Abstract:
:Platelet adenylate cyclase activity was measured in 16 control subjects and 16 patients who developed post-traumatic stress disorder (PTSD) as a result of damage inflicted on their homes during the Iraqi Scud missile attacks on Israel which occurred during the 1991 Gulf War. There were no differences in basal, NaF-stimulated, PGE1-stimulated or forskolin-stimulated activity between controls and PTSD subjects. Epinephrine inhibition of forskolin-stimulated activity, an effect mediated by alpha 2 adrenergic receptors, was slightly but not significantly increased in the PTSD patients compared to the controls, while 5-HT induced inhibition, an effect mediated by putative 5-HT1a-like receptors, was unchanged. The relationship of these activities to measures of anxiety and depression in these patients is discussed.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Weizmann R,Gur E,Laor N,Reiss A,Muller U,Yoresh A,Lerer B,Newman MEdoi
10.1007/BF02249343subject
Has Abstractpub_date
1994-04-01 00:00:00pages
509-12issue
3eissn
0033-3158issn
1432-2072journal_volume
114pub_type
临床试验,杂志文章abstract::This experiment examined the effect of destruction of the ascending 5-hydroxytryptaminergic (5HTergic) pathways on performance in a free-operant timing schedule. Rats received either injections of 5,7-dihydroxytryptamine into the dorsal and median raphe nuclei or sham lesions. They were trained to press levers for a s...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050096
更新日期:1996-10-01 00:00:00
abstract::The ability of 5-HT1 receptor agonists to modulate a chemically induced defence response has been studied in Lister hooded rats. Microinjections of the excitatory amino acid D,L-homocysteic acid (DLH) in both rostral and caudal dorsal periaqueductal gray matter (PAG) caused explosive motor behaviour characteristic of ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245294
更新日期:1992-01-01 00:00:00
abstract::Two experiments were conducted to study the effects of anxiogenic drugs on dopamine release and metabolism in nucleus accumbens. Microdialysis probes were implanted into the nucleus accumbens, and rats were tested the day after implantation. In the first experiment, groups of rats received injections of saline, 1.25 o...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245888
更新日期:1992-01-01 00:00:00
abstract::Cholinergic neurotransmission has been implicated in various forms of neural plasticity such as kindling and learning. We have previously shown that blockade of muscarinic cholinergic receptors prevents the development of locomotor sensitization to methamphetamine. The present study was conducted to examine whether sc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245625
更新日期:1995-09-01 00:00:00
abstract::A neutral stimulus can acquire conditioned rewarding properties through association with an intrinsically rewarding stimulus. The acquisition of responding for conditioned rewards requires that environmental stimuli and reward processes interact in a highly specific manner; analyses of this phenomenon may provide valu...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s002130050982
更新日期:1999-05-01 00:00:00
abstract::The intensity of the head-twitch response and the 5-hydroxytryptamine (5-HT) syndrome (tremor, fore-paw treading, head-weaving and hind-limb abduction) was measured in male CFLP mice following IP injection of 5 mg/kg 5-methoxy-N,N-dimethyltryptamine (5-MeODMT). The results of separate experiments carried out at 1.5-h ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431714
更新日期:1985-01-01 00:00:00
abstract:RATIONALE:Dysfunction of executive neuropsychological performance, mediated by the prefrontal cortex, has been the central focus of recent attention deficit/ hyperkinetic disorder (AD-HKD) research. The role of other potential neuropsychological "risk factors", such as recognition memory, remains understudied. Further,...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00213-004-1833-7
更新日期:2004-09-01 00:00:00
abstract:RATIONALE:Buprenorphine reduces both heroin and cocaine intake in opioid addicts, but the mechanisms remain unclear. OBJECTIVES:To determine the effects of chronic buprenorphine treatment on intake of heroin and/or cocaine and measure nucleus accumbens (NAc) dopamine (DA) levels during self-administration. METHODS:In...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0485-1
更新日期:2006-09-01 00:00:00
abstract::The effects on memory and psychomotor functions of four antidepressants which differ in sedative and anticholinergic properties were assessed. Amitriptyline (37.5, 70 mg), trazodone (100, 200 mg) viloxazine (100, 200 mg), protriptyline (10, 20 mg) or placebo were administered in a double blind, independent groups desi...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00172967
更新日期:1988-01-01 00:00:00
abstract::The cognitive deficits, particularly memory impairment, observed in association with organic brain damage caused by chronic alcohol ingestion, are consistent with the profile of benzodiazepine-induced amnesia. This study examined the cognitive capabilities of a group of heavy social drinkers (n = 11) and a group of lo...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02244897
更新日期:1993-01-01 00:00:00
abstract::The purpose of this study was to compare the subchronic, low-dose effects of clozapine with those of olanzapine in a learned behavioral task previously shown to distinguish between clozapine and haloperidol with acute and subchronic treatment regimes. Rats were trained to use a single forelimb to press a force-recordi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050363
更新日期:1997-08-01 00:00:00
abstract::We investigated the possible role of dopamine receptors in the mediation of copulatory disorder induced by defeat experience in male mice, using L-dopa and apomorphine. To generate the copulatory disorder, male mice were attacked 20 times daily for 5 consecutive days, as intruders in confrontation with an aggressive r...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050398
更新日期:1997-10-01 00:00:00
abstract:RATIONALE:Performance on progressive ratio schedules has been proposed as a means of assessing the effects of drugs on the value or "efficacy" of reinforcers. A mathematical model affords a basis for quantifying the effects of drugs on progressive ratio schedule performance. According to this model, the relation betwee...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-2049-6
更新日期:2005-05-01 00:00:00
abstract::Clozapine and molindone administered to mice for 21 days did not elevate the density of striatal 3H-spiperone binding sites at doses clinically equivalent to 1.5 mg/kg haloperidol, which elevated binding by 29%. Thioridazine (25 mg/kg) elevated binding by 25%. It appears that clinically equivalent doses of clozapine a...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432038
更新日期:1984-01-01 00:00:00
abstract:RATIONALE:Studies of the discriminative stimulus effects of drug mixtures provide an approach to polydrug abuse and studies on single drugs with multiple effects. OBJECTIVE:This study was designed to investigate whether the use of the AND-OR procedure increases the specificity of drug mixture discriminations. METHODS...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050919
更新日期:1999-03-01 00:00:00
abstract:RATIONALE:Asenapine, a psychopharmacologic agent developed for schizophrenia and bipolar disorder, has higher affinity for 5-HT(2A/C,6,7) and alpha(2) adrenergic receptors than for D(2) receptors. Asenapine exhibits potent antipsychotic-like effects without inducing catalepsy, increases cortical and subcortical dopamin...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1456-5
更新日期:2009-06-01 00:00:00
abstract::On the heels of clozapine, we now have a number of newer agents (risperidone, olanzapine, quetiapine, sertindole, and ziprasidone). Are they all the same? What are the differences? How do we best understand them? In this article we review current clinical evidence to compare these issues on four measures of atypicalit...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s002130050017
更新日期:2000-01-01 00:00:00
abstract:RATIONALE:Corticostriatal circuits are widely implicated in the top-down control of attention including inhibitory control and behavioural flexibility. However, recent neurophysiological evidence also suggests a role for thalamic inputs to striatum in behaviours related to salient, reward-paired cues. OBJECTIVES:Here,...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4627-4
更新日期:2017-08-01 00:00:00
abstract::Different benzodiazepines, when administered to fasting cats, increased both the total amount of food eaten and also the rate at which food was ingested. Moreover, when injected to foodsatiated cats, these compounds made them resume eating voraciously. Pentobarbital also stimulated food intake, but was much less poten...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00428710
更新日期:1976-05-05 00:00:00
abstract:RATIONALE:Glucose administration may decrease desire to smoke in abstinent smokers. Moreover, glucose administration has been associated with improved performance on measures of attention in healthy humans but evidence remains modest. OBJECTIVE:The present study aimed to determine whether reported craving and nicotine...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00213-002-1035-0
更新日期:2002-05-01 00:00:00
abstract:RATIONALE:Electronic cigarettes (ECs) are becoming popular alternatives for smokers, but there has been limited study of their abuse liability. OBJECTIVES:The objective of this study was to evaluate the abuse liability of three Vuse Solo ECs, ranging from 14 to 36 mg in nicotine content, relative to high- and low-abus...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-017-4665-y
更新日期:2017-09-01 00:00:00
abstract::Phencyclidine (PCP) and sigma ligands produce a typical excitatory behaviour in rats, characterized by circling and head- and body-weaving. Excitatory amino acid antagonists such as 2-amino 5-phosphonovaleric acid (AP5) or 3-(+/-)-2-carboxypiperazin-4-yl)propyl-l-phosphonic acid (CPP) also produce a PCP-like excitator...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244368
更新日期:1991-01-01 00:00:00
abstract:RATIONALE:Many previous studies have reported that alcohol and cannabis produce additive psychomotor effects in acute combination, but few have explicitly tested whether chronic exposure to cannabis, in the absence of acute administration, alters the effects of alcohol on psychomotor performance. OBJECTIVES:To test wh...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-001-0955-4
更新日期:2002-03-01 00:00:00
abstract:RATIONALE:Heavy ecstasy use in humans has been associated with cognitive impairments and changes in cognitive brain function supposedly due to damage to the serotonin system. There is concern that even a single dose of 3,4-methylenedioxymethamphetamine may be neurotoxic, but very little is known about the consequences ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-007-0792-1
更新日期:2007-08-01 00:00:00
abstract:RATIONALE:Neuropeptide Y (NPY) is implicated in the pathophysiology of affective illness. Multiple receptor subtypes (Y1R, Y2R, and Y5R) have been suggested to contribute to NPY's effects on rodent anxiety and depression-related behaviors. OBJECTIVES:To further elucidate the role of Y1R in (1) NPY's anxiolytic-like ef...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-007-0945-2
更新日期:2008-01-01 00:00:00
abstract:RATIONALE:We recently reported that simultaneous exposure to amphetamine and various stressors resulted in reduced hypothalamic-pituitary-adrenal (HPA) and glycemic responses to the stressors. Since this is a new and relevant phenomenon, we wanted to further explore this interaction. OBJECTIVES:This study aims (i) to ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4675-9
更新日期:2017-10-01 00:00:00
abstract:RATIONALE:Several previous neuroendocrine studies have demonstrated reduced 5-HT1A receptor function in major depressive disorder (MDD). However, hypercortisolaemia or previous drug treatment may have been significant confounds. OBJECTIVES:To replicate previous studies in subjects with MDD who had been drug free for a...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-003-1475-1
更新日期:2003-08-01 00:00:00
abstract::Several behaviors associated with the serotonin syndrome have been reported in rats following administration of the 5-HT1A receptor agonist 8-OH-DPAT. The present investigation approached this phenomenon from an ethopharmacological perspective, and provided a detailed temporal analysis of the behavioral effects of thi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02247363
更新日期:1993-01-01 00:00:00
abstract::Two experiments were conducted to test the hypothesis that tolerance to the hypothermic effect of ethanol fails to develop if rats are denied the unconditional stimulus represented by hypothermia. In both experiments, rats were injected with either ethanol (1.9 or 2.5 g/kg) or saline and given microwave hyperthermia (...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00175187
更新日期:1986-01-01 00:00:00
abstract::Exposure to 10 min of footshock stress (1 mA; 0.5 s on, with a mean off period of 40 s) reinstated heroin-seeking behavior in heroin-experienced, drug-free rats after many sessions of extinction and up to 6 weeks after last exposure to heroin. In reinstating the behavior, the footshock mimicked the effect of a non-con...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246300
更新日期:1995-06-01 00:00:00