Abstract:
RATIONALE:Sex differences in the dopaminergic response to psychostimulants could have implications for drug abuse risk and other psychopathology involving the dopamine system, but human data are limited and mixed. OBJECTIVES:Here, we sought to investigate sex differences in dopamine release after oral D-amphetamine administration. METHODS:We used [18F]fallypride positron emission tomography (PET) to measure the change in dopamine D2/3 receptor availability (%ΔBPND, an index of dopamine release) between placebo and D-amphetamine sessions in two independent datasets containing a total of 39 females (on either hormonal birth control n = 18, postmenopausal n = 10, or studied in the first 10 days of their menstrual cycle n = 11) and 37 males. RESULTS:Using both a priori anatomical regions of interest based on previous findings and voxelwise analyses, we failed to consistently detect broad sex differences in D-amphetamine-induced dopamine release. Nevertheless, there was limited evidence for greater right ventral striatal dopamine release in young adult males relative to similarly aged females, but this was not consistently observed across samples. Plasma estradiol did not correlate with dopamine release and this measure did not differ in females on and off hormonal birth control. CONCLUSIONS:While our finding in young adults from one dataset of greater %ΔBPND in males is partially consistent with a previously published study on sex differences in D-amphetamine-induced dopamine release, our data do not support the presence of consistent widespread sex differences in this measure of dopamine release.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Smith CT,Dang LC,Burgess LL,Perkins SF,San Juan MD,Smith DK,Cowan RL,Le NT,Kessler RM,Samanez-Larkin GR,Zald DHdoi
10.1007/s00213-018-5083-5subject
Has Abstractpub_date
2019-02-01 00:00:00pages
581-590issue
2eissn
0033-3158issn
1432-2072pii
10.1007/s00213-018-5083-5journal_volume
236pub_type
杂志文章abstract:RATIONALE:The endocannabinoid system has been implicated in the pathogenesis of major depression (MD) as well as in the mediation of antidepressant drug effects. OBJECTIVES:To analyze CNR1 gene variants in MD and clinical response to citalopram (selective serotonin re-uptake inhibitors [SSRI]). METHODS:The role of CN...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-2995-y
更新日期:2013-06-01 00:00:00
abstract:RATIONALE:Acute nicotine abstinence is associated with disruption of executive function and reward processes; however, the neurobiological basis of these effects has not been fully elucidated. METHODS:The effects of nicotine abstinence on brain function during reward-based probabilistic decision making were preliminar...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2404-3
更新日期:2012-01-01 00:00:00
abstract::6-Hydroxydopamine (6OH-DA) pretreatment increased the aggressive behavior induced by marihuana in REM sleep-deprived rats. Brain catecholamine assays revealed that 6OH-DA depleted popamine (DA) and norepinephrine (NE) to a different extent, increasing the DA/NE ratio. Intraventricular injection of NE significantly dec...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00423257
更新日期:1976-07-28 00:00:00
abstract::Repeated amphetamine (AMPH) administration into the nucleus accumbens does not enhance (sensitize) the locomotor activity produced by a subsequent systemic AMPH challenge. We report here, however, that pretreatment with systemic injections of AMPH does produce a significant enhancement in the locomotor stimulant effec...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244569
更新日期:1991-01-01 00:00:00
abstract::The effects of scopolamine, an anticholinergic drug, of trimipramine, a tricyclic antidepressant with both anticholinergic and sedative properties, of diazepam and a placebo, on explicit memory and repetition priming were assessed using a free-recall task and a word-stem completion task. Forty-eight healthy volunteers...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02244116
更新日期:1990-01-01 00:00:00
abstract:RATIONALE:The exact role of delta opioid receptors in drug-induced conditioned place preference (CPP) remains debated. Under classical experimental conditions, morphine-induced CPP is decreased in mice lacking delta opioid receptors (Oprd1 (-/-)). Morphine self-administration, however, is maintained, suggesting that dr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2693-1
更新日期:2012-09-01 00:00:00
abstract::The development of tolerance to the behavioral and biochemical effects of ethanol was studied. Rats were made tolerant to ethanol by the administration of daily ethanol injections (3 g/kg, IP) for 7 and 28 days. Tolerance developed both to the behavioral (hypothermic, sedative) and biochemical (accumulation of dopamin...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244097
更新日期:1990-01-01 00:00:00
abstract:RATIONALE:3,4-Methylenedioxymethamphetamine (MDMA or ecstasy) is a potent and selective serotonin neurotoxin whose use is growing among adolescents. Although cognitive deficits among adult MDMA users are well documented, little is known of the cognitive and brain functional sequelae of MDMA use during adolescence. OBJ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1679-4
更新日期:2004-05-01 00:00:00
abstract:RATIONALE:Buprenorphine reduces both heroin and cocaine intake in opioid addicts, but the mechanisms remain unclear. OBJECTIVES:To determine the effects of chronic buprenorphine treatment on intake of heroin and/or cocaine and measure nucleus accumbens (NAc) dopamine (DA) levels during self-administration. METHODS:In...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0485-1
更新日期:2006-09-01 00:00:00
abstract:RATIONALE:Lithium is the most widely prescribed mood stabilizer, but the precise mechanism of lithium is unresolved. OBJECTIVE:We examine the effects of the administration of therapeutically relevant concentrations of lithium on the expression of brain-derived neurotrophic factor (BDNF) and its receptor, Trk B, as wel...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100871
更新日期:2001-10-01 00:00:00
abstract::The effects of the selective 5-HT1A agonists 8-OH-DPAT and flesinoxan and the selective 5-HT2 antagonists ritanserin and ketanserin on immobility time in rats bred for predisposition to catalepsy have been studied. Treatment with 8-OH-DPAT as well as flesinoxan caused a marked dose-dependent decrease in immobility tim...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245460
更新日期:1994-02-01 00:00:00
abstract::The effects of alcohol on locomotor activity of group- and individually-housed mice were studied using direct ethological observations, including a detailed postural analysis and measures of both locomotion and immobility. Ethanol (0, 0.5, 1.0 and 2.0 g/kg, IP) was given to subjects placed alone in a novel cage, and v...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00464793
更新日期:1984-01-01 00:00:00
abstract::The effects of clozapine (CLOZ) upon acquired schedule-induced polydipsia in rats were compared to the effects of the dopamine (DA) D1 antagonist SCH 23390 (SCH) and the DA D2 antagonist raclopride (RAC). All three compounds suppressed water consumption, but only SCH and RAC decreased drinking efficiency. SCH was the ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245706
更新日期:1993-01-01 00:00:00
abstract::Development of tolerance to neuroleptic compounds tested in the conditional avoidance model was investigated. Since tolerance may manifest itself by a diminished potency and/or a shortened duration of effect, the complete time course of effect was registered in these experiments. Rats were pretreated approximately 2 w...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426314
更新日期:1976-12-21 00:00:00
abstract:RATIONALE:The touchscreen continuous trial-unique non-matching-to-location task (cTUNL) has been developed to optimise a battery of tasks under NEWMEDS (Novel Methods leading to New Medication in Depression and Schizophrenia, http://www.newmeds-europe.com ). It offers novel task features of both a practical and a theor...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-4019-6
更新日期:2015-11-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00496071
更新日期:1979-08-08 00:00:00
abstract:RATIONALE:The metabotropic glutamate (mGlu5) receptor subtype 5 antagonist MPEP attenuates self-administration of numerous drugs of abuse. OBJECTIVES:The purpose of the present study was to explore whether MPEP-induced decreases in nicotine and cocaine self-administration reflect attenuation of the reinforcing and inc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-2070-9
更新日期:2005-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVE:Schizophrenia displays sex differences in many aspects. Decreased brain-derived neurotrophic factor (BDNF) levels have been reported to be associated with high body weight or obesity as well as other psychopathological aspects in schizophrenia patients. This study aimed to explore sex difference...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5107-1
更新日期:2019-02-01 00:00:00
abstract::Previous work in this and another laboratory has shown that nicotine tablets improve the performance of a rapid information processing task and reduce the Stroop effect, whereas scopolamine has the opposite effects. The purpose of this study was to extend these previous findings by determining whether, when administer...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1984-01-01 00:00:00
abstract:RATIONALE:Hypericum perforatum L., known as St. John's wort (SJW), is used as a phytotherapeutic agent for the treatment of mild to moderate forms of depression. OBJECTIVES:The aim of the present study was to evaluate the effect of SJW extract (STW 3-VI; 250 and 500 mg/kg; p.o.) and fluoxetine (10 mg/kg, p.o.) on gene...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-2032-3
更新日期:2011-02-01 00:00:00
abstract:RATIONALE:Despite the critical role attributed to phosphorylated extracellular signal regulated kinase (pERK1/2) in the nucleus accumbens (Acb) in the actions of addictive drugs, the effects of morphine on ERK1/2 phosphorylation in this area are still controversial. OBJECTIVES:In order to investigate further this issu...
journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2016-08-01 00:00:00
abstract::On the heels of clozapine, we now have a number of newer agents (risperidone, olanzapine, quetiapine, sertindole, and ziprasidone). Are they all the same? What are the differences? How do we best understand them? In this article we review current clinical evidence to compare these issues on four measures of atypicalit...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s002130050017
更新日期:2000-01-01 00:00:00
abstract::Ethanol-induced locomotor stimulation has been proposed to be positively correlated with the rewarding effects of ethanol (Wise and Bozarth 1987). The present experiments provided a test of this hypothesis using a genetic model. Three behavioral indices of the motivational effects of ethanol (drinking, taste condition...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245064
更新日期:1994-10-01 00:00:00
abstract::Different benzodiazepines, when administered to fasting cats, increased both the total amount of food eaten and also the rate at which food was ingested. Moreover, when injected to foodsatiated cats, these compounds made them resume eating voraciously. Pentobarbital also stimulated food intake, but was much less poten...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00428710
更新日期:1976-05-05 00:00:00
abstract::The differential sensitivity of young and elderly healthy adults to the impairment effects of benzodiazepines was assessed by tasks with several levels of difficulty. Using a double-blind procedure, single doses of placebo, alprazolam (0.75 and 1.5 mg) and triazolam (0.25 and 0.5 mg) were ingested orally by 10 young m...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02245796
更新日期:1990-01-01 00:00:00
abstract::Chronic nicotine infusion has been found in a series of studies in our laboratory to significantly improve choice accuracy of rats in the eight-arm radial maze. The current study was designed to compare the effects of chronic nicotine infusion on working and reference memory in a 16-arm radial maze. Nicotine was admin...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02805971
更新日期:1996-09-01 00:00:00
abstract:RATIONALE:Varenicline is believed to work, in part, by reducing craving responses to smoking cues and by reducing general levels of craving; however, these hypotheses have never been evaluated with craving assessed in the natural environments of treatment-seeking smokers. OBJECTIVES:Ecological momentary assessment pro...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
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更新日期:2012-09-01 00:00:00
abstract:RATIONALE:The efficacy of methadone for treating heroin dependence derives, in part, from suppression of opiate withdrawal and attenuation of the effects of heroin. OBJECTIVES:The purpose of this double-blind, within-subject, inpatient study was to determine whether larger doses of methadone, which are more effective ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1027-0
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVE:Several lines of evidence suggest that brain-derived neurotrophic factor (BDNF) plays a critical role in activity-dependent neuroplasticity underlying learning and memory in the hippocampus. Schizophrenia has a range of cognitive deficits that may evolve from decreased BDNF, and this study examines this assoc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2643-y
更新日期:2012-07-01 00:00:00
abstract::The effect of the dopamine receptor antagonist haloperidol on the development of sensitization to ethanol-induced increases in locomotor activity was examined in DBA/2J mice. In Experiment 1, different groups of mice were given saline or ethanol (2 g/kg) immediately before each of four locomotor activity sessions (48-...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245821
更新日期:1995-08-01 00:00:00