Chlordiazepoxide-induced disruption of discrimination behaviour: a signal detection analysis.

Abstract:

:To assess the effects of chlordiazepoxide (CDP) on a stable discrimination performance, eight rats were trained on a simple brightness discrimination and injected with three dosages (0, 5, and 10 mg/kg) once performance was stable. Signal detection analysis of the results was used to differentiate sensory from motor/responsivity effects of the drug. At 5 mg/kg, CDP increased general responsiveness which is consistent with the hypothesis that CDP disinhibits responding. At 10 mg/kg, however, this effect on responsivity was reversed and there was also a suppression of stimulus sensitivity.

journal_title

Psychopharmacology

authors

Francis RL,Cooper SJ

doi

10.1007/BF00433568

subject

Has Abstract

pub_date

1979-06-21 00:00:00

pages

307-10

issue

3

eissn

0033-3158

issn

1432-2072

journal_volume

63

pub_type

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