Abstract：
RATIONALE:Nicotine and other agonists of nicotinic cholinergic receptors (nAChR) have been shown to improve performance in specific memory domains in rodents and monkeys. Such beneficial effects are observed in preclinical models of age-related cognitive decline, stimulating interest in nAChR ligands as possible therapeutics. Prior work has typically focused on assays of spatial working memory in rodent studies and visual recognition memory in monkey studies. OBJECTIVE:The current study was conducted to determine the role played by nAChRs in multiple types of memory in monkeys. METHODS:Rhesus monkeys (n=6) were trained to perform a battery of six behavioral tasks and then serially challenged with acute doses of nicotine (3.2-56 microg/kg, i.m.) and the nAChR antagonist mecamylamine (0.32-1.78 mg/kg, i.m.). RESULTS:Nicotine improved performance on tests designed to assay visual recognition memory, spatial working memory and visuo-spatial associative memory, while mecamylamine impaired visuo-spatial associative memory. Ballistic and fine motor performance was not significantly improved by nicotine but fine motor performance was impaired by mecamylamine. CONCLUSIONS:Although nicotine may improve performance in multiple domains, effects on visuo-spatial associative memory is the most specifically attributable to nAChR signaling.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Katner SN,Davis SA,Kirsten AJ,Taffe MAdoi
10.1007/s00213-004-1804-zsubject
Has Abstractpub_date
2004-09-01 00:00:00pages
225-40issue
2eissn
0033-3158issn
1432-2072journal_volume
175pub_type
杂志文章abstract：RATIONALE:Gonadal steroid hormones altered opioid antinociception under some conditions in rodents, and we reported previously that chronic estradiol enhanced kappa but not mu opioid antinociception in ovariectomized rhesus monkeys. Sex differences have also been observed in the antinociceptive effects of opioid agonis...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130100912
更新日期：2002-01-01 00:00:00
abstract：:Each morning eight adults with caffeine versus placebo discrimination histories ingested letter-coded capsules containing 100 mg caffeine or placebo and then engaged in a relaxation or vigilance activity. Subjects were first exposed to caffeine and placebo once each with each activity. Then each day for 10 days subjec...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02249332
更新日期：1994-04-01 00:00:00
abstract：RATIONALE:We recently reported that simultaneous exposure to amphetamine and various stressors resulted in reduced hypothalamic-pituitary-adrenal (HPA) and glycemic responses to the stressors. Since this is a new and relevant phenomenon, we wanted to further explore this interaction. OBJECTIVES:This study aims (i) to ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-017-4675-9
更新日期：2017-10-01 00:00:00
abstract：RATIONALE:Serotonin 5-HT2A and 5-HT2C receptors are thought to be the primary pharmacological mechanisms for serotonin-mediated hallucinogenic drugs, but recently there has been interest in metabotropic glutamate (mGluR2) receptors as contributors to the mechanism of hallucinogens. OBJECTIVE:The present study assesses...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3658-3
更新日期：2015-01-01 00:00:00
abstract：:This study compared the efficacy of buprenorphine to methadone for decreasing cocaine use in patients with combined opioid and cocaine use. Participants (n = 51) were enrolled in a 26-week treatment program and randomly assigned to either buprenorphine or methadone. Dosing was double-blind and double-dummy. Patients w...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02247469
更新日期：1994-12-01 00:00:00
abstract：RATIONALE:Alzheimer disease (AD), a progressive neurodegenerative disorder, is the leading cause of dementia in the elderly. A combination of cholinergic and glutamatergic dysfunction appears to underlie the symptomatology of AD, and thus, treatment strategies should address impairments in both systems. Evidence sugges...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-008-1092-0
更新日期：2008-05-01 00:00:00
abstract：:Chronic nicotine infusion has been found in a series of studies in our laboratory to significantly improve choice accuracy of rats in the eight-arm radial maze. The current study was designed to compare the effects of chronic nicotine infusion on working and reference memory in a 16-arm radial maze. Nicotine was admin...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02805971
更新日期：1996-09-01 00:00:00
abstract：RATIONALE:Early life exposure to stress and to GABAA receptor modulators have well-defined and persistent behavioral effects. A single neonatal injection of the GABAergic neurosteroid allopregnanolone (3alpha-hydroxy,5alpha-pregnane-20-one, 10 mg/kg, i.p.) alters the localization of prefrontal cortex (PFC) interneurons...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0360-0
更新日期：2006-06-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00433038
更新日期：1979-10-01 00:00:00
abstract：:Plasma fluphenazine levels and plasma total neuroleptic activity (as quantitated by the neuroleptic receptor binding assay) were related to therapeutic response in 15 DSM-III schizophrenic patients who received a predetermined, fixed dose of fluphenazine for 14 days. Mean neuroleptic activity of the plasma was 84% gre...
journal_title：Psychopharmacology
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doi：10.1007/BF00181256
更新日期：1986-01-01 00:00:00
abstract：:In a phase II study the antidepressive effect of citalopram, a selective and potent serotonin reuptake inhibitor, was examined in 20 endogenously and three non-endogenously depressed hospitalized patients. Four endogenously depressed patients dropped out due to deterioration early in the treatment period. The remainin...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00464566
更新日期：1982-01-01 00:00:00
abstract：:Two experiments were conducted to study the effects of anxiogenic drugs on dopamine release and metabolism in nucleus accumbens. Microdialysis probes were implanted into the nucleus accumbens, and rats were tested the day after implantation. In the first experiment, groups of rats received injections of saline, 1.25 o...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245888
更新日期：1992-01-01 00:00:00
abstract：:The anorectic activity of the d and l isomers of d-fenfluramine (d-FF) (l-FF) were compared with d-amphetamine (d-amp) when given separately and together in 12 healthy male volunteers. The study was double blind and placebo controlled. Food intake was measured using an automated food dispenser. Anorectic activity was ...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02801976
更新日期：1992-01-01 00:00:00
abstract：RATIONALE:Drug-paired stimuli elicit drug craving and relapse in addicts and drug-seeking behavior in rats. The functional integrity of the basolateral amygdala (BLA) is necessary for reinstatement of cocaine-seeking behavior elicited by cocaine-conditioned stimuli, but not by cocaine itself. It is unclear, however, wh...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-001-0997-7
更新日期：2002-04-01 00:00:00
abstract：RATIONALE:Understanding factors contributing to individual differences in vulnerability to opioid addiction is essential for developing more effective preventions and treatments, yet few reliable behavioral predictors of subsequent opioid self-administration have been identified in rodents. Sensitivity to the acute eff...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-020-05532-w
更新日期：2020-08-01 00:00:00
abstract：:The effect of electroconvulsive shock (ECS) on the responsiveness to pain (measured by the hot-plate test) and on the characteristics of L-type calcium channels (measured as [3H]nitrendipine binding sites) in the cortex and hippocampus was tested on the Wistar rat. In animals receiving a single ECS, the calcium channe...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244133
更新日期：1990-01-01 00:00:00
abstract：RATIONALE:Previous studies from our laboratory and others have indicated a role for the hypothalamo-pituitary-adrenal (HPA) axis in the extinction/reinstatement animal model of cocaine relapse OBJECTIVE:This present study was designed to investigate the potential role for the HPA axis in the cue- and methamphetamine-i...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0625-7
更新日期：2007-02-01 00:00:00
abstract：RATIONALE:Considerable research indicates that "ecstasy" users perceive their memory for future intentions (prospective memory) to be impaired. However, only one empirical study to date has directly tested how this capacity is affected by ecstasy use, and this study provided relatively limited information regarding the...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s00213-007-0859-z
更新日期：2007-11-01 00:00:00
abstract：RATIONALE:Repeated exposure to psychostimulants that either increase dopamine (DA) release or target N-methyl-D-aspartate (NMDA) receptors can induce behavioural sensitisation, a phenomenon that may be important for the processes of addiction and even psychosis. A critical component of behavioural sensitisation is an i...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3689-9
更新日期：2015-02-01 00:00:00
abstract：RATIONALE:Cannabinoid CB1 receptors are expressed in the prefrontal cortex, but their role in mediating executive functions such as behavioral flexibility is unclear. OBJECTIVE:The present study examined the effect of pharmacological activation or blockade of the cannabinoid CB1 receptors on behavioral flexibility usi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0421-4
更新日期：2006-08-01 00:00:00
abstract：RATIONALE:Repeated exposure to psychostimulant drugs causes a long-lasting increase in the psychomotor and reinforcing effects of these drugs and an array of neuroadaptations. One such alteration is a hypersensitivity of striatal activity such that a low dose of amphetamine in sensitized animals produces dorsal striata...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-008-1100-4
更新日期：2008-05-01 00:00:00
abstract：:The effects of 6-OHDA lesions of dopamine terminals within the amygdala were investigated on i) (+) amphetamine-induced locomotor hyperactivity and ii) the acquisition of intravenous self-administration of (+) amphetamine. The lesioned rats exhibited increased locomotor activity in response to (+) amphetamine (0.75 an...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00176851
更新日期：1988-01-01 00:00:00
abstract：RATIONALE:The party drug ecstasy is frequently used in combination with other drugs like marihuana and alcohol. In addition, a substantial proportion of the MDMA users has claimed to drive a car when under the influence of MDMA and/or other drugs. OBJECTIVE:To assess the effects of MDMA and alcohol, combined and alone...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-006-0434-z
更新日期：2006-09-01 00:00:00
abstract：:SCH 39166 is the first selective D1-dopamine receptor antagonist developed for clinical trials in schizophrenia. SCH 39166 was evaluated as a radioligand for PET, labeled with 11C, and as a D1-dopamine receptor antagonist after single oral doses in healthy men. After intravenous injection of [11C]SCH 39166 distributio...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF02246067
更新日期：1995-10-01 00:00:00
abstract：RATIONALE:Central application of MTII, a melanocortin 3/4 receptor agonist, reduces food intake. The behavioral mechanisms underlying the anorexia, however, have not been evaluated. OBJECTIVES:We examined the ingestive behavioral effects of MTII at the microstructural level using two complementary approaches. METHODS...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1022-5
更新日期：2002-04-01 00:00:00
abstract：:The effects of phencyclidine (PCP) on locomotor activity were compared to those of the stereoisomers of N-allylnormetazocine (NAN) after acute administration to rats. PCP produced swaying and falling movements, increased sniffing behavior, and enhanced horizontal locomotor activity. d-NAN also induced swaying, falling...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00310633
更新日期：1986-01-01 00:00:00
abstract：:The sensitivity of the dopaminergic hypothalamic pituitary system, as indicated by growth hormone (GH) release after apomorphine (0.5 mg SC), was studied in 11 chronic schizophrenic in-patients under long-term neuroleptic (NL) therapy and after 12 and 30 days' drug withdrawal. GH peak levels after a 12-day drug-free p...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00555228
更新日期：1984-01-01 00:00:00
abstract：:3,4-Methylenedioxymethamphetamine (MDMA) is a psychoactive phenylisopropylamine which is structurally similar to both amphetamine-related sympathomimetics and the hallucinogen, mescaline. MDMA produces pleasurable effects which include euphoria, and recent reports continue to demonstrate its widespread recreational us...
journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：1988-01-01 00:00:00
abstract：:The effects of monoamine oxidase inhibitors (MAOIs) that selectively inhibit the MAO-A or MAO-B forms of MAO were studied in rats performing under a differential-reinforcement-of-low-rate 72-s (DRL 72-s) schedule of reinforcement. Clorgyline and CGP11'305A, irreversible and reversible MAO-A inhibitors, respectively, i...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00177554
更新日期：1988-01-01 00:00:00
abstract：INTRODUCTION:Model psychosis is characterised by experimentally induced symptoms of withdrawal from reality, frequently accompanied by perceptual disturbances, thought disorders, delusional ideas and sometimes by hallucinations. These "altered states of consciousness" provide a long-standing and valid approach to enhan...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-009-1591-7
更新日期：2009-11-01 00:00:00
