Tolerance to morphine stimulus control: role of morphine maintenance dose.


:Experiments assessed the development of tolerance to morphine stimulus control during treatment with selected maintenance doses of morphine. Separate groups of rats were trained to discriminate saline and either 3.2 mg/kg or 5.6 mg/kg morphine under fixed-ratio schedules of food delivery. Dose-response functions for generalization of morphine stimulus control were determined before, during, and after repeated treatment with selected doses of morphine. Similar experiments were performed with repeated pentobarbital treatment in order to assess the pharmacological selectivity of tolerance. Repeated treatment with saline, 3.2 mg/kg morphine, or twice daily injections of 17.8 mg/kg pentobarbital produced no tolerance to morphine stimulus control. In contrast, treatment with daily injections of 10 mg/kg or twice daily injections of 10 or 17.8 mg/kg morphine produced a dose-dependent increase in the dose of morphine required for stimulus control. The magnitude of tolerance to morphine stimulus control varied directly with the maintenance dose of morphine and was slightly greater for a lower than a higher morphine training dose. Termination of repeated treatment was followed by a return to initial sensitivity, without additional training. Tolerance to morphine stimulus control was not necessarily accompanied by tolerance to its rate-suppressing effects.




Young AM,Sannerud CA,Steigerwald ES,Doty MD,Lipinski WJ,Tetrick LE




Has Abstract


1990-01-01 00:00:00












  • Reciprocal cross-sensitization of D1 and D3 receptors following pharmacological stimulation in the hemiparkinsonian rat.

    abstract::In the majority of Parkinson's disease (PD) patients, long-term dopamine (DA) replacement therapy leads to dyskinesia characterized by abnormal involuntary movements (AIMs). There are various mechanisms of dyskinesia, such as the sensitization of striatal DA D1 receptors (D1R) and upregulation of DA D3 receptors (D3R)...


    pub_type: 杂志文章


    authors: Lanza K,Chemakin K,Lefkowitz S,Saito C,Chambers N,Bishop C

    更新日期:2020-01-01 00:00:00

  • Systematic review of the relationship between the 3-hydroxycotinine/cotinine ratio and cigarette dependence.

    abstract:RATIONALE:Individual differences in the rate of nicotine metabolism (RNM) could be related to dependence and success in stopping smoking. A range of studies have examined RNM measured by the ratio of trans-3'-hydroxycotinine and cotinine in body fluids (the ratio). A systematic review of this literature is needed to dr...


    pub_type: 杂志文章,评审


    authors: West O,Hajek P,McRobbie H

    更新日期:2011-11-01 00:00:00

  • Effects of prior amphetamine exposure on approach strategy in appetitive Pavlovian conditioning in rats.

    abstract:RATIONALE:Pavlovian conditioning with a discrete reward-predictive visual cue can elicit two classes of behaviors: "sign-tracking" (approach toward and contact with the cue) and "goal-tracking" (approach toward the site of reward delivery). Sign-tracking has been proposed to be linked to behavioral disorders involving ...


    pub_type: 杂志文章


    authors: Simon NW,Mendez IA,Setlow B

    更新日期:2009-03-01 00:00:00

  • Treatment of Schizophrenia with ergot derivatives.

    abstract::Seven neuroleptic-free schizophrenic patients received bromocriptine and eight schizophrenic patients received CF 25-397, both ergot derivatives with dopamine agonist activity. Psychosis failed to improve in response to either drug at the relatively low doses administered. Unlike the antipsychotic property of apomorph...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Tamminga CA,Schaffer MH

    更新日期:1979-01-01 00:00:00

  • Absence of central effects in man of the benzodiazepine antagonist Ro 15-1788.

    abstract::The benzodiazepines are typified by a profile of side effects which includes drowsiness, ataxia and incoordination. Ro 15-1788, an imidazodiazepine derivative, exhibits marked antagonism of the behavioural and biochemical effects of the benzodiazepines in animals and man. It is devoid of any behavioural activity in an...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Darragh A,Lambe R,O'Boyle C,Kenny M,Brick I

    更新日期:1983-01-01 00:00:00

  • Inhibitory influences of the adrenal steroid, 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone [correction of tetrahydroxycorticosterone] on aggression and defeat-induced analgesia in mice.

    abstract::The effects of intraperitoneal administrations of the deoxycorticosterone metabolite, 5 alpha-pregnane-, 21 diol-20-one (3 alpha, 5 alpha-tetrahydrodeoxycorticosterone; alpha-THDOC) on the responses to aggression and defeat-induced analgesia were examined in subordinate intruder male mice in "resident-intruder" pairin...


    pub_type: 杂志文章


    authors: Kavaliers M

    更新日期:1988-01-01 00:00:00

  • Female rats display dose-dependent differences to the rewarding and aversive effects of nicotine in an age-, hormone-, and sex-dependent manner.

    abstract:INTRODUCTION:The objective of this study was to examine age-, hormone-, and sex-dependent differences to the behavioral effects of nicotine using place-conditioning procedures in female rats. METHODS:Animals received nicotine in their initially non-preferred side and saline on alternate days in their initially preferr...


    pub_type: 杂志文章


    authors: Torres OV,Natividad LA,Tejeda HA,Van Weelden SA,O'Dell LE

    更新日期:2009-10-01 00:00:00

  • In vivo effects of psychotropic agents on the physical properties of cell membranes in the rat brain.

    abstract::Marked changes in biophysical properties, including structural order, have been observed in the hydrophobic core of cell membranes exposed to phenothiazines in vitro. In this study, similar changes are reported in vivo in cell membranes from the brains of rats treated with phenothiazines at doses thought to yield tiss...


    pub_type: 杂志文章


    authors: Cohen BM,Zubenko GS

    更新日期:1985-01-01 00:00:00

  • Influence of naloxone upon motor activity induced by psychomotor stimulant drugs.

    abstract::Naloxone, an opioid receptor antagonist, attenuates a wide range of behavioral effects of d-amphetamine, such as the stimulation of motor activity. To investigate the pharmacological selectivity of the naloxone/amphetamine interaction, we assessed the effects of naloxone (5.0 mg/kg SC) upon motor activity induced in r...


    pub_type: 杂志文章


    authors: Jones DN,Holtzman SG

    更新日期:1994-03-01 00:00:00

  • Contributions of hippocampus and neocortex to the expression of ethanol effects.

    abstract::The distinctive effects of ethanol on behavior suggest that certain parts of the CNS may be especially sensitive to it. One of the primary candidates is the hippocampal formation. Damage to this structure mimics acute ethanol treatment across a wide variety of behavioral tasks and processes. The possibility of a hippo...


    pub_type: 杂志文章


    authors: Devenport LD,Hale RL

    更新日期:1989-01-01 00:00:00

  • Platelet adenylate cyclase activity in Israeli victims of Iraqi Scud missile attacks with post-traumatic stress disorder.

    abstract::Platelet adenylate cyclase activity was measured in 16 control subjects and 16 patients who developed post-traumatic stress disorder (PTSD) as a result of damage inflicted on their homes during the Iraqi Scud missile attacks on Israel which occurred during the 1991 Gulf War. There were no differences in basal, NaF-sti...


    pub_type: 临床试验,杂志文章


    authors: Weizmann R,Gur E,Laor N,Reiss A,Muller U,Yoresh A,Lerer B,Newman ME

    更新日期:1994-04-01 00:00:00

  • The neuroendocrinological profile of roxindole, a dopamine autoreceptor agonist, in schizophrenic patients.

    abstract::Roxindole is a potent autoreceptor-selective dopamine agonist with additional properties as a serotonin reuptake inhibitor and 5-HT1A agonist. In order to get more insight into its mode of action in various psychiatric populations, we evaluated the effects of subchronic roxindole treatment on pituitary and adrenal hor...


    pub_type: 杂志文章


    authors: Gründer G,Wetzel H,Hillert A,Jochum E,Hiemke C,Benkert O

    更新日期:1995-02-01 00:00:00

  • The benzodiazepine antagonist flumazenil blocks the effects of CCK receptor agonists and antagonists in the elevated plus-maze.

    abstract::Peripheral administration of the unsulphated cholecystokinin octapeptide (CCK-8us) led to an anxiogenic-like action in the elevated plus-maze model of anxiety in rats. Devazepide and L-365,260 showed potent anxiolytic-like effects at similar doses. The fact that devazepide is 1000 times more potent as a CCK-A receptor...


    pub_type: 杂志文章


    authors: Chopin P,Briley M

    更新日期:1993-01-01 00:00:00

  • Psychopharmacologic treatment of pediatric major depressive disorder.

    abstract:RATIONALE:The role of pharmacotherapy in the treatment of major depressive disorder (MDD) in youth has received much attention in recent years due to concerns of efficacy and safety of the antidepressants for the treatment of MDD in youth. OBJECTIVES:This review describes the existing published and unpublished literat...


    pub_type: 杂志文章,评审


    authors: Boylan K,Romero S,Birmaher B

    更新日期:2007-03-01 00:00:00

  • Metabolic correlates of toluene abuse: decline and recovery of function in adolescent animals.

    abstract:RATIONALE:Children and adolescents will readily abuse household products that contain solvents such as toluene. It is likely that reinforcing exposures to toluene alter brain glucose metabolism. OBJECTIVE:Using an animal model of drug reinforcement, we sought to identify a metabolic signature of toluene abuse in the a...


    pub_type: 杂志文章


    authors: Schiffer WK,Lee DE,Alexoff DL,Ferrieri R,Brodie JD,Dewey SL

    更新日期:2006-06-01 00:00:00

  • Effects of disrupting medial prefrontal cortex GABA transmission on decision-making in a rodent gambling task.

    abstract:RATIONALE:Decision-making is a complex cognitive process that is mediated, in part, by subregions of the medial prefrontal cortex (PFC). Decision-making is impaired in a number of psychiatric conditions including schizophrenia. Notably, people with schizophrenia exhibit reductions in GABA function in the same PFC areas...


    pub_type: 杂志文章


    authors: Paine TA,O'Hara A,Plaut B,Lowes DC

    更新日期:2015-05-01 00:00:00

  • Evaluating the utility of administering a reaction time task in an ecological momentary assessment study.

    abstract:RATIONALE:Cognitive processes underlying drug use have typically been assessed in laboratory settings. More detailed and ecologically valid data may be possible if assessments were conducted in an ecological momentary assessment (EMA) setting. OBJECTIVES:We evaluated the feasibility and utility of administering a reac...


    pub_type: 杂志文章


    authors: Waters AJ,Li Y

    更新日期:2008-03-01 00:00:00

  • Chlordiazepoxide-induced disruption of discrimination behaviour: a signal detection analysis.

    abstract::To assess the effects of chlordiazepoxide (CDP) on a stable discrimination performance, eight rats were trained on a simple brightness discrimination and injected with three dosages (0, 5, and 10 mg/kg) once performance was stable. Signal detection analysis of the results was used to differentiate sensory from motor/r...


    pub_type: 杂志文章


    authors: Francis RL,Cooper SJ

    更新日期:1979-06-21 00:00:00

  • Stereoselective discriminative stimulus effects of zopiclone in rhesus monkeys.

    abstract:RATIONALE:The behavioral effects of racemic zopiclone are similar to those of benzodiazepines that positively modulate GABA at the GABA(A) receptor complex; however, it is not clear how enantiomers or metabolites of zopiclone contribute to the benzodiazepine-like behavioral effects of racemic zopiclone. OBJECTIVES:Rac...


    pub_type: 杂志文章


    authors: McMahon LR,Jerussi TP,France CP

    更新日期:2003-01-01 00:00:00

  • Experimental catalepsy is both enhanced and disrupted by apomorphine.

    abstract::In mice that were scored for the length of time they remained immobile in awkward postures (cataleptic) on an inclined wire grid, a large IP dose of pilocarpine (80 mg/kg) caused a clear catalepsy, which was prevented by both dopamine agonists that were tested, apomorphine (4 or 8 mg/kg, IP) and bromocriptine (8 mg/kg...


    pub_type: 杂志文章


    authors: Klemm WR

    更新日期:1985-01-01 00:00:00

  • Effects of sodium amylobarbitone on memory processes in the pigeon.

    abstract::An experiment was carried out in the pigeon to assess the effects of sodium amylobarbitone (SAB) on memory, using a delayed pair comparison task. Performance was disrupted at all delays by doses of 10 and 20 mg/kg SAB and it was concluded that this effect was not due to perceptual impairment or stereotyped responding,...


    pub_type: 杂志文章


    authors: Hulme M,Sahgal A,Iversen SD

    更新日期:1979-03-29 00:00:00

  • Dose-dependent noradrenergic and serotonergic properties of venlafaxine in animal models indicative of antidepressant activity.

    abstract::The present study was undertaken to investigate thoroughly the preclinical psychopharmacological profile of venlafaxine, testing a wide range of doses in animal models indicative of antidepressant-like effects. Venlafaxine was found to be active in mouse forced swimming test (at 8, 16, 32 and 64 mg/kg) and to increase...


    pub_type: 杂志文章


    authors: Redrobe JP,Bourin M,Colombel MC,Baker GB

    更新日期:1998-07-01 00:00:00

  • Baseline prepulse inhibition expression predicts the propensity of developing sensitization to the motor stimulant effects of amphetamine in C57BL/6 mice.

    abstract:RATIONALE:The startle reflex to a sudden intense acoustic pulse stimulus is attenuated if the pulse is shortly preceded by a weak prepulse stimulus. This represents a form of sensory gating, known as prepulse inhibition (PPI), observable across species. PPI is modulated by dopamine and readily disrupted by acute amphet...


    pub_type: 杂志文章


    authors: Peleg-Raibstein D,Hauser J,Llano Lopez LH,Feldon J,Gargiulo PA,Yee BK

    更新日期:2013-01-01 00:00:00

  • Risk-seeking for losses is associated with 5-HTTLPR, but not with transient changes in 5-HT levels.

    abstract:RATIONALE:Serotonin (5-HT) plays a key role in different aspects of value-based decision-making. A recent framework proposed that tonic 5-HT (together with dopamine, DA) codes future average reward expectations, providing a baseline against which possible choice outcomes are compared to guide decision-making. OBJECTIV...


    pub_type: 杂志文章


    authors: Neukam PT,Kroemer NB,Deza Araujo YI,Hellrung L,Pooseh S,Rietschel M,Witt SH,Schwarzenbolz U,Henle T,Smolka MN

    更新日期:2018-07-01 00:00:00

  • Cocaine toxicity: concurrent influence of dopaminergic, muscarinic and sigma receptors in mediating cocaine-induced lethality.

    abstract::The concurrent influence of dopaminergic, sigma and muscarinic neurotransmitter systems in mediating cocaine-induced lethality is predicted by previous receptor binding results from our laboratories. The present results demonstrate that pharmacological manipulations of these predicted neurotransmitter systems alter th...


    pub_type: 杂志文章


    authors: Ritz MC,George FR

    更新日期:1997-02-01 00:00:00

  • Simultaneous intra-accumbens remifentanil and dopamine kinetics suggest that neither determines within-session operant responding.

    abstract:RATIONALE:The ultra-short-acting mu opioid agonist analgesic/anesthetic remifentanil (RMF) is extremely rapidly eliminated from blood (half-life in rats, 0.3-0.7 min). This extremely fast elimination is thought to be the main reason why RMF maintains such high rates of responding in animal operant-conditioning models o...


    pub_type: 杂志文章


    authors: Crespo JA,Sturm K,Saria A,Zernig G

    更新日期:2005-12-01 00:00:00

  • D-2 but not D-1 dopamine agonists produce augmented behavioral response in rats after subchronic treatment with methamphetamine or cocaine.

    abstract::A study was performed to examine behavioral response to a challenge of selective dopamine D-1 and D-2 agonists in rats previously sensitized by subchronic administration of methamphetamine or cocaine. Rats in three groups received repeated injections (IP) of saline, methamphetamine (4 mg/kg/day) or cocaine (20 mg/kg/d...


    pub_type: 杂志文章


    authors: Ujike H,Akiyama K,Otsuki S

    更新日期:1990-01-01 00:00:00

  • Differences between d-methamphetamine and d-amphetamine in rats: working memory, tolerance, and extinction.

    abstract:RATIONALE:Previously, we have shown that d-amphetamine (AMPH) was more potent than d-methamphetamine (METH) at increasing extracellular levels of dopamine (DA) in the prefrontal cortex (PFC) at doses that had similar effects in the nucleus accumbens. Since working memory depends on PFC DA, it was postulated that AMPH w...


    pub_type: 杂志文章


    authors: Shoblock JR,Maisonneuve IM,Glick SD

    更新日期:2003-11-01 00:00:00

  • Trait differences in response to chronic nicotine and nicotine withdrawal in rats.

    abstract:INTRODUCTION:Understanding an individual's vulnerability to drug addiction has important implications for the development of effective personal treatment plans. Although theories acknowledge impulsive behaviour as a key component of drug addiction, little is known about the influence of trait impulsivity on an individu...


    pub_type: 杂志文章


    authors: Kolokotroni KZ,Rodgers RJ,Harrison AA

    更新日期:2014-02-01 00:00:00

  • Effects of low doses of caffeine on cognitive performance, mood and thirst in low and higher caffeine consumers.

    abstract:RATIONALE:Caffeine is present in many widely consumed drinks and some foods. In the fairly extensive literature on the psychostimulant effects of caffeine, there are few dose-response studies and even fewer studies of the effects of doses of caffeine lower than 50 mg (the range of the amounts of caffeine contained in, ...


    pub_type: 杂志文章


    authors: Smit HJ,Rogers PJ

    更新日期:2000-10-01 00:00:00