Abstract:
RATIONALE:The use and misuse of prescription opiates in adolescent populations, and in particular, adolescent female populations, has increased dramatically in the past two decades. Given the significant role that opioids play in neuroendocrine function, exposure to opiates during this critical developmental period could have significant consequences for the female, as well as her offspring. OBJECTIVES:In the current set of studies, we utilized the female rat to model the transgenerational impact of adolescent opiate exposure. METHODS:We examined locomotor sensitization in response to the dopamine D2/D3 receptor agonist quinpirole in the adult male progeny (F1 and F2 generations) of females exposed to morphine during adolescence. All females were drug-free for at least 3 weeks prior to conception, eliminating the possibility of direct fetal exposure to morphine. RESULTS:Both F1 and F2 progeny of morphine-exposed females demonstrated attenuated locomotor sensitization following repeated quinpirole administration. These behavioral effects were coupled with increased quinpirole-induced corticosterone secretion and upregulated kappa opioid receptor and dopamine D2 receptor (D2R) gene expression within the nucleus accumbens. CONCLUSIONS:These results suggest significant modifications in response to repeated D2R activation in the progeny of females exposed to opiates during adolescence. Given the significant role that the D2R plays in psychopathology, adolescent opiate exposure could shift the vulnerability of future offspring to psychological disorders, including addiction. Moreover, that effects are also observed in the F2 generation suggests that adolescent opiate exposure can trigger transgenerational epigenetic modifications impacting systems critical for motivated behavior.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Byrnes JJ,Johnson NL,Carini LM,Byrnes EMdoi
10.1007/s00213-012-2960-1subject
Has Abstractpub_date
2013-05-01 00:00:00pages
263-72issue
2eissn
0033-3158issn
1432-2072journal_volume
227pub_type
杂志文章abstract:OBJECTIVES:Recent studies using positron emission tomography (PET) have established the relationship between an intravenous dose of cocaine and the percentage occupancy of the dopamine transporter in humans, and have documented the requirement of more than 50% occupancy for perception of the "high". The present experim...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051093
更新日期:1999-09-01 00:00:00
abstract::Depression in children is currently an area of considerable controversy, as is the use of potent psychopharmacologic agents in children. Since EEG sleep techniques have proven to be useful in understanding the mechanisms of depression in adults and in predicting their response to antidepressants, a pilot study employi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432281
更新日期:1979-01-31 00:00:00
abstract:RATIONALE:Most adult smokers start smoking during their adolescence. This adolescent initiation may be due to multiple factors, but little evidence is available regarding whether their brains are differentially sensitive to the addictive effects of nicotine during adolescence. OBJECTIVE:To test the hypothesis that ado...
journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2004-07-01 00:00:00
abstract:RATIONALE:Schizophrenia is a disorder with cognitive deficits that could stem from cholinergic dysfunction. OBJECTIVES:Our aim was to examine if donepezil administered to stable, medicated outpatients with schizophrenia improves cognition and psychopathology. METHODS:We conducted a double-blind placebo-controlled tri...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-005-2235-1
更新日期:2005-09-01 00:00:00
abstract:RATIONALE:Alcohol intoxication can dampen negative affective reactions to stressors. Recently, it has been proposed that these acute anxiolytic effects of alcohol may extend to dampening of negative affective reactions to error commission during cognitive control tasks. Nonetheless, empirical verification of this claim...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05619-4
更新日期:2020-11-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00310626
更新日期:1986-01-01 00:00:00
abstract::The predatory behavior of ferrets (Putorius putorius furo L.) consists mainly of instinctive behavioral patterns that are elicited by simple external stimuli. For the ferret, the time needed to catch and kill rats depends on the size of the rats in relation to that of the ferret. Killing success decreases with a relat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427754
更新日期:1978-10-31 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-4079-7
更新日期:2016-05-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-03-01 00:00:00
abstract::In order to study the role of dopamine (DA) in the regulation of seizure mechanisms in man, a non-emetic dose of apomorphine, a direct stimulant of DA receptors, was administered to eight patients effected by different types of epilepsy. The EEG changes induced by apomorphine administration in comparison to those elic...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1983-01-01 00:00:00
abstract::We investigated the possibility that repeated electrical stimulation of the basolateral amygdala (kindling) would increase punished behavior, a pre-clinical indicator of anti-anxiety activity. Male Sprague-Dawley rats, prepared with electrodes in the left basolateral nucleus and frontal cortex, were trained to bar-pre...
journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVE:Schizophrenia displays sex differences in many aspects. Decreased brain-derived neurotrophic factor (BDNF) levels have been reported to be associated with high body weight or obesity as well as other psychopathological aspects in schizophrenia patients. This study aimed to explore sex difference...
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更新日期:2019-02-01 00:00:00
abstract::Seven neuroleptic-free schizophrenic patients received bromocriptine and eight schizophrenic patients received CF 25-397, both ergot derivatives with dopamine agonist activity. Psychosis failed to improve in response to either drug at the relatively low doses administered. Unlike the antipsychotic property of apomorph...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1979-01-01 00:00:00
abstract::The serotonin 5-HT(3) receptor is thought to play a role in the reward pathway and drug abuse by modulating dopamine release within the mesolimbic pathway. Dopamine release stimulated by cocaine and methamphetamine is blocked by administration of 5-HT(3) receptor antagonists. Animal studies demonstrate that 5-HT(3) re...
journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2001-10-01 00:00:00
abstract:INTRODUCTION:Alcohol has been shown to increase smoking urges and smoking behavior. However, alcohol's effects on specific components of smoking behavior for nicotine versus non-nicotine factors and potential sex differences in this response have not been investigated. METHODS:Forty-two young male and female non-depen...
journal_title:Psychopharmacology
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更新日期:2009-11-01 00:00:00
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更新日期:2008-03-01 00:00:00
abstract:RATIONALE:Impulsive behavior is associated with both alcohol use disorders and a family history of alcoholism (FHA). One operational definition of impulsive behavior is the stop-signal task (SST) which measures the time needed to stop a ballistic hand movement. OBJECTIVE:Employ functional magnetic resonance imaging (f...
journal_title:Psychopharmacology
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doi:10.1007/s00213-013-3038-4
更新日期:2013-07-01 00:00:00
abstract::Two 2-(di-n-propylamino)tetralin (DPAT) compounds, 8-OH-DPAT and 5-OH-DPAT, with reported effects on central 5-HT and DA receptors respectively, were tested for their effects on the acoustic startle response in rats. 8-OH-DPAT was given in doses of 0.25-2.0 mg/kg IP and 5-OH-DPAT in doses of 1.0-8.0 mg/kg IP. Both com...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427793
更新日期:1983-01-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:2014-09-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:2002-04-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:2005-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246191
更新日期:1995-07-01 00:00:00
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journal_title:Psychopharmacology
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doi:10.1007/BF00496865
更新日期:1976-08-17 00:00:00
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更新日期:2006-01-01 00:00:00
abstract:RATIONALE:Reductions in cue-induced craving and subjective response to drugs of abuse are commonly used as initial outcome measures when testing novel medications for the treatment of addiction. Yet neither the relationship between these two measures at the individual level nor the moderating effects of pharmacotherapi...
journal_title:Psychopharmacology
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更新日期:2017-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244921
更新日期:1993-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1983-01-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:2005-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2001-04-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00