Chlordiazepoxide-induced disruption of discrimination behaviour: a signal detection analysis.


:To assess the effects of chlordiazepoxide (CDP) on a stable discrimination performance, eight rats were trained on a simple brightness discrimination and injected with three dosages (0, 5, and 10 mg/kg) once performance was stable. Signal detection analysis of the results was used to differentiate sensory from motor/responsivity effects of the drug. At 5 mg/kg, CDP increased general responsiveness which is consistent with the hypothesis that CDP disinhibits responding. At 10 mg/kg, however, this effect on responsivity was reversed and there was also a suppression of stimulus sensitivity.




Francis RL,Cooper SJ




Has Abstract


1979-06-21 00:00:00












  • Conditioned ultrasonic distress vocalizations in adult male rats as a behavioural paradigm for screening anti-panic drugs.

    abstract::Rats may produce ultrasonic vocalizations (USV) in threatening situations. USV of adult male rats in association with aversive stimulation was evaluated as a screening method for anxiolytic drugs. The triazolobenzodiazepine alprazolam, the 5-HT uptake inhibitors fluvoxamine and clomipramine, the mixed 5-HT/NA uptake i...


    pub_type: 杂志文章


    authors: Molewijk HE,van der Poel AM,Mos J,van der Heyden JA,Olivier B

    更新日期:1995-01-01 00:00:00

  • Rearing paradigm in a nonhuman primate affects response to beta-CCE challenge.

    abstract::Two groups of socially housed rhesus monkeys were raised under conditions differing in the degree of control or mastery over appetitive stimuli (food, water, and treats) in the 1st year of life. At age 18-24 months, a benzodiazepine receptor inverse agonist, beta-carboline-3-carboxylic acid ethyl ester (beta-CCE), was...


    pub_type: 杂志文章


    authors: Insel TR,Scanlan J,Champoux M,Suomi SJ

    更新日期:1988-01-01 00:00:00

  • Reasoning deficits in ecstasy (MDMA) polydrug users.

    abstract:RATIONALE/OBJECTIVES:Previous research has shown that ecstasy users are impaired in thinking and reasoning. The present study sought to explore the possibility that syllogistic reasoning errors in ecstasy users were due to an inability to construct a model of the premises due to working memory limitations. METHODS:Twe...


    pub_type: 杂志文章


    authors: Fisk JE,Montgomery C,Wareing M,Murphy PN

    更新日期:2005-09-01 00:00:00

  • Acute treatment with trimethyltin alters alcohol self-selection.

    abstract::Male rats of the Long-Evans strain were divided into two equal groups of nine each and given either 7.0 mg/kg trimethyltin (TMT) or 0.9% saline by intragastric gavage. The pattern of self-selection of alcohol in concentrations of 3%--30% was examined in both groups at 21 and 150 days following the gavage. The TMT-trea...


    pub_type: 杂志文章


    authors: Myers RD,Swartzwelder HS,Dyer RS

    更新日期:1982-01-01 00:00:00

  • Effect of the benzodiazepine receptor agonist, zolpidem, on palatable fluid consumption in the rat.

    abstract::Two experiments examined the effect of the benzodiazepine receptor agonist, zolpidem, on palatable fluid intake in water-deprived rats. In the first experiment, pretreatment with 3.0 or 10.0 mg/kg zolpidem IP was found to increase consumption of a novel glucose drink (3% d-glucose and 0.15 sodium saccharine w/v in wat...


    pub_type: 杂志文章


    authors: Stanhope KJ,Roe S,Dawson G,Draper F,Jackson A

    更新日期:1993-01-01 00:00:00

  • Prospective memory impairment in "ecstasy" (MDMA) users.

    abstract:RATIONALE:Considerable research indicates that "ecstasy" users perceive their memory for future intentions (prospective memory) to be impaired. However, only one empirical study to date has directly tested how this capacity is affected by ecstasy use, and this study provided relatively limited information regarding the...


    pub_type: 临床试验,杂志文章


    authors: Rendell PG,Gray TJ,Henry JD,Tolan A

    更新日期:2007-11-01 00:00:00

  • The highly efficacious actions of N-desmethylclozapine at muscarinic receptors are unique and not a common property of either typical or atypical antipsychotic drugs: is M1 agonism a pre-requisite for mimicking clozapine's actions?

    abstract:RATIONALE:Recent studies have suggested that the salutary actions of clozapine in schizophrenia may be due to selective activation of M(1) muscarinic receptors by clozapine and/or its major active metabolite N-desmethylclozapine. OBJECTIVE:We systematically tested this hypothesis by screening a large number of psychoa...


    pub_type: 杂志文章


    authors: Davies MA,Compton-Toth BA,Hufeisen SJ,Meltzer HY,Roth BL

    更新日期:2005-04-01 00:00:00

  • The analysis and disposition of imipramine and its active metabolites in man.

    abstract::Single oral and intramuscular (i.m.) doses of imipramine (IMI) were administered to four normal males. Serum and urine concentrations of IMI, desipramine (DMI) and their unconjugated 2-hydroxy metabolites were measured by high-pressure liquid chromatography (HPLC). Urinary conjugated 2-hydroxy metabolites were also me...


    pub_type: 临床试验,杂志文章


    authors: Sutfin TA,DeVane CL,Jusko WJ

    更新日期:1984-01-01 00:00:00

  • Sensitization to systemic amphetamine produces an enhanced locomotor response to a subsequent intra-accumbens amphetamine challenge in rats.

    abstract::Repeated amphetamine (AMPH) administration into the nucleus accumbens does not enhance (sensitize) the locomotor activity produced by a subsequent systemic AMPH challenge. We report here, however, that pretreatment with systemic injections of AMPH does produce a significant enhancement in the locomotor stimulant effec...


    pub_type: 杂志文章


    authors: Paulson PE,Robinson TE

    更新日期:1991-01-01 00:00:00

  • The effect of cannabidiol and URB597 on conditioned gaping (a model of nausea) elicited by a lithium-paired context in the rat.

    abstract:RATIONALE:Anticipatory nausea (AN) experienced by chemotherapy patients is resistant to current anti-nausea treatments. In this study, the effect of manipulation of the endocannabinoid (EC) system on a rat model of nausea (conditioned gaping) was determined. OBJECTIVE:The potential of cannabidiol (CBD) and the fatty a...


    pub_type: 杂志文章


    authors: Rock EM,Limebeer CL,Mechoulam R,Piomelli D,Parker LA

    更新日期:2008-02-01 00:00:00

  • Role of extracellular serotonin levels in the effect of 5-HT1B receptor blockade.

    abstract::The release of serotonin (5-HT) at serotonergic nerve terminals is regulated by 5-HT(1B) autoreceptors. Several studies have reported that the effects of selective 5-HT reuptake inhibitors (SSRIs) on extracellular 5-HT are augmented by 5-HT(1B) receptor antagonists, whereas administration of these antagonists alone do...


    pub_type: 杂志文章


    authors: de Groote L,Klompmakers AA,Olivier B,Westenberg HG

    更新日期:2003-05-01 00:00:00

  • Subjective, psychomotor, and analgesic effects of oral codeine and morphine in healthy volunteers.

    abstract::The subjective, psychomotor, and physiological effects of analgesic doses of oral codeine and morphine were examined in 12 healthy volunteers. Subjects ingested placebo, morphine 20 or 40 mg, or codeine 60 or 120 mg in a randomized, double-blind, crossover design. The smaller and larger doses of each drug were putativ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Walker DJ,Zacny JP

    更新日期:1998-11-01 00:00:00

  • Profile of acute tolerance to three sedative anxiolytics.

    abstract::Acute tolerance, defined as a decreasing drug effect relative to drug-plasma levels (DPL) over a period of minutes to a few hours, is pronounced following single doses of diazepam or pentobarbital. Both of these lipid-soluble drugs produce an early peak behavioral impairment and subsequent rapid recovery component tha...


    pub_type: 杂志文章


    authors: Ellinwood EH Jr,Linnoila M,Easler ME,Molter DW

    更新日期:1983-01-01 00:00:00

  • Sucrose intake predicts rate of acquisition of cocaine self-administration.

    abstract:RATIONALE:A number of studies have indicated a relationship between the intake of palatable foods or fluids and drug self-administration. OBJECTIVES:Two experiments were conducted to determine whether the intake of sucrose or fat was related to subsequent cocaine self-administration. METHODS:In separate groups of rat...


    pub_type: 杂志文章


    authors: Gosnell BA

    更新日期:2000-04-01 00:00:00

  • Repeated methylphenidate treatment induces behavioral sensitization and decreases protein kinase A and dopamine-stimulated adenylyl cyclase activity in the dorsal striatum.

    abstract::The behavioral effects of repeated methylphenidate (MPH) treatment were assessed in the adult rat. Protein kinase A (PKA) and adenylyl cyclase (basal and DA-stimulated) activity in the dorsal striatum (i.e., caudate-putamen) were measured to determine whether MPH-induced alterations in these enzymes correlate with the...


    pub_type: 杂志文章


    authors: Crawford CA,McDougall SA,Meier TL,Collins RL,Watson JB

    更新日期:1998-03-01 00:00:00

  • Histamine H3-receptor blockade in the rat nucleus basalis magnocellularis improves place recognition memory.

    abstract:RATIONALE:Several lines of evidence have indicated that the central histaminergic system might be involved in learning and memory OBJECTIVES:The aim of the present study was to ascertain the impact on memory processes of putative histaminergic-cholinergic interactions in the nucleus basalis magnocellularis (NBM) of th...


    pub_type: 杂志文章


    authors: Orsetti M,Ferretti C,Gamalero R,Ghi P

    更新日期:2002-01-01 00:00:00

  • Ethanol attenuation of morphine dependence: comparison to dizocilpine.

    abstract::Recent studies indicate that morphine dependence, assessed as the severity of naloxone-precipitated opiate withdrawal in rats, is attenuated by dizocipline, a non-competitive, excitatory amino acid antagonist. Because ethanol is a putative excitatory amino acid antagonist, the present study compared the effects of co-...


    pub_type: 杂志文章


    authors: Shoemaker WJ,Kosten TA,Muly SM

    更新日期:1997-11-01 00:00:00

  • Acute effects of methadone on EEG power spectrum and event-related potentials among heroin dependents.

    abstract::Methadone as the most prevalent opioid substitution medication has been shown to influence the neurophysiological functions among heroin addicts. However, there is no firm conclusion on acute neuroelectrophysiological changes among methadone-treated subjects as well as the effectiveness of methadone in restoring brain...


    pub_type: 杂志文章


    authors: Motlagh F,Ibrahim F,Rashid R,Shafiabady N,Seghatoleslam T,Habil H

    更新日期:2018-11-01 00:00:00

  • Relative insensitivity to time-out punishments induced by win-paired cues in a rat gambling task.

    abstract:RATIONALE:Pairing rewarding outcomes with audiovisual cues in simulated gambling games increases risky choice in both humans and rats. However, the cognitive mechanism through which this sensory enhancement biases decision-making is unknown. OBJECTIVES:To assess the computational mechanisms that promote risky choice d...


    pub_type: 杂志文章


    authors: Langdon AJ,Hathaway BA,Zorowitz S,Harris CBW,Winstanley CA

    更新日期:2019-08-01 00:00:00

  • Quantitative assessment of the microstructure of rat behavior: II. Distinctive effects of dopamine releasers and uptake inhibitors.

    abstract::The effects of four indirect dopamine agonists, d-amphetamine (0.25-4.0 mg/kg), cocaine (2.5-40.0 mg/kg), GBR 12909 (10.0-30.0 mg/kg), and nomifensine (5.0-20.0 mg/kg), on the behavioral organization of movements in an unconditioned motor paradigm were investigated in rats. The extended scaling hypothesis using the fl...


    pub_type: 杂志文章


    authors: Paulus MP,Callaway CW,Geyer MA

    更新日期:1993-01-01 00:00:00

  • The effect of midazolam and beta-carboline carboxylic acid ethyl ester on behaviour, steroid hormones and central monoamine metabolites in social groups of talapoin monkeys.

    abstract::Established social groups of talapoin monkeys show rank-related differences in aggressive, social and sexual behaviours and visual monitoring, as well as in endocrine and monoamine profiles. Here we describe the effects on these variables of an "anxiogenic drug", beta-carboline carboxylic acid ethyl ester (beta-CCE), ...


    pub_type: 杂志文章


    authors: Vellucci SV,Herbert J,Keverne EB

    更新日期:1986-01-01 00:00:00

  • A new method for the evaluation of benzodiazepines based on their ability to block muscimol-induced myoclonic jerks in mice.

    abstract::A number of clinically used benzodiazepines were tested for their effectiveness in blocking muscimol-induced myoclonic jerks in mice. Their ED50 values were determined from their dose-response curves. These data gave the following relative potencies with respect to diazepam: diazepam = 1, medazepam = 0.24, oxazepam = ...


    pub_type: 杂志文章


    authors: Menon MK,Vivonia CA,Haddox VG

    更新日期:1981-01-01 00:00:00

  • Long-term haloperidol administration enhances and short-term administration attenuates the behavioral effects of cocaine in a place conditioning procedure.

    abstract::Many behavioral effects of cocaine are attenuated by dopamine (DA) receptor antagonists. Yet, long-term DA antagonist administration enhances neuronal responsiveness to DA in several pathways, including the mesolimbic system. This study compared the effects of short-term versus long-term administration of the DA antag...


    pub_type: 杂志文章


    authors: Kosten TA,DeCaprio JL,Nestler EJ

    更新日期:1996-12-01 00:00:00

  • Effects on cocaine and food self-administration of (+)-HA-966, a partial agonist at the glycine/NMDA modulatory site, in rats.

    abstract:RATIONALE:(+)-HA-966, a partial agonist at the glycine/NMDA modulatory site, significantly reduced i.v. cocaine self-administration in a fixed-ratio (FR) schedule. Since this effect was observed studying only one dose of cocaine and considering the characteristic bell-shaped curve generated by cocaine in self-administr...


    pub_type: 杂志文章


    authors: Cervo L,Cocco A,Carnovali F

    更新日期:2004-04-01 00:00:00

  • The effects of adrenaline injections on human platelet monoamine oxidase and related measures.

    abstract::A double-blind, placebo-controlled, cross-over study in ten normal volunteers assessed the effects of the subcutaneous administration of adrenaline on platelet MAO activity, in an attempt to replicate previous findings of increased MAO activity following adrenaline. Platelet counts, cortisol plasma concentrations, and...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gentil V,McCurdy RL,Alevizos B,Lader MH

    更新日期:1976-11-10 00:00:00

  • Infusions of cholecystokinin octapeptide into the ventral tegmental area potentiate amphetamine conditioned place preferences.

    abstract::Cholecystokinin (CCK) and dopamine (DA) coexist in both cell body and terminal areas of a mesolimbic pathway that projects from the ventral tegmental area (VTA) to the nucleus accumbens (N ACC). Autoradiography reveals extensive CCK binding sites in the N ACC, but not in the VTA. However, iontophoresis of CCK into the...


    pub_type: 杂志文章


    authors: Pettit HO,Mueller K

    更新日期:1989-01-01 00:00:00

  • Differential effects of intra-accumbens and systemic amphetamine on latent inhibition using an on-baseline, within-subject conditioned suppression paradigm.

    abstract::Latent inhibition (LI) is a phenomenon in which repeated, non-reinforced presentation of a stimulus retards subsequent conditioning to that stimulus. Several recent experiments have suggested that LI is abolished following acute, low doses of amphetamine given during pre-exposure and conditioning, and this effect has ...


    pub_type: 杂志文章


    authors: Killcross AS,Robbins TW

    更新日期:1993-01-01 00:00:00

  • The role of NMDA receptors in the signal attenuation rat model of obsessive-compulsive disorder.

    abstract:RATIONALE:In recent years, an increasing body of evidence points to the involvement of the glutamatergic system and specifically the glutamatergic ionotropic N-methyl-D-aspartate (NMDA) receptor in the pathophysiology of obsessive-compulsive disorder (OCD). OBJECTIVES:To test the role of NMDA receptors in compulsive b...


    pub_type: 杂志文章


    authors: Albelda N,Bar-On N,Joel D

    更新日期:2010-05-01 00:00:00

  • Purine nucleoside--mediated immobility in mice: reversal by antidepressants.

    abstract::In the forced swimming-induced immobility (despair) test model, adenosine, and 2-chloroadenosine treatment prolonged the immobilization period in mice. Dipyridamole, which is known to inhibit adenosine uptake, potentiated the adenosine effect. The purinoceptor antagonists caffeine and theophylline blocked purine nucle...


    pub_type: 杂志文章


    authors: Kulkarni SK,Mehta AK

    更新日期:1985-01-01 00:00:00

  • Individual and morphological differences in the behavioural response to apomorphine in rats.

    abstract::The topography of stereotyped behaviour produced by apomorphine in rats was studied by using either a scoring system, based on observation in a wire cage, or by quantification of horizontal and vertical activities, and of the total distances run in an open field, using an automatic recording system. The latter design ...


    pub_type: 杂志文章


    authors: Havemann U,Magnus B,Möller HG,Kuschinsky K

    更新日期:1986-01-01 00:00:00