Abstract:
:In the conditioned reinforcement paradigm, animals learn a new instrumental response reinforced solely by conditioned reward (a stimulus that has previously been associated with primary reward). It has been shown that psychostimulants potentiate responding for conditioned reward and there is evidence that the nucleus accumbens is involved in this effect. The present experiments extend this work and examine the roles of various striatal subregions in the enhancement of responding for conditioned reward. In the conditioning phase, hungry rats were trained to associate a light/click stimulus with food delivery, with no levers present in the operant chamber. In the test phase, two levers were present and responding on one provided conditioned reward (presentation of the compound stimulus but no food). During this phase, microinjections of d-amphetamine (0, 0.2, 2.0, 20.0 micrograms/0.5 microliters) were made into seven striatal subregions in separate groups of rats. Injection of amphetamine into the nucleus accumbens elicited a dose-dependent, selective increase in responding for CR. Injections into posterior regions of the striatum had no effect. Significant and selective increases in CR responding were noted after injections into two regions neighboring the nucleus accumbens, the anterior dorsal and the ventromedial striatum, although the magnitude of these effects was considerably less than that following accumbens injections. Injections into ventrolateral regions increased responding in some rats, but this effect was very variable and not selective for the CR lever. These results are interpreted as evidence for functional heterogeneity of the striatum with regard to enhancement of conditioned reinforcement. The findings are discussed in relation to the theory that increased dopaminergic activity in the nucleus accumbens results in amplification of the response to a previously learned reward-related signal.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Kelley AE,Delfs JMdoi
10.1007/BF02244202subject
Has Abstractpub_date
1991-01-01 00:00:00pages
187-96issue
2eissn
0033-3158issn
1432-2072journal_volume
103pub_type
杂志文章abstract:RATIONALE:Mesocorticolimbic reactivity to alcohol-associated cues has been shown to be associated with relapse to renewed drinking and to be decreased by cue-exposure-based extinction training (CET). Evidence from preclinical studies suggests that the extinction of conditioned alcohol-seeking behavior might be facilita...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-015-3882-5
更新日期:2015-07-01 00:00:00
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更新日期:2015-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1978-04-14 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-01-01 00:00:00
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更新日期:1976-07-28 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00213-002-1327-4
更新日期:2003-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02246290
更新日期:1995-06-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-010-2112-4
更新日期:2011-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:1995-10-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00174371
更新日期:1986-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00422418
更新日期:1981-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00174688
更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00213-013-3101-1
更新日期:2013-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051101
更新日期:1999-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244833
更新日期:1992-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00431273
更新日期:1980-01-01 00:00:00