Abstract:
:The issue of whether tolerance develops to the motivational effects of opioids was addressed by use of an unbiased place preference conditioning procedure. Administration of the mu-opioid agonists morphine or fentanyl produced dose-related preferences for the drug-associated place in control rats. In contrast, the kappa-opioid agonist, U-69593 produced conditioned place aversions. Non-contingent administration of morphine (5.0 mg/kg/12 h) for 4 days prior to conditioning resulted in tolerance to its reinforcing effects, and cross-tolerance to the effects of fentanyl. No cross-tolerance to the motivational effects of the psychostimulant d-amphetamine or the kappa-opioid agonist U-69593 was observed. Chronic administration of U-69593 prior to conditioning produced tolerance to its aversive effects. This treatment did not, however, modify the reinforcement produced by morphine. These data demonstrate that tolerance develops to both the reinforcing and aversive properties of opioids and suggest that differential cross-tolerance may provide a useful method for determining the pharmacological basis underlying drug-induced motivational effects.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Shippenberg TS,Emmett-Oglesby MW,Ayesta FJ,Herz Adoi
10.1007/BF02431542subject
Has Abstractpub_date
1988-01-01 00:00:00pages
110-5issue
1eissn
0033-3158issn
1432-2072journal_volume
96pub_type
杂志文章abstract::The effects of methylglucamine orotate (MGO) were studied on polygraphic sleep recordings in rats for 8 h per day between 8 a.m. and 4 p.m. MGO (225 mg/kg) was injected intraperitoneally immediately prior to the onset of recording. In the acute experiment, the effect of MGO was compared to pre- and post-drug control d...
journal_title:Psychopharmacology
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doi:10.1007/BF00428551
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更新日期:2009-09-01 00:00:00
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更新日期:2008-12-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00429199
更新日期:1981-01-01 00:00:00
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更新日期:2005-08-01 00:00:00
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更新日期:2009-06-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2012-04-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1997-12-01 00:00:00
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更新日期:1976-08-26 00:00:00
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journal_title:Psychopharmacology
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更新日期:2016-10-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1996-04-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-2164-z
更新日期:2005-07-01 00:00:00