Abstract：
RATIONALE:Antidepressants are known to modify human sleep patterns. OBJECTIVES:Duloxetine is a new antidepressant with a mechanism of action involving reuptake inhibition of both serotonin (5-HT) and norepinephrine (NE). In this study, the effects of two dosing regimens of duloxetine on sleep electroencephalography (EEG) were investigated at steady-state plasma concentrations in young, healthy, male subjects. METHODS:Placebo (n=12), desipramine (50 mg BID; n=12) and two regimens of duloxetine (80 mg QD, n=6; or 60 mg BID, n=6) were compared in a randomized, double-blind, three-period crossover study, each treatment being administered from day 1 to day 7. Sleep polygraphic recordings took place at baseline (day -1) and day 6 of each period. The Leeds sleep evaluation questionnaire (LSEQ) was also administered on the morning of day 7. RESULTS:Both regimens of duloxetine produced a significant increase in the onset latency of REM sleep as well as a significant mean decrease in total REM sleep duration. Desipramine exhibited comparable effects. When compared to placebo, sleep continuity was significantly reduced with desipramine and duloxetine 60 mg BID whereas a significant improvement was observed with duloxetine 80 mg QD. On the LSEQ, duloxetine 80 mg QD produced a significant improvement in the "getting to sleep" subscale compared to placebo, whereas desipramine demonstrated a significant reduction (worsening) in the "quality of sleep" score versus placebo. CONCLUSIONS:The two dose regimens of duloxetine (80 mg QD and 60 mg BID) produced a REM sleep pattern comparable to that of most antidepressant medications. Duloxetine 80 mg QD appeared to exhibit less impact upon sleep quality than duloxetine 60 mg BID in healthy subjects.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Chalon S,Pereira A,Lainey E,Vandenhende F,Watkin JG,Staner L,Granier LAdoi
10.1007/s00213-004-1961-0subject
Has Abstractpub_date
2005-02-01 00:00:00pages
357-65issue
4eissn
0033-3158issn
1432-2072journal_volume
177pub_type
临床试验,杂志文章,随机对照试验abstract：RATIONALE:Group I metabotropic glutamate receptor antagonists, which block both the mGlu1 and mGlu5 receptors, have been shown to have anxiolytic effects in the lick suppression test in rats. OBJECTIVE:The anxiolytic potential of the selective mGlu1 antagonist 3,4-dihydro-2H-pyrano[2,3]beta-quinolin-7-yl)(cis-4-methox...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-004-2056-7
更新日期：2005-04-01 00:00:00
abstract：RATIONALE:Schizophrenia is a complex psychiatric disorder comprised of three main classes of symptoms: positive, negative and cognitive symptoms. Currently, no approved treatment exists for the cognitive symptoms. There is thus a great need for research aiming at identifying novel targets for treatment of this indicati...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-2039-9
更新日期：2011-03-01 00:00:00
abstract：RATIONALE:Clinical trials show that chronic cocaine users suffer from sleep disturbances and preclinical research has shown that acute sleep deprivation increases the rate of cocaine self-administration in rats. OBJECTIVE:This study examined the effect of cocaine self-administration on behavioral indices of sleep and ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3101-1
更新日期：2013-09-01 00:00:00
abstract：RATIONALE:The influence of the main dopaminergic brain regions controlling copulation, the medial preoptic area (mPOA) and the nucleus accumbens (NAcc), on male rat sexual behavior expression has not been fully established. OBJECTIVE:This work analyzes the sexual effects of dopamine (DA) receptor activation in the mPO...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-5142-y
更新日期：2019-04-01 00:00:00
abstract：:The purpose of this review was to establish in vivo apparent pA2 and pKB values for antagonism of the discriminative stimulus effects of benzodiazepine ligands, and to compare these values to those obtained from other behavioral procedures. Articles were chosen from the Medline data base from January 1976 to August 19...
journal_title：Psychopharmacology
pub_type： 杂志文章,meta分析
doi：10.1007/s002130050103
更新日期：1996-11-01 00:00:00
abstract：RATIONALE:Concurrent abuse of cocaine and heroin is a common form of polydrug abuse, but the interactions between the reinforcing effects of cocaine and heroin are poorly understood. Dose-addition analysis is a tool for the quantitative assessment of drug interactions, but this analysis has not been applied to evaluati...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-004-2133-y
更新日期：2005-06-01 00:00:00
abstract：INTRODUCTION:Alcohol has been shown to increase smoking urges and smoking behavior. However, alcohol's effects on specific components of smoking behavior for nicotine versus non-nicotine factors and potential sex differences in this response have not been investigated. METHODS:Forty-two young male and female non-depen...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-009-1638-9
更新日期：2009-11-01 00:00:00
abstract：RATIONALE:Although both contain behaviourally significant concentrations of caffeine, tea is commonly perceived to be a less stimulating drink than coffee. At least part of the explanation for this may be that theanine, which is present in tea but not coffee, has relaxing effects. There is also some evidence that thean...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-007-0938-1
更新日期：2008-01-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:We previously found that systemic injections of the 5-HT uptake blocker fluoxetine attenuate intermittent footshock stress-induced reinstatement of alcohol seeking in rats, while inhibition of 5-HT neurons in the median raphe induces reinstatement of alcohol seeking. In this study, we further e...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0346-y
更新日期：2006-05-01 00:00:00
abstract：RATIONALE:Interrelationships between the discriminative stimulus and reinforcing properties of psychoactive drugs and the way in which they may interact to control drug intake are unclear. Studies have shown that drug history can influence the expression of drug-produced behavioral effects. OBJECTIVE:The present study...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0364-9
更新日期：2006-06-01 00:00:00
abstract：:To investigate the mood response of schizophrenic subjects to psychostimulant challenge, 29 neuroleptic-treated subjects (22 with schizophrenia and 7 with schizoaffective disorder) in clinical remission received two infusions, one with methylphenidate 0.5 mg/kg and the other with normal saline, under double-blind cond...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02244317
更新日期：1991-01-01 00:00:00
abstract：RATIONALE:Typical neuroleptic medications are still administered to as many as 40% of patients receiving antipsychotic treatment in the US. Intermittent administration or interruption of long-term neuroleptic medication for schizophrenia may increase the incidence of human tardive dyskinesias, and similarly may produce...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130000572
更新日期：2001-01-01 00:00:00
abstract：RATIONALE:The party drug ecstasy is frequently used in combination with other drugs like marihuana and alcohol. In addition, a substantial proportion of the MDMA users has claimed to drive a car when under the influence of MDMA and/or other drugs. OBJECTIVE:To assess the effects of MDMA and alcohol, combined and alone...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-006-0434-z
更新日期：2006-09-01 00:00:00
abstract：RATIONALE:Emerging evidence from agonist-antagonist studies suggests a role for the dopamine D(3) receptor subtype in the regulation of PPI in animals, but such evidence is lacking for human subjects. OBJECTIVES:This study examines the effect of the preferential D(3) agonist ropinirole on PPI in humans. METHODS:PPI w...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-007-0843-7
更新日期：2007-10-01 00:00:00
abstract：INTRODUCTION:Gelsemine is a natural alkaloid extracted from Gelsemium elegans Benth., a traditional Chinese medicinal herb. Gelsemine has been shown to penetrate the brain, and could produce neurological activities, such as anxiolytic and neuralgia-alleviating effects, suggesting that this natural compound might be use...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-020-05522-y
更新日期：2020-07-01 00:00:00
abstract：RATIONALE:The role of pharmacotherapy in the treatment of major depressive disorder (MDD) in youth has received much attention in recent years due to concerns of efficacy and safety of the antidepressants for the treatment of MDD in youth. OBJECTIVES:This review describes the existing published and unpublished literat...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-006-0442-z
更新日期：2007-03-01 00:00:00
abstract：:Evidence has been provided for impaired neurotransmitter functioning in the brain of elderly subjects. In order to assess central GABAergic transmission, the activity of the hypothalamic GABA system may be investigated by basal growth hormone (GH) response to the GABAergic drug sodium valproate (SV). For this purpose ...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00690918
更新日期：1987-01-01 00:00:00
abstract：RATIONALE:Recent animal research has shown that, aside from its primary and secondary reinforcing effects, nicotine may enhance reinforcement from stimuli unrelated to nicotine intake. Little human research has directly examined this potentially important influence of nicotine. OBJECTIVES:We report two virtually ident...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-009-1574-8
更新日期：2009-09-01 00:00:00
abstract：:Twenty-nine subjects performed a reaction time task with four levels of choice-task complexity under non-smoking, sham smoking, and low, medium and high nicotine cigarette conditions. Nicotine reduced decision time, while sham smoking increased decision time. This effect was independent of subjects' habitual levels of...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF02244860
更新日期：1994-03-01 00:00:00
abstract：RATIONALE:Anticipatory nausea (AN) experienced by chemotherapy patients is resistant to current anti-nausea treatments. In this study, the effect of manipulation of the endocannabinoid (EC) system on a rat model of nausea (conditioned gaping) was determined. OBJECTIVE:The potential of cannabidiol (CBD) and the fatty a...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-007-0970-1
更新日期：2008-02-01 00:00:00
abstract：:Metergoline given IP reduced the response to noxious stimulation in the mouse formalin test. Tolerance to this effect developed after a chronic treatment schedule consisting of ten daily injections of 5 mg/kg. Twenty four hours after the last injection a test dose of metergoline (2.5 mg/kg) reduced the licking time in...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02439580
更新日期：1987-01-01 00:00:00
abstract：RATIONALE:There is a requirement to ensure that UK armed forces are provided with the best possible medical countermeasures to prevent or mitigate the effects of exposure to nerve agents. When pretreatments are under consideration, it is of particular importance to ensure that they do not in themselves give rise to adv...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1324-7
更新日期：2003-03-01 00:00:00
abstract：:Offensive and defensive components of aggressive behavior were determined in resident and intruder mice. Withdrawal aggression was measured after the removal of a subcutaneous morphine pellet or after precipitation by naloxone in naive mice and after removal of a morphine pellet in mice with prior fighting experience....
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00174059
更新日期：1986-01-01 00:00:00
abstract：RATIONALE:Brain waves reflect collective behavior of neurons and provide insight into distributed network processing. Frontal and hippocampal theta oscillations (4-7 Hz) were linked to cognitive tasks and animal studies have suggested an involvement of glutamatergic neurotransmission in integrative frontal-hippocampal ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0397-0
更新日期：2006-07-01 00:00:00
abstract：RATIONALE:In Koriat's accessibility model (Koriat, Psychol Rev, 100:609-639, 1993; Koriat, J Exp Psychol Gen, 124:311-333, 1995), when a person fails to recall a required target, he or she can nevertheless provide some partial information about the target. Moreover, individuals are able to provide feeling-of-knowing (F...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-006-0492-2
更新日期：2006-11-01 00:00:00
abstract：RATIONALE:Impulsivity has been strongly linked to addictive behaviors, but can be operationalized in a number of ways that vary considerably in overlap, suggesting multidimensionality. OBJECTIVE:This study tested the hypothesis that the latent structure among multiple measures of impulsivity would reflect the followin...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-016-4372-0
更新日期：2016-09-01 00:00:00
abstract：:This study compared the efficacy of buprenorphine to methadone for decreasing cocaine use in patients with combined opioid and cocaine use. Participants (n = 51) were enrolled in a 26-week treatment program and randomly assigned to either buprenorphine or methadone. Dosing was double-blind and double-dummy. Patients w...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02247469
更新日期：1994-12-01 00:00:00
abstract：RATIONALE:The mechanism involved in AD is complex, which has prompted to develop compounds that could simultaneously interact with several potential targets. Here, we report a new synthesized compound SCR-1693 which is designed to target both AChE and calcium channels that are potential for AD therapy. OBJECTIVES:We i...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-4133-5
更新日期：2016-02-01 00:00:00
abstract：RATIONALE:Pediatric bipolar disorder (PBD) is a chronic and debilitating psychiatric illness. It is associated with many short-term and long-term complications including poor academic and social performance, legal problems and increased risk of suicide. Moreover, it is often complicated by other serious psychiatric dis...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-006-0569-y
更新日期：2007-03-01 00:00:00
abstract：:Postsynaptic dopamine-cholecystokinin (CCK) interactions in the nucleus accumbens were studied in two behavioral preparations of DA receptor supersensitivity: chronic-neuroleptic treated and 6-hydroxydopamine (6-OHDA) denervated rats. Subcutaneous (SC) injections of apomorphine (APO; 0.15 mg/kg) in experiment 1 produc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00445568
更新日期：1989-01-01 00:00:00
