Abstract:
:Several behaviors associated with the serotonin syndrome have been reported in rats following administration of the 5-HT1A receptor agonist 8-OH-DPAT. The present investigation approached this phenomenon from an ethopharmacological perspective, and provided a detailed temporal analysis of the behavioral effects of this compound over a 2-h period, in both male and female rats in the home cage. In addition, in order to further characterize the nature of the forepaw-treading and locomotor elements, and assess the extent of influence of the physical characteristics of the test arena, this study provided a detailed analysis of these behaviors in both the home cage and a large oval runway. In the initial analysis, the data indicate a distinct chronological sequence of effects following 8-OH-DPAT treatment. For example, "flat back" activity and lower lip retraction were apparent within a few minutes post-injection, the former dissipating after about 30 min and being replaced as the prepotent response by a more general (curved back) locomotor enhancement, while the latter effect remained throughout the 2-h test period. Interestingly, there were reliable gender differences in terms of the onset and disappearance of several behavioral components, with females generally being more rapidly affected, but recovering earlier than males. The detailed analysis of locomotor activity and forepaw treading would suggest that the locomotor syndrome primarily involves forward movement, heavily guided by the physical environment. Furthermore, forepaw-treading would seem only to occur when an animal reaches a barrier and forward movement is briefly interrupted, as no reliable incidence of this behavior was observed in the open area of the test area. Together, these findings provide further characterization of the behavioral syndrome induced by 8-OH-DPAT, and indicate the importance of time post-administration, gender of the subject, and the physical characteristics of the test environment, when considering stereotypical drug effects.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Blanchard RJ,Shepherd JK,Armstrong J,Tsuda SF,Blanchard DCdoi
10.1007/BF02247363subject
Has Abstractpub_date
1993-01-01 00:00:00pages
55-63issue
1eissn
0033-3158issn
1432-2072journal_volume
112pub_type
杂志文章abstract:RATIONALE:Neurosteroids are implicated in various stages of drug dependence, including the acquisition phase, tolerance, and withdrawal. The neurosteroid allopregnanolone is also able to substitute for drugs with abuse potential and possesses reinforcing properties. OBJECTIVES:The effects of acute treatment with, and ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-0111-7
更新日期:2006-06-01 00:00:00
abstract::Ethanol-induced locomotor stimulation has been proposed to be positively correlated with the rewarding effects of ethanol (Wise and Bozarth 1987). The present experiments provided a test of this hypothesis using a genetic model. Three behavioral indices of the motivational effects of ethanol (drinking, taste condition...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245064
更新日期:1994-10-01 00:00:00
abstract:RATIONALE:Contemporary animal models of cocaine addiction focus on increasing the amount of drug consumption to produce addiction-like behavior. However, another critical factor is the temporal pattern of consumption, which in humans is characterized by intermittency, both within and between bouts of use. OBJECTIVE:To...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4393-8
更新日期:2016-10-01 00:00:00
abstract:RATIONALE:Preclinical studies suggest that medications enhancing the brain gamma amino butyric acid (GABA) system attenuate the rewarding effects of stimulants including nicotine. These preclinical studies have not been followed up in systematic human studies. OBJECTIVES:This study was conducted to examine the effects...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-005-0010-y
更新日期:2005-09-01 00:00:00
abstract::Two groups of schizophrenic outpatients were treated with perphenazine decanoate (N = 20) and cis(z)-flupentixol decanoate (N = 24) respectively. Every 3 months the dose was gradually reduced until symptoms appeared that were suggestive of a prodromal phase of a psychotic episode. A slightly higher dose was then promp...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02316862
更新日期:1991-01-01 00:00:00
abstract:RATIONALE:Previous work has shown that environmental enrichment alters amphetamine-induced locomotor activity and conditioned place preference. OBJECTIVE:The present study examined the effect of environmental enrichment on amphetamine self-administration. METHODS:Female and male rats were raised from 21 days of age i...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100720
更新日期:2001-05-01 00:00:00
abstract:RATIONALE:Nearly 60-80% of women experience some form of sadness, anxiety, or anhedonia in the weeks following the birth of a child (Patel et al. 23(2):534-42, 2012; Degner 10: 359;j4692, 2017); however, the exact mechanisms that precipitate these changes in mood postpartum are still unknown. It is well-known that the ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05194-3
更新日期:2019-10-01 00:00:00
abstract::An error in Fig. 3 was introduced in the production process which the authors have asked to be rectified. Below is the correct figure. ...
journal_title:Psychopharmacology
pub_type: 已发布勘误
doi:10.1007/s00213-019-05340-x
更新日期:2019-11-01 00:00:00
abstract::Neuroimaging has been identified as a potentially powerful probe for the in vivo study of drug effects on the brain with utility across several phases of drug development spanning preclinical and clinical investigations. Specifically, neuroimaging can provide insight into drug penetration and distribution, target enga...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-015-3968-0
更新日期:2015-11-01 00:00:00
abstract:RATIONALE:Recently, we showed that 2-bromoterguride acted as a dopamine D2 receptor partial agonist, a serotonin 5-HT2A and α2C-adrenergic receptor antagonist, and exhibited antidopaminergic efficacy in amphetamine-induced locomotion (AIL) in rats without inducing catalepsy. OBJECTIVE:To extend our knowledge on the an...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-016-4356-0
更新日期:2016-08-01 00:00:00
abstract:RATIONALE:Carrageenan-induced hyperalgesia is a widely used pain model in rodents. However, characteristics of carrageenan-induced hyperalgesia and effects of analgesic drugs under these conditions are unknown in nonhuman primates. OBJECTIVE:The aims of this study were to develop carrageenan-induced hyperalgesia in rh...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3341-0
更新日期:2014-04-01 00:00:00
abstract::Both muscarinic antagonists, such as scopolamine, and benzodiazepine receptor (BZR) agonists, such as diazepam, produce a reliable impairment in the performance of one trial passive avoidance. Such deficits are frequently interpreted as drug-induced amnesia. However, these deficits could also result from a learning im...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245247
更新日期:1995-03-01 00:00:00
abstract:INTRODUCTION:The present study was designed to investigate the rewarding effects induced by tramadol and its active metabolite O-desmethyltramadol (M1) under a neuropathic pain-like state. RESULTS:In opioid receptor binding and G protein activation, we confirmed that M1, but not tramadol, showed mu-opioid receptor (MO...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1180-1
更新日期:2008-10-01 00:00:00
abstract::Preclinical studies have exploded our knowledge about the behavioral and biological underpinnings of alcoholism. These studies suggest that certain neurotransmitters, particularly those interacting with the opioid, N-methyl-D-aspartate, and monoamine systems, may play a critical role in the expression of alcohol-drink...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s002130000371
更新日期:2000-05-01 00:00:00
abstract:RATIONALE:Dysfunction of executive neuropsychological performance, mediated by the prefrontal cortex, has been the central focus of recent attention deficit/ hyperkinetic disorder (AD-HKD) research. The role of other potential neuropsychological "risk factors", such as recognition memory, remains understudied. Further,...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00213-004-1833-7
更新日期:2004-09-01 00:00:00
abstract::Chronic oral administration of cannabis extract to rats (daily delta 9-tetrahydrocannabinol dose 20 mg/kg) was examined in three experiments for its residual effect on radial-arm maze learning following a 1-month drug-free period. Learning a simple eight-arm maze was significantly impaired in rats treated for either 6...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431932
更新日期:1982-01-01 00:00:00
abstract::Chronic treatment of rats with choline caused a decrease in the hypothermic response to pilocarpine. The action of choline on the muscarinic receptors is consistent with electrophysiological and binding studies, supporting a direct muscarinic action for choline. Administration of direct muscarinic agonists has been sh...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427955
更新日期:1983-01-01 00:00:00
abstract::Continuous low-level (0.825 mg/kg/h for 20 h) administration of AP through SC in-dwelling silicone reservoirs in the rat induced behavioral and biochemical changes that were similar to those induced by low levels (0.1 mg/kg) of acutely administered AP (decreased behavioral activity and decreased dopamine metabolism in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427314
更新日期:1985-01-01 00:00:00
abstract::Spontaneous and amphetamine-elicited locomotor activity in rats is reduced by most clinically effective antipsychotic drugs. We have recently demonstrated that intracerebroventricular infusion of kainic acid (KA), which produces cell loss in the hippocampus and other limbic-cortical brain regions, increases spontaneou...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050509
更新日期:1998-02-01 00:00:00
abstract:RATIONALE:Opioids remain the drugs of choice for treating moderate to severe pain, although adverse effects often limit use. Drugs acting concomitantly as agonists at μ opioid receptors and antagonists at δ opioid receptors produce antinociceptive effects with a reduced profile of adverse effects; one such drug, benzyl...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05638-1
更新日期:2020-12-01 00:00:00
abstract::Pigeons trained to discriminate between the presence and absence of delta 9-THC (0.56 mg/kg, IM, intramuscularly) were tested with diazepam (5.6-30 mg/kg), administered IG (intragastrically), and were found to generalize the response associated with the THC training to the diazepam treatment only to a limited extent. ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00174684
更新日期:1988-01-01 00:00:00
abstract:RATIONALE:A substantial portion of cigarette smokers prefer menthol-flavored cigarettes. To date, however, no studies have examined whether menthol in cigarettes has central pharmacological effects. OBJECTIVE:We investigated psychophysiological and subjective effects of smoking menthol versus non-menthol cigarettes in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050947
更新日期:1999-04-01 00:00:00
abstract::The results confirm that NMDA receptor blockade can result in improved retention performance of mice in step-down passive avoidance. A series of behavioural variations and analyses revealed that memory in the task depended mainly on the appearance of the grid that had been associated with shock, rather than on the exe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244300
更新日期:1991-01-01 00:00:00
abstract:RATIONALE:Though interoceptive properties of antidepressants have been described, discriminative stimulus (DS) properties of mirtazapine, which does not affect monoamine reuptake, remain uncharacterized. OBJECTIVES:The objectives of the study are to train rats to recognize a mirtazapine DS, then perform substitution s...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1259-8
更新日期:2009-04-01 00:00:00
abstract::It has been suggested that anxiety may be a critical factor in certain forms of non-opioid environmental analgesia. In the present study, 5-min exposure to the elevated plus-maze test of anxiety (EPM) induced a mild, though enduring, elevation in tail-flick latencies in male mice. Pretreatment with the opiate antagoni...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02247133
更新日期:1990-01-01 00:00:00
abstract::Behaviour was observed in mice given L-tryptophan, L-tyrosine or L-phenylalanine and then placed either in an open field or in water in a narrow cylinder. Animals placed in water (swim test) soon assume a characteristic immobile posture. Most antidepressants, including pharmacologically atypical ones, decrease immobil...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00435264
更新日期:1982-01-01 00:00:00
abstract::This study tested placebo responses in psychomotor performance when caffeine or alcohol was expected. Fifty male university students were assigned to one of four placebo groups or to a no-treatment control group. Two groups received placebo caffeine and two received placebo alcohol. Subjects performed 12 trials on a p...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02245081
更新日期:1994-07-01 00:00:00
abstract::Few studies have examined the association between ethanol use and cigarette smoking topography. In particular, no study has objectively investigated the relationship between chronic ethanol exposure and cigarette smoking. The aim of this study was to quantify the relationship between cigarette smoking and past and cur...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245794
更新日期:1990-01-01 00:00:00
abstract::Clozapine and molindone administered to mice for 21 days did not elevate the density of striatal 3H-spiperone binding sites at doses clinically equivalent to 1.5 mg/kg haloperidol, which elevated binding by 29%. Thioridazine (25 mg/kg) elevated binding by 25%. It appears that clinically equivalent doses of clozapine a...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432038
更新日期:1984-01-01 00:00:00
abstract:RATIONALE:Aminoadamantanes represent a class of NMDA glutamate receptor antagonists that reduce alcohol consumption and may prevent alcohol-induced neuronal adaptations and side effects. OBJECTIVE:Behavioral specificity of memantine and amantadine on alcohol drinking in a schedule-induced polydipsia (SIP) task was inv...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0465-5
更新日期:2006-09-01 00:00:00