Abstract：
:Experiments assessed the development of tolerance to morphine stimulus control during treatment with selected maintenance doses of morphine. Separate groups of rats were trained to discriminate saline and either 3.2 mg/kg or 5.6 mg/kg morphine under fixed-ratio schedules of food delivery. Dose-response functions for generalization of morphine stimulus control were determined before, during, and after repeated treatment with selected doses of morphine. Similar experiments were performed with repeated pentobarbital treatment in order to assess the pharmacological selectivity of tolerance. Repeated treatment with saline, 3.2 mg/kg morphine, or twice daily injections of 17.8 mg/kg pentobarbital produced no tolerance to morphine stimulus control. In contrast, treatment with daily injections of 10 mg/kg or twice daily injections of 10 or 17.8 mg/kg morphine produced a dose-dependent increase in the dose of morphine required for stimulus control. The magnitude of tolerance to morphine stimulus control varied directly with the maintenance dose of morphine and was slightly greater for a lower than a higher morphine training dose. Termination of repeated treatment was followed by a return to initial sensitivity, without additional training. Tolerance to morphine stimulus control was not necessarily accompanied by tolerance to its rate-suppressing effects.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Young AM,Sannerud CA,Steigerwald ES,Doty MD,Lipinski WJ,Tetrick LEdoi
10.1007/BF02245745subject
Has Abstractpub_date
1990-01-01 00:00:00pages
59-67issue
1eissn
0033-3158issn
1432-2072journal_volume
102pub_type
杂志文章abstract：:Each morning eight adults with caffeine versus placebo discrimination histories ingested letter-coded capsules containing 100 mg caffeine or placebo and then engaged in a relaxation or vigilance activity. Subjects were first exposed to caffeine and placebo once each with each activity. Then each day for 10 days subjec...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02249332
更新日期：1994-04-01 00:00:00
abstract：RATIONALE:Many of the biochemical, physiological, and behavioral effects of ethanol are known to be mediated by ionotropic glutamate receptors. Emerging evidence implicates metabotropic glutamate receptors (mGluRs) in the biobehavioral effects of ethanol and other drugs of abuse, but there is little information regardi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-005-0217-y
更新日期：2006-01-01 00:00:00
abstract：RATIONALE AND OBJECTIVE:Drug-associated memories are hypothesized to underlie the high risk of relapse in addiction. Recent studies show that post-retrieval extinction training erases fear memories by reconsolidation blockade. Here, we examine the efficacy of this non-invasive procedure in rats with drug-associated mem...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-011-2545-4
更新日期：2012-05-01 00:00:00
abstract：:We investigated the possible role of dopamine receptors in the mediation of copulatory disorder induced by defeat experience in male mice, using L-dopa and apomorphine. To generate the copulatory disorder, male mice were attacked 20 times daily for 5 consecutive days, as intruders in confrontation with an aggressive r...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050398
更新日期：1997-10-01 00:00:00
abstract：:In a randomised, double-blind, parallel groups study, 40 patients referred for surgical removal of impacted third molars received either (a) temazepam 40 mg orally followed at 35 min by IV saline or (b) oral placebo followed by IV diazepam 10 mg (Diazemuls). Patients were divided into High-Anxious and Low-Anxious grou...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00652245
更新日期：1986-01-01 00:00:00
abstract：:In an operant learning lever-pressing procedure on an FR10 schedule of milk reinforcement, male Wistar rats were trained to discriminate between saline and 3 mg/kg IP DN-2327, a new anxiolytic which acts on benzodiazepine receptors, 3 mg/kg IP diazepam or 15 mg/kg IP pentylenetetrazol (PTZ). More than 80% appropriate ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02251282
更新日期：1993-01-01 00:00:00
abstract：RATIONALE:Cocaine and opioids are often co-abused. As yet, however, there is no clear evidence that the drugs interact to make the mixture a more effective reinforcer. OBJECTIVE:The present study examined the relative reinforcing potency and maximum effectiveness of the cocaine-opioid combination in monkeys given a ch...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-2131-1
更新日期：2011-05-01 00:00:00
abstract：INTRODUCTION:Alterations in protein kinase (PKA) protein levels have been implicated in the regulation of responses to and development of cocaine addiction. However, the contribution of differences in PKA intracellular cascade to the known sex differences in responses to cocaine is not well understood. This study exami...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-008-1411-5
更新日期：2009-04-01 00:00:00
abstract：RATIONALE:Corticostriatal circuits are widely implicated in the top-down control of attention including inhibitory control and behavioural flexibility. However, recent neurophysiological evidence also suggests a role for thalamic inputs to striatum in behaviours related to salient, reward-paired cues. OBJECTIVES:Here,...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-017-4627-4
更新日期：2017-08-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00431455
更新日期：1984-01-01 00:00:00
abstract：:Sibutramine hydrochloride, a novel monoamine reuptake inhibitor antidepressant, has been studied to determine whether it alters dopaminergic function in the brain. Its effects have been compared with bupropion, a dopamine reuptake inhibitor, and methamphetamine, a dopamine reuptake inhibitor and releasing agent. Sibut...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245152
更新日期：1992-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-2017-2
更新日期：2011-01-01 00:00:00
abstract：RATIONALE:Alcohol intoxication produces effects that can impair judgment and increase engagement in risky behaviors, including alcohol-impaired driving (AID). Real-world AID decisions are informed by contextual circumstances and judgments of associated risk. How individuals vary in their AID decision-making across cont...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-020-05639-0
更新日期：2020-12-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-012-2942-3
更新日期：2013-05-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050496
更新日期：1998-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050638
更新日期：1998-07-01 00:00:00
abstract：RATIONALE:Previous work has shown that clozapine suppressed tacrine-induced jaw movements at lower doses than those required for suppression of lever pressing. OBJECTIVE:The novel atypical antipsychotic olanzapine was assessed in these behavioral tests. METHODS:The effect of acute olanzapine on the suppression of tac...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130051063
更新日期：1999-08-01 00:00:00
abstract：RATIONALE:The involvement of glutamate in fear extinction is perhaps the most promising in terms of facilitating clinical interventions for posttraumatic stress disorder (PTSD). This study was aimed at elucidating the possible role of zif268 on the D-cycloserine (DCS) facilitation effect on extinction. OBJECTIVE:We in...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-4042-7
更新日期：2015-10-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00442007
更新日期：1989-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-016-4464-x
更新日期：2017-02-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244370
更新日期：1991-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427828
更新日期：1983-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00433058
更新日期：1980-01-01 00:00:00
abstract：RATIONALE:The cholinergic system is linked extensively to memory, but its exact role remains controversial. In particular, scopolamine-induced impairment in rodents is not task specific, which may be due to difficulty in developing rodent protocols to assess deficits in recent memory, in which the remembered event is b...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-004-1777-y
更新日期：2004-08-01 00:00:00
abstract：RATIONALE:Repeated exposure to psychostimulant drugs causes a long-lasting increase in the psychomotor and reinforcing effects of these drugs and an array of neuroadaptations. One such alteration is a hypersensitivity of striatal activity such that a low dose of amphetamine in sensitized animals produces dorsal striata...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-008-1100-4
更新日期：2008-05-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02246211
更新日期：1995-02-01 00:00:00
abstract：:Preclinical studies suggest that acoustic startle amplitude is increased during ethanol withdrawal. The current study evaluated the effects of intravenous infusion of the alpha 2-adrenergic antagonist, yohimbine (0.4 mg/kg), the serotonin partial agonist m-chlorophenylpiperazine (mCPP, 0.1 mg/kg), and placebo administ...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002130050285
更新日期：1997-06-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00172956
更新日期：1988-01-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Addiction to psychostimulant methamphetamine (METH) remains a major public health problem in the world. Animal models that use METH self-administration incorporate many features of human drug-taking behavior and are very helpful in elucidating mechanisms underlying METH addiction. These models ...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-016-4235-8
更新日期：2016-05-01 00:00:00
abstract：:The effect of long-term treatment with clozapine in schizophrenia and schizoaffective disorder was evaluated in a retrospective study comprising 96 patients treated with the drug during the period 1974-1986 at the Psychiatric Research Center in Uppsala. All patients had previously been treated with different kinds of ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00442567
更新日期：1989-01-01 00:00:00
