Abstract:
:Young adult rats (5 months) were compared with aged (28 months) rats in their ability to learn and perform in a diazepam drug discrimination. Both groups of rats were drug naive at the onset of the experiment. Adult and aged animals learned to discriminate diazepam. In general, the response rates under both drug and vehicle conditions were significantly lower for the aged group. The diazepam stimuli were dose-dependent in each group. Similar dose-dependent generalization with chlordiazepoxide, pentobarbital, and methocarbamol was also noted in both the aged and adult animals. These data suggest that aged animals, who have experienced anxiolytic compounds over a period of time (in this case, repeated administration of diazepam in the discrimination procedure), respond in a similar fashion to drug treatment as do young adult animals, verifying the reliability and validity of results obtained in aging rats who are repeatedly exposed to drug treatment.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Amrick CL,Bennett DAdoi
10.1007/BF00187245subject
Has Abstractpub_date
1987-01-01 00:00:00pages
292-5issue
3eissn
0033-3158issn
1432-2072journal_volume
93pub_type
杂志文章abstract:INTRODUCTION:Dysfunction of brain dopamine systems is involved in various neuropsychiatric disorders. Challenge studies with dopamine receptor agonists have been performed to assess dopamine receptor functioning, classically using the release of growth hormone (GH) from the hindbrain as primary outcome measure. The obj...
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pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章
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pub_type: 杂志文章,随机对照试验
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更新日期:2012-03-01 00:00:00
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更新日期:2020-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1996-03-01 00:00:00
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