The role of machine learning in neuroimaging for drug discovery and development.

abstract：RATIONALE:Group I metabotropic glutamate receptor antagonists, which block both the mGlu1 and mGlu5 receptors, have been shown to have anxiolytic effects in the lick suppression test in rats. OBJECTIVE:The anxiolytic potential of the selective mGlu1 antagonist 3,4-dihydro-2H-pyrano[2,3]beta-quinolin-7-yl)(cis-4-methox...

journal_title：Psychopharmacology

authors： Steckler T,Lavreysen H,Oliveira AM,Aerts N,Van Craenendonck H,Prickaerts J,Megens A,Lesage AS

更新日期：2005-04-01 00:00:00

abstract：RATIONALE:Combining neuroleptics with 5-HT1A ligands is thought to improve the preclinical profile of neuroleptics and may be of interest in the development of new compounds that have greater therapeutic potential and/or are better tolerated. OBJECTIVE:To examine 1) the ability of 5-HT1A ligands to alter the effects o...

journal_title：Psychopharmacology

authors： Prinssen EP,Kleven MS,Koek W

更新日期：1999-05-01 00:00:00

abstract：:The release of serotonin (5-HT) at serotonergic nerve terminals is regulated by 5-HT(1B) autoreceptors. Several studies have reported that the effects of selective 5-HT reuptake inhibitors (SSRIs) on extracellular 5-HT are augmented by 5-HT(1B) receptor antagonists, whereas administration of these antagonists alone do...

journal_title：Psychopharmacology

authors： de Groote L,Klompmakers AA,Olivier B,Westenberg HG

更新日期：2003-05-01 00:00:00

abstract：:Spontaneous and amphetamine-elicited locomotor activity in rats is reduced by most clinically effective antipsychotic drugs. We have recently demonstrated that intracerebroventricular infusion of kainic acid (KA), which produces cell loss in the hippocampus and other limbic-cortical brain regions, increases spontaneou...

journal_title：Psychopharmacology

authors： Bardgett ME,Jackson JL,Taylor BM,Csernansky JG

更新日期：1998-02-01 00:00:00

abstract：RATIONALE:A previously reported pharmacokinetic interaction between bromperidol and carbamazepine, an inducer of cytochrome P450 (CYP) 3A4, suggests possible involvement of CYP3A4 in the metabolism of bromperidol. OBJECTIVE:We investigated pharmacokinetic interaction between bromperidol and itraconazole, a potent inhi...

journal_title：Psychopharmacology

authors： Furukori H,Kondo T,Yasui N,Otani K,Tokinaga N,Nagashima U,Kaneko S,Inoue Y

更新日期：1999-07-01 00:00:00

abstract：RATIONALE:Cocaethylene is a pharmacologically active homolog and metabolite of cocaine, formed by transesterification of cocaine in the presence of ethanol. Here we relate findings from a randomized, placebo-controlled, double-blind study in which we examined the physiological and subjective effects and pharmacokinetic...

journal_title：Psychopharmacology

authors： Hart CL,Jatlow P,Sevarino KA,McCance-Katz EF

更新日期：2000-04-01 00:00:00

abstract：:The importance of brain noradrenaline synthesis and receptor activation for the hyperkinesia induced by carbidopa plus L-Dopa in reserpine-treated or normal mice was analyzed in four different models. After pretreatment with reserpine and the monoamine oxidase inhibitor nialamide, the hyperkinesia induced by L-Dopa (2...

journal_title：Psychopharmacology

authors： Andén NE,Strömbom U,Svensson TH

更新日期：1977-11-15 00:00:00

abstract：:There is increasing interest in the potential functional role of the octapeptide angiotensin II (AII) in psychiatric and cognitive disorders. The novel angiotensin II (AII) receptor antagonists, losartan and PD123177, selective for the AT1 and AT2 receptor subtypes respectively, constitute important pharmacological to...

journal_title：Psychopharmacology

authors： Shepherd J,Bill DJ,Dourish CT,Grewal SS,McLenachan A,Stanhope KJ

更新日期：1996-08-01 00:00:00

abstract：:The action of copper (CuSO4, 5 mg/kg, oral) on selected neuropharmacological actions of cannabis resin (CI, oral) was studied on albino rats and mice. Copper potentiated the barbiturate hypnosis-potentiating activity of CI in albino rats and mice and had no effect on hypothermic activity in albino rats. Single doses o...

journal_title：Psychopharmacology

authors： Singh PP,Das PK

更新日期：1978-04-11 00:00:00

abstract：:The effects of six putative dopamine receptor agonists on exploratory behaviour in rats were assessed: pergolide, (+)- and (-)-3-PPP, bromocriptine, mesulergine and CQ 32-084. Behaviour was automatically recorded in a holeboard apparatus and the data were analysed by the novel multivariate statistical method of partia...

journal_title：Psychopharmacology

authors： Ståhle L,Ungerstedt U

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:Pharmacokinetics of melatonin in children might differ from that in adults. OBJECTIVES:This study aims to establish a dose-response relationship for melatonin in advancing dim light melatonin onset (DLMO), sleep onset (SO), and reducing sleep onset latency (SOL) in children between 6 and 12 years with chroni...

journal_title：Psychopharmacology

authors： van Geijlswijk IM,van der Heijden KB,Egberts AC,Korzilius HP,Smits MG

更新日期：2010-10-01 00:00:00

abstract：:Administration of 10 mg/kg TRH to mice was found to reduce the sleep and hypothermia induced by 4.7 g/kg ethanol. However, TRH did not reduce the sleep of mice that were given gamma-hydroxybutyric acid (GHBA), baclophen, or aminooxyacetic acid (AOAA) in combination with 3 g/kg/ ethanol. TRH also failed to reverse the ...

journal_title：Psychopharmacology

authors： Cott J,Engel J

更新日期：1977-04-29 00:00:00

abstract：:There were marked strain differences in the duration of the protective effects of diazepam against the convulsant actions of penylenetetrazole and picrotoxin in mice. In no case was significant protection found at 12 h or longer, regardless of whether the incidence of or the latencies to myoclonus or tonic-clonic conv...

journal_title：Psychopharmacology

authors： File SE,Greenblatt DJ,Martin IL,Brown C

更新日期：1985-01-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Major depressive disorder (MDD) is associated with an increased risk for cardiovascular disease (CVD). Apart from biological and life style factors, the use of antidepressants and their potentially adverse effects might contribute to the increased CVD risk. Therefore, we compared cardiovascular...

journal_title：Psychopharmacology

authors： Kuehl LK,Muhtz C,Hinkelmann K,Dettenborn L,Wingenfeld K,Spitzer C,Otte C

更新日期：2016-09-01 00:00:00

abstract：:Experiments assessed the development of tolerance to morphine stimulus control during treatment with selected maintenance doses of morphine. Separate groups of rats were trained to discriminate saline and either 3.2 mg/kg or 5.6 mg/kg morphine under fixed-ratio schedules of food delivery. Dose-response functions for g...

journal_title：Psychopharmacology

authors： Young AM,Sannerud CA,Steigerwald ES,Doty MD,Lipinski WJ,Tetrick LE

更新日期：1990-01-01 00:00:00

abstract：:Nine human subjects were exposed to a multiple fixed-ratio (FR) differential-reinforcement-of-low-rate (DRL) schedule of monetary reinforcement. Presses on a manipulandum requiring relatively high force were occasionally followed by an increased money total displayed on a computer screen. Subjects were exposed to the ...

journal_title：Psychopharmacology

authors： Rumbold GR,White JM

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:Cognitive impairment in schizophrenia is particularly evident in the domains of attention and executive functions. Atypical antipsychotics are somewhat more effective than conventional antipsychotics in improving cognitive functioning in these patients. OBJECTIVE:The aim of this study was to compare the effe...

journal_title：Psychopharmacology

authors： Baviera M,Invernizzi RW,Carli M

更新日期：2008-02-01 00:00:00

abstract：RATIONALE:A substantial body of research suggests that the neuropeptide oxytocin promotes social affiliative behaviors in a wide range of animals including humans. However, its antiaggressive action has not been unequivocally demonstrated in male laboratory rodents. OBJECTIVE:Our primary goal was to examine the putati...

journal_title：Psychopharmacology

authors： Calcagnoli F,de Boer SF,Althaus M,den Boer JA,Koolhaas JM

更新日期：2013-10-01 00:00:00

abstract：:Dopaminergic involvement in the regulation of operant behavior was examined by monitoring responding after administration of different dopaminergic agonists. A chain schedule of reinforcement was used to classify the effects of these agonists in long-tailed macaques (Macaca fascicularis). The schedule included the fol...

journal_title：Psychopharmacology

authors： Dooley DJ,Bowden DM

更新日期：1983-01-01 00:00:00

abstract：:Offensive and defensive components of aggressive behavior were determined in resident and intruder mice. Withdrawal aggression was measured after the removal of a subcutaneous morphine pellet or after precipitation by naloxone in naive mice and after removal of a morphine pellet in mice with prior fighting experience....

journal_title：Psychopharmacology

authors： Kantak KM,Miczek KA

更新日期：1986-01-01 00:00:00

abstract：:There have been a number of claims that high-dose administration of cocaine to rats leads to neurotoxic effects on dopamine neurons. In this study possible neurotoxic effects on monoamine neurons were examined by measuring the effects of cocaine (35 mg/kg daily for 10 days) on the binding of radioligands to uptake sit...

journal_title：Psychopharmacology

authors： Benmansour S,Tejani-Butt SM,Hauptmann M,Brunswick DJ

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:Cotreatment with clorgyline shifts the development of sensitization to the D2/D3 dopamine receptor agonist quinpirole from locomotion to mouthing, an effect apparently unrelated to the monoamine oxidase inhibition property of clorgyline. This phenomenon was demonstrated in rats examined in small activity cham...

journal_title：Psychopharmacology

authors： Dvorkin A,Culver KE,Szechtman H

更新日期：2006-07-01 00:00:00

abstract：:Serotonergic mechanisms mediate the expression of personality traits (such as impulsivity, aggression and anxiety) that are linked to vulnerability to psychological illnesses, and modulate the identification of emotional expressions in the face as well as learning about broader classes of appetitive and aversive signa...

journal_title：Psychopharmacology

authors： Ward R,Sreenivas S,Read J,Saunders KEA,Rogers RD

更新日期：2017-07-01 00:00:00

abstract：:The purpose of this review was to establish in vivo apparent pA2 and pKB values for antagonism of the discriminative stimulus effects of benzodiazepine ligands, and to compare these values to those obtained from other behavioral procedures. Articles were chosen from the Medline data base from January 1976 to August 19...

journal_title：Psychopharmacology

authors： Rowlett JK,Woolverton WL

更新日期：1996-11-01 00:00:00

abstract：:The effects of bilateral nucleus accumbens microinjections of d-ala-met-enkephalinamide (DALA) were assessed in behavioral activation and lateral hypothalamic self-stimulation (LHSS) rate-frequency curve-shift paradigms in normal and accumbens 6-OHDA (4.0 micrograms) treated rats. Microinjections of DALA (2.5 microgra...

journal_title：Psychopharmacology

authors： Johnson PL,Stellar JR

更新日期：1994-05-01 00:00:00

abstract：RATIONALE:Non-contingent chronic nicotine exposure procedures have evolved rapidly in recent years, culminating in electronic nicotine delivery systems (ENDS or e-cigarettes) to deliver vaporized drugs to rodents in standard housing chambers. OBJECTIVES:The aim of the current work was to use ENDS to test concentration...

journal_title：Psychopharmacology

authors： Montanari C,Kelley LK,Kerr TM,Cole M,Gilpin NW

更新日期：2020-03-01 00:00:00

abstract：:Previous studies have shown that dihydropyridine (DHP) calcium channel blockers can potentiate yawning induced by apomorphine in rats. The present study was undertaken to examine whether or not this interaction was seen with other compounds that induce yawning or if it represented a specific interaction with dopaminer...

journal_title：Psychopharmacology

authors： Bourson A,Moser PC

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Second-generation antipsychotics are the first-line medications prescribed for schizophrenic patients; however, some of them, such as olanzapine and risperidone, may induce metabolic dysfunctions during short-term treatment. Metformin is an effective adjuvant that attenuates antipsychotic-induced metabolic dy...

journal_title：Psychopharmacology

authors： Luo C,Wang X,Mao X,Huang H,Liu Y,Zhao J,Zhou H,Liu Z,Li X

更新日期：2020-08-01 00:00:00

abstract：RATIONALE:H(3)-receptor inverse agonists raise a great interest as innovative therapeutics in several central disorders. Whereas their procognitive properties are well established, their antipsychotic-like properties are still debated. OBJECTIVES:We further explored the effect of maximal doses (3-10 mg/kg) of ciproxif...

journal_title：Psychopharmacology

authors： Burban A,Sadakhom C,Dumoulin D,Rose C,Le Pen G,Frances H,Arrang JM

更新日期：2010-07-01 00:00:00

abstract：RATIONALE:Cannabis (CB) use and dependence are associated with regionally specific alterations to brain circuitry and substantial psychosocial impairment. OBJECTIVES:The objective of this study was to investigate the association between CB use and dependence, and the volumes of brain regions critically involved in goa...

journal_title：Psychopharmacology

authors： Chye Y,Solowij N,Suo C,Batalla A,Cousijn J,Goudriaan AE,Martin-Santos R,Whittle S,Lorenzetti V,Yücel M

更新日期：2017-07-01 00:00:00