Abstract:
BACKGROUND:Rats reared in social isolation exhibit various cognitive and behavioural abnormalities in adulthood. However, impulsivity following this treatment still remains unclear, especially in response to medications used in attention deficit hyperactivity disorder, such as amphetamine. METHODS:Using an isolation-rearing (IR) manipulation, the present study examined the effects of IR on impulsive action and impulsive choice when also treated with doses of D-amphetamine, by employing the five-choice serial reaction time task (5-CSRTT) and a temporal discounting of reward task (TDRT), respectively. RESULTS:IR rats showed similar acquisition of the 5-CSRTT. Amphetamine increased premature responding in both groups; however, IR rats showed less responding overall. For the TDRT, IR rats revealed a greater preference for the large but delayed reward during task acquisition (i.e. were less impulsive) with a higher rate of nose poking during the delay, and exhibited a compressed dose-response function (i.e. reduced dose sensitivity) for amphetamine. DISCUSSION:Impulsive action and impulsive choice were reduced in IR rats under certain conditions, and a blunted response to D-amphetamine was found on these measures. These reductions in impulsivity contrast with locomotor hyperactivity normally shown in IR rats and the findings have implications for the utility of IR as a model of psychopathology.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Liu YP,Wilkinson LS,Robbins TWdoi
10.1007/s00213-017-4579-8subject
Has Abstractpub_date
2017-05-01 00:00:00pages
1587-1601issue
9-10eissn
0033-3158issn
1432-2072pii
10.1007/s00213-017-4579-8journal_volume
234pub_type
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