIONALE:Cocaethylene is a pharmacologically active homolog and metabolite of cocaine, formed by transesterification of cocaine in the presence of ethanol. Here we relate findings from a randomized, placebo-controlled, double-blind study in which we examined the physiological and subjective effects and pharmacokinetic...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002139900363
更新日期:2000-04-01 00:00:00
abstract::Rats were maintained on a regimen of restricted access to water. Desipramine (DMI) IP 1 h prior to the access period dose-dependently reduced water intake. Following completion of the dose-response determination for the effect of desipramine or water intake, rats were divided into three groups for repeated administrat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431934
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Ketamine, a non-competitive N-methyl-D: -aspartic acid antagonist, has been widely used for anaesthetic purposes. At sub-anaesthetic dosage, it induces a dissociative state similar to schizophrenia. The discovery of this effect on dissociative state has led to its use as a pharmacological model of schizophre...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1797-8
更新日期:2010-05-01 00:00:00
abstract:AIM:The purpose of this study was to determine if acute nicotine attenuated ketamine-induced regional cerebral blood flow (rCBF). METHOD:Following 2-4 h of nicotine abstinence, healthy chronic smokers participated in four sets of rCBF studies, H2(15)O positron emission tomography, during a simple sensory motor control...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1758-2
更新日期:2010-03-01 00:00:00
abstract::The effects of the CCKB-receptor agonist pentagastrin, a synthetic analogue of the cholecystokinin tetrapeptide (CCK-4), were studied in seven patients suffering from obsessive compulsive disorder (OCD) and seven healthy controls. All subjects were challenged with an IV dose of 0.6 micrograms/kg pentagastrin or placeb...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02247385
更新日期:1996-08-01 00:00:00
abstract::The augmentation effect of (-)pindolol as used in combination with SSRI to treat major depression has been ascribed to blocking of dorsal raphe nucleus cell body 5-HT autoreceptors. In this study, the radioligand [carbonyl-11C]WAY-100635 and positron emission tomography were used to establish whether pindolol at a cli...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051009
更新日期:1999-06-01 00:00:00
abstract::Cebus apella monkeys were chronically administered the antipsychotic drug fluphenazine decanoate for periods ranging from 3.5 to 5.5 years. In the present study, four of these monkeys and two controls were tested for cognitive abilities on a spatial learning task, which consisted of an original discrimination and four...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00439554
更新日期:1989-01-01 00:00:00
abstract:RATIONALE/OBJECTIVES:Previous research has shown that ecstasy users are impaired in thinking and reasoning. The present study sought to explore the possibility that syllogistic reasoning errors in ecstasy users were due to an inability to construct a model of the premises due to working memory limitations. METHODS:Twe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-0006-7
更新日期:2005-09-01 00:00:00
abstract::Phenelzine (PLZ) is a non-selective monoamine oxidase (MAO) inhibitor commonly used to treat depression and panic disorder. In addition to increasing levels of biogenic amines in the brain, PLZ elevates brain levels of the amino acid gamma-aminobutyric acid (GABA; Baker et al. 1991; present study). Given the extensive...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050890
更新日期:1999-03-01 00:00:00
abstract::The place-preference paradigm was evaluated as a measure of morphine's positive reinforcing properties. Previous place-preference studies obtained a morphine place preference of 26%-63%. In order to examine whether differences in procedure may account for this scatter, the present experiment investigated whether there...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432040
更新日期:1984-01-01 00:00:00
abstract:RATIONALE:Nearly 60-80% of women experience some form of sadness, anxiety, or anhedonia in the weeks following the birth of a child (Patel et al. 23(2):534-42, 2012; Degner 10: 359;j4692, 2017); however, the exact mechanisms that precipitate these changes in mood postpartum are still unknown. It is well-known that the ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05194-3
更新日期:2019-10-01 00:00:00
abstract::Two principal oblique factors are identified in the Bass Social Acquiescence Scale, a measure previously shown to correlate positively with placebo response and negatively with anxiolytic drug response. The two factors appeared very similar in separate analyses of data from samples of 941 psychiatric outpatients and 1...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00433044
更新日期:1979-10-01 00:00:00
abstract:RATIONALE:The metabotropic glutamate (mGlu5) receptor subtype 5 antagonist MPEP attenuates self-administration of numerous drugs of abuse. OBJECTIVES:The purpose of the present study was to explore whether MPEP-induced decreases in nicotine and cocaine self-administration reflect attenuation of the reinforcing and inc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-2070-9
更新日期:2005-04-01 00:00:00
abstract:RATIONALE:Schizophrenia is a severe, persistent, and fairly common mental illness. Haloperidol is widely used and is effective against the symptoms of psychosis seen in schizophrenia. Chronic oral haloperidol administration decreased the number of astrocytes in the parietal cortex of macaque monkeys (Konopaske et al., ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3136-3
更新日期:2013-11-01 00:00:00
abstract:RATIONALE:A rigorously investigated model of stress and antidepressant administration during pregnancy is needed to evaluate possible effects on the mother. OBJECTIVE:The objective of this study was to develop a model of clinically relevant prenatal exposure to an antidepressant and stress during pregnancy to evaluate...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3030-z
更新日期:2013-07-01 00:00:00
abstract::The effects of lormetazepam (0.03 mg/kg IV) a benzodiazepine (BZ) derivative in combination with ZK 93 426 (0.04 mg/kg IV) a beta-carboline, benzodiazepine receptor antagonist were evaluated in humans. Independently, the effects of ZK 93 426 on its own were investigated. A psychometric test battery to evaluate sedatio...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00172956
更新日期:1988-01-01 00:00:00
abstract:RATIONALE:Carrageenan-induced hyperalgesia is a widely used pain model in rodents. However, characteristics of carrageenan-induced hyperalgesia and effects of analgesic drugs under these conditions are unknown in nonhuman primates. OBJECTIVE:The aims of this study were to develop carrageenan-induced hyperalgesia in rh...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3341-0
更新日期:2014-04-01 00:00:00
abstract:RATIONALE:Repeated exposure to psychostimulant drugs causes a long-lasting increase in the psychomotor and reinforcing effects of these drugs and an array of neuroadaptations. One such alteration is a hypersensitivity of striatal activity such that a low dose of amphetamine in sensitized animals produces dorsal striata...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1100-4
更新日期:2008-05-01 00:00:00
abstract:RATIONAL:It has been suggested that phosphodiesterase 5 inhibitors such as sildenafil may be effective in the treatment of negative symptoms of schizophrenia. OBJECTIVE:This study was designed to investigate the effect of sildenafil added to risperidone as augmentation therapy in patients with chronic schizophrenia an...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-010-2044-z
更新日期:2011-02-01 00:00:00
abstract:RATIONALE:3,4-methylenedioxymethamphetamine (MDMA, ecstasy) produces an acute release of 5-HT in the brain, together with increased locomotion and hyperthermia. OBJECTIVE:This study examined whether the acute functional changes of locomotor activity and body temperature are related to enhanced 5-HT release induced by ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1921-9
更新日期:2011-02-01 00:00:00
abstract:INTRODUCTION:Dysfunction of brain dopamine systems is involved in various neuropsychiatric disorders. Challenge studies with dopamine receptor agonists have been performed to assess dopamine receptor functioning, classically using the release of growth hormone (GH) from the hindbrain as primary outcome measure. The obj...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1686-1
更新日期:2010-01-01 00:00:00
abstract:RATIONALE:Relapse to drug-seeking in abstinent heroin addicts and reinstatement in experimental animals are observed when exposed to drug-associated stimuli or cues, the drug itself, and stressful events. It has been shown that footshock-induced stress increases the rewarding effects of opiates, delays extinction, and ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0345-z
更新日期:2006-05-01 00:00:00
abstract::Fifty-nine depressed female inpatients were treated with 100 mg amitriptyline (AMT) IM for 4 weeks. Depression ratings and determinations of the parent drug and nortriptyline (NT) were performed weekly. No direct relationship between plasma AMT + NT concentrations and therapeutic response was apparent, but beneficial ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244602
更新日期:1990-01-01 00:00:00
abstract:RATIONALE:Naturally low prepulse inhibition (PPI) in DBA/2 mice is increased by marketed antipsychotics and compounds acting at novel targets relevant to schizophrenia. Whether other mouse strains with naturally low PPI respond similarly and could be translational models of schizophrenia is unknown. OBJECTIVE:Baseline...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2196-5
更新日期:2011-06-01 00:00:00