Persistent catalepsy associated with severe dyskinesias in rats treated with chronic injections of haloperidol decanoate.


:Patients who develop persistent parkinsonism while on chronic neuroleptic therapy may be predisposed towards the development of tardive dyskinesia (TD). We investigated this issue in an animal model of TD by examining the association between catalepsy and the syndrome of neuroleptic-induced vacuous chewing movements (VCMs). VCMs were measured every 3 weeks for 33 weeks while rats received injections of haloperidol decanoate. Catalepsy was measured after the second through the seventh injections of the depot neuroleptic. There were no correlations between the severity of catalepsy scores after the second or third injections of haloperidol and the severity of the overall VCM syndrome. However, the severity of the catalepsy score following the third through seventh injections of haloperidol strongly correlated with the concurrent number of VCMs. Persistent high catalepsy scores across the six catalepsy rating sessions were strongly associated with the development of persistent severe VCMs. These findings suggest that, to the extent that persistent parkinsonian signs in humans are associated with a propensity towards the development of TD, the VCM syndrome in rats is at least a partially faithful animal model of this relationship.




Hyde TM,Egan MF,Wing LL,Wyatt RJ,Weinberger DR,Kleinman JE




Has Abstract


1995-03-01 00:00:00












  • Modulation of the effects of alcohol on driving-related psychomotor skills by chronic exposure to cannabis.

    abstract:RATIONALE:Many previous studies have reported that alcohol and cannabis produce additive psychomotor effects in acute combination, but few have explicitly tested whether chronic exposure to cannabis, in the absence of acute administration, alters the effects of alcohol on psychomotor performance. OBJECTIVES:To test wh...


    pub_type: 临床试验,杂志文章


    authors: Wright A,Terry P

    更新日期:2002-03-01 00:00:00

  • Naltrexone blockade of nicotine effects in cigarette smokers.

    abstract:RATIONALE:The role of endogenous opiate systems in cigarette smoking remains unclear. In laboratory animals, opiate antagonists block many of the effects of nicotine, but in humans they do not consistently alter smoking behavior. OBJECTIVE:This study explored the effects of naltrexone, alone and in combination with ni...


    pub_type: 临床试验,杂志文章


    authors: Brauer LH,Behm FM,Westman EC,Patel P,Rose JE

    更新日期:1999-04-01 00:00:00

  • Cocaine seeking over extended withdrawal periods in rats: time dependent increases of responding induced by heroin priming over the first 3 months.

    abstract:RATIONALE:Using a rat relapse model, recent studies reported time dependent increases in cocaine seeking induced by re-exposure to cocaine cues, but not cocaine itself, over withdrawal periods of up to 3 months. OBJECTIVES:In the present study, we explored the time course of cocaine seeking induced by priming injectio...


    pub_type: 杂志文章


    authors: Lu L,Dempsey J

    更新日期:2004-10-01 00:00:00

  • Cocaine- and food-maintained responding under a multiple schedule in rhesus monkeys: environmental context and the effects of a dopamine antagonist.

    abstract:RATIONALE:Environmental context has been shown to influence responding under multiple schedules of food reinforcement and to modify the behavioral effects of drugs. However, no systematic study has been conducted under conditions of cocaine self-administration. The hypothesis was that changes in the magnitude of food r...


    pub_type: 杂志文章


    authors: Nader MA,Sinnott RS,Mach RH,Morgan D

    更新日期:2002-10-01 00:00:00

  • Caffeine intake and cognitive functions in children.

    abstract:RATIONALE:There is a growing concern over excessive caffeine use and development of caffeine use disorder in children. OBJECTIVES:This study aimed to identify the association between caffeine intake and cognitive functioning in children. METHODS:This study included 11,718 youths aged 9-10 years with cognitive and caf...


    pub_type: 杂志文章


    authors: Zhang H,Lee ZX,Qiu A

    更新日期:2020-10-01 00:00:00

  • Reinstatement of ethanol-seeking behavior by drug cues following single versus multiple ethanol intoxication in the rat: effects of naltrexone.

    abstract:RATIONALE:A positive relationship exists between chronic ethanol intoxication experiences and the severity of neural hyperactivity and withdrawal seizures. An important possibility is that withdrawal reactions also influence the motivation to obtain and consume ethanol. OBJECTIVES:To test this hypothesis, the effects ...


    pub_type: 杂志文章


    authors: Ciccocioppo R,Lin D,Martin-Fardon R,Weiss F

    更新日期:2003-07-01 00:00:00

  • Oral cortisol impairs implicit sequence learning.

    abstract:RATIONALE:Glucocorticoids have been shown to affect declarative memory, an explicit form of memory for facts and events operated by medial temporal lobe structures. Recent neuroimaging data suggest that the medial temporal lobe (including the hippocampus) is also active in implicit sequence learning. OBJECTIVES:The ai...


    pub_type: 杂志文章,随机对照试验


    authors: Römer S,Schulz A,Richter S,Lass-Hennemann J,Schächinger H

    更新日期:2011-05-01 00:00:00

  • Effects of nicotine administration following 12 h of tobacco deprivation: assessment on computerized performance tasks.

    abstract::The purpose of this study was to assess the effects of acute nicotine administration, following a 12-h cigarette deprivation period, using a computerized performance assessment battery (PAB). The PAB was comprised of five tasks which were selected to reflect a variety of complex acquired behaviors, sometimes referred ...


    pub_type: 临床试验,杂志文章


    authors: Snyder FR,Henningfield JE

    更新日期:1989-01-01 00:00:00

  • An in vivo microdialysis assessment of concurrent MDMA and cocaine administration in Sprague-Dawley rats.

    abstract:BACKGROUND AND RATIONALE:Despite the popularity of polysubstance abuse among recreational methylendioxymethamphetamine (MDMA) users, relatively few controlled experimental studies have documented the neurobehavioral effects of MDMA in combination with other abused substances. OBJECTIVE:In this study, the combined acut...


    pub_type: 杂志文章


    authors: Panos JJ,Baker LE

    更新日期:2010-03-01 00:00:00

  • Cocaine and salicylate: documentation of hydroxyl radical formation in hearts and brains of 18-day-old chick embryos and unexpected interactive toxicity.

    abstract:RATIONALE:Multiple low doses of cocaine (COC) may cause intermittent vasoconstriction and reperfusion, leading to elevations in damaging reactive oxygen species, such as hydroxyl free radicals (*OH). Salicylate may offer protection because it reacts with *OH and/or because of its anti-inflammatory actions. OBJECTIVE:T...


    pub_type: 杂志文章


    authors: Castelli MC,Venturini L,Sparber SB

    更新日期:2001-06-01 00:00:00

  • Complex motor and sensorimotor functions of striatal and accumbens dopamine: involvement in instrumental behavior processes.

    abstract::The suggestions that dopamine (DA) systems are involved in "motor control" and "reward" represent the classic working hypotheses on the behavioral functions of these systems. The research generated by these hypotheses has yielded results that are far more complicated than the simplest form of either hypothesis would i...


    pub_type: 杂志文章,评审


    authors: Salamone JD

    更新日期:1992-01-01 00:00:00

  • Synergistic interaction between nicotine and social rewards in adolescent male rats.

    abstract:RATIONALE:Smoking typically begins during adolescence and is largely reinforced by social cues. During adolescence in rats, sensitivity to both social cues and drugs of abuse is enhanced. OBJECTIVES:We have previously demonstrated in adolescent male rats that a low dose of cocaine interacts with social reward to produ...


    pub_type: 杂志文章


    authors: Thiel KJ,Sanabria F,Neisewander JL

    更新日期:2009-06-01 00:00:00

  • Effects of dopamine receptor antagonists on sucrose consumption and preference.

    abstract::Effects of the dopamine D2 receptor antagonist sulpiride and the D1 antagonist SCH-23390 were examined, in rats, in two-bottle preference tests (sucrose versus water) and in single-bottle tests, at different sucrose concentrations. Both drugs decreased sucrose intake in single bottle tests, at low sucrose concentratio...


    pub_type: 杂志文章


    authors: Muscat R,Willner P

    更新日期:1989-01-01 00:00:00

  • An animal model of copulatory disorder induced by social stress in male mice: effects of apomorphine and L-dopa.

    abstract::We investigated the possible role of dopamine receptors in the mediation of copulatory disorder induced by defeat experience in male mice, using L-dopa and apomorphine. To generate the copulatory disorder, male mice were attacked 20 times daily for 5 consecutive days, as intruders in confrontation with an aggressive r...


    pub_type: 杂志文章


    authors: Sugiura K,Yoshimura H,Yokoyama M

    更新日期:1997-10-01 00:00:00

  • Cortisol response to diazepam: its relationship to age, dose, duration of treatment, and presence of generalized anxiety disorder.

    abstract:OBJECTIVE:Acute diazepam administration has been shown to decrease plasma cortisol levels consistent with decreased activity of the hypothalamic-pituitary-adrenal axis, especially in individuals experiencing stress. However, the effects of chronic diazepam treatment on cortisol have been less studied, and the relations...


    pub_type: 临床试验,杂志文章


    authors: Pomara N,Willoughby LM,Sidtis JJ,Cooper TB,Greenblatt DJ

    更新日期:2005-02-01 00:00:00

  • Analysis of licking microstructure provides no evidence for a reduction in reward value following acute or sub-chronic phencyclidine administration.

    abstract:RATIONALE:The N-methyl D-aspartate antagonist phencyclidine (PCP) is purported to mimic the negative, cognitive and positive symptoms of schizophrenia. Thus, acute and sub-chronic PCP treatment in rodents might produce anhedonia, a decrease in the pleasure produced by rewards. OBJECTIVES:Experiment 1 investigated whet...


    pub_type: 杂志文章


    authors: Lydall ES,Gilmour G,Dwyer DM

    更新日期:2010-04-01 00:00:00

  • The inhibitory effects on sexual behavior and ambulatory activity of the mixed GABAA/GABAB agonist progabide are differentially blocked by GABA receptor antagonists.

    abstract::Progabide inhibited male rat sexual behavior at a dose of 200 mg/kg. This dose had only modest effects on ambulatory activity and no effect at all on motor coordination as evaluated by a rotarod test. The GABAA antagonist bicuculline, at a dose of 1 mg/kg, blocked the effects of progabide on sex behavior. In contrast,...


    pub_type: 杂志文章


    authors: Agmo A,Paredes RG,Sierra L,Garcés I

    更新日期:1997-01-01 00:00:00

  • GABA(B) receptor blockade in the hippocampus affects sensory and sensorimotor gating in Long-Evans rats.

    abstract:RATIONALE:Sensory and sensorimotor gating deficits are observed in schizophrenia. GABA(B) receptor deficiency is also detected in the hippocampus of schizophrenic patients. OBJECTIVES:The present study tested the hypothesis that GABA(B) receptors in the hippocampus contribute to paired-pulse gating of hippocampal audi...


    pub_type: 杂志文章


    authors: Ma J,Leung LS

    更新日期:2011-09-01 00:00:00

  • Effects of voluntary exercise and sex on multiply-triggered heroin reinstatement in male and female rats.

    abstract:BACKGROUND:The rise in heroin addiction has heightened the need for novel and effective treatments. Physical exercise has been shown as an effective treatment for stimulant abuse in clinical and pre-clinical research. However, this treatment has not yet been tested on opioid addiction. This study examined the effects o...


    pub_type: 杂志文章


    authors: Smethells JR,Greer A,Dougen B,Carroll ME

    更新日期:2020-02-01 00:00:00

  • Dipropylacetate-induced quasi-morphine abstinence behaviour in the rat: suppression by alpha 2-adrenoceptor stimulation.

    abstract::The anti-withdrawal effect of clonidine was studied using quasi-morphine abstinence behaviour induced by dipropylacetate (DPA) in naive rats. Clonidine potently suppressed body shakes and locomotor activity (ID50 30 and 40 micrograms/kg IP respectively). Phenoxybenzamine and prazosine did not antagonize the anti-withd...


    pub_type: 杂志文章


    authors: van der Laan JW,Weick G,Hillen FC

    更新日期:1983-01-01 00:00:00

  • Effects of chronic amphetamine or reserpine on self-stimulation responding: animal model of depression?

    abstract::The mood-altering properties of amphetamine (AMPH) in humans (euphoria and depression) have been postulated to be related to the increases and decreases respectively which this drug produces in the sensitivity of the reward system of the brain. The present study further evaluated this relationship by testing the effec...


    pub_type: 杂志文章


    authors: Leith NJ,Barrett RJ

    更新日期:1980-01-01 00:00:00

  • A comparison of the acute behavioral effects of triazolam and temazepam in normal volunteers.

    abstract::Two experiments were conducted to assess the acute behavioral effects of triazolam and temazepam in healthy, non-drug abusing men in double-blind, placebo-controlled, crossover trials, where all subjects received all possible doses. These drugs were compared to examine allegations that triazolam produces greater behav...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rush CR,Higgins ST,Hughes JR,Bickel WK

    更新日期:1993-01-01 00:00:00

  • Efficacy and safety of quetiapine extended release monotherapy in bipolar depression: a multi-center, randomized, double-blind, placebo-controlled trial.

    abstract:RATIONALE:Quetiapine extended release (XR) has been used to treat various psychiatric disorders, including depressive episodes associated with bipolar I and II disorders. Quetiapine XR is the first approved drug in China for the treatment of bipolar disorder. OBJECTIVES:The study evaluated the efficacy and safety of s...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Li H,Gu N,Zhang H,Wang G,Tan Q,Yang F,Ning Y,Zhang H,Lu Z,Xu X,Shi J,Gao C,Li L,Zhang K,Tian H,Wang X,Li K,Li H,Xu Y,Xie S,Yu X

    更新日期:2016-04-01 00:00:00

  • Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities.

    abstract:OBJECTIVE:The pharmacological profile of escitalopram, the S-(+)-enantiomer of citalopram, was studied and compared with citalopram and the R-(-)-enantiomer, R-citalopram. METHODS:Inhibition of the serotonin transporter (5-HTT) was studied in COS-1 cells expressing the human 5-HTT (h-5-HTT) and in rat brain synaptosom...


    pub_type: 杂志文章


    authors: Sánchez C,Bergqvist PB,Brennum LT,Gupta S,Hogg S,Larsen A,Wiborg O

    更新日期:2003-06-01 00:00:00

  • Effects on cocaine and food self-administration of (+)-HA-966, a partial agonist at the glycine/NMDA modulatory site, in rats.

    abstract:RATIONALE:(+)-HA-966, a partial agonist at the glycine/NMDA modulatory site, significantly reduced i.v. cocaine self-administration in a fixed-ratio (FR) schedule. Since this effect was observed studying only one dose of cocaine and considering the characteristic bell-shaped curve generated by cocaine in self-administr...


    pub_type: 杂志文章


    authors: Cervo L,Cocco A,Carnovali F

    更新日期:2004-04-01 00:00:00

  • Beta receptor-mediated modulation of the oddball P3 but not error-related ERP components in humans.

    abstract:RATIONALE:The P3 is a ubiquitous component of stimulus-driven neural activity that can be observed in scalp electrophysiological recordings. Multiple lines of evidence suggest an important role for the noradrenergic system in the generation of the P3. However, pharmacological studies of the P3 using noradrenergic manip...


    pub_type: 杂志文章,随机对照试验


    authors: de Rover M,Brown SB,Band GP,Giltay EJ,van Noorden MS,van der Wee NJ,Nieuwenhuis S

    更新日期:2015-09-01 00:00:00

  • A cFos activation map of remote fear memory attenuation.

    abstract:RATIONALE:The experience of strong traumata leads to the formation of enduring fear memories that may degenerate into post-traumatic stress disorder. One of the most successful treatments for this condition consists of extinction training during which the repeated exposure to trauma-inducing stimuli in a safe environme...


    pub_type: 杂志文章


    authors: Silva BA,Burns AM,Gräff J

    更新日期:2019-01-01 00:00:00

  • Memory impairment and alterations in prefrontal cortex gamma band activity following methamphetamine sensitization.

    abstract:RATIONALE:Repeated methamphetamine (MA) use leads to increases in the incentive motivational properties of the drug as well as cognitive impairments. These behavioral alterations persist for some time following abstinence, and neuroadaptations in the structure and function of the prefrontal cortex (PFC) are particularl...


    pub_type: 杂志文章


    authors: Janetsian SS,Linsenbardt DN,Lapish CC

    更新日期:2015-06-01 00:00:00

  • Extended access nicotine self-administration with periodic deprivation increases immature neurons in the hippocampus.

    abstract:RATIONALE:Limited access nicotine self-administration decreases hippocampal neurogenesis, providing a mechanism for the deleterious effects of nicotine on hippocampal neuronal plasticity. However, recent studies have shown that limited access nicotine self-administration does not exhibit key features of nicotine depend...


    pub_type: 杂志文章


    authors: Cohen A,Soleiman MT,Talia R,Koob GF,George O,Mandyam CD

    更新日期:2015-01-01 00:00:00

  • Gelsemine, a natural alkaloid extracted from Gelsemium elegans Benth. alleviates neuroinflammation and cognitive impairments in Aβ oligomer-treated mice.

    abstract:INTRODUCTION:Gelsemine is a natural alkaloid extracted from Gelsemium elegans Benth., a traditional Chinese medicinal herb. Gelsemine has been shown to penetrate the brain, and could produce neurological activities, such as anxiolytic and neuralgia-alleviating effects, suggesting that this natural compound might be use...


    pub_type: 杂志文章


    authors: Chen L,Pan H,Bai Y,Li H,Yang W,Lin ZX,Cui W,Xian YF

    更新日期:2020-07-01 00:00:00