Abstract:
RATIONALE:Opioid use disorder (OUD) is a major epidemic in the USA. Despite evidence indicating that OUD may be particularly severe for women, preclinical models have yet to establish sex as a major factor in OUD. OBJECTIVES:Here, we examined sex differences in vulnerability to relapse following intermittent access fentanyl self-administration and protracted abstinence and used buprenorphine, the FDA-approved treatment for OUD, to test the validity of our model. METHODS:Following acquisition of fentanyl self-administration under one of two training conditions, male and female rats were given extended, 24-h/day access to fentanyl (0.25 μg/kg/infusion, 10 days) using an intermittent access procedure. Vulnerability to relapse was assessed using an extinction/cue-induced reinstatement procedure following 14 days of abstinence; buprenorphine (0 or 3 mg/kg/day) was administered throughout abstinence. RESULTS:Levels of drug-seeking were high following extended-access fentanyl self-administration and abstinence; buprenorphine markedly decreased drug-seeking supporting the validity of our relapse model. Females self-administered more fentanyl and responded at higher levels during subsequent extinction testing. Buprenorphine was effective in both sexes and eliminated sex and estrous phase differences in drug-seeking. Interestingly, the inclusion of a time-out during training had a major impact on later fentanyl self-administration in females, but not males, indicating that the initial exposure conditions can persistently impact vulnerability in females. CONCLUSIONS:These findings demonstrate the utility of this rat model for determining sex and hormonal influences on the development and treatment of OUD.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Bakhti-Suroosh A,Towers EB,Lynch WJdoi
10.1007/s00213-020-05750-2subject
Has Abstractpub_date
2021-01-06 00:00:00eissn
0033-3158issn
1432-2072pii
10.1007/s00213-020-05750-2pub_type
杂志文章abstract::The effect of electroconvulsive shock (ECS) on the responsiveness to pain (measured by the hot-plate test) and on the characteristics of L-type calcium channels (measured as [3H]nitrendipine binding sites) in the cortex and hippocampus was tested on the Wistar rat. In animals receiving a single ECS, the calcium channe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244133
更新日期:1990-01-01 00:00:00
abstract::Cortical and hippocampal EEGs in animal models of schizophrenia were compared to those obtained with psychotomimetics or antipsychotic agents by utilizing power spectral analysis. Models of positive schizophrenic symptoms were created with methamphetamine (MAP) and cocaine, and a model of both negative and positive sy...
journal_title:Psychopharmacology
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0397-0
更新日期:2006-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244833
更新日期:1992-01-01 00:00:00
abstract::The effect of ovarian steroids on the benzodiazepine receptor was assessed in the elevated plus-maze and, after restraint stress, in benzodiazepine receptor binding assays. Vehicle-treated proestrous rats displayed anxiolytic behavior, relative to diestrus or estrous rats. Anxiolytic behavior was observed after 1 or 2...
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更新日期:1996-05-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00179930
更新日期:1987-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1998-08-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:1988-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1998-11-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:1986-01-01 00:00:00
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更新日期:1989-01-01 00:00:00
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更新日期:2014-09-01 00:00:00
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更新日期:1985-01-01 00:00:00
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更新日期:1977-08-31 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:1999-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00
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更新日期:1985-01-01 00:00:00
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更新日期:2010-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00