Abstract:
:Various dopamine receptor antagonists have divergent clinical and neurochemical properties. The relative ability of anticholinergics (benztropine and scopolamine) to reverse these drugs was assessed in squirrel monkeys and rats performing a Sidman avoidance task. In monkeys, benztropine markedly attenuated the effects of oxiperomide, metoclopramide, halopemide, tiapride and mezilamine as well as haloperidol. Chlorpromazine and fluphenazine were antagonized to a moderate extent; thioridazine and perlapine were not antagonized; and clozapine was actually potentiated by benztropine. In the rat, benztropine antagonized haloperidol strongly but reversed fluphenazine, thioridazine or clozapine only weakly or not at all. The overall effects of scopolamine in both species were similar to those of benztropine. The dopamine receptor antagonists that were most completely reversed by benztropine were found to inhibit 3H-spiroperidol more strongly than 3H-WB-4101 binding in calf caudate, while the reverse was true for drugs that were antagonized only moderately or not at all by benztropine. These results support a previous suggestion that anticholinergic reversal is less marked against dopamine antagonists with alpha-adrenergic blocking properties. Benztropine reversal of experimental dopamine receptor antagonists in the squirrel monkey Sidman avoidance test may contribute to their preclinical characterization.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Liebman JM,Neale R,Noreika L,Braunwalder Adoi
10.1007/BF00432433subject
Has Abstractpub_date
1981-01-01 00:00:00pages
248-53issue
3eissn
0033-3158issn
1432-2072journal_volume
75pub_type
杂志文章abstract:RATIONALE AND OBJECTIVES:The mechanisms underlying relapse to cocaine seeking induced by exposure to priming cocaine injections, cues associated with cocaine self-administration and environmental stressors have been studied in rats. Here we describe a reinstatement method for studying relapse to cocaine seeking in mice...
journal_title:Psychopharmacology
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2011-03-01 00:00:00
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journal_title:Psychopharmacology
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