Abstract:
RATIONALE:Zidovudine (AZT) and lamivudine (3TC) are nucleoside analogues administered prenatally in clinical practice, separately or in combination, as antiretroviral drugs to prevent HIV mother-to-child transmission by inhibiting viral reverse transcriptase. In animal studies pre- and/or perinatal exposure to AZT and 3TC induce age- and sex-dependent neurobehavioural alterations in the offspring. OBJECTIVE:Investigation of short- and medium-term effects of in utero exposure to AZT or 3TC on development of the GABAergic system. METHODS:Pregnant CD-1 mice were given orally twice daily AZT (160 mg/kg), 3TC (500 mg/kg) or vehicle solution (NaCl 0.9%) from pregnancy day 10 to delivery. Offspring locomotion and nociceptive sensitivity were examined on postnatal day (pnd) 8, 14, and 28 after administration of two doses of GABAergic agonist muscimol (pnd 8 and 14: 0.05 and 0.2 mg/kg; pnd 28: 0.2 and 1.0 mg/kg). A 30-min locomotor activity test and a 60 s hot-plate test (50+/-1 degrees C) were used. RESULTS:AZT and 3TC treated mice showed a mild increase of locomotor activity after administration of the high dose muscimol on pnd 8. On pnd 14 the low muscimol dose enhanced locomotor activity in vehicle and 3TC, but not in AZT pups, whereas no prenatal treatment effect was evident on pnd 28. AZT increased nociceptive sensitivity at all ages considered. CONCLUSIONS:Prenatal AZT effects on locomotor activity appear clearly detectable after GABAergic challenge and seem to be transient. AZT effects on pain sensitivity did not appear to be dependent on GABA regulated nociceptive mechanisms. Prenatal 3TC exposure had rather limited effects on locomotor activity development, and no effect on nociception.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Ricceri L,Venerosi A,Valanzano A,Sorace A,Alleva Edoi
10.1007/s002130000585subject
Has Abstractpub_date
2001-02-01 00:00:00pages
434-42issue
4eissn
0033-3158issn
1432-2072journal_volume
153pub_type
杂志文章abstract::NCQ 298 ((S)-3-iodo-N-[(l-ethyl-2-pyrrolidinyl)methyl]-5,6- dimethoxysalicylamide) has an iodine substituent. We have labelled NCQ 298 with 123I and 125I, and used the radioligands as tracers in receptor studies in vitro, in vivo in autoradiography and in SPECT studies on Cynomolgus monkeys. [125I]NCQ 298 bound in vit...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244067
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245291
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pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-010-1819-6
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
doi:10.1007/s00213-006-0479-z
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pub_type: 杂志文章
doi:10.1007/BF02805971
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00496061
更新日期:1979-08-08 00:00:00
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doi:10.1007/s00213-018-5142-y
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pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1992-01-01 00:00:00
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更新日期:2014-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s002130050859
更新日期:1999-02-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1007/BF00429014
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00181959
更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00427276
更新日期:1983-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-006-0542-9
更新日期:2007-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427650
更新日期:1980-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00436092
更新日期:1982-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-005-0275-1
更新日期:2006-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
abstract:RATIONALE:Intramuscular (IM) conventional antipsychotics and/or benzodiazepines are effective in the short-term treatment of acutely agitated psychotic patients but may be associated with adverse effects. A short-acting IM formulation of the novel antipsychotic, ziprasidone, which may offer advantages over conventional...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/s002130000658
更新日期:2001-05-01 00:00:00
abstract:RATIONALE:Animal models of alcohol-seeking are useful for understanding alcohol addiction and for treatment development, but throughput in these models is limited by the extensive pretraining required to overcome the aversive taste of ethanol. Work by Augier et al. (Psychopharmacology 231: 4561-4568, 2014) indicates th...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4824-1
更新日期:2018-04-01 00:00:00