Effect of low-dose bromocriptine in treatment of psychosis: the dopamine autoreceptor-stimulation strategy.


:Bromocriptine (0.5-6.0 mg/day) was administered to seven unmedicated chronic schizophrenic and two schizoaffective patients. Transient slight improvement was noted in four patients and marked improvement in one other. Clinical improvement was associated with nausea and drowsiness. These doses of bromocriptine stimulated serum growth hormone and inhibited serum prolactin levels in some subjects. These results suggest that bromocriptine may stimulate dopamine autoreceptors and, through this mechanism, attenuate symptoms in a small proportion of psychiatric patients.




Meltzer HY,Kolakowska T,Robertson A,Tricou BJ




Has Abstract


1983-01-01 00:00:00












  • The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of m-chlorophenylpiperazine.

    abstract::m-Chlorophenylpiperazine (mCPP), a major metabolite of the atypical antidepressant trazadone, has been observed to produce marked physiological and behavioral effects in both humans and animals. These effects have been attributed to the interaction of mCPP with serotonergic receptors. The present study was designed to...


    pub_type: 杂志文章


    authors: Fiorella D,Rabin RA,Winter JC

    更新日期:1995-05-01 00:00:00

  • Effects on hypothalamic self-stimulation of drugs influencing dopaminergic neurotransmission injected into nucleus accumbens and corpus striatum of rats.

    abstract::The role of the nucleus accumbens septi (ACB) and corpus striatum (CPU) in self-stimulation were investigated by injecting directly or indirectly acting stimulant drugs or a dopamine-(DA)-receptor blocking agent into each site bilaterally. d-Amphetamine (68 nmol) facilitated hypothalamic self-stimulation when injected...


    pub_type: 杂志文章


    authors: Stephens DN,Herberg LJ

    更新日期:1977-08-31 00:00:00

  • Topographical features of smokeless tobacco use.

    abstract::There is an increasing prevalence of smokeless tobacco use. However, very little descriptive information is available on the pattern of use. This study examines topographical features of smokeless tobacco use in a male college-age population (N = 56). Subjects were required to use smokeless tobacco ad lib. for a perio...


    pub_type: 杂志文章


    authors: Hatsukami DK,Keenan RM,Anton DJ

    更新日期:1988-01-01 00:00:00

  • A randomized controlled trial of ganaxolone in posttraumatic stress disorder.

    abstract::Preclinical and clinical research supports a role for neuroactive steroids in the pathophysiology of posttraumatic stress disorder (PTSD). We investigated ganaxolone (a synthetic 3β-methylated derivative of allopregnanolone, a GABAergic neuroactive steroid) for treatment of PTSD in a proof-of-concept, multisite, doubl...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Rasmusson AM,Marx CE,Jain S,Farfel GM,Tsai J,Sun X,Geracioti TD,Hamner MB,Lohr J,Rosse R,Summerall L,Naylor JC,Cusin C,Lang AJ,Raman R,Stein MB

    更新日期:2017-08-01 00:00:00

  • Effects of haloperidol in a response-reinstatement model of heroin relapse.

    abstract::The present study employed an animal model of drug relapse in which previously extinguished heroin self-administration behavior was reinstated following a single reinforced trial. Male albino rats were trained to traverse a straight-alley for a reinforcer consisting of a single IV injection of 0.06 mg/kg diacetylmorph...


    pub_type: 杂志文章


    authors: Ettenberg A,MacConell LA,Geist TD

    更新日期:1996-04-01 00:00:00

  • Reinstatement of drug-seeking behavior produced by heroin-predictive environmental stimuli.

    abstract::The current study examined whether stimuli predictive of heroin availability were capable of inducing a relapse of drug-seeking behavior in an operant runway task. Olfactory stimuli (orange and almond food extract) served as discriminative cues about the availability (S+) or unavailability (S-) of heroin reinforcement...


    pub_type: 杂志文章


    authors: McFarland K,Ettenberg A

    更新日期:1997-05-01 00:00:00

  • Association between major depression and cardiovascular risk: the role of antidepressant medication.

    abstract:RATIONALE AND OBJECTIVES:Major depressive disorder (MDD) is associated with an increased risk for cardiovascular disease (CVD). Apart from biological and life style factors, the use of antidepressants and their potentially adverse effects might contribute to the increased CVD risk. Therefore, we compared cardiovascular...


    pub_type: 杂志文章


    authors: Kuehl LK,Muhtz C,Hinkelmann K,Dettenborn L,Wingenfeld K,Spitzer C,Otte C

    更新日期:2016-09-01 00:00:00

  • Behavioral processes underlying the intake suppressive effects of melanocortin 3/4 receptor activation in the rat.

    abstract:RATIONALE:Central application of MTII, a melanocortin 3/4 receptor agonist, reduces food intake. The behavioral mechanisms underlying the anorexia, however, have not been evaluated. OBJECTIVES:We examined the ingestive behavioral effects of MTII at the microstructural level using two complementary approaches. METHODS...


    pub_type: 杂志文章


    authors: Williams DL,Grill HJ,Weiss SM,Baird JP,Kaplan JM

    更新日期:2002-04-01 00:00:00

  • Effects of short-term citicoline treatment on acute cocaine intoxication and cardiovascular effects.

    abstract:RATIONALE:The majority of pharmacotherapies proposed for cocaine dependence have been marginally effective and frequently have undesirable side effects. We recently demonstrated that short-term treatment with citicoline decreased self-reported desire to use cocaine in crack cocaine users. OBJECTIVE:The present study w...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lukas SE,Kouri EM,Rhee C,Madrid A,Renshaw PF

    更新日期:2001-09-01 00:00:00

  • Dose-dependent noradrenergic and serotonergic properties of venlafaxine in animal models indicative of antidepressant activity.

    abstract::The present study was undertaken to investigate thoroughly the preclinical psychopharmacological profile of venlafaxine, testing a wide range of doses in animal models indicative of antidepressant-like effects. Venlafaxine was found to be active in mouse forced swimming test (at 8, 16, 32 and 64 mg/kg) and to increase...


    pub_type: 杂志文章


    authors: Redrobe JP,Bourin M,Colombel MC,Baker GB

    更新日期:1998-07-01 00:00:00

  • Nicotine delivery to users from cigarettes and from different types of e-cigarettes.

    abstract:BACKGROUND:Delivering nicotine in the way smokers seek is likely to be the key factor in e-cigarette (EC) success in replacing cigarettes. We examined to what degree different types of EC mimic nicotine intake from cigarettes. METHODS:Twelve participants ('dual users' of EC and cigarettes) used their own brand cigaret...


    pub_type: 杂志文章


    authors: Hajek P,Przulj D,Phillips A,Anderson R,McRobbie H

    更新日期:2017-03-01 00:00:00

  • Ethanol seeking triggered by environmental context is attenuated by blocking dopamine D1 receptors in the nucleus accumbens core and shell in rats.

    abstract:RATIONALE:Conditioned behavioral responses to discrete drug-associated cues can be modulated by the environmental context in which those cues are experienced, a process that may facilitate relapse in humans. Rodent models of drug self-administration have been adapted to reveal the capacity of contexts to trigger drug s...


    pub_type: 杂志文章


    authors: Chaudhri N,Sahuque LL,Janak PH

    更新日期:2009-12-01 00:00:00

  • Experiential constraints on the development of tolerance to amphetamine hypophagia following sensitization of stereotypy: instrumental contingencies regulate the expression of sensitization.

    abstract::In previous research, sensitization of stereotypy induced by injections of 2.5 mg/kg amphetamine did not interfere with subsequent tolerance development to the hypophagic effect of 2 mg/kg. This study examined the effect of a higher sensitizing dose. Rats given intermittent injections of 5 mg/kg amphetamine and then c...


    pub_type: 杂志文章


    authors: Hughes KM,Popi L,Wolgin DL

    更新日期:1998-12-01 00:00:00

  • A comparison of some psychological and physiological effects exerted by zetidoline (DL308) and by oxazepam.

    abstract::In a double-blind, balanced crossover study, eight healthy male volunteers ingested either DL-308 (10 mg), DL-308 (20 mg), oxazepam (30 mg) or placebo. Subjective estimates of coordination and anxiety, objective performance measurements and cardiovascular measurements were taken at 1, 3, 5 and 8 h after ingestion. DL-...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Herbert M,Standen PJ,Short AH,Birmingham AT

    更新日期:1983-01-01 00:00:00

  • Double blind controlled trials of cholecystokinin octapeptide in neuroleptic-refractory schizophrenia.

    abstract::A group of 14 schizophrenics who remained symptomatic after neuroleptic treatment received either 0.02 mcg/kg CCK-8 or saline placebo intravenously. Thereafter, 13 received the alternative infusion as a crossover treatment. A second group of 16 such patients received 0.04 mcg/kg CCK-8 or saline intravenously and, ther...


    pub_type: 临床试验,杂志文章


    authors: Peselow E,Angrist B,Sudilovsky A,Corwin J,Siekierski J,Trent F,Rotrosen J

    更新日期:1987-01-01 00:00:00

  • Olanzapine, an atypical antipsychotic, increases rates of punished responding in pigeons.

    abstract::The effects of olanzapine [LY 170053; 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2, 3b] [1,5]benzodiazepine), a potential atypical antipsychotic, were determined in pigeons whose keypeck responding was punished. These effects were compared to the anxiolytic agents chlordiazepoxide and pentobarbital, and to other a...


    pub_type: 杂志文章


    authors: Benvenga MJ,Leander JD

    更新日期:1995-05-01 00:00:00

  • Effect of ICV taurine on the impairment of learning, convulsions and death caused by hypoxia.

    abstract::The effect of the intracerebroventricular (ICV) administration of taurine on amnesia, convulsions and death caused by hypoxia was investigated in mice. Taurine in doses of 80-100 micrograms/mouse impaired acquisition of a single trial in passive avoidance performance, but protected mice from the learning impairment in...


    pub_type: 杂志文章


    authors: Malcangio M,Bartolini A,Ghelardini C,Bennardini F,Malmberg-Aiello P,Franconi F,Giotti A

    更新日期:1989-01-01 00:00:00

  • Stereoselective discriminative stimulus effects of zopiclone in rhesus monkeys.

    abstract:RATIONALE:The behavioral effects of racemic zopiclone are similar to those of benzodiazepines that positively modulate GABA at the GABA(A) receptor complex; however, it is not clear how enantiomers or metabolites of zopiclone contribute to the benzodiazepine-like behavioral effects of racemic zopiclone. OBJECTIVES:Rac...


    pub_type: 杂志文章


    authors: McMahon LR,Jerussi TP,France CP

    更新日期:2003-01-01 00:00:00

  • Dose-specific effects of scopolamine on canine cognition: impairment of visuospatial memory, but not visuospatial discrimination.

    abstract:RATIONALE:The cholinergic system is linked extensively to memory, but its exact role remains controversial. In particular, scopolamine-induced impairment in rodents is not task specific, which may be due to difficulty in developing rodent protocols to assess deficits in recent memory, in which the remembered event is b...


    pub_type: 杂志文章


    authors: Araujo JA,Chan AD,Winka LL,Seymour PA,Milgram NW

    更新日期:2004-08-01 00:00:00

  • The time and space machine: continuous measurement of drug-induced behavior patterns in the rat.

    abstract::Because of the increasing demand for refined techniques to record drug-induced motoric changes, we designed and evaluated a computer monitoring system with continuous measurement of different parameters of rat motor activity. This system is particularly useful for chronic drug studies because it can characterize patte...


    pub_type: 杂志文章


    authors: Stoff DM,Stauderman K,Wyatt RJ

    更新日期:1983-01-01 00:00:00

  • Randomized, controlled, double-blind trial of taranabant for smoking cessation.

    abstract:RATIONALE:It has been proposed that cannabinoid-1 receptor inverse agonists might be effective for smoking cessation. We evaluated this hypothesis with the cannabinoid-1 receptor inverse agonist taranabant. METHODS:Adults who smoked > or =10 cigarettes a day for >1 year and had an expired CO level of > or =10 ppm part...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Morrison MF,Ceesay P,Gantz I,Kaufman KD,Lines CR

    更新日期:2010-04-01 00:00:00

  • Effects of diazepam on operant behavior in man.

    abstract::The effects of diazepam (10 mg orally) on the responding of normal human volunteers was studied in a procedure that involved the maintenance of operant behavior by monetary reinforcement and its suppression by monetary loss (punishment). Diazepam produced an antipunishment effect as shown by an increase in behavior su...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Carlton PL,Siegel JL,Murphree HB,Cook L

    更新日期:1981-01-01 00:00:00

  • Behavioural effects of selective dopamine D-1 and D-2 agonists and antagonists in guinea-pigs.

    abstract::This study describes specific behaviours in guinea-pigs after dopamine D-1 and D-2 receptor activation which differed to those described in other rodent species. Intraperitoneal (IP) administration of the dopamine D-2 receptor agonist quinpirole (1.5, 3 and 6 mg/kg) to guinea-pigs dose-dependently initiated locomotor ...


    pub_type: 杂志文章


    authors: Brent PJ

    更新日期:1991-01-01 00:00:00

  • Localisation of NMU1R and NMU2R in human and rat central nervous system and effects of neuromedin-U following central administration in rats.

    abstract:RATIONALE:Neuromedin-U (NmU) is an agonist at NMU1R and NMU2R. The brain distribution of NmU and its receptors, in particular NMU2R, suggests widespread central roles for NmU. In agreement, centrally administered NmU affects feeding behaviour, energy expenditure and pituitary output. Further central nervous system (CNS...


    pub_type: 杂志文章


    authors: Gartlon J,Szekeres P,Pullen M,Sarau HM,Aiyar N,Shabon U,Michalovich D,Steplewski K,Ellis C,Elshourbagy N,Duxon M,Ashmeade TE,Harrison DC,Murdock P,Wilson S,Ennaceur A,Atkins A,Heidbreder C,Hagan JJ,Hunter AJ,Jones

    更新日期:2004-12-01 00:00:00

  • Multigenerational effects of adolescent morphine exposure on dopamine D2 receptor function.

    abstract:RATIONALE:The use and misuse of prescription opiates in adolescent populations, and in particular, adolescent female populations, has increased dramatically in the past two decades. Given the significant role that opioids play in neuroendocrine function, exposure to opiates during this critical developmental period cou...


    pub_type: 杂志文章


    authors: Byrnes JJ,Johnson NL,Carini LM,Byrnes EM

    更新日期:2013-05-01 00:00:00

  • Another look at amphetamine-induced stereotyped locomotor activity in rats using a new statistic to measure locomotor stereotypy.

    abstract::Rat open field behavior is often used as a tool to study the behavioral effects of drugs. In this report, drug-induced patterns of locomotion in an open field were studied with the aid of a simple new statistic. Briefly, the animal's path through the open field is converted into a series of trips. Gamma (gamma) estima...


    pub_type: 杂志文章


    authors: Mueller K,Hollingsworth EM,Cross DR

    更新日期:1989-01-01 00:00:00

  • Influence of benzodiazepine tranquilizers on scopolamine-induced locomotor stimulation in mice.

    abstract::Four benzodiazepine tranquilizers have been tested, alone or in combination with scopolamine, on the spontaneous locomotor activity of BALB/c mice. Scopolamine-induced locomotor stimulation was enhanced by chlordiazepoxide, diazepam, and medazepam, but not by bromazepam. These effects are similar to those exerted by t...


    pub_type: 杂志文章


    authors: Sansone M

    更新日期:1980-01-01 00:00:00

  • Behavioral effects of caffeine, (-)N-((R)-1-methyl-2-phenylethyl)-adenosine (PIA), and their combination in the mouse.

    abstract::The effects of caffeine (1-100 mg/kg, IP), (-)N-((R)-1-methyl-2-phenylethyl)-adenosine (PIA) (0.01-1 mg/kg, IP), and of the two drugs in combination were studied in mice responding under a mult FR30 FI600 s schedule of food presentation. The lowest dose of caffeine, 1 mg/kg, had no effect on responding under either co...


    pub_type: 杂志文章


    authors: Glowa JR,Sobel E,Malaspina S,Dews PB

    更新日期:1985-01-01 00:00:00

  • Behavioural and ligand-binding studies in rats with 1-acetyl-4-methylpiperazine, a novel nicotinic agonist.

    abstract::The novel nicotinic agonist 1-acetyl-4-methylpiperazine (AMP) has been studied in ligand-binding and behavioural studies. AMP methiodide potently inhibited [3H]-(-)-nicotine and [125I]-alpha-bungarotoxin binding to P2 membranes from rat brain and [125I]-alpha-bungarotoxin binding to rat skeletal muscles. AMP HCl also ...


    pub_type: 杂志文章


    authors: Garcha HS,Thomas P,Spivak CE,Wonnacott S,Stolerman IP

    更新日期:1993-01-01 00:00:00

  • Assessing physiological dependence and withdrawal potential of mitragynine using schedule-controlled behaviour in rats.

    abstract:RATIONALE:Kratom is proposed to exhibit therapeutic potential as an opium substitute, but little is known about its dependence-producing profile, particularly of its main psychoactive compound, mitragynine (MG). OBJECTIVES:This study examined the dependence-producing effects of MG using operant-scheduled behaviour in ...


    pub_type: 杂志文章


    authors: Harun N,Johari IS,Mansor SM,Shoaib M

    更新日期:2020-03-01 00:00:00