Abstract：
:The effect of electroconvulsive shock (ECS) on the responsiveness to pain (measured by the hot-plate test) and on the characteristics of L-type calcium channels (measured as [3H]nitrendipine binding sites) in the cortex and hippocampus was tested on the Wistar rat. In animals receiving a single ECS, the calcium channel density and affinity 24 h after treatment did not differ from the controls; the response to pain was also at the control level. Repeated ECS (eight once-daily shocks) resulted in an increased responsiveness to pain (shortening of response latency) and in an increase in the density of cortical, but not hippocampal, calcium channels. The KD value for [3H]nitrendipine binding sites in either brain region remained unaltered by ECS. The calcium channel antagonist nifedipine, which by itself did not significantly alter the response to pain, prevented the enhancement of pain sensitivity brought about by ECS. The results suggest activation of calcium-dependent mechanisms by repeated ECS and confirm the involvement of calcium channels in pain mechanisms.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Antkiewicz-Michaluk L,Michaluk J,Romańska I,Vetulani Jdoi
10.1007/BF02244133subject
Has Abstractpub_date
1990-01-01 00:00:00pages
240-3issue
2eissn
0033-3158issn
1432-2072journal_volume
101pub_type
杂志文章abstract：:N-carbamoyl-2-(2,6-dichlorophenyl) acetamidine hydrochloride (LON 954) causes a reproducible rest tremor in mice, of rapid onset and short duration with no associated rigidity or akinesia and in the absence of any marked changes in body temperature or accompanying peripheral parasympathomimetic effects. This tremor ca...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00439104
更新日期：1977-04-29 00:00:00
abstract：:Lithium pretreatment in rats potentiates the epileptogenic effects of pilocarpine and other cholinergic agonists. In order to determine if this effect of lithium could be reversed by myo-inositol, rats were pretreated with intracerebroventricular (ICV) injections of myoinositol, artificial CSF or L-chiro-inositol. Lit...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02246978
更新日期：1993-01-01 00:00:00
abstract：RATIONALE:Cocaine (COC), ethanol (EtOH), and methamphetamine (MA) are widely abused substances and share the ability to induce behavioral stimulation in mice and humans. Understanding the biological basis of behavioral stimulation to COC, EtOH, and MA may provide a greater understanding of drug and alcohol abuse. OBJE...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-007-0969-7
更新日期：2008-02-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s00213-007-0823-y
更新日期：2007-10-01 00:00:00
abstract：:The selective serotonin reuptake inhibitor fluvoxamine interferes with the metabolism of tricyclic antidepressants. The present investigation was set out to characterize these interactions in vitro using rat liver microsomes and in vivo by analysing levels of clomipramine and metabolites in sera of depressed patients ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245180
更新日期：1995-01-01 00:00:00
abstract：RATIONALE:Nicotine improves cognitive function in a number of animal models including rats, mice, monkeys, and recently, zebrafish. The zebrafish model allows higher throughput and ease in discovering mechanisms of cognitive improvement. MATERIALS AND METHODS:To further characterize the neural bases of nicotine effect...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-008-1287-4
更新日期：2009-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-019-05400-2
更新日期：2020-03-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-4140-6
更新日期：2016-05-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：2009-08-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02439598
更新日期：1987-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00443406
更新日期：1989-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00634151
更新日期：1976-10-20 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245247
更新日期：1995-03-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1233-9
更新日期：2002-12-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-009-1731-0
更新日期：2010-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/s00213-016-4514-4
更新日期：2017-03-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-005-2183-9
更新日期：2005-07-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050496
更新日期：1998-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02245081
更新日期：1994-07-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-5045-y
更新日期：2018-12-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1337-2
更新日期：2003-07-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 已发布勘误
doi：10.1007/s00213-020-05673-y
更新日期：2020-11-01 00:00:00
abstract：:The effects of the enantiomers of 3-PPP on the maintenance of conditioned avoidance responding (CAR) were studied. The weak classical dopamine (DA) agonist (+)-3-PPP failed to interfere with CAR at any dose tested (0.8-13.6 mg/kg). Low doses of the drug produced sedation, while high doses produced behavioural stimulat...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00439266
更新日期：1983-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00433011
更新日期：1983-01-01 00:00:00
abstract：RATIONALE:Research on the effects of nicotine abstinence and nicotine replacement has not provided consistent information about the impact of replacement therapies on tobacco withdrawal and craving. OBJECTIVE:. This study investigated craving and withdrawal symptoms over a 72-h period of abstinence from cigarettes. M...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00213-002-1176-1
更新日期：2002-11-01 00:00:00
abstract：RATIONALE:Mesocorticolimbic reactivity to alcohol-associated cues has been shown to be associated with relapse to renewed drinking and to be decreased by cue-exposure-based extinction training (CET). Evidence from preclinical studies suggests that the extinction of conditioned alcohol-seeking behavior might be facilita...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-015-3882-5
更新日期：2015-07-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00439560
更新日期：1989-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-017-4675-9
更新日期：2017-10-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245333
更新日期：1994-11-01 00:00:00
abstract：RATIONALE:Anxiety and aggression are associated with ethanol self-administration, but these behaviors can serve as either risk factors for or consequences of heavy drinking in rodents and humans. Baseline levels of aggressive-like and anxious-like behavior in non-human primates have not yet been characterized in relati...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-016-4427-2
更新日期：2016-12-01 00:00:00
