Experimental comparison between the effect of standardized trazodone-amitriptyline and placebo treatment in vitalized depressive patients.

abstract：RATIONALE:The startle reflex to a sudden intense acoustic pulse stimulus is attenuated if the pulse is shortly preceded by a weak prepulse stimulus. This represents a form of sensory gating, known as prepulse inhibition (PPI), observable across species. PPI is modulated by dopamine and readily disrupted by acute amphet...

journal_title：Psychopharmacology

authors： Peleg-Raibstein D,Hauser J,Llano Lopez LH,Feldon J,Gargiulo PA,Yee BK

更新日期：2013-01-01 00:00:00

abstract：:Two experiments were conducted to assess the acute behavioral effects of triazolam and temazepam in healthy, non-drug abusing men in double-blind, placebo-controlled, crossover trials, where all subjects received all possible doses. These drugs were compared to examine allegations that triazolam produces greater behav...

journal_title：Psychopharmacology

authors： Rush CR,Higgins ST,Hughes JR,Bickel WK

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:Diazepam, a benzodiazepine with a relatively rapid onset of clinical effects, has been associated with suicide and other self-aggressive acts. The evidence for this association, however, comes exclusively from retrospective non-experimental studies. Although suggestive, the results of these studies do not sup...

journal_title：Psychopharmacology

authors： Berman ME,Jones GD,McCloskey MS

更新日期：2005-02-01 00:00:00

abstract：RATIONALE:The neuronal actions of methamphetamine (MA) include an increase in extracellular levels of monoamines, presumably via reverse transport involving the monoamine transporters. This action is thought to play an important role in the effects of MA. Therefore, in the present experiment, it was hypothesized that a...

journal_title：Psychopharmacology

authors： Ranaldi R,Anderson KG,Carroll FI,Woolverton WL

更新日期：2000-12-01 00:00:00

abstract：INTRODUCTION:Marchigian Sardinian alcohol-preferring (msP) rats exhibit innate preference for alcohol along with anxious phenotype. In these animals, two single-nucleotide polymorphisms in position -1,836 and -2,097 from the first start codon of the CRF1-R transcript have been found. MATERIALS AND METHODS:Here, we exa...

journal_title：Psychopharmacology

authors： Cippitelli A,Ayanwuyi LO,Barbier E,Domi E,Lerma-Cabrera JM,Carvajal F,Scuppa G,Li H,Ubaldi M,Heilig M,Roberto M,Ciccocioppo R

更新日期：2015-03-01 00:00:00

abstract：:The aim of the present study was to (i) characterise the mouse behavioural profile (particularly social interactions) during the preweaning period, (ii) assess the effects of prenatal exposure to an anticonvulsant drug widely used in clinical practice, (iii) examine possible genetic differences both in baseline behavi...

journal_title：Psychopharmacology

authors： Laviola G,Terranova ML,Sedowofia K,Clayton R,Manning A

更新日期：1994-01-01 00:00:00

abstract：RATIONALE:The cAMP-dependent protein kinase A (PKA) signaling transduction pathway has been shown to play an important role in the modulation of several ethanol-induced behaviors. Different studies have demonstrated intracellular calcium (Ca(2+))-dependent activation of the PKA cascade after ethanol administration. Thu...

journal_title：Psychopharmacology

authors： Baliño P,Ledesma JC,Aragon CM

更新日期：2014-12-01 00:00:00

abstract：:Oxytocin plays an important role in the regulation of normal cognitive functions and behaviors, which are disturbed in schizophrenia. Several studies suggest that oxytocinergic function is abnormal in schizophrenia patients. Thus, oxytocin may be involved in the pathophysiology associated with this disorder. This stud...

journal_title：Psychopharmacology

authors： Feifel D,Reza T

更新日期：1999-01-01 00:00:00

abstract：AIM:It is widely assumed that the upcoming therapeutics for Alzheimer's disease will require to act on more than one target to be effective. We investigated here whether a combination of the nicotinic receptor allosteric modulator/cholinesterase inhibitor galantamine can act synergistically with the type 4 serotonin re...

journal_title：Psychopharmacology

authors： Freret T,Lelong-Boulouard V,Lecouflet P,Hamidouche K,Dauphin F,Boulouard M

更新日期：2017-08-01 00:00:00

abstract：RATIONALE:Tolerance to delay of gratification, taken to reflect impulsiveness, has been proposed to be under the preferential control of central serotonin (5-HT) processes. OBJECTIVE:The present study further examined the effects of drugs which directly or indirectly alter 5-HT transmission, on behaviour controlled by...

journal_title：Psychopharmacology

authors： Bizot J,Le Bihan C,Puech AJ,Hamon M,Thiébot M

更新日期：1999-10-01 00:00:00

abstract：:In order to study the role of dopamine (DA) in the regulation of seizure mechanisms in man, a non-emetic dose of apomorphine, a direct stimulant of DA receptors, was administered to eight patients effected by different types of epilepsy. The EEG changes induced by apomorphine administration in comparison to those elic...

journal_title：Psychopharmacology

authors： Del Zompo M,Tocco F,Marrosu F,Passino N,Corsini GU

更新日期：1983-01-01 00:00:00

abstract：RATIONALE:Latent inhibition (LI), namely, poorer performance on a learning task involving a previously pre-exposed non-reinforced stimulus, is disrupted in the rat by the dopamine (DA) releaser amphetamine which produces and exacerbates psychotic (positive) symptoms, and this is reversed by treatment with typical and a...

journal_title：Psychopharmacology

authors： Weiner I

更新日期：2003-09-01 00:00:00

abstract：:Low doses of 8-OH-DPAT (62.5-250 micrograms/kg) were reinforcing in the place preference conditioning procedure, while a higher dose (1 mg/kg) supported a conditioned place aversion. The 5-HT synthesis inhibitor PCPA, and the DA antagonists pimozide and sulpiride, had no effect when administered alone, but abolished t...

journal_title：Psychopharmacology

authors： Papp M,Willner P

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:Studies suggest that brain-derived neurotrophic factor (BDNF) plays an essential role in regulating memory-related neuroplasticity in the hippocampus. Type 2 diabetes (T2DM) is associated with impairment in many domains of cognitive function which may result from reduced BDNF; however, the correlation of BDNF...

journal_title：Psychopharmacology

authors： Zhen YF,Zhang J,Liu XY,Fang H,Tian LB,Zhou DH,Kosten TR,Zhang XY

更新日期：2013-05-01 00:00:00

abstract：:This study examined the role of the strychnine-insensitive glycine binding site of the NMDA receptor in prepulse inhibition (PPI) of the acoustic startle response (ASR) in rats. PPI is an operational measure of gating processes which normally lead to a diminished ASR when a startling stimulus is preceded by a weak pre...

journal_title：Psychopharmacology

authors： Kretschmer BD,Koch M

更新日期：1997-03-01 00:00:00

abstract：:Offensive and defensive components of aggressive behavior were determined in resident and intruder mice. Withdrawal aggression was measured after the removal of a subcutaneous morphine pellet or after precipitation by naloxone in naive mice and after removal of a morphine pellet in mice with prior fighting experience....

journal_title：Psychopharmacology

authors： Kantak KM,Miczek KA

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:We have recently shown that post-extinction exposure of rats to a sub-threshold reminder shock can reactivate extinguished context-related freezing and found that chronic treatment with fluoxetine before fear extinction prevents this phenomenon. OBJECTIVES:In the present study, we examined whether these find...

journal_title：Psychopharmacology

authors： Deschaux O,Spennato G,Moreau JL,Garcia R

更新日期：2011-05-01 00:00:00

abstract：RATIONALE:Prepulse inhibition (PPI) represents a normal sensorimotor gating response that is typically impaired in schizophrenic patients. It is known that cannabinoid CB1 agonists reduce sensorimotor gating in rats, suggesting that the CB1 receptor and the cannabinoid system are involved in sensorimotor gating. OBJEC...

journal_title：Psychopharmacology

authors： Fernandez-Espejo E,Galan-Rodriguez B

更新日期：2004-09-01 00:00:00

abstract：:Tolerance to nicotine occurs in mice after its chronic administration. This tolerance is accompanied by an up-regulation of nicotinic receptors as assessed by the binding of (3H)-nicotine and alpha-(125I)-bungarotoxin (BTX). Past studies (Marks et al. 1983, 1986) have shown that the increase in BTX binding sites is mo...

journal_title：Psychopharmacology

authors： Miner LL,Collins AC

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Glucose administration may decrease desire to smoke in abstinent smokers. Moreover, glucose administration has been associated with improved performance on measures of attention in healthy humans but evidence remains modest. OBJECTIVE:The present study aimed to determine whether reported craving and nicotine...

journal_title：Psychopharmacology

authors： Harakas P,Foulds J

更新日期：2002-05-01 00:00:00

abstract：:The effects of methaqualone on isonicotinic acid hydrazide, 6-mercapto propionic acid, picrotoxin, and strychnine-induced convulsion were studied in mice and the results compared with diazepam. Methaqualone, like diazepam, was found to be a selective antagonist of isoniazid-induced convulsion and a much less effective...

journal_title：Psychopharmacology

authors： Naik SR,Naid PR,Sheth UK

更新日期：1978-04-14 00:00:00

abstract：RATIONALE:Depressed patients robustly exhibit affective biases in emotional processing which are altered by SSRIs and predict clinical outcome. OBJECTIVES:The objective of this study is to investigate whether psilocybin, recently shown to rapidly improve mood in treatment-resistant depression (TRD), alters patients' e...

journal_title：Psychopharmacology

authors： Stroud JB,Freeman TP,Leech R,Hindocha C,Lawn W,Nutt DJ,Curran HV,Carhart-Harris RL

更新日期：2018-02-01 00:00:00

abstract：RATIONALE:N-methyl-D-aspartate (NMDA) receptor antagonists (e.g., PCP, ketamine) have been shown to impair learning/memory. Well documented in animal models, only limited research in humans has been reported. Findings to date are similar to results of animal studies; however, antagonists are typically administered befo...

journal_title：Psychopharmacology

authors： LaPorte DJ,Blaxton TA,Michaelidis T,Robertson DU,Weiler MA,Tamminga CA,Lahti AC

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:The rise in heroin addiction has heightened the need for novel and effective treatments. Physical exercise has been shown as an effective treatment for stimulant abuse in clinical and pre-clinical research. However, this treatment has not yet been tested on opioid addiction. This study examined the effects o...

journal_title：Psychopharmacology

authors： Smethells JR,Greer A,Dougen B,Carroll ME

更新日期：2020-02-01 00:00:00

abstract：RATIONALE:Receptor mechanisms underlying the behavioral effects of clinically used nicotinic acetylcholine receptor agonists have not been fully established. OBJECTIVE:Drug discrimination was used to compare receptor mechanisms underlying the effects of smoking cessation aids. METHODS:Separate groups of male C57BL/6J...

journal_title：Psychopharmacology

authors： Cunningham CS,McMahon LR

更新日期：2013-07-01 00:00:00

abstract：RATIONALE:One third of US smokers are intermittent smokers (ITS) who do not smoke daily. Unlike daily smokers (DS), whose smoking is negatively reinforced by withdrawal relief, ITS may be motivated by immediate positive reinforcement. In contrast, incentive salience theory posits hypothesis that "liking" of drug effect...

journal_title：Psychopharmacology

authors： Shiffman S,Terhorst L

更新日期：2017-10-01 00:00:00

abstract：RATIONALE:A subset of male rats that self-administer 3,4-methylenedioxypyrovalerone (MDPV) have unusually high levels of drug intake; however, factor(s) that influence this behavior (e.g., reinforcement history and sex) are unknown. OBJECTIVES:Characterize the reinforcing potency and effectiveness of MDPV in female ra...

journal_title：Psychopharmacology

authors： Doyle MR,Sulima A,Rice KC,Collins GT

更新日期：2020-11-24 00:00:00

abstract：:The effects of four indirect dopamine agonists, d-amphetamine (0.25-4.0 mg/kg), cocaine (2.5-40.0 mg/kg), GBR 12909 (10.0-30.0 mg/kg), and nomifensine (5.0-20.0 mg/kg), on the behavioral organization of movements in an unconditioned motor paradigm were investigated in rats. The extended scaling hypothesis using the fl...

journal_title：Psychopharmacology

authors： Paulus MP,Callaway CW,Geyer MA

更新日期：1993-01-01 00:00:00

abstract：:The present dose-response study investigated the effects of the benzodiazepine oxazepam (Serax) on anxiety as measured by autonomic and self-report indices in a nonclinical sample. Given Fowles' (1980, 1988) theory that electrodermal activity primarily reflects the activity of the behavioral inhibition system (BIS) wh...

journal_title：Psychopharmacology

authors： Landon JF,Sher KJ,Shah JH

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:Dopamine (DA) and glutamate (Glu) interactions in the mesocorticolimbic pathway may regulate motivation and reward and contribute to schizophrenia and drug abuse. We have recently demonstrated synergistic effects of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptor blockade and ...

journal_title：Psychopharmacology

authors： Clements RL,Greenshaw AJ

更新日期：2005-10-01 00:00:00