Persistent catalepsy associated with severe dyskinesias in rats treated with chronic injections of haloperidol decanoate.

abstract：RATIONALE:Epilepsy is a debilitating seizure disorder that affects approximately 50 million people. Noradrenaline reduces neuronal excitability, has anticonvulsant effects and is protective against seizure onset. OBJECTIVE:We investigated the role of α2-adrenoceptors in vivo in a neonatal domoic acid (DOM) rat model o...

journal_title：Psychopharmacology

authors： Thomsen MB,Lillethorup TP,Jakobsen S,Nielsen EH,Simonsen M,Wegener G,Landau AM,Tasker RA

更新日期：2016-10-01 00:00:00

abstract：:The present report investigated several parametric and pharmacological aspects of the enhanced self-grooming behavior of rats following systemic administration of the selective D1 dopamine (DA) receptor agonist SKF 38393. The amount of time that rats spent grooming themselves was measured continuously for 30 min follo...

journal_title：Psychopharmacology

authors： Wachtel SR,Brooderson RJ,White FJ

更新日期：1992-01-01 00:00:00

abstract：:Male rats of the Long-Evans strain were divided into two equal groups of nine each and given either 7.0 mg/kg trimethyltin (TMT) or 0.9% saline by intragastric gavage. The pattern of self-selection of alcohol in concentrations of 3%--30% was examined in both groups at 21 and 150 days following the gavage. The TMT-trea...

journal_title：Psychopharmacology

authors： Myers RD,Swartzwelder HS,Dyer RS

更新日期：1982-01-01 00:00:00

abstract：:The effects on memory and psychomotor functions of four antidepressants which differ in sedative and anticholinergic properties were assessed. Amitriptyline (37.5, 70 mg), trazodone (100, 200 mg) viloxazine (100, 200 mg), protriptyline (10, 20 mg) or placebo were administered in a double blind, independent groups desi...

journal_title：Psychopharmacology

authors： Curran HV,Sakulsriprong M,Lader M

更新日期：1988-01-01 00:00:00

abstract：:The 2-[14C]deoxyglucose method was used to compare the effects of the acute administration of cocaine by two different routes, intravenous and intraperitoneal, on rates of local cerebral glucose utilization in freely moving rats. Doses were initially chosen on the basis of their ability to elicit equivalent increases ...

journal_title：Psychopharmacology

authors： Porrino LJ

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:Synthesis of ligands inactive or with low activity at α₁ GABA(A) receptors has become the key concept for development of novel, more tolerable benzodiazepine (BZ)-like drugs. WYS8, a remarkably (105 times) α₁-subtype selective partial positive modulator, may serve as a pharmacological tool for refining the ro...

journal_title：Psychopharmacology

authors： Joksimović S,Varagic Z,Kovačević J,Van Linn M,Milić M,Rallapalli S,Timić T,Sieghart W,Cook JM,Savić MM

更新日期：2013-11-01 00:00:00

abstract：:Four macaques with lesions of dorsolateral frontal cortex and 4 normal monkeys were injected with 1 mg/kg d-amphetamine. Observations of social behaviors and motor activity were conducted over a 1-month period. The results of this experiment show a partial dissociation of effects of amphetamines on behavior of normal ...

journal_title：Psychopharmacology

authors： Miller MH

更新日期：1976-05-05 00:00:00

abstract：RATIONALE:N-methyl-D-aspartate (NMDA) receptors play crucial roles in learning and memory, but the role of each NMDA receptor subtype in a specific cognitive process is unclear. Non-selective blockers of NMDA receptor are used to model the cognitive impairment in schizophrenia and Alzheimer's disease. Counter-intuitive...

journal_title：Psychopharmacology

authors： Kumar G,Olley J,Steckler T,Talpos J

更新日期：2015-11-01 00:00:00

abstract：RATIONALE:Nicotine infusions that are self-administered (contingent) or response-independent (noncontingent) increase lever pressing for a reinforcing nonpharmacological stimulus in rats, suggesting that in addition to primary reinforcement, nicotine self-administration may result from nicotine enhancing the reinforcem...

journal_title：Psychopharmacology

authors： Chaudhri N,Caggiula AR,Donny EC,Booth S,Gharib M,Craven L,Palmatier MI,Liu X,Sved AF

更新日期：2007-02-01 00:00:00

abstract：:In order to study experimental alcohol intake that leads to heightened aggression, we established ethanol self-administration in aggressive rats. The focus was on low doses of self-administered ethanol and to assess their effects on aggressive behavior in resident rats, using a limited access paradigm followed by a 5-...

journal_title：Psychopharmacology

authors： van Erp AM,Miczek KA

更新日期：1997-06-01 00:00:00

abstract：:Suriclone is a new anxiolytic drug belonging to the family of cyclopyrrolones. Although chemically entirely different from the benzodiazepines, it acts as a benzodiazepine agonist with very high affinity for the benzodiazepine receptors. In the present cross-over study, 33 out-patients with a diagnosis of neurotic anx...

journal_title：Psychopharmacology

authors： Gerlach J,Christensen JK,Christensen TL,Elley J,Jensen JP,Larsen SB

更新日期：1987-01-01 00:00:00

abstract：:The effects of vitamin B12 are compared to those of aspirin and 0.9% saline in three different experimental pain models in rats and mice; an electric shock test, the hot-plate test, and the phenylbenzoquinone writhing test. Neither cyanocobalamin nor hydroxocobalamin showed any antinociceptive activity in any of the t...

journal_title：Psychopharmacology

authors： Eschalier A,Aumaître O,Decamps A,Dordain G

更新日期：1983-01-01 00:00:00

abstract：:A simple new method, the "tape test" has been developed for studying the enhancement of learning by drugs in "learning-dull" rats. A piece of adhesive tape is pressed on the left front pad of the rats. The time of tape removal by the animal, i.e., the problem-solving time is measured. In our experiments the selected l...

journal_title：Psychopharmacology

authors： Ezer E,Szporny L

更新日期：1976-07-09 00:00:00

abstract：:The aim of the present study was to evaluate the effects of nicotinic acetylcholine receptor (nACh-R) agonists such as (-)-nicotine and related compounds on brain monoamine turnover. A single administration of (-)-nicotine (0.04, 0.2, 1.0, and 5.0 mg/kg SC) increased both noradrenaline (NA) and dopamine (DA) turnover ...

journal_title：Psychopharmacology

authors： Tani Y,Saito K,Tsuneyoshi A,Imoto M,Ohno T

更新日期：1997-02-01 00:00:00

abstract：:Acute (50.0 mg/kg) and repeated (0.1-10.0 mg/kg) administration of dihydroergosine (DHESN) to rats over 5 days lowered the concentration of 5-HIAA in the brain. DHESN given acutely increased the brain 5-HT in p-CPA-treated animals and diminished the probenecid-induced increase in brain 5-HIAA. In pargyline-treated rat...

journal_title：Psychopharmacology

authors： Pericić D,Manev H,Levanat S,Jernej B,Vujić D,Djordjević N

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Previous studies have shown that the effect of setting on drug-taking is substance specific in both humans and rats. In particular, we have shown that when the setting of drug self-administration (SA) coincides with the home environment of the rats (resident rats), the rats tend to prefer heroin to cocaine. T...

journal_title：Psychopharmacology

authors： Montanari C,Stendardo E,De Luca MT,Meringolo M,Contu L,Badiani A

更新日期：2015-07-01 00:00:00

abstract：RATIONALE:The phenomenon of sensitization has been theoretically implicated in mediating various aspects of drug addiction. Recent dose-response studies demonstrated that pretreatment with the putative antiaddictive agent, ibogaine (IBO), and a synthetic iboga alkaloid congener, 18-methoxycoronaridine (18-MC), increase...

journal_title：Psychopharmacology

authors： Szumlinski KK,Balogun MY,Maisonneuve IM,Glick SD

更新日期：2000-08-01 00:00:00

abstract：:We investigated the possible role of dopamine receptors in the mediation of copulatory disorder induced by defeat experience in male mice, using L-dopa and apomorphine. To generate the copulatory disorder, male mice were attacked 20 times daily for 5 consecutive days, as intruders in confrontation with an aggressive r...

journal_title：Psychopharmacology

authors： Sugiura K,Yoshimura H,Yokoyama M

更新日期：1997-10-01 00:00:00

abstract：:The issue of whether tolerance develops to the motivational effects of opioids was addressed by use of an unbiased place preference conditioning procedure. Administration of the mu-opioid agonists morphine or fentanyl produced dose-related preferences for the drug-associated place in control rats. In contrast, the kap...

journal_title：Psychopharmacology

authors： Shippenberg TS,Emmett-Oglesby MW,Ayesta FJ,Herz A

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Although environmental enrichment renders rats more sensitive to the neurobehavioral effects of acute amphetamine, a previous study found that enriched rats self-administer less amphetamine than isolated rats at a low unit dose (0.03 mg/kg per infusion). In that study, however, acquisition of self-administrat...

journal_title：Psychopharmacology

authors： Green TA,Gehrke BJ,Bardo MT

更新日期：2002-08-01 00:00:00

abstract：:The relationship between each of two pharmacologic effects (tachycardia and psychological "high") of delta-9-tetrahydrocannabinol (THC) and plasma THC concentration was investigated in three male and three female experienced marihuana smokers. Each subject smoked 1% THC cigarette on two occasions separated by 2 h. Hea...

journal_title：Psychopharmacology

authors： Cocchetto DM,Owens SM,Perez-Reyes M,DiGuiseppi S,Miller LL

更新日期：1981-01-01 00:00:00

abstract：:The study compares the behavioral profiles induced in rats (N = 118) by the D2-dopaminergic receptor agonist quinpirole (0.03 and 0.5 mg/kg), and the D1-agonist SKF38393 (1.25-40 mg/kg), and both agonists administered together. Locomotion and snout contact frequency were reduced by the low but increased by the high do...

journal_title：Psychopharmacology

authors： Eilam D,Talangbayan H,Canaran G,Szechtman H

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:The antidepressant action of acute nicotine administration in clinical and animal studies is well recognized. But the underlying mechanism for this effect has not been carefully discovered. OBJECTIVES:We attempted to evaluate the possible role of N-Methyl-D-aspartate (NMDA) receptors in the antidepressant-li...

journal_title：Psychopharmacology

authors： Haj-Mirzaian A,Kordjazy N,Haj-Mirzaian A,Ostadhadi S,Ghasemi M,Amiri S,Faizi M,Dehpour A

更新日期：2015-10-01 00:00:00

abstract：RATIONALE:Manipulations of the endocannabinoid system could potentially produce therapeutic effects with minimal risk of adverse cannabis-like side effects. Inhibitors of fatty acid amide hydrolase (FAAH) increase endogenous levels of the cannabinoid-receptor agonist, anandamide, and show promise for treating a wide ra...

journal_title：Psychopharmacology

authors： Panlilio LV,Thorndike EB,Nikas SP,Alapafuja SO,Bandiera T,Cravatt BF,Makriyannis A,Piomelli D,Goldberg SR,Justinova Z

更新日期：2016-05-01 00:00:00

abstract：:The present study compared cocaine-induced hyperlocomotion and cocaine i.v. self-administration in DBA/2J and C57BL/6J mice. In the locomotor activity experiment, these strains were tested for hyperlocomotion after i.p. cocaine injection (0-60.0 mg/kg), using a Digiscan Animal Activity Monitoring System. In the cocain...

journal_title：Psychopharmacology

authors： Rocha BA,Odom LA,Barron BA,Ator R,Wild SA,Forster MJ

更新日期：1998-07-01 00:00:00

abstract：RATIONALE:Stimulant medications for attention-deficit/hyperactivity disorder (ADHD) in adolescents remain controversial with respect to later development of cocaine abuse. Past research demonstrated that adolescent methylphenidate treatment increased several aspects of cocaine self-administration during adulthood using...

journal_title：Psychopharmacology

authors： Jordan CJ,Lemay C,Dwoskin LP,Kantak KM

更新日期：2016-12-01 00:00:00

abstract：RATIONALE:Pre-clinical and clinical studies have suggested that the antidepressant efficacy of escitalopram (ESC) can be augmented by co-administration of aripiprazole (ARI). OBJECTIVE:To establish if the effects of ESC + ARI can be altered by modulating the 5-HT1a receptor. METHODS:Sprague-Dawley male rats received ...

journal_title：Psychopharmacology

authors： Lapointe T,Hudson R,Daniels S,Melanson B,Zhou Y,Leri F

更新日期：2019-07-01 00:00:00

abstract：:Rats were trained to discriminate fenfluramine (1.0 mg/kg) from saline in a two-lever drug discrimination task. The dose-response curve for this discrimination was orderly with an ED50 of about one-half of the training dose (0.52 mg/kg). In substitution tests, indirect (p-chloroamphetamine) and direct (quipazine, MK-2...

journal_title：Psychopharmacology

authors： White FJ,Appel JB

更新日期：1981-01-01 00:00:00

abstract：:Rats were chronically administered either haloperidol (HAL) or fluphenazine (FLU) via depot injections for 8 months, given these same drugs in their drinking water for the next 2 months, and then withdrawn from the drugs. Throughout the experiment the animals were tested repeatedly in an enclosed tube using a computer...

journal_title：Psychopharmacology

authors： See RE,Levin ED,Ellison GD

更新日期：1988-01-01 00:00:00

abstract：:Experiments assessed the development of tolerance to morphine stimulus control during treatment with selected maintenance doses of morphine. Separate groups of rats were trained to discriminate saline and either 3.2 mg/kg or 5.6 mg/kg morphine under fixed-ratio schedules of food delivery. Dose-response functions for g...

journal_title：Psychopharmacology

authors： Young AM,Sannerud CA,Steigerwald ES,Doty MD,Lipinski WJ,Tetrick LE

更新日期：1990-01-01 00:00:00