Effects of selective D1 and D2 dopamine antagonists on the development of behavioral sensitization to apomorphine.

abstract：RATIONALE:Reelin, a large extracellular matrix glycoprotein, is down-regulated in the brain of schizophrenic patients and of heterozygous reeler mice (rl/+). The behavioral phenotype of rl/- mice, however, matches only partially the schizophrenia hallmarks. OBJECTIVES:We recently reported (Marrone et al., Eur J Neuros...

journal_title：Psychopharmacology

authors： Ammassari-Teule M,Sgobio C,Biamonte F,Marrone C,Mercuri NB,Keller F

更新日期：2009-06-01 00:00:00

abstract：:Antipsychotic drugs, such as haloperidol and risperidone, are used in long-term treatment of psychiatric patients and thus increase the risk of obesity and other metabolic dysfunctions. Available evidence suggests that these drugs have pro-inflammatory effect, which contributes to the establishment of endocrine distur...

journal_title：Psychopharmacology

authors： da Cruz Jung IE,Machado AK,da Cruz IB,Barbisan F,Azzolin VF,Duarte T,Duarte MM,do Prado-Lima PA,Bochi GV,Scola G,Moresco RN

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Rats reared in social isolation exhibit various cognitive and behavioural abnormalities in adulthood. However, impulsivity following this treatment still remains unclear, especially in response to medications used in attention deficit hyperactivity disorder, such as amphetamine. METHODS:Using an isolation-r...

journal_title：Psychopharmacology

authors： Liu YP,Wilkinson LS,Robbins TW

更新日期：2017-05-01 00:00:00

abstract：RATIONALE:Evidences indicate that methylglyoxal, a highly reactive metabolite of hyperglycemia, can enhance protein glycation, oxidative stress, or inflammation. Mangiferin, a polyphenol compound of C-glucoside, has many beneficial biological activities, including anti-inflammation, anti-oxidation, neuroprotection, cog...

journal_title：Psychopharmacology

authors： Liu YW,Zhu X,Yang QQ,Lu Q,Wang JY,Li HP,Wei YQ,Yin JL,Yin XX

更新日期：2013-08-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Major depressive disorder (MDD) is associated with an increased risk for cardiovascular disease (CVD). Apart from biological and life style factors, the use of antidepressants and their potentially adverse effects might contribute to the increased CVD risk. Therefore, we compared cardiovascular...

journal_title：Psychopharmacology

authors： Kuehl LK,Muhtz C,Hinkelmann K,Dettenborn L,Wingenfeld K,Spitzer C,Otte C

更新日期：2016-09-01 00:00:00

abstract：:The aim of the present study was to investigate the locomotor stimulant effects of the atypical antipsychotic agent, olanzapine, in mice depleted of their dopamine by reserpine and alpha-methyl-DL-p-tyrosine pretreatment. Olanzapine (0.5, 1 and 2 mg/kg) dose-dependently increased locomotor activity, which was complete...

journal_title：Psychopharmacology

authors： Ninan I,Kulkarni SK

更新日期：1999-02-01 00:00:00

abstract：:In order to assess the possible effects of central GABA activation on the consolidation of shock avoidance, the GABA-T inhibitor amino-oxyacetic acid (AOAA) was administered posttrial to adult male rats. Learning was assessed over nine widely spaced sessions of 20 trials each. AOAA-treated animals showed learning with...

journal_title：Psychopharmacology

authors： Katz RJ,Liebler L

更新日期：1978-03-01 00:00:00

abstract：:Several studies have demonstrated a paradoxical form of antinociception induced by the repeated administration of opioid antagonists accompanied by exposure to a painful stimulus. The underlying mechanism of this naloxone-induced antinociception (NIA) is still unknown, but the results of several studies suggest that i...

journal_title：Psychopharmacology

authors： Walker MJ,Poulos CX,Le AD

更新日期：1994-01-01 00:00:00

abstract：RATIONALE:Increased anxiety is a characteristic of the acute ethanol withdrawal syndrome. Repeated exposure of rats to withdrawal from chronic ethanol increases sensitivity to seizures. OBJECTIVES:We investigated whether repeated withdrawal experience increases withdrawal-induced anxiety and stress, and if it changes ...

journal_title：Psychopharmacology

authors： Borlikova GG,Le Merrer J,Stephens DN

更新日期：2006-04-01 00:00:00

abstract：:Serotonergic mechanisms mediate the expression of personality traits (such as impulsivity, aggression and anxiety) that are linked to vulnerability to psychological illnesses, and modulate the identification of emotional expressions in the face as well as learning about broader classes of appetitive and aversive signa...

journal_title：Psychopharmacology

authors： Ward R,Sreenivas S,Read J,Saunders KEA,Rogers RD

更新日期：2017-07-01 00:00:00

abstract：:In the conditioned reinforcement paradigm, animals learn a new instrumental response reinforced solely by conditioned reward (a stimulus that has previously been associated with primary reward). It has been shown that psychostimulants potentiate responding for conditioned reward and there is evidence that the nucleus ...

journal_title：Psychopharmacology

authors： Kelley AE,Delfs JM

更新日期：1991-01-01 00:00:00

abstract：:Acute alcohol administration to rats has in preliminary studies been reported to drastically increase the binding of the benzodiazepine (BZ) receptor antagonist [3H]flumazenil (Ro 15-1788) to central BZ receptors. In the present study the effect of acute alcohol ingestion on the disposition of [11C]flumazenil in the h...

journal_title：Psychopharmacology

authors： Pauli S,Liljequist S,Farde L,Swahn CG,Halldin C,Litton JE,Sedvall G

更新日期：1992-01-01 00:00:00

abstract：:Chronic treatment (2 weeks) with piracetam (500 mg/kg, once daily PO) elevated m-cholinoceptor density in the frontal cortex of aged (18 months) female mice by about 30-40%, but had no effect on m-cholinoceptor density in the frontal cortex of young (4 weeks) mice. The effect of piracetam on m-cholinoceptor density as...

journal_title：Psychopharmacology

authors： Pilch H,Müller WE

更新日期：1988-01-01 00:00:00

abstract：:The effects of the antiepilepsy drugs methsuximide and mephenytoin were examined in pigeons responding under a fixed-consecutive-number (FCN) schedule with and without an added external discriminative stimulus. On this schedule, food was delivered whenever subjects responded between 8 and 12 times on one response key ...

journal_title：Psychopharmacology

authors： Schlinger H,Wilkenfield J,Poling A

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Cue avoidance training (CAT) reduces alcohol consumption in the laboratory. However, the neural mechanisms that underlie the effects of this intervention are poorly understood. OBJECTIVES:The present study investigated the effects of a single session of CAT on event-related and readiness potentials during pr...

journal_title：Psychopharmacology

authors： Di Lemma LCG,Stancak A,Soto V,Fallon N,Field M

更新日期：2020-05-01 00:00:00

abstract：RATIONALE:Serotonin and especially serotonin 2A (5-HT(2A)) receptor signaling are important in the etiology and treatment of schizophrenia and affective disorders. We previously reported a novel 5-HT(2A) receptor effector, increased transglutaminase (TGase)-catalyzed transamidation, and activation of the small G protei...

journal_title：Psychopharmacology

authors： Dai Y,Dudek NL,Li Q,Muma NA

更新日期：2011-02-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Previous studies show that electrical stimulation of the ventral subiculum (vSub) can reinstate drug-seeking behavior in rats following extinction. This study examined whether vSub stimulation could also evoke reinitiation of d-amphetamine (d-AMPH) self-administration during voluntary abstinenc...

journal_title：Psychopharmacology

authors： Taepavarapruk P,Phillips AG

更新日期：2003-07-01 00:00:00

abstract：RATIONALE:Varenicline is believed to work, in part, by reducing craving responses to smoking cues and by reducing general levels of craving; however, these hypotheses have never been evaluated with craving assessed in the natural environments of treatment-seeking smokers. OBJECTIVES:Ecological momentary assessment pro...

journal_title：Psychopharmacology

authors： Gass JC,Wray JM,Hawk LW,Mahoney MC,Tiffany ST

更新日期：2012-09-01 00:00:00

abstract：:Experiments assessed the development of tolerance to morphine stimulus control during treatment with selected maintenance doses of morphine. Separate groups of rats were trained to discriminate saline and either 3.2 mg/kg or 5.6 mg/kg morphine under fixed-ratio schedules of food delivery. Dose-response functions for g...

journal_title：Psychopharmacology

authors： Young AM,Sannerud CA,Steigerwald ES,Doty MD,Lipinski WJ,Tetrick LE

更新日期：1990-01-01 00:00:00

abstract：:We are performing a double-blind trial with inward psychiatric patients. The indication for our psychotropic or psychotherapeutic intervention is mainly severe depression (= major depressive disorders DSM III). For a 3-week trial course trazodone (400 mg daily), amitriptyline (150 mg/die) or placebo capsules were give...

journal_title：Psychopharmacology

authors： Klieser E,Lehmann E

更新日期：1988-01-01 00:00:00

abstract：:In the studies reported here, we investigated the effects of nicotine on memory for unrelated word lists. Nicotine was delivered through cigarette smoking, and memory performance was assessed using both intentional and incidental recall tasks, and employing an additional, indirect measure of memory. We report the resu...

journal_title：Psychopharmacology

authors： Rusted J,Graupner L,Warburton D

更新日期：1995-06-01 00:00:00

abstract：:Basal morning humoral (H)-endorphin blood levels were assessed in ten autistic patients, 12 chronic schizophrenic patients and 11 healthy control subjects. Four autistic patients and four schizophrenic patients were drug free for at least 6 months while all other psychiatric patients were under treatment with antidopa...

journal_title：Psychopharmacology

authors： Weizman R,Weizman A,Tyano S,Szekely G,Weissman BA,Sarne Y

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:Zotepine is an antipsychotic drug with proven efficacy for treatment of acute episodes of schizophrenia. Antipsychotic drugs also require to be effective in prevention of recurrence. OBJECTIVE:This trial was designed to compare the effects of zotepine and placebo in the prevention of recurrence of acute epis...

journal_title：Psychopharmacology

authors： Cooper SJ,Butler A,Tweed J,Welch C,Raniwalla J

更新日期：2000-06-01 00:00:00

abstract：RATIONALE:Individual differences in the rate of nicotine metabolism (RNM) could be related to dependence and success in stopping smoking. A range of studies have examined RNM measured by the ratio of trans-3'-hydroxycotinine and cotinine in body fluids (the ratio). A systematic review of this literature is needed to dr...

journal_title：Psychopharmacology

authors： West O,Hajek P,McRobbie H

更新日期：2011-11-01 00:00:00

abstract：:Five elderly depressed patients were treated with amitriptyline (AT) and nortriptyline (NT) in turn, in a cross-over design. Steady-state plasma drug levels were compared with those calculated for eight healthy subjects of previous single-dose studies. Plasma clearances were on average about 2.5 times lower in the pat...

journal_title：Psychopharmacology

authors： Burch JE

更新日期：1983-01-01 00:00:00

abstract：RATIONALE:The exact role of delta opioid receptors in drug-induced conditioned place preference (CPP) remains debated. Under classical experimental conditions, morphine-induced CPP is decreased in mice lacking delta opioid receptors (Oprd1 (-/-)). Morphine self-administration, however, is maintained, suggesting that dr...

journal_title：Psychopharmacology

authors： Le Merrer J,Faget L,Matifas A,Kieffer BL

更新日期：2012-09-01 00:00:00

abstract：:Clonidine is a clinically used antihypertensive which has been suggested to produce physiological changes in children after exposure in utero. The aim of our study was to test the hypothesis that chronic exposure of the developing brain to an alpha 2-adrenergic agonist like clonidine would influence the adult neuroche...

journal_title：Psychopharmacology

authors： Feenstra MG,van Galen H,Boer GJ

更新日期：1992-01-01 00:00:00

abstract：:Preclinical studies have exploded our knowledge about the behavioral and biological underpinnings of alcoholism. These studies suggest that certain neurotransmitters, particularly those interacting with the opioid, N-methyl-D-aspartate, and monoamine systems, may play a critical role in the expression of alcohol-drink...

journal_title：Psychopharmacology

authors： Johnson BA,Ait-Daoud N

更新日期：2000-05-01 00:00:00

abstract：RATIONALE:The low self-administration (LS)/Kgras (LS) and high self-administration (HS)/Kgras (HS) rat lines were generated by selective breeding for low- and high-intravenous cocaine self-administration, respectively, from a common outbred Wistar stock (Crl:WI). This trait has remained stable after 13 generations of b...

journal_title：Psychopharmacology

authors： Xu H,Das S,Sturgill M,Hodgkinson C,Yuan Q,Goldman D,Grasing K

更新日期：2017-08-01 00:00:00

abstract：RATIONALE:Environmental stimuli associated with drugs of abuse are believed to play a major role in the motivation to take drugs, drug dependence, and relapse. Previous work from this laboratory demonstrated that the response-contingent presentation of drug-related, visual cues was at least as important as nicotine in ...

journal_title：Psychopharmacology

authors： Caggiula AR,Donny EC,White AR,Chaudhri N,Booth S,Gharib MA,Hoffman A,Perkins KA,Sved AF

更新日期：2002-09-01 00:00:00