6-Hydroxydopamine and the aggressive behavior induced by marihuana in REM sleep-deprived rats.

abstract：:Rat open field behavior is often used as a tool to study the behavioral effects of drugs. In this report, drug-induced patterns of locomotion in an open field were studied with the aid of a simple new statistic. Briefly, the animal's path through the open field is converted into a series of trips. Gamma (gamma) estima...

journal_title：Psychopharmacology

authors： Mueller K,Hollingsworth EM,Cross DR

更新日期：1989-01-01 00:00:00

abstract：:Corticotropin releasing factor (CRF), a neuropeptide secreted by hypothalamic and extrahypothalamic neurons, is thought to mediate stress-related behaviors. The tension reduction hypothesis suggests that ethanol drinking reduces stress; that drinking is reinforced by this reduced stress; and that the probability of dr...

journal_title：Psychopharmacology

authors： Bell SM,Reynolds JG,Thiele TE,Gan J,Figlewicz DP,Woods SC

更新日期：1998-09-01 00:00:00

abstract：RATIONAL:Prefrontal cortex (PFC) and dorsal striatum are part of the neural circuit critical for executive attention. The relationship between 5-HT and aspects of attention and executive control is complex depending on experimental conditions and the level of activation of different 5-HT receptors within the nuclei of ...

journal_title：Psychopharmacology

authors： Agnoli L,Carli M

更新日期：2012-01-01 00:00:00

abstract：RATIONALE:Elevated whole-blood serotonin (5-HT) is a robust biomarker in ~ 30% of patients with autism spectrum disorders, in which repetitive behavior is a core symptom. Furthermore, elevated whole-blood 5-HT has also been described in patients with pediatric obsessive-compulsive disorder. The 5-HT1B receptor is assoc...

journal_title：Psychopharmacology

authors： O'Reilly KC,Connor M,Pierson J,Shuffrey LC,Blakely RD,Ahmari SE,Veenstra-VanderWeele J

更新日期：2021-01-29 00:00:00

abstract：RATIONALE:Cannabis (CB) use and dependence are associated with regionally specific alterations to brain circuitry and substantial psychosocial impairment. OBJECTIVES:The objective of this study was to investigate the association between CB use and dependence, and the volumes of brain regions critically involved in goa...

journal_title：Psychopharmacology

authors： Chye Y,Solowij N,Suo C,Batalla A,Cousijn J,Goudriaan AE,Martin-Santos R,Whittle S,Lorenzetti V,Yücel M

更新日期：2017-07-01 00:00:00

abstract：:Sixty-two DSM III chronic schizophrenic inpatients were selected for a double-blind, placebo controlled, multi-centre, relapse prevention study of remoxipride, a selective dopamine (D2)-receptor antagonist. After a 1 month placebo washout, 23 patients had relapsed and were withdrawn. Of the remaining patients 19 were ...

journal_title：Psychopharmacology

authors： King DJ,Blomqvist M,Cooper SJ,Doherty MM,Mitchell MJ,Montgomery RC

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:Increasing concomitant abuse of cocaine and morphine-like opioids has prompted a number of studies aimed at understanding how these drugs interact. OBJECTIVE:The present study was designed to determine if variations in opioid pretreatment time would affect how mu opioid agonists interact with cocaine. METHO...

journal_title：Psychopharmacology

authors： Green-Jordan K,Warren L,Kantak KM

更新日期：2001-08-01 00:00:00

abstract：:Rats selectively bred for high alcohol sleep times (HAS) and those that are less affected (LAS) by hypnotic doses (3.0-3.6 g/kg) of ethanol were tested for differential responses to the aversive effects of 1.0 g/kg ethanol in a conditioned place preference task. Likewise, the effects of 0.3-1.0 g/kg ethanol on spontan...

journal_title：Psychopharmacology

authors： Schechter MD,Krimmer EC

更新日期：1992-01-01 00:00:00

abstract：:Ferret predation on rats was examined in an arena. One hour before the test one of the following drugs was administered. d-Amphetamine (0.8 and 1.4 mg/kg IM), MAPROTILINE (10 AND 40 Mg/kg orally), L-dopa (30 and 60 mg/kg orally), or haloperidol (0.14 and 0.6 mg/kg IM). Provided that capture was successful, the sequenc...

journal_title：Psychopharmacology

authors： Schmidt WJ

更新日期：1979-09-01 00:00:00

abstract：RATIONALE:Buprenorphine reduces both heroin and cocaine intake in opioid addicts, but the mechanisms remain unclear. OBJECTIVES:To determine the effects of chronic buprenorphine treatment on intake of heroin and/or cocaine and measure nucleus accumbens (NAc) dopamine (DA) levels during self-administration. METHODS:In...

journal_title：Psychopharmacology

authors： Sorge RE,Stewart J

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Soda manufacturers claim that caffeine is added to soda as a flavor enhancer, but many researchers have speculated that caffeine is added to increase the hedonic and reinforcing properties of the soda. Studies in adults have demonstrated that caffeine can condition flavor preferences when added to novel-flav...

journal_title：Psychopharmacology

authors： Temple JL,Ziegler AM,Graczyk A,Bendlin A,O'Leary S,Schnittker YS

更新日期：2012-09-01 00:00:00

abstract：:This study investigated behavioural effects of very potent 5-HT reuptake inhibitors after acute treatment (cianopramine and citalopram), as well as after chronic treatment (cianopramine), in two behavioural models of anxiety: 1) the light/dark choice procedure in mice and 2) the elevated plus-maze test in rats. In add...

journal_title：Psychopharmacology

authors： Griebel G,Moreau JL,Jenck F,Misslin R,Martin JR

更新日期：1994-01-01 00:00:00

abstract：RATIONALE:The widespread deficits in cognitive flexibility observed across psychiatric disorders call for improved rodent tests to understand the biology of cognitive flexibility and development of better psychotherapeutics. Current reversal learning paradigms have a forced-choice setup that challenges the interpretati...

journal_title：Psychopharmacology

authors： Odland AU,Sandahl R,Andreasen JT

更新日期：2021-02-01 00:00:00

abstract：RATIONALE:Nitric oxide (NO) is a messenger synthesized in both the neuronal and glial populations by nitric oxide synthase type 1 (NOS1). Nicotine regulates NO production in a sex-dependent manner, both molecules being involved in motor function. OBJECTIVE:The present study evaluates sex differences in motor coordinat...

journal_title：Psychopharmacology

authors： Muñoz-Castañeda R,Díaz D,Avila-Zarza CA,Alonso JR,Weruaga E

更新日期：2014-02-01 00:00:00

abstract：:This study was designed to compare the therapeutic and adverse effects of tranylcypromine (a monoamine oxidase inhibitor), nortriptyline (a tricyclic antidepressant), and placebo. A total of 122 depressed outpatients randomly assigned to double-blind treatment with one of these agents completed the 4-week protocol. Tr...

journal_title：Psychopharmacology

authors： White K,Razani J,Cadow B,Gelfand R,Palmer R,Simpson G,Sloane RB

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:Previous studies have postulated functional links between GABA and cannabinoid systems in the hippocampus. The aim of the present study was to investigate any possible interaction between these systems in spatial change and object novelty discrimination memory consolidation in the dorsal hippocampus (CA1 regi...

journal_title：Psychopharmacology

authors： Nasehi M,Alaghmandan-Motlagh N,Ebrahimi-Ghiri M,Nami M,Zarrindast MR

更新日期：2017-10-01 00:00:00

abstract：:The purpose of this study was to determine whether repeated treatment (15 days) with d-amphetamine (AMP) or fenfluramine (FEN), administered after a daily 3 h feeding session (e.g. post-session), would result in tolerance or cross-tolerance to the decrement in food consumption induced by treatment with either drug bef...

journal_title：Psychopharmacology

authors： Hunsinger RN,Barnes TB,Kapeghian JC,Wilson MC

更新日期：1981-01-01 00:00:00

abstract：:Clozapine and molindone administered to mice for 21 days did not elevate the density of striatal 3H-spiperone binding sites at doses clinically equivalent to 1.5 mg/kg haloperidol, which elevated binding by 29%. Thioridazine (25 mg/kg) elevated binding by 25%. It appears that clinically equivalent doses of clozapine a...

journal_title：Psychopharmacology

authors： Severson JA,Robinson HE,Simpson GM

更新日期：1984-01-01 00:00:00

abstract：:We have studied striatal D2 dopamine binding in schizophrenic patients treated with the novel atypical antipsychotic drug, olanzapine. 123I iodobenzamide (IBZM) single photon emission tomography (SPET) was used to estimate striatal dopamine D2 receptor binding in vivo. Patients were recruited from a prospective, doubl...

journal_title：Psychopharmacology

authors： Pilowsky LS,Busatto GF,Taylor M,Costa DC,Sharma T,Sigmundsson T,Ell PJ,Nohria V,Kerwin RW

更新日期：1996-03-01 00:00:00

abstract：:Twelve healthy male volunteers took part in a double-blind randomised cross-over study composed of three treatment sessions: remoxipride 100 mg; remoxipride 100 mg plus biperiden 4 mg; and biperiden 4 mg. Plasma and urine concentrations of remoxipride and biperiden, plasma prolactin levels, salivary flow and adverse e...

journal_title：Psychopharmacology

authors： Yisak W,Farde L,von Bahr C,Nilsson LB,Fredriksson G,Ogenstad S

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:Nicotine and other agonists of nicotinic cholinergic receptors (nAChR) have been shown to improve performance in specific memory domains in rodents and monkeys. Such beneficial effects are observed in preclinical models of age-related cognitive decline, stimulating interest in nAChR ligands as possible therap...

journal_title：Psychopharmacology

authors： Katner SN,Davis SA,Kirsten AJ,Taffe MA

更新日期：2004-09-01 00:00:00

abstract：RATIONALE:Abnormalities of cortical evoked potentials and background electroencephalographic (EEG) frequencies occur in several psychiatric disorders, some of which, especially depression, are associated with hypercortisolaemia. However, there have been few investigations of the effects of exogenously administered cort...

journal_title：Psychopharmacology

authors： Ashton CH,Lunn B,Marsh VR,Young AH

更新日期：2000-09-01 00:00:00

abstract：RATIONALE:Dependence on both alcohol and cocaine is a widespread example of polydrug abuse/dependence. It has been hypothesized that ethanol reward is mediated via increased dopaminergic neurotransmission in mesolimbic striatum, as is the case for cocaine. However, little is known about the neurobiology of ethanol in p...

journal_title：Psychopharmacology

authors： Bradberry CW

更新日期：2002-12-01 00:00:00

abstract：RATIONALE:Research on the effects of nicotine abstinence and nicotine replacement has not provided consistent information about the impact of replacement therapies on tobacco withdrawal and craving. OBJECTIVE:. This study investigated craving and withdrawal symptoms over a 72-h period of abstinence from cigarettes. M...

journal_title：Psychopharmacology

authors： Teneggi V,Tiffany ST,Squassante L,Milleri S,Ziviani L,Bye A

更新日期：2002-11-01 00:00:00

abstract：:The release of serotonin (5-HT) at serotonergic nerve terminals is regulated by 5-HT(1B) autoreceptors. Several studies have reported that the effects of selective 5-HT reuptake inhibitors (SSRIs) on extracellular 5-HT are augmented by 5-HT(1B) receptor antagonists, whereas administration of these antagonists alone do...

journal_title：Psychopharmacology

authors： de Groote L,Klompmakers AA,Olivier B,Westenberg HG

更新日期：2003-05-01 00:00:00

abstract：:Behaviour was observed in mice given L-tryptophan, L-tyrosine or L-phenylalanine and then placed either in an open field or in water in a narrow cylinder. Animals placed in water (swim test) soon assume a characteristic immobile posture. Most antidepressants, including pharmacologically atypical ones, decrease immobil...

journal_title：Psychopharmacology

authors： Gibson CJ,Deikel SM,Young SN,Binik YM

更新日期：1982-01-01 00:00:00

abstract：:It has been proposed that serotonin (5-HT) antagonists counteract neuroleptic-induced extrapyramidal symptoms by disinhibition of dopamine activity. The effects of the 5-HT antagonist mianserin, the anticholinergic drug procyclidine and placebo were evaluated in 16 psychiatric patients with chronic neuroleptic-induced...

journal_title：Psychopharmacology

authors： Korsgaard S,Friis T

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Over the last decade, many new psychostimulant analogues have appeared on the recreational drug market and most are derivatives of amphetamine or cathinone. Another class of designer drugs is derived from the 2-aminoindan structural template. Several members of this class, including the parent compound 2-amin...

journal_title：Psychopharmacology

authors： Halberstadt AL,Brandt SD,Walther D,Baumann MH

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND AND RATIONALE:More than two decades ago, Wise proposed his "anhedonia hypothesis" to explain the role of dopamine in motivated behaviors. The hypothesis posits that dopamine mediates the pleasure experienced by reward obtainment. However, some experimental findings have contested this hypothesis and several ...

journal_title：Psychopharmacology

authors： Barbano MF,Cador M

更新日期：2007-04-01 00:00:00

abstract：:A prospective study of response to treatment with nortriptyline was carried out in a group of 14 inpatients with mixed symptoms of depression and dementia. Platelet membrane fluidity, as reflected by the fluorescence anisotropy of DPH labeled membranes, was determined for all 14 drug-free subjects prior to treatment b...

journal_title：Psychopharmacology

authors： Zubenko GS,Reynolds CF 3rd,Perel JM,Decker C,Malinakova I

更新日期：1988-01-01 00:00:00