Effect of low-dose bromocriptine in treatment of psychosis: the dopamine autoreceptor-stimulation strategy.

Abstract:

:Bromocriptine (0.5-6.0 mg/day) was administered to seven unmedicated chronic schizophrenic and two schizoaffective patients. Transient slight improvement was noted in four patients and marked improvement in one other. Clinical improvement was associated with nausea and drowsiness. These doses of bromocriptine stimulated serum growth hormone and inhibited serum prolactin levels in some subjects. These results suggest that bromocriptine may stimulate dopamine autoreceptors and, through this mechanism, attenuate symptoms in a small proportion of psychiatric patients.

journal_title

Psychopharmacology

authors

Meltzer HY,Kolakowska T,Robertson A,Tricou BJ

doi

10.1007/BF00439271

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

37-41

issue

1

eissn

0033-3158

issn

1432-2072

journal_volume

81

pub_type

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