Abstract：
RATIONALE:Repeated exposure to psychostimulants that either increase dopamine (DA) release or target N-methyl-D-aspartate (NMDA) receptors can induce behavioural sensitisation, a phenomenon that may be important for the processes of addiction and even psychosis. A critical component of behavioural sensitisation is an increase in DA release within mesocorticolimbic circuits. In particular, sensitisation to amphetamine leads to increased DA release within well-known sub-cortical brain regions and also regulatory regions such as prefrontal cortex (PFC). However, it is unknown how DA release within the PFC of animals is altered by sensitisation to NMDA receptor antagonists. OBJECTIVES:The aims of the present study were twofold, firstly to examine whether a single dose of dizocilpine maleate (MK-801) could induce long-term behavioural sensitisation and secondly to examine DA release in the PFC of sensitised rats. MATERIALS AND METHODS:Behavioural sensitisation was assessed by measuring locomotion after drug exposure. DA release in the PFC was measured using freely moving microdialysis. RESULTS:We show that a single dose of MK-801 can induce sensitisation to subsequent MK-801 exposure in a high percentage of rats (66 %). Furthermore, rats sensitised to MK-801 have altered DA release and turnover in the PFC compared with non-sensitised rats. CONCLUSION:Schizophrenia patients have been postulated to have 'endogenous sensitisation' to psychostimulants. MK-801-induced sensitised rats, in particular when compared with non-sensitised rats, provide a useful model for studying PFC dysfunction in schizophrenia.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Cui X,Lefevre E,Turner KM,Coelho CM,Alexander S,Burne TH,Eyles DWdoi
10.1007/s00213-014-3689-9subject
Has Abstractpub_date
2015-02-01 00:00:00pages
509-17issue
3eissn
0033-3158issn
1432-2072journal_volume
232pub_type
杂志文章abstract：RATIONALE:The party drug ecstasy is frequently used in combination with other drugs like marihuana and alcohol. In addition, a substantial proportion of the MDMA users has claimed to drive a car when under the influence of MDMA and/or other drugs. OBJECTIVE:To assess the effects of MDMA and alcohol, combined and alone...
journal_title：Psychopharmacology
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更新日期：2006-09-01 00:00:00
abstract：RATIONALE:Withdrawal seizure-prone and withdrawal seizure-resistant mice were selectively bred to exhibit differences in handling-induced convulsion severity during ethanol withdrawal. The glutamatergic system has been implicated in seizure activity as well as ethanol withdrawal symptoms. OBJECTIVE:This study assessed...
journal_title：Psychopharmacology
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doi：10.1007/s002130050933
更新日期：1999-04-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-1827-6
更新日期：2010-06-01 00:00:00
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journal_title：Psychopharmacology
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doi：10.1007/s00213-010-2086-2
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426773
更新日期：1977-10-20 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-004-1921-8
更新日期：2004-12-01 00:00:00
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doi：10.1007/s00213-010-1973-x
更新日期：2010-12-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00432172
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00423259
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journal_title：Psychopharmacology
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journal_title：Psychopharmacology
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02246300
更新日期：1995-06-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00634456
更新日期：1989-01-01 00:00:00
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journal_title：Psychopharmacology
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doi：10.1007/s002130050999
更新日期：1999-06-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130051020
更新日期：1999-06-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00443416
更新日期：1989-01-01 00:00:00
abstract：RATIONALE:Gonadal steroid hormones altered opioid antinociception under some conditions in rodents, and we reported previously that chronic estradiol enhanced kappa but not mu opioid antinociception in ovariectomized rhesus monkeys. Sex differences have also been observed in the antinociceptive effects of opioid agonis...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130100912
更新日期：2002-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-005-2248-9
更新日期：2005-06-01 00:00:00
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journal_title：Psychopharmacology
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doi：10.1007/BF00451681
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pub_type： 临床试验,杂志文章
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journal_title：Psychopharmacology
pub_type： 杂志文章
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245494
更新日期：1992-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：1983-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2005-02-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：2008-05-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章,评审
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更新日期：2013-03-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00433246
更新日期：1980-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0454-8
更新日期：2007-02-01 00:00:00
abstract：RATIONALE:Greater incidence of anxiety and depressive disorders of women compared to men may be due in part to progesterone (P) and its neuroactive metabolite, 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP), acting in limbic regions, such as the amygdala. OBJECTIVE:If P's metabolism via 5alpha-reduction to 3alpha...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-005-0100-x
更新日期：2006-06-01 00:00:00
abstract：:Platelet adenylate cyclase activity was measured in 16 control subjects and 16 patients who developed post-traumatic stress disorder (PTSD) as a result of damage inflicted on their homes during the Iraqi Scud missile attacks on Israel which occurred during the 1991 Gulf War. There were no differences in basal, NaF-sti...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
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更新日期：1994-04-01 00:00:00
