Social drinkers underestimate the additive impairing effects of alcohol and visual degradation on behavioral functioning.

abstract：INTRODUCTION:Understanding an individual's vulnerability to drug addiction has important implications for the development of effective personal treatment plans. Although theories acknowledge impulsive behaviour as a key component of drug addiction, little is known about the influence of trait impulsivity on an individu...

journal_title：Psychopharmacology

authors： Kolokotroni KZ,Rodgers RJ,Harrison AA

更新日期：2014-02-01 00:00:00

abstract：RATIONALE:The zebrafish dopaminergic system is thought to be evolutionarily conserved and may be amenable to pharmacological manipulation using drugs developed for mammalian receptors. However, only few studies have examined the role of specific receptor subtypes in behaviour of adult zebrafish. OBJECTIVES:The objecti...

journal_title：Psychopharmacology

authors： Tran S,Nowicki M,Muraleetharan A,Gerlai R

更新日期：2015-02-01 00:00:00

abstract：RATIONALE:Convergent evidence shows that alcohol exerts its effects on social behavior via modulation of amygdala reactivity to affective stimuli. Given that affective processing involves dynamic interactions between the amygdala and the prefrontal cortex (PFC), alcohol's effects are likely to extend beyond regional ch...

journal_title：Psychopharmacology

authors： Gorka SM,Fitzgerald DA,King AC,Phan KL

更新日期：2013-09-01 00:00:00

abstract：RATIONALE:Acute tryptophan depletion (ATD) is a widely used method to study the role of serotonin (5-HT) in affect and cognition. ATD results in a strong but transient decrease in plasma tryptophan and central 5-HT synthesis and availability. Although its use is widespread, the evidence that the numerous functional eff...

journal_title：Psychopharmacology

authors： van der Plasse G,Meerkerk DT,Lieben CK,Blokland A,Feenstra MG

更新日期：2007-12-01 00:00:00

abstract：:The effect of ovarian steroids on the benzodiazepine receptor was assessed in the elevated plus-maze and, after restraint stress, in benzodiazepine receptor binding assays. Vehicle-treated proestrous rats displayed anxiolytic behavior, relative to diestrus or estrous rats. Anxiolytic behavior was observed after 1 or 2...

journal_title：Psychopharmacology

authors： Bitran D,Dowd JA

更新日期：1996-05-01 00:00:00

abstract：RATIONALE:Executive function impairment, as classically assessed using the Wisconsin Card Sort Test or intradimensional/extradimensional tests, is a key feature of schizophrenia but remains inadequately treated by existing therapies. Recently, however, erythropoietin has been shown to improve attentional set-shifting p...

journal_title：Psychopharmacology

authors： Goetghebeur PJ,Lerdrup L,Sylvest A,Dias R

更新日期：2010-12-01 00:00:00

abstract：RATIONALE:Several recent studies have focused on glutamate modulating agents for symptoms relief in schizophrenia, especially negative symptoms which are resistant to conventional therapies. OBJECTIVES:We aimed to assess the efficacy and tolerability of riluzole, an anti-glutamate agent with neuroprotective properties...

journal_title：Psychopharmacology

authors： Farokhnia M,Sabzabadi M,Pourmahmoud H,Khodaie-Ardakani MR,Hosseini SM,Yekehtaz H,Tabrizi M,Rezaei F,Salehi B,Akhondzadeh S

更新日期：2014-02-01 00:00:00

abstract：:Nefiracetam is undergoing preclinical and clinical tests as a cognition-enhancing drug in Alzheimer's disease (AD). Nicotinic cholinergic receptors are lost in AD, and nicotinic as well as muscarinic cholinergic receptors are involved in the modulation of eyeblink conditioning. Experiments were carried out using young...

journal_title：Psychopharmacology

authors： Woodruff-Pak DS,Hinchliffe RM

更新日期：1997-05-01 00:00:00

abstract：:The influence of practice while under intoxication was tested on the development of acute tolerance to the motor impairment effect of ethanol. In experiment 1, the motor impairment effect induced by an IP injection of 1.8 g/kg ethanol was quantified after various intervals in separate groups of animals. Lower impairme...

journal_title：Psychopharmacology

authors： Lê AD,Kalant H

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:The synthetic progestin medroxyprogesterone acetate (MPA), widely used in hormone therapy (HT) and as the contraceptive Depo Provera, is implicated in detrimental cognitive effects in women. Recent evidence in aged ovariectomized (Ovx) rodents shows that short-term MPA treatment impairs cognition and alters t...

journal_title：Psychopharmacology

authors： Braden BB,Garcia AN,Mennenga SE,Prokai L,Villa SR,Acosta JI,Lefort N,Simard AR,Bimonte-Nelson HA

更新日期：2011-11-01 00:00:00

abstract：RATIONALE:Enhancement of dopamine (DA) release by corticosteroids may be of aetiological importance in substance misuse. OBJECTIVES:To examine the effect of sub-chronic administration of hydrocortisone on the response to amphetamine in healthy male volunteers. METHODS:Following baseline assessment, 20 volunteers were...

journal_title：Psychopharmacology

authors： Hearn AJ,Gallagher P,Owen BM,Smith MS,Watson S,Young AH

更新日期：2004-02-01 00:00:00

abstract：RATIONALE:Noncontingent administration of amphetamine into the ventral striatum or systemic nicotine increases responses rewarded by inconsequential visual stimuli. When these drugs are contingently administered, rats learn to self-administer them. We recently found that rats self-administer the GABA(B) receptor agonis...

journal_title：Psychopharmacology

authors： Vollrath-Smith FR,Shin R,Ikemoto S

更新日期：2012-03-01 00:00:00

abstract：:Ethologic analysis has been used to study the behavioural effects following injection of delta-aminolaevulinic acid (ALA) in mice. After a dose level of 1.6 mmol ALA/kg, male and female mice showed periods of immobility and scanned less frequently than saline-injected controls. Exploration of the cage was significantl...

journal_title：Psychopharmacology

authors： Cutler MG,Moore MR,Ewart FG

更新日期：1979-03-22 00:00:00

abstract：RATIONALE:Treatment of attention-deficit/hyperactivity disorder (ADHD) has for many years relied on psychostimulants, particularly various formulations of amphetamines and methylphenidate. These are central nervous system stimulants and are scheduled because of their abuse potential. Atomoxetine (atomoxetine hydrochlor...

journal_title：Psychopharmacology

authors： Upadhyaya HP,Desaiah D,Schuh KJ,Bymaster FP,Kallman MJ,Clarke DO,Durell TM,Trzepacz PT,Calligaro DO,Nisenbaum ES,Emmerson PJ,Schuh LM,Bickel WK,Allen AJ

更新日期：2013-03-01 00:00:00

abstract：:Oral administration of the serotonin (5-HT) precursor L-5-hydroxytryptophan (5-HTP), 200 mg, significantly increased plasma cortisol levels in man. L-5-HTP had no significant effect on the plasma prolactin levels. A borderline effect of 5-HTP on plasma ACTH levels was found. Pretreatment with the 5-HT2/5-HT1c antagoni...

journal_title：Psychopharmacology

authors： Lee MA,Nash JF,Barnes M,Meltzer HY

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:A substantial portion of cigarette smokers prefer menthol-flavored cigarettes. To date, however, no studies have examined whether menthol in cigarettes has central pharmacological effects. OBJECTIVE:We investigated psychophysiological and subjective effects of smoking menthol versus non-menthol cigarettes in...

journal_title：Psychopharmacology

authors： Pritchard WS,Houlihan ME,Guy TD,Robinson JH

更新日期：1999-04-01 00:00:00

abstract：:The effects of intra-amygdala injections of corticotropin-releasing factor (CRF) on memory and exploratory behavior in rats were examined in the present study. Rats with chronically implanted cannulae received intra-amygdala injections of vehicle or CRF at a dose of 0.01, 0.1 or 1.0 micrograms, either immediately afte...

journal_title：Psychopharmacology

authors： Liang KC,Lee EH

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Glucose administration may decrease desire to smoke in abstinent smokers. Moreover, glucose administration has been associated with improved performance on measures of attention in healthy humans but evidence remains modest. OBJECTIVE:The present study aimed to determine whether reported craving and nicotine...

journal_title：Psychopharmacology

authors： Harakas P,Foulds J

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:New psychoactive substances (NPS) are chemical analogues designed to mimic the effects of various classic recreational drugs of abuse including MDMA, LSD, and cannabis. NPS use is associated with concern about the acute and longer-term effects particular substances might have, with abuse and addiction as pot...

journal_title：Psychopharmacology

authors： Kuypers KPC,de Sousa Fernandes Perna EB,Dolder PC,Toennes SW,Theunissen EL,Mason NL,Hutten NRPW,Ramaekers JG

更新日期：2018-08-01 00:00:00

abstract：:Twelve healthy chronic schizophrenic patients were treated with the long-acting oral dopamine (DA) receptor blocker penfluridol (100 mg orally) for 6 weeks. Plasma prolactin (PRL) levels were measured during insulin-tolerance tests (ITT) performed at the end of the drug-free period (7-10 days) and during weeks 1 and 6...

journal_title：Psychopharmacology

authors： Nathan RS,Sachar EJ,Ostrow L,Asnis GM,Halbreich U,Halpern F,Renzi NL,Slotnick V

更新日期：1983-01-01 00:00:00

abstract：:This study compared the efficacy of buprenorphine to methadone for decreasing cocaine use in patients with combined opioid and cocaine use. Participants (n = 51) were enrolled in a 26-week treatment program and randomly assigned to either buprenorphine or methadone. Dosing was double-blind and double-dummy. Patients w...

journal_title：Psychopharmacology

authors： Strain EC,Stitzer ML,Liebson IA,Bigelow GE

更新日期：1994-12-01 00:00:00

abstract：:Oral movements (OMs) in rats administered chronic haloperidol (HAL) were quantified simultaneously by a human observer and via a computerized video analysis system which monitored the distance between the upper and low lips using TV images. The human observer data indicated that during HAL administration the total dur...

journal_title：Psychopharmacology

authors： Ellison G,See R,Levin E,Kinney J

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:The aim of our study was to test whether ketamine produces an antidepressant effect in animal model of olfactory bulbectomy and assess the role of mammalian target of rapamycin (mTOR) pathway in ketamine's antidepressant effect. METHODS:Bulbectomized (OBX) rats and sham controls were assigned to four subgrou...

journal_title：Psychopharmacology

authors： Holubova K,Kleteckova L,Skurlova M,Ricny J,Stuchlik A,Vales K

更新日期：2016-06-01 00:00:00

abstract：RATIONALE:Sex differences in the dopaminergic response to psychostimulants could have implications for drug abuse risk and other psychopathology involving the dopamine system, but human data are limited and mixed. OBJECTIVES:Here, we sought to investigate sex differences in dopamine release after oral D-amphetamine ad...

journal_title：Psychopharmacology

authors： Smith CT,Dang LC,Burgess LL,Perkins SF,San Juan MD,Smith DK,Cowan RL,Le NT,Kessler RM,Samanez-Larkin GR,Zald DH

更新日期：2019-02-01 00:00:00

abstract：:Rhesus monkeys were trained in a discrete-trials choice procedure and allowed to choose between intravenous injections of cocaine (0.01-1.0 mg/kg/injection) and food presentation (1 or 4 pellets; 1 g/pellet) during daily 7-h experimental sessions. When each reinforcer was available under a fixed-ratio (FR) 30 schedule...

journal_title：Psychopharmacology

authors： Nader MA,Woolverton WL

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:Previous experiments have shown that d-amphetamine disrupts timing behaviour in rats. It has been proposed that d-amphetamine's effects reflect a reduction in the period of the pacemaker of the hypothetical internal clock. However, some studies have obtained conflicting results. OBJECTIVE:To examine the effe...

journal_title：Psychopharmacology

authors： Chiang TJ,Al-Ruwaitea AS,Mobini S,Ho MY,Bradshaw CM,Szabadi E

更新日期：2000-06-01 00:00:00

abstract：RATIONALE:During the course of our investigation of antalarmin, a corticotropin-releasing hormone (CRH) antagonist, in rhesus monkeys, we noticed that large, intravenous doses of antalarmin resulted in behavioral changes that resembled intoxication. OBJECTIVES:Antalarmin was evaluated in rhesus monkeys for its reinfor...

journal_title：Psychopharmacology

authors： Broadbear JH,Winger G,Rice KC,Woods JH

更新日期：2002-11-01 00:00:00

abstract：RATIONALE:Typical neuroleptic medications are still administered to as many as 40% of patients receiving antipsychotic treatment in the US. Intermittent administration or interruption of long-term neuroleptic medication for schizophrenia may increase the incidence of human tardive dyskinesias, and similarly may produce...

journal_title：Psychopharmacology

authors： Linn GS,Lifshitz K,O'Keeffe RT,Lee K,Camp-Lifshitz J

更新日期：2001-01-01 00:00:00

abstract：:There is little evidence concerning the effects of caffeine in doses typical of one cup of tea. The present study investigated the effect of 60 mg caffeine, consumed in either tea or hot water, on performance on a subset of the CANTAB test battery. Eight males participated in a practice session and four test sessions....

journal_title：Psychopharmacology

authors： Durlach PJ

更新日期：1998-11-01 00:00:00

abstract：:There is a latency period of several weeks before the onset of clinical effect of antidepressant drugs. The detailed mechanisms underlying drug-induced adaptive neuronal changes are not known. To elucidate the involvement of changes in gene expression of candidate transcription factors, we treated rats for 21 days wit...

journal_title：Psychopharmacology

authors： Bjartmar L,Johansson IM,Marcusson J,Ross SB,Seckl JR,Olsson T

更新日期：2000-07-01 00:00:00