Abstract:
:The title of this article is "Effect of a dual orexin receptor antagonist (DORA-12) on sleep and event-related oscillations in rats exposed to ethanol vapor during adolescence".
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Ehlers CL,Benedict J,Wills D,Sanchez-Alavez Mdoi
10.1007/s00213-020-05673-ysubject
Has Abstractpub_date
2020-11-01 00:00:00pages
3507issue
11eissn
0033-3158issn
1432-2072pii
10.1007/s00213-020-05673-yjournal_volume
237pub_type
已发布勘误abstract::The authors review the literature regarding the pharmacokinetics of long-acting injectable neuroleptic drugs (LINS). There are important differences between LINS and oral neuroleptics that affect their pharmacokinetics. By avoiding first pass metabolism in gut and liver, LINS result in lower circulating concentrations...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/BF00441937
更新日期:1989-01-01 00:00:00
abstract:RATIONALE:Synergistic or supra-additive interactions between the anorectics (dex)fenfluramine and phentermine have been reported previously in the rat and in the clinic. Studies with 5-HT2C antagonists and 5-HT2C knockouts have demonstrated dexfenfluramine hypophagia in the rodent to be mediated by actions at the 5-HT2...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3829-2
更新日期:2015-06-01 00:00:00
abstract::The concentration of kynurenine in plasma from depressed patients and control subjects has been measured using a sensitive and specific method. The levels of kynurenine in the plasma of depressed patients and controls are not significantly different and are not influenced by age or sex. The severity of affective distu...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00426632
更新日期:1978-12-08 00:00:00
abstract::Cholecystokinin (CCK) and dopamine (DA) coexist in both cell body and terminal areas of a mesolimbic pathway that projects from the ventral tegmental area (VTA) to the nucleus accumbens (N ACC). Autoradiography reveals extensive CCK binding sites in the N ACC, but not in the VTA. However, iontophoresis of CCK into the...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00445571
更新日期:1989-01-01 00:00:00
abstract:RATIONALE:Little is known about the smoking topography characteristics of heavy cannabis users. Such measures may be able to predict cannabis use-related outcomes and could be used to validate self-reported measures of cannabis use. OBJECTIVES:The current study was conducted to measure cannabis smoking topography char...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-011-2480-4
更新日期:2012-03-01 00:00:00
abstract:RATIONALE:Prepulse inhibition (PPI) of the startle reflex is a model of pre-attentional inhibitory function. The dopamine baseline in the nucleus accumbens plays a key role in PPI regulation as well as in the rewarding effects of cocaine. OBJECTIVES:The aim of this study was to evaluate the predictive ability of PPI t...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-4959-8
更新日期:2018-09-01 00:00:00
abstract::During the third week of life, a hyperactive period for laboratory rat, the occurrence of 8 behavioral categories was recorded in individual littermates transferred to a novel environment. Neonatal destruction of the catecholaminergic system by intraventricular injection of 6-OH-DA resulted in increased motor activity...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426882
更新日期:1978-04-28 00:00:00
abstract:RATIONALE:We test methods to advance (shift earlier) circadian rhythms without producing misalignment between rhythms and sleep. We previously tested (1) a gradually advancing sleep/dark schedule plus morning bright light and afternoon/evening melatonin and (2) the same sleep schedule with only morning bright light. No...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2869-8
更新日期:2013-02-01 00:00:00
abstract:RATIONALE:Stimulation of central beta(2) adrenergic receptors produces antidepressant-like effects on behavior. At present, it is not known what brain sites are involved in mediating such effects, although some recent evidence suggests the importance of the dorsal hippocampus. OBJECTIVE:Experiments were carried out to...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1512-0
更新日期:2003-10-01 00:00:00
abstract:RATIONALE:The social interaction test is a valuable behavioural model for testing anxiolytic drugs in rodents, quantifying the level of social behaviour between pairs of rats. OBJECTIVE:The aim of the present study was to assess the appropriateness of the social interaction test for use with a Sprague-Dawley rat line,...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-1914-7
更新日期:2004-12-01 00:00:00
abstract::3,4-Methylenedioxymethamphetamine (MDMA) is a psychoactive phenylisopropylamine which is structurally similar to both amphetamine-related sympathomimetics and the hallucinogen, mescaline. MDMA produces pleasurable effects which include euphoria, and recent reports continue to demonstrate its widespread recreational us...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00212765
更新日期:1988-01-01 00:00:00
abstract::The ventral tegmental area (VTA) evaluates salience of environmental stimuli and provides dopaminergic innervation to many brain areas affected by acute and chronic ethanol exposure. While primarily associated with rewarding and reinforcing stimuli, recent evidence indicates a role for the VTA in aversion as well. Eth...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-018-4875-y
更新日期:2018-06-01 00:00:00
abstract::The increasing interest in subjective well-being and quality of life of schizophrenic patients represents a conceptual shift in therapeutic outcome criteria. Symptom reduction alone was the most essential outcome parameter for a long time; with the development of atypical antipsychotics more ambitious success criteria...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-002-1052-z
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND:Acute administration of selective serotonin and noradrenaline re-uptake blockers to healthy volunteers affects the processing of emotional information but it is not known if similar effects occur with antidepressants acting through other pharmacological mechanisms. Mirtazapine is a clinically established ant...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-008-1410-6
更新日期:2009-05-01 00:00:00
abstract:RATIONALE:Increased anxiety is a characteristic of the acute ethanol withdrawal syndrome. Repeated exposure of rats to withdrawal from chronic ethanol increases sensitivity to seizures. OBJECTIVES:We investigated whether repeated withdrawal experience increases withdrawal-induced anxiety and stress, and if it changes ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-0301-3
更新日期:2006-04-01 00:00:00
abstract::In the majority of Parkinson's disease (PD) patients, long-term dopamine (DA) replacement therapy leads to dyskinesia characterized by abnormal involuntary movements (AIMs). There are various mechanisms of dyskinesia, such as the sensitization of striatal DA D1 receptors (D1R) and upregulation of DA D3 receptors (D3R)...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05353-6
更新日期:2020-01-01 00:00:00
abstract:RATIONALE:We hypothesized that valerian root might prevent cognitive dysfunction in coronary artery bypass graft (CABG) surgery patients through stimulating serotonin receptors and anti-inflammatory activity. OBJECTIVES:The aim of this study was to evaluate the effect of Valeriana officinalis root extract on preventio...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-014-3716-x
更新日期:2015-03-01 00:00:00
abstract::Lithium elicits opposite effects on two behavioural syndromes in rats: enhancement of the 5-HT1A-linked serotonin syndrome and attenuation of the 5-HT2-linked wet dog shakes. The ability of intracerebroventricular (ICV) myo-inositol or forskolin to reverse the enhancement of the serotonin syndrome by lithium was teste...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245842
更新日期:1995-03-01 00:00:00
abstract:RATIONALE:Although the behavioral effects of systemic injection of lipopolysaccharide (LPS) have been extensively investigated, the modulation of these effects by natural environmental factors has received little attention. OBJECTIVES:The present study investigated whether or not locomotor activity reductions and the ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1554-3
更新日期:2003-12-01 00:00:00
abstract::Various dopamine receptor antagonists have divergent clinical and neurochemical properties. The relative ability of anticholinergics (benztropine and scopolamine) to reverse these drugs was assessed in squirrel monkeys and rats performing a Sidman avoidance task. In monkeys, benztropine markedly attenuated the effects...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432433
更新日期:1981-01-01 00:00:00
abstract::The objective of the present study was to determine whether the development of behavioral sensitization to apomorphine could be blocked by either D1 or D2 selective dopamine antagonists. In three experiments, male rats received 10-21 daily injections of a selective D1 (SCH 23390; 0 or 0.5 mg/kg IP) or D2 (sulpiride; 0...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244370
更新日期:1991-01-01 00:00:00
abstract::The central effects of acetylsalicylic acid (ASA) are discussed controversially. In animal models, it has been shown that ASA can interact with the central serotonergic and catecholaminergic neuronal system. However, the relevance of this interaction for humans is still unknown. We performed a study on the influence o...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130050683
更新日期:1998-08-01 00:00:00
abstract:RATIONALE:The efficacy of methadone for treating heroin dependence derives, in part, from suppression of opiate withdrawal and attenuation of the effects of heroin. OBJECTIVES:The purpose of this double-blind, within-subject, inpatient study was to determine whether larger doses of methadone, which are more effective ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1027-0
更新日期:2002-05-01 00:00:00
abstract::In mice that were scored for the length of time they remained immobile in awkward postures (cataleptic) on an inclined wire grid, a large IP dose of pilocarpine (80 mg/kg) caused a clear catalepsy, which was prevented by both dopamine agonists that were tested, apomorphine (4 or 8 mg/kg, IP) and bromocriptine (8 mg/kg...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431769
更新日期:1985-01-01 00:00:00
abstract::Serotonin(5-HT)-stimulated intracellular calcium(Ca) mobilization was measured in the platelets of depressed patients to assess 5-HT2 receptor function. The 5-HT-induced Ca response was significantly higher in unmedicated patients with bipolar depression and melancholic major depression than in those with non-melancho...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02245204
更新日期:1994-01-01 00:00:00
abstract:RATIONALE:Psychopharmacology needs novel quantitative measures and theoretical approaches based on computational modelling that can be used to help translate behavioural findings from experimental animals to humans, including patients with neuropsychiatric disorders. OBJECTIVES:This brief review exemplifies this appro...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-019-05302-3
更新日期:2019-08-01 00:00:00
abstract::Triadimefon is a triazole fungicide that produces hyperactivity in both mice and rats similar to that seen following administration of compounds with catecholaminergic activity (e.g., d-amphetamine). To determine whether the triadimefon-induced hyperactivity is due to an action on CNS catecholaminergic systems, we eva...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00439445
更新日期:1989-01-01 00:00:00
abstract::Different venlafaxine doses (1, 5, and 10 mg/kg) and saline solution were administered to ten male Wistar rats (Latin-Square design). Compared with saline, venlafaxine produced a dose-related suppression of REM sleep and an increase in wake time while slow wave sleep was reduced. This effect is similar to the one that...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050194
更新日期:1997-02-01 00:00:00
abstract:RATIONALE:Opioid receptor antagonists reliably alter the expression or extinction of ethanol's conditioned motivational effects as indexed by the place conditioning procedure, suggesting endogenous opioids are normally involved. These studies examined how exogenous stimulation of opioid receptors alters ethanol's condi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05658-x
更新日期:2021-01-01 00:00:00
abstract::Responding maintained under progressive ratio (PR) and fixed ratio (FR 160) schedules of IV saline or cocaine (0.01-4.0 mg/kg) injections was studied in baboons. Each injection was followed by a time-out period which was 3-h with the PR schedule and was either 3 or 12 with the FR schedule. On the PR schedule the ratio...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00433038
更新日期:1979-10-01 00:00:00