Assessment of benzodiazepine receptor heterogeneity in vivo: apparent pA2 and pKB analyses from behavioral studies.

abstract：:The effects of 4 weeks of treatment with the selective monoamine oxidase (MAO) inhibiting antidepressant clorgyline and pargyline on the sleep of affectively disordered patients were studied. Both inhibitors resulted in near total suppression of REM sleep, a decrease in total sleep time, and an increase in the percent...

journal_title：Psychopharmacology

authors： Cohen RM,Pickar D,Garnett D,Lipper S,Gillin JC,Murphy DL

更新日期：1982-01-01 00:00:00

abstract：:Two experiments were carried out on pigeons to assess the effects of acute ethanol (ETOH) administration on a delayed pair comparison procedure. ETOH disrupted performance at the two higher doses (1.0 and 2.0 g/kg, given orally). When the initial (zero delay) performance levels of treated and untreated birds were equa...

journal_title：Psychopharmacology

authors： Sahgal A,Ekberg SC,Howell SJ,Iversen SD

更新日期：1980-01-01 00:00:00

abstract：:We examined the effects on sucrose consumption of a dopamine (DA) D2/D3 antagonist (raclopride, 0-0.3 mg/kg), a serotonin 5-HT2/2c antagonist (ritanserin, 0-0.4 mg/kg), and raclopride (0.15 mg/kg) combined with ritanserin (0-0.4 mg/kg). Three different concentrations of sucrose solution (0.7%, 7.0% and 34%) were teste...

journal_title：Psychopharmacology

authors： Montgomery AM,Suri A

更新日期：1996-01-01 00:00:00

abstract：:Intracerebroventricular injections of gamma-aminobutyric acid (GABA) and of the GABA-transaminase inhibitor, ethanolamine-O-sulphate (EOS), decreased the food intake of freely-fed (GABA and EOS) and food-deprived rats (EOS). The effect, still evident 24 h after treatment, was not decreased by the GABA receptor-blocker...

journal_title：Psychopharmacology

authors： Olgiati VR,Netti C,Guidobono F,Pecile A

更新日期：1980-01-01 00:00:00

abstract：:In an attempt to define the nature of the involvement of delta 9-tetrahydrocannabinol (THC) with central cholinergic neurotransmission, the effects of THC on direct cholinergic stimulation of the rat brain were investigated. THC, in doses of 3 mg/kg and 6 mg/kg, administered intraperitoneally (i.p.), potentiated the e...

journal_title：Psychopharmacology

authors： Duncan GE,Dagirmanjian R

更新日期：1979-02-28 00:00:00

abstract：:Aniamls were administered increasing doses of morphine for 16 days. During withdrawal they were challenged with an apomorphine ester or lergotrile. These dopamine agonists produced quantitatively different effects on behaviour. The results suggest that chronic morphine administration leads to dopamine supersensitivity...

journal_title：Psychopharmacology

authors： Tye NC,Horsman L,Wright FC,Pullar IA

更新日期：1979-05-15 00:00:00

abstract：:Neuroleptic-free schizophrenic patients received caerulein, a potent analogue of cholecystokinin octapeptide, in a fixed- and rising-dose schedule. In addition, neuroleptic-treated patients received a single dose of the peptide with a 4-week follow-up. No significant change in mental status was observed after any of t...

journal_title：Psychopharmacology

authors： Tamminga CA,Littman RL,Alphs LD,Chase TN,Thaker GK,Wagman AM

更新日期：1986-01-01 00:00:00

abstract：:First, it was confirmed that systemic injection of the neurotoxin 6-hydroxydopamine HBr (30 mg/kg IP) depleted noradrenaline levels in rat heart, but not centrally. Losses averaged 90% of control 1 day after injection, and 50% at 42 days. The same drug and dose was then administered to 50% of a group of rats which had...

journal_title：Psychopharmacology

authors： Salmon P,Stanford C,Gray JA

更新日期：1985-01-01 00:00:00

abstract：RATIONALE:Reduction of body temperature is used as predictor of psychotropic drug action. The cutaneous circulation functions as a heat-loss component of temperature regulation. Clozapine and olanzapine reverse hyperthermia and sympathetically-mediated cutaneous vasoconstriction induced by MDMA (3,4-methylenedioxymetha...

journal_title：Psychopharmacology

authors： Blessing WW

更新日期：2004-10-01 00:00:00

abstract：:5-Hydroxytryptamine1A (5-HT1A) receptors have been shown to be suppressed by corticosteroid hormones in a variety of animal experimental paradigms. It has been suggested that this effect may be central to the pathophysiology of severe clinical depressive illness, a condition in which 5-HT1A receptor function is reduce...

journal_title：Psychopharmacology

authors： Porter RJ,McAllister-Williams RH,Lunn BS,Young AH

更新日期：1998-10-01 00:00:00

abstract：:The effect of 15 min/day of immobilization (IM) stress on oral self-administration (SA) of morphine (0.5 mg/ml) or fentanyl (25 micrograms/ml) and withdrawal was examined in rats. In addition, the role of conditioning factors in these effects was assessed. For each drug, four groups of subjects were exposed for 50 day...

journal_title：Psychopharmacology

authors： Shaham Y

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:Studies have shown that social drinkers are poor estimators of alcohol-induced impairment. Underestimates of blood alcohol concentration and other indices of intoxication are associated with decisions to perform risky behaviors, such as operating a motor vehicle. It is possible that self-evaluations of impair...

journal_title：Psychopharmacology

authors： Harrison EL,Fillmore MT

更新日期：2005-02-01 00:00:00

abstract：:Each morning eight adults with caffeine versus placebo discrimination histories ingested letter-coded capsules containing 100 mg caffeine or placebo and then engaged in a relaxation or vigilance activity. Subjects were first exposed to caffeine and placebo once each with each activity. Then each day for 10 days subjec...

journal_title：Psychopharmacology

authors： Silverman K,Mumford GK,Griffiths RR

更新日期：1994-04-01 00:00:00

abstract：:Adult hooded rats exposed to a repeated maternal separation procedure during the neonatal period showed a blunted expression of locomotor hyperactivity conditioned to the presentation of the daily food ration. We have demonstrated that the expression of food-conditioned anticipatory hyperactivity is sensitive to the r...

journal_title：Psychopharmacology

authors： Matthews K,Hall FS,Wilkinson LS,Robbins TW

更新日期：1996-07-01 00:00:00

abstract：RATIONALE:N-methyl-D-aspartate (NMDA) receptors play crucial roles in learning and memory, but the role of each NMDA receptor subtype in a specific cognitive process is unclear. Non-selective blockers of NMDA receptor are used to model the cognitive impairment in schizophrenia and Alzheimer's disease. Counter-intuitive...

journal_title：Psychopharmacology

authors： Kumar G,Olley J,Steckler T,Talpos J

更新日期：2015-11-01 00:00:00

abstract：:When injected IP, the M1 muscarinic receptor antagonist pirenzepine dose-dependently induced a deficit in passive avoidance learning in rats. This activity was optimal at 75 mg/kg injected 1 h before the acquisition session. The deficit induced by pirenzepine was antagonized by oxotremorine (0.03-0.3 mg/kg SC) and phy...

journal_title：Psychopharmacology

authors： Worms P,Gueudet C,Pério A,Soubrié P

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:The cAMP-dependent protein kinase A (PKA) signaling transduction pathway has been shown to play an important role in the modulation of several ethanol-induced behaviors. Different studies have demonstrated intracellular calcium (Ca(2+))-dependent activation of the PKA cascade after ethanol administration. Thu...

journal_title：Psychopharmacology

authors： Baliño P,Ledesma JC,Aragon CM

更新日期：2014-12-01 00:00:00

abstract：RATIONALE:Prepulse inhibition (PPI) and locomotor activity have been used to investigate the effects of antipsychotic and stimulant drugs and their underlying dopaminergic mechanisms. Whereas D2-like agonists consistently decreased PPI and increased locomotion in rats in previous studies, we recently reported that thes...

journal_title：Psychopharmacology

authors： Ralph RJ,Caine SB

更新日期：2007-04-01 00:00:00

abstract：:Serotonin(5-HT)-stimulated intracellular calcium(Ca) mobilization was measured in the platelets of depressed patients to assess 5-HT2 receptor function. The 5-HT-induced Ca response was significantly higher in unmedicated patients with bipolar depression and melancholic major depression than in those with non-melancho...

journal_title：Psychopharmacology

authors： Kusumi I,Koyama T,Yamashita I

更新日期：1994-01-01 00:00:00

abstract：RATIONALE:Cannabinoid CB1 receptors are expressed in the prefrontal cortex, but their role in mediating executive functions such as behavioral flexibility is unclear. OBJECTIVE:The present study examined the effect of pharmacological activation or blockade of the cannabinoid CB1 receptors on behavioral flexibility usi...

journal_title：Psychopharmacology

authors： Hill MN,Froese LM,Morrish AC,Sun JC,Floresco SB

更新日期：2006-08-01 00:00:00

abstract：RATIONALE:Neuromedin-U (NmU) is an agonist at NMU1R and NMU2R. The brain distribution of NmU and its receptors, in particular NMU2R, suggests widespread central roles for NmU. In agreement, centrally administered NmU affects feeding behaviour, energy expenditure and pituitary output. Further central nervous system (CNS...

journal_title：Psychopharmacology

authors： Gartlon J,Szekeres P,Pullen M,Sarau HM,Aiyar N,Shabon U,Michalovich D,Steplewski K,Ellis C,Elshourbagy N,Duxon M,Ashmeade TE,Harrison DC,Murdock P,Wilson S,Ennaceur A,Atkins A,Heidbreder C,Hagan JJ,Hunter AJ,Jones

更新日期：2004-12-01 00:00:00

abstract：:Herrnstein's matching equation was used to analyze drug effects on performance in random interval reinforcement schedules. Pimozide caused effects compatible with both motor and motivational impairments, in a 5-component multiple schedule, a 3-schedule 3-day cycle (ALT-3), and a 2-schedule 2-day cycle (ALT-2). However...

journal_title：Psychopharmacology

authors： Willner P,Sampson D,Phillips G,Muscat R

更新日期：1990-01-01 00:00:00

abstract：:Benzodiazepines and other compounds which act at benzodiazepine binding sites have been shown previously to attenuate the acquisition of conditioned fear in rodents when administered before the acquisition session, an effect which may parallel the disruption of human memory produced by anxiolytics and sedatives. Such ...

journal_title：Psychopharmacology

authors： Sanger DJ,Joly D,Zivkovic B

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:An important goal of addiction research is to discover neurobiological markers that could predict the severity of addiction and help to determine appropriate treatment. Brain-derived neurotrophic factor (BDNF) and thiobarbituric acid reactive substances (TBARS) are being related to cerebral plasticity and imp...

journal_title：Psychopharmacology

authors： Sordi AO,Pechansky F,Kessler FH,Kapczinski F,Pfaffenseller B,Gubert C,de Aguiar BW,de Magalhães Narvaez JC,Ornell F,von Diemen L

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Abnormalities of membrane phospholipid metabolism have been described in Alzheimer's disease (AD). We investigated, with the aid of (31)P magnetic resonance spectroscopy, the in vivo intracerebral availability of phosphomonoesters (PME) and phosphodiesters (PDE) in patients with AD. METHODS:Eighteen outpati...

journal_title：Psychopharmacology

authors： Forlenza OV,Wacker P,Nunes PV,Yacubian J,Castro CC,Otaduy MC,Gattaz WF

更新日期：2005-07-01 00:00:00

abstract：RATIONALE:Typical neuroleptic medications are still administered to as many as 40% of patients receiving antipsychotic treatment in the US. Intermittent administration or interruption of long-term neuroleptic medication for schizophrenia may increase the incidence of human tardive dyskinesias, and similarly may produce...

journal_title：Psychopharmacology

authors： Linn GS,Lifshitz K,O'Keeffe RT,Lee K,Camp-Lifshitz J

更新日期：2001-01-01 00:00:00

abstract：RATIONALE:The metabotropic glutamate (mGlu5) receptor subtype 5 antagonist MPEP attenuates self-administration of numerous drugs of abuse. OBJECTIVES:The purpose of the present study was to explore whether MPEP-induced decreases in nicotine and cocaine self-administration reflect attenuation of the reinforcing and inc...

journal_title：Psychopharmacology

authors： Paterson NE,Markou A

更新日期：2005-04-01 00:00:00

abstract：RATIONALE:The majority of volumetric magnetic resonance imaging (MRI) studies of the hippocampus in patients with bipolar disorder (BD) show no differences in hippocampal volume between patients and healthy controls. Significant variability, however, exists in the medication status of patients included in these studies...

journal_title：Psychopharmacology

authors： Yucel K,McKinnon MC,Taylor VH,Macdonald K,Alda M,Young LT,MacQueen GM

更新日期：2007-12-01 00:00:00

abstract：RATIONALE:Therapeutic efficacy of antidepressant drugs appears to be related to their ability in producing neuroadaptive changes that restore normal brain function. Activity-regulated cytoskeletal associated protein (Arc) is an effector immediate early gene that plays a fundamental role in activity-dependent neural pla...

journal_title：Psychopharmacology

authors： Molteni R,Calabrese F,Mancini M,Racagni G,Riva MA

更新日期：2008-12-01 00:00:00

abstract：:The aim of the present study was to investigate the locomotor stimulant effects of the atypical antipsychotic agent, olanzapine, in mice depleted of their dopamine by reserpine and alpha-methyl-DL-p-tyrosine pretreatment. Olanzapine (0.5, 1 and 2 mg/kg) dose-dependently increased locomotor activity, which was complete...

journal_title：Psychopharmacology

authors： Ninan I,Kulkarni SK

更新日期：1999-02-01 00:00:00