Antagonism of the analeptic activity of thyrotropin-releasing hormone (TRH) by agents which enhance GABA transmission.

abstract：RATIONALE:Glucose administration may decrease desire to smoke in abstinent smokers. Moreover, glucose administration has been associated with improved performance on measures of attention in healthy humans but evidence remains modest. OBJECTIVE:The present study aimed to determine whether reported craving and nicotine...

journal_title：Psychopharmacology

authors： Harakas P,Foulds J

更新日期：2002-05-01 00:00:00

abstract：:Animals responding for biphasic square wave stimulation to the VTA were treated for 26 days with a low dose (0.07 mg/kg) of the neuroleptic haloperidol and tested at 1 h post-injection. Initially the drug induced a pronounced lateral displacement of the baseline rate-intensity function, concomitant with a depression i...

journal_title：Psychopharmacology

authors： Lynch MR,Carey RJ

更新日期：1990-01-01 00:00:00

abstract：:After publication of this paper, the authors determined an error in the calculation of the norepinephrine standard concentrations for the HPLC calibration curves. ...

journal_title：Psychopharmacology

authors： Shnitko TA,Taylor SC,Stringfield SJ,Zandy SL,Cofresí RU,Doherty JM,Lynch WB,Boettiger CA,Gonzales RA,Robinson DL

更新日期：2018-09-01 00:00:00

abstract：:The results confirm that NMDA receptor blockade can result in improved retention performance of mice in step-down passive avoidance. A series of behavioural variations and analyses revealed that memory in the task depended mainly on the appearance of the grid that had been associated with shock, rather than on the exe...

journal_title：Psychopharmacology

authors： Weiskrantz L,Mondadori C

更新日期：1991-01-01 00:00:00

abstract：:Two experiments were conducted to test the hypothesis that tolerance to the hypothermic effect of ethanol fails to develop if rats are denied the unconditional stimulus represented by hypothermia. In both experiments, rats were injected with either ethanol (1.9 or 2.5 g/kg) or saline and given microwave hyperthermia (...

journal_title：Psychopharmacology

authors： Hjeresen DL,Reed DR,Woods SC

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:A cue-modulated startle test recently confirmed that smoking cues in smokers may not be withdrawal-like and aversive as traditionally believed. OBJECTIVE:Analogous tests were applied to alcohol cues in inpatient alcoholics. METHODS:Twenty-six withdrawn alcoholics (18 men) were examined. Alcohol-related pict...

journal_title：Psychopharmacology

authors： Mucha RF,Geier A,Stuhlinger M,Mundle G

更新日期：2000-09-01 00:00:00

abstract：RATIONALE:Amphetamine administration has been found to affect the degree of cerebral dominance for motor control in animals. In humans, cerebral dopamine neurotransmission is also correlated to motor dominance. Since language dominance is related to motor dominance, amphetamine might also affect cerebral dominance for ...

journal_title：Psychopharmacology

authors： Sommer IE,Oranje B,Ramsey NF,Klerk FA,Mandl RC,Westenberg HG,Kahn RS

更新日期：2006-01-01 00:00:00

abstract：RATIONALE:Opioid use disorder (OUD) is a major epidemic in the USA. Despite evidence indicating that OUD may be particularly severe for women, preclinical models have yet to establish sex as a major factor in OUD. OBJECTIVES:Here, we examined sex differences in vulnerability to relapse following intermittent access fe...

journal_title：Psychopharmacology

authors： Bakhti-Suroosh A,Towers EB,Lynch WJ

更新日期：2021-01-06 00:00:00

abstract：RATIONALE:Smokers show heightened activation toward smoking-related stimuli and experience increased cravings which can precipitate smoking cessation relapse. Exercise can be effective for modulating cigarette cravings and attenuating reactivity to smoking cues, but the mechanism by which these effects occur remains un...

journal_title：Psychopharmacology

authors： Janse Van Rensburg K,Taylor A,Benattayallah A,Hodgson T

更新日期：2012-06-01 00:00:00

abstract：:Mice ran in a circular runway. Some received milk at every third circuit in a designated direction, clockwise or counterclockwise, in daily 1000-s sessions. Under control conditions, about 10 times as many circuits were made in the reinforced direction as in the non-reinforced direction. Cocaine (10, 30, 100 microM/kg...

journal_title：Psychopharmacology

authors： Dews PB

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Studies about whether or not the cognitive performance of women is influenced by changes in levels of sex steroid hormones across the menstrual cycle have produced ambiguous results. OBJECTIVES:This study tested whether flight simulator performance differs significantly between the menstrual and the luteal p...

journal_title：Psychopharmacology

authors： Mumenthaler MS,O'Hara R,Taylor JL,Friedman L,Yesavage JA

更新日期：2001-05-01 00:00:00

abstract：:The present study employed an animal model of drug relapse in which previously extinguished heroin self-administration behavior was reinstated following a single reinforced trial. Male albino rats were trained to traverse a straight-alley for a reinforcer consisting of a single IV injection of 0.06 mg/kg diacetylmorph...

journal_title：Psychopharmacology

authors： Ettenberg A,MacConell LA,Geist TD

更新日期：1996-04-01 00:00:00

abstract：:In a one-trial step-through passive avoidance task, pretraining administration of ethanol was shown to decrease the latencies to step through at both training (day 1) and testing (day 2) for both rats and mice. A detailed analysis of these effects showed that they differed from those reported previously by others. The...

journal_title：Psychopharmacology

authors： Bammer G,Chesher GB

更新日期：1982-01-01 00:00:00

abstract：:Preclinical studies have exploded our knowledge about the behavioral and biological underpinnings of alcoholism. These studies suggest that certain neurotransmitters, particularly those interacting with the opioid, N-methyl-D-aspartate, and monoamine systems, may play a critical role in the expression of alcohol-drink...

journal_title：Psychopharmacology

authors： Johnson BA,Ait-Daoud N

更新日期：2000-05-01 00:00:00

abstract：RATIONALE:The low self-administration (LS)/Kgras (LS) and high self-administration (HS)/Kgras (HS) rat lines were generated by selective breeding for low- and high-intravenous cocaine self-administration, respectively, from a common outbred Wistar stock (Crl:WI). This trait has remained stable after 13 generations of b...

journal_title：Psychopharmacology

authors： Xu H,Das S,Sturgill M,Hodgkinson C,Yuan Q,Goldman D,Grasing K

更新日期：2017-08-01 00:00:00

abstract：RATIONALE:Cortisol levels rise sharply immediately after electroconvulsive therapy (ECT); the resultant stimulation of steroid receptors in the hippocampus may be beneficial or harmful to cognition, depending on the magnitude of the stimulation. Steroid mechanisms may therefore modulate ECT-induced amnesia. OBJECTIVES...

journal_title：Psychopharmacology

authors： Nagaraja N,Andrade C,Sudha S,Madan Singh N,Chandra JS,Venkataraman BV

更新日期：2007-01-01 00:00:00

abstract：RATIONALE/OBJECTIVES:Previous research has shown that ecstasy users are impaired in thinking and reasoning. The present study sought to explore the possibility that syllogistic reasoning errors in ecstasy users were due to an inability to construct a model of the premises due to working memory limitations. METHODS:Twe...

journal_title：Psychopharmacology

authors： Fisk JE,Montgomery C,Wareing M,Murphy PN

更新日期：2005-09-01 00:00:00

abstract：RATIONALE:Concurrent abuse of cocaine and heroin is a common form of polydrug abuse, but the interactions between the reinforcing effects of cocaine and heroin are poorly understood. Dose-addition analysis is a tool for the quantitative assessment of drug interactions, but this analysis has not been applied to evaluati...

journal_title：Psychopharmacology

authors： Negus SS

更新日期：2005-06-01 00:00:00

abstract：RATIONALE:Abstinence from drug occurs in human addicts for several reasons, including the avoidance of adverse consequences. OBJECTIVES:To explore a model of drug use in the face of adverse consequences in rats through intermittent punishment of drug seeking and to investigate whether the ability to withhold seeking r...

journal_title：Psychopharmacology

authors： Pelloux Y,Everitt BJ,Dickinson A

更新日期：2007-09-01 00:00:00

abstract：:Rats selectively bred for high alcohol sleep times (HAS) and those that are less affected (LAS) by hypnotic doses (3.0-3.6 g/kg) of ethanol were tested for differential responses to the aversive effects of 1.0 g/kg ethanol in a conditioned place preference task. Likewise, the effects of 0.3-1.0 g/kg ethanol on spontan...

journal_title：Psychopharmacology

authors： Schechter MD,Krimmer EC

更新日期：1992-01-01 00:00:00

abstract：:The effects on one-way active avoidance conditioning of pre-training, systemic administration of the selective mu-receptor agonist [D-Ala2,N-Me-Phe4, Gly-ol]enkephalin (DAGO), and the selective mu-receptor antagonist (D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP), were determined in Swiss-Webster mice. A low dose of ...

journal_title：Psychopharmacology

authors： Schulteis G,Martinez JL Jr

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:Aminoadamantanes represent a class of NMDA glutamate receptor antagonists that reduce alcohol consumption and may prevent alcohol-induced neuronal adaptations and side effects. OBJECTIVE:Behavioral specificity of memantine and amantadine on alcohol drinking in a schedule-induced polydipsia (SIP) task was inv...

journal_title：Psychopharmacology

authors： Escher T,Call SB,Blaha CD,Mittleman G

更新日期：2006-09-01 00:00:00

abstract：:Fifty-nine depressed female inpatients were treated with 100 mg amitriptyline (AMT) IM for 4 weeks. Depression ratings and determinations of the parent drug and nortriptyline (NT) were performed weekly. No direct relationship between plasma AMT + NT concentrations and therapeutic response was apparent, but beneficial ...

journal_title：Psychopharmacology

authors： Corona GL,Cucchi ML,Frattini P,Santagostino G,Schinelli S,Zerbi F,Savoldi F

更新日期：1990-01-01 00:00:00

abstract：:Herrnstein's matching equation was used to analyze drug effects on performance in random interval reinforcement schedules. Pimozide caused effects compatible with both motor and motivational impairments, in a 5-component multiple schedule, a 3-schedule 3-day cycle (ALT-3), and a 2-schedule 2-day cycle (ALT-2). However...

journal_title：Psychopharmacology

authors： Willner P,Sampson D,Phillips G,Muscat R

更新日期：1990-01-01 00:00:00

abstract：:The concurrent influence of dopaminergic, sigma and muscarinic neurotransmitter systems in mediating cocaine-induced lethality is predicted by previous receptor binding results from our laboratories. The present results demonstrate that pharmacological manipulations of these predicted neurotransmitter systems alter th...

journal_title：Psychopharmacology

authors： Ritz MC,George FR

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:The pharmacological profile of escitalopram, the S-(+)-enantiomer of citalopram, was studied and compared with citalopram and the R-(-)-enantiomer, R-citalopram. METHODS:Inhibition of the serotonin transporter (5-HTT) was studied in COS-1 cells expressing the human 5-HTT (h-5-HTT) and in rat brain synaptosom...

journal_title：Psychopharmacology

authors： Sánchez C,Bergqvist PB,Brennum LT,Gupta S,Hogg S,Larsen A,Wiborg O

更新日期：2003-06-01 00:00:00

abstract：:The purpose of this study was to determine if multiple aspects of drug and food-reinforced behavior could be measured in a single study. Drug or food seeking can be observed under four conditions: 1) internal drug or food cues and external stimulus cues present; self-administration, 2) only internal cues present; prim...

journal_title：Psychopharmacology

authors： Foltin RW,Evans SM

更新日期：1997-08-01 00:00:00

abstract：RATIONALE:The exact role of delta opioid receptors in drug-induced conditioned place preference (CPP) remains debated. Under classical experimental conditions, morphine-induced CPP is decreased in mice lacking delta opioid receptors (Oprd1 (-/-)). Morphine self-administration, however, is maintained, suggesting that dr...

journal_title：Psychopharmacology

authors： Le Merrer J,Faget L,Matifas A,Kieffer BL

更新日期：2012-09-01 00:00:00

abstract：RATIONALE:Zotepine is an antipsychotic drug with proven efficacy for treatment of acute episodes of schizophrenia. Antipsychotic drugs also require to be effective in prevention of recurrence. OBJECTIVE:This trial was designed to compare the effects of zotepine and placebo in the prevention of recurrence of acute epis...

journal_title：Psychopharmacology

authors： Cooper SJ,Butler A,Tweed J,Welch C,Raniwalla J

更新日期：2000-06-01 00:00:00

abstract：RATIONALE:Gabolysat PC60 is a fish protein hydrolysate with anxiolytic properties commonly used as a nutritional supplement. OBJECTIVE:The diazepam-like effects of PC60 on stress responsiveness of the rat pituitary-adrenal system and on sympathoadrenal activity were studied. METHODS:The activity of the pituitary-adre...

journal_title：Psychopharmacology

authors： Bernet F,Montel V,Noël B,Dupouy JP

更新日期：2000-03-01 00:00:00