Abstract:
:Clozapine and molindone administered to mice for 21 days did not elevate the density of striatal 3H-spiperone binding sites at doses clinically equivalent to 1.5 mg/kg haloperidol, which elevated binding by 29%. Thioridazine (25 mg/kg) elevated binding by 25%. It appears that clinically equivalent doses of clozapine and molindone have reduced ability to induce striatal D-2 dopamine receptor supersensitivity. These data are discussed in relationship to in vitro potencies and toxicity. The dose-response relationship of chronic haloperidol treatment and specific striatal 3H-spiperone binding was complex, i.e., binding was elevated at all doses, but the dose-response curve was concave upward. These data suggest that supersensitization is a complex interactive phenomenon comprised of elevation of striatal D-2 dopamine receptor density and other compensatory mechanisms.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Severson JA,Robinson HE,Simpson GMdoi
10.1007/BF00432038subject
Has Abstractpub_date
1984-01-01 00:00:00pages
115-9issue
1eissn
0033-3158issn
1432-2072journal_volume
84pub_type
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