Abstract:
:Naloxone, an opioid receptor antagonist, attenuates a wide range of behavioral effects of d-amphetamine, such as the stimulation of motor activity. To investigate the pharmacological selectivity of the naloxone/amphetamine interaction, we assessed the effects of naloxone (5.0 mg/kg SC) upon motor activity induced in rats by a range of psychomotor stimulant drugs with a mechanism of action either similar to or different from that of d-amphetamine. Each of the drugs tested caused dose-dependent increases in both gross and fine activity. Naloxone attenuated the gross but not the fine activity response to d- and l-amphetamine, but had no influence upon the other catecholamine-releasing drugs, methamphetamine and phendimetrazine. In contrast, naloxone increased the gross but not the fine activity response to the catecholamine uptake inhibitors cocaine and mazindol, but had no effects upon the motor response to methylphenidate. The responses to other stimulant drugs (apomorphine, caffeine, scopolamine) were unaffected by naloxone pretreatment. The present findings extend the range of conditions under which naloxone and, by inference, endogenous opioid systems, modulate the behavioral response to psychomotor stimulants. However, the differential effects of naloxone upon the motor response to individual stimulant drugs support previous suggestions of fundamental differences in mechanisms of action among these compounds.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Jones DN,Holtzman SGdoi
10.1007/BF02244839subject
Has Abstractpub_date
1994-03-01 00:00:00pages
215-24issue
2eissn
0033-3158issn
1432-2072journal_volume
114pub_type
杂志文章abstract:RATIONALE:Fluoxetine (Prozac®) is the most frequently prescribed drug to battle depression in pregnant women, but its safety in the unborn child has not yet been established. Fluoxetine, a selective serotonin reuptake inhibitor, crosses the placenta, leading to increased extracellular serotonin levels and potentially n...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2299-z
更新日期:2011-10-01 00:00:00
abstract:RATIONALE:Flumazenil, a competitive antagonist of benzodiazepine receptors (BZRs), has been used as a probe to detect effects of putative endogenous ligands for BZRs in anxiety. Flumazenil is renowned for its highly inconsistent behavioral effects. OBJECTIVE:To ascertain effects of flumazenil in the social conflict te...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1583-y
更新日期:2004-01-01 00:00:00
abstract::Recent work with humans and animals has suggested that the cholinergic system plays an important role in the active control of attention. This study was designed to investigate the effects of scopolamine upon subjects' ability to utilize knowledge of the spatial probability bias in a display in the detection of briefl...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00175197
更新日期:1986-01-01 00:00:00
abstract::Serotonin (5-HT) afferents may modulate the dopamine mesoaccumbens circuit, which has been shown to be critically involved in the locomotor stimulatory, discriminative stimulus, and rewarding properties of cocaine. In the present study, we investigated the role of 5-HT1A receptors in the ventral tegmental area (VTA) i...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050586
更新日期:1998-05-01 00:00:00
abstract:RATIONALE:Pavlovian conditioning with a discrete reward-predictive visual cue can elicit two classes of behaviors: "sign-tracking" (approach toward and contact with the cue) and "goal-tracking" (approach toward the site of reward delivery). Sign-tracking has been proposed to be linked to behavioral disorders involving ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1353-y
更新日期:2009-03-01 00:00:00
abstract:RATIONALE:Kratom is proposed to exhibit therapeutic potential as an opium substitute, but little is known about its dependence-producing profile, particularly of its main psychoactive compound, mitragynine (MG). OBJECTIVES:This study examined the dependence-producing effects of MG using operant-scheduled behaviour in ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05418-6
更新日期:2020-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Blood oxygen level dependent (BOLD) contrast pharmacological magnetic resonance imaging (phMRI) is an increasingly popular technique that allows the non-invasive investigation of spatial and temporal changes in rat brain function in response to pharmacological stimulation in vivo. Rat brain BOL...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-005-2213-7
更新日期:2005-08-01 00:00:00
abstract:RATIONALE:Pramipexole is a dopamine agonist which binds selectively to dopamine D(3) and D(2) receptors. There is evidence that, in addition to its beneficial effects in parkinsonism, this compound may also be of value in addressing symptomatology associated with depressive diseases. OBJECTIVES:The present study was a...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1199-7
更新日期:2002-10-01 00:00:00
abstract:RATIONALE:Enhancement of dopamine (DA) release by corticosteroids may be of aetiological importance in substance misuse. OBJECTIVES:To examine the effect of sub-chronic administration of hydrocortisone on the response to amphetamine in healthy male volunteers. METHODS:Following baseline assessment, 20 volunteers were...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00213-003-1609-5
更新日期:2004-02-01 00:00:00
abstract:INTRODUCTION:The objective of this study was to examine age-, hormone-, and sex-dependent differences to the behavioral effects of nicotine using place-conditioning procedures in female rats. METHODS:Animals received nicotine in their initially non-preferred side and saline on alternate days in their initially preferr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1607-3
更新日期:2009-10-01 00:00:00
abstract::In squirrel monkeys trained to discriminate between two tones, morphine consistently increased the percent of response failures during tone periods; however, it had no consistent effect on the percent correct responses. In contrast, scopolamine decreased percent correct responses as well as increasing percent response...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00428404
更新日期:1985-01-01 00:00:00
abstract:RATIONALE:During the course of our investigation of antalarmin, a corticotropin-releasing hormone (CRH) antagonist, in rhesus monkeys, we noticed that large, intravenous doses of antalarmin resulted in behavioral changes that resembled intoxication. OBJECTIVES:Antalarmin was evaluated in rhesus monkeys for its reinfor...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1187-y
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:Abnormalities of membrane phospholipid metabolism have been described in Alzheimer's disease (AD). We investigated, with the aid of (31)P magnetic resonance spectroscopy, the in vivo intracerebral availability of phosphomonoesters (PME) and phosphodiesters (PDE) in patients with AD. METHODS:Eighteen outpati...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-2168-8
更新日期:2005-07-01 00:00:00
abstract:RATIONALE:Selective serotonin reuptake inhibitor (SSRI) antidepressants are increasingly prescribed during pregnancy. Changes in serotonergic signaling during human fetal development have been associated with changes in brain development and with changes in affective behavior in adulthood. The suprachiasmatic nucleus (...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05556-2
更新日期:2020-08-01 00:00:00
abstract::The effects of the CCKB-receptor agonist pentagastrin, a synthetic analogue of the cholecystokinin tetrapeptide (CCK-4), were studied in seven patients suffering from obsessive compulsive disorder (OCD) and seven healthy controls. All subjects were challenged with an IV dose of 0.6 micrograms/kg pentagastrin or placeb...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02247385
更新日期:1996-08-01 00:00:00
abstract:RATIONALE:The ability of tobacco harm reduction strategies to produce significant reductions in toxin exposure is limited by compensatory increases in smoking behavior. Characterizing factors contributing to the marked individual variability in compensation may be useful for understanding this phenomenon and assessing ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-009-1567-7
更新日期:2009-09-01 00:00:00
abstract:RATIONALE:The non-selective nicotinic acetylcholine receptor (nAChR) agonist nicotine has been argued to improve attention via enhanced filtering of irrelevant stimuli. Here, we tested this hypothesis in the context of smooth pursuit eye movements (SPEMs), an oculomotor function previously shown to improve with nicotin...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-019-05223-1
更新日期:2019-07-01 00:00:00
abstract::Primiparous rats received 0.05, 0.25, 0.50, or 1.50 mg d-amphetamine/kg body weight, injected IP, when offspring reached 3-4 and 10-11 days of age. A multidimensional analysis of their maternal behavior revealed that at doses as low as 0.25 mg/kg, amphetamine had a disruptive effect on mother-pup intercontact interval...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00435314
更新日期:1980-01-01 00:00:00
abstract::The relationship between nicotine yield as determined by the FTC method and nicotine absorption was examined in 72 smokers in a more rigorous repetition of a previous study of 33 smokers. For this study, 113 smokers evenly distributed across four FTC "tar" yield ranges were recruited, only 72 demonstrated reasonable c...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s002130050720
更新日期:1998-10-01 00:00:00
abstract:RATIONALE:Acute ethanol administration induces hypothermia in genetically susceptible animals. Tolerance to this effect may develop with repeated administration. Allopregnanolone is an endogenously produced neuroactive steroid that acts at the GABA-A receptor. We postulated that allopregnanolone would induce hypothermi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1106-2
更新日期:2002-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:We previously found that systemic injections of the 5-HT uptake blocker fluoxetine attenuate intermittent footshock stress-induced reinstatement of alcohol seeking in rats, while inhibition of 5-HT neurons in the median raphe induces reinstatement of alcohol seeking. In this study, we further e...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0346-y
更新日期:2006-05-01 00:00:00
abstract:RATIONALE:Cocaine (COC), ethanol (EtOH), and methamphetamine (MA) are widely abused substances and share the ability to induce behavioral stimulation in mice and humans. Understanding the biological basis of behavioral stimulation to COC, EtOH, and MA may provide a greater understanding of drug and alcohol abuse. OBJE...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-007-0969-7
更新日期:2008-02-01 00:00:00
abstract::Cebus apella monkeys were chronically administered the antipsychotic drug fluphenazine decanoate for periods ranging from 3.5 to 5.5 years. In the present study, four of these monkeys and two controls were tested for cognitive abilities on a spatial learning task, which consisted of an original discrimination and four...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00439554
更新日期:1989-01-01 00:00:00
abstract::In mice, quipazine has shown several behavioral effects: It antagonizes hypothermia induced by a high dose of apomorphine without altering climbing or stereotyped behavior; it antagonizes oxotremorine-induced hypothermia without altering tremors or peripheral signs; and it increases the toxicity of yohimbine. These th...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431273
更新日期:1980-01-01 00:00:00
abstract:RATIONALE:Opioid receptor antagonists reliably alter the expression or extinction of ethanol's conditioned motivational effects as indexed by the place conditioning procedure, suggesting endogenous opioids are normally involved. These studies examined how exogenous stimulation of opioid receptors alters ethanol's condi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05658-x
更新日期:2021-01-01 00:00:00
abstract:RATIONALE:Studies of the discriminative stimulus effects of drug mixtures provide an approach to polydrug abuse and studies on single drugs with multiple effects. OBJECTIVE:This study was designed to investigate whether the use of the AND-OR procedure increases the specificity of drug mixture discriminations. METHODS...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050919
更新日期:1999-03-01 00:00:00
abstract:RATIONALE:Decision-making is a complex cognitive process that is mediated, in part, by subregions of the medial prefrontal cortex (PFC). Decision-making is impaired in a number of psychiatric conditions including schizophrenia. Notably, people with schizophrenia exhibit reductions in GABA function in the same PFC areas...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3816-7
更新日期:2015-05-01 00:00:00
abstract:RATIONALE:Recent studies have shown that metabotropic glutamate receptor 5 (mGluR5) can modulate N-methyl-D-aspartate (NMDA) receptor function in vivo. For example, the mGluR5 antagonist, 2-methyl-6-(phenylethynyl)-pyridine (MPEP) can potentiate PCP (phencyclidine)-evoked hyperactivity and PCP-induced disruptions in pr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-1827-5
更新日期:2004-09-01 00:00:00
abstract:RATIONALE:Repeated administration of psychoactive drugs results in a progressive enhancement of the behavioral effects of these compounds, a phenomenon termed sensitization. OBJECTIVE:We tested whether repeated administration of the non-competitive NMDA receptor antagonist dizocilpine (MK-801) induces sensitization of...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100776
更新日期:2001-07-01 00:00:00
abstract:RATIONALE:Atypical antipsychotic drug (APD)-induced weight gain causes non-compliance, increasing the risk of relapse and medical complications. OBJECTIVES:In an animal model, we assessed body weights, food intake, body fat/lean body mass contents and blood serum levels of glucose and lipids in female rats treated wit...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-0081-9
更新日期:2005-10-01 00:00:00