Extrasynaptic GABAA receptor activation reverses recognition memory deficits in an animal model of schizophrenia.

abstract：:Abnormal beta-adrenergic receptor (betaAR) density in the brains of suicide victims has been reported, although results of studies are inconsistent. Ethanol modifies betaAR-mediated signal transduction. Moreover abnormal betaAR function has been implicated in alcoholism. BetaAR antagonists, which were used as ligands ...

journal_title：Psychopharmacology

authors： Gurguis GN,Turkka J,Laruelle M,Kleinman J,Linnoila M

更新日期：1999-07-01 00:00:00

abstract：:The issue of whether tolerance develops to the motivational effects of opioids was addressed by use of an unbiased place preference conditioning procedure. Administration of the mu-opioid agonists morphine or fentanyl produced dose-related preferences for the drug-associated place in control rats. In contrast, the kap...

journal_title：Psychopharmacology

authors： Shippenberg TS,Emmett-Oglesby MW,Ayesta FJ,Herz A

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Synthetic psychostimulant abuse, including cathinone-derived 3,4-methylenedioxypyrovalerone (MDPV), continues to increase in many countries. Similar to cocaine but with greater potency, MDPV elicits a transient sympathomimetic response by blocking cellular uptake of dopamine (DA) and norepinephrine (NE)-admin...

journal_title：Psychopharmacology

authors： Simmons SJ,Martorana R,Philogene-Khalid H,Tran FH,Gentile TA,Xu X,Su S,Rawls SM,Muschamp JW

更新日期：2017-11-01 00:00:00

abstract：RATIONALE:Marijuana and alcohol, when used separately and in combination, contribute to automobile accidents and failed sobriety tests of standing balance. However, the extent to which the drugs have additive effects on both of these measures is unknown. OBJECTIVES:This study was designed to compare directly the separ...

journal_title：Psychopharmacology

authors： Liguori A,Gatto CP,Jarrett DB

更新日期：2002-10-01 00:00:00

abstract：RATIONALE:Patients with obsessive compulsive disorder (OCD) demonstrate impaired cognition in some selected domains. Although serotoninergic dysfunction has been implicated in OCD, recent evidence suggests that dopamine may play a role as well. OBJECTIVE:The aim of the study was to evaluate learning and working memory...

journal_title：Psychopharmacology

authors： Morein-Zamir S,Craig KJ,Ersche KD,Abbott S,Muller U,Fineberg NA,Bullmore ET,Sahakian BJ,Robbins TW

更新日期：2010-10-01 00:00:00

abstract：RATIONALE:Understanding factors contributing to individual differences in vulnerability to opioid addiction is essential for developing more effective preventions and treatments, yet few reliable behavioral predictors of subsequent opioid self-administration have been identified in rodents. Sensitivity to the acute eff...

journal_title：Psychopharmacology

authors： Swain Y,Muelken P,Skansberg A,Lanzdorf D,Haave Z,LeSage MG,Gewirtz JC,Harris AC

更新日期：2020-08-01 00:00:00

abstract：INTRODUCTION:Smoking rates among depressed individuals is higher than among healthy subjects, and nicotine alleviates depressive symptoms. Nicotine increases serotonergic and noradrenergic neuronal activity and facilitates serotonin and noradrenaline release. In mice, acute nicotine administration enhances the activity...

journal_title：Psychopharmacology

authors： Andreasen JT,Nielsen EO,Redrobe JP

更新日期：2009-08-01 00:00:00

abstract：:A variety of behaviors were studied in an open-field setting after i.v. amphetamine (0.5, 2.0, 8.0 mg/kg), phenmetrazine (1.0, 4.0, 16.0 mg/kg), or fenfluramine (1.0, 4.0, 16.0 mg/kg). Amphetamine and phenmetrazine increased ambulation initially and rearing during the whole experiment, and decreased grooming. At 30 an...

journal_title：Psychopharmacology

authors： Lindquist MP,Götestam KG

更新日期：1977-12-19 00:00:00

abstract：:Rats selectively bred for high alcohol sleep times (HAS) and those that are less affected (LAS) by hypnotic doses (3.0-3.6 g/kg) of ethanol were tested for differential responses to the aversive effects of 1.0 g/kg ethanol in a conditioned place preference task. Likewise, the effects of 0.3-1.0 g/kg ethanol on spontan...

journal_title：Psychopharmacology

authors： Schechter MD,Krimmer EC

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:Depressive disorders are conditions that often require continuous treatment, and it is therefore important to evaluate the consequences of prolonged administration. There are few studies assessing cognitive functions of depressed patients after long-term use of antidepressants. OBJECTIVES:This study evaluate...

journal_title：Psychopharmacology

authors： Gorenstein C,de Carvalho SC,Artes R,Moreno RA,Marcourakis T

更新日期：2006-03-01 00:00:00

abstract：:The central effects of acetylsalicylic acid (ASA) are discussed controversially. In animal models, it has been shown that ASA can interact with the central serotonergic and catecholaminergic neuronal system. However, the relevance of this interaction for humans is still unknown. We performed a study on the influence o...

journal_title：Psychopharmacology

authors： Austermann M,Grotemeyer KH,Evers S,Rödding D,Husstedt IW

更新日期：1998-08-01 00:00:00

abstract：RATIONALE:Previous studies indicate that the rewarding effect of D-1 dopamine receptor stimulation in nucleus accumbens (NAc) shell is greater in food-restricted (FR) than in ad libitum fed (AL) rats. The D-1 receptor is positively coupled to adenylyl cyclase and activates protein kinase A (PKA). OBJECTIVES:The purpos...

journal_title：Psychopharmacology

authors： de Vaca SC,Peng XX,Concors S,Farin C,Lascu E,Carr KD

更新日期：2012-06-01 00:00:00

abstract：:Two experiments examined the effect of the benzodiazepine receptor agonist, zolpidem, on palatable fluid intake in water-deprived rats. In the first experiment, pretreatment with 3.0 or 10.0 mg/kg zolpidem IP was found to increase consumption of a novel glucose drink (3% d-glucose and 0.15 sodium saccharine w/v in wat...

journal_title：Psychopharmacology

authors： Stanhope KJ,Roe S,Dawson G,Draper F,Jackson A

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:The pharmacological profile of escitalopram, the S-(+)-enantiomer of citalopram, was studied and compared with citalopram and the R-(-)-enantiomer, R-citalopram. METHODS:Inhibition of the serotonin transporter (5-HTT) was studied in COS-1 cells expressing the human 5-HTT (h-5-HTT) and in rat brain synaptosom...

journal_title：Psychopharmacology

authors： Sánchez C,Bergqvist PB,Brennum LT,Gupta S,Hogg S,Larsen A,Wiborg O

更新日期：2003-06-01 00:00:00

abstract：:5,7-Dihydroxytryptamine (5,7-DHT) or the vehicle was administered once into both lateral ventricles of the rat. Desmethylimipramine (DMI) was administered IP prior to the intraventricular injection of 5,7-DHT to prevent the destruction of norepinephrine (NE) terminals. Following recovery from surgery, ethanol (5 g/kg,...

journal_title：Psychopharmacology

authors： Lê AD,Khanna JM,Kalant H,LeBlanc AE

更新日期：1980-02-01 00:00:00

abstract：RATIONALE:The integrity of cortical cholinergic transmission is vital to attentional processing. A growing literature suggests that alterations in attentional processing accompany addictive drug use. This study examined the effects of acute and repeated administration of nicotine on cortical acetylcholine release. OBJ...

journal_title：Psychopharmacology

authors： Arnold HM,Nelson CL,Sarter M,Bruno JP

更新日期：2003-02-01 00:00:00

abstract：:The effects of morphine, ketocyclazocine, cyclazocine, and SKF-10,047 were tested alone and in conjunction with naltrexone or naloxone, in rats responding under a multiple fixed-interval 3-min schedule of food presentation. Under this paradigm, electric shock was delivered on a fixed-ratio schedule for responses occur...

journal_title：Psychopharmacology

authors： Snell D,Harris RA

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:Toluene is a misused inhalant with hallucinogenic properties and complex effects. Toluene blocks N-methyl-D-aspartate (NMDA) receptors, releases dopamine (DA), and modifies several neurotransmitter levels; nonetheless, the mechanism by which it produces hallucinations is not well characterized. OBJECTIVES:Th...

journal_title：Psychopharmacology

authors： Rivera-García MT,López-Rubalcava C,Cruz SL

更新日期：2015-10-01 00:00:00

abstract：:While chronic intermittent administration of stimulants often induces behavioral sensitization in adulthood, stimulant sensitization has rarely been reported prior to weaning [around postnatal day (P) 21]. Consistent pairing of drug administration with the test context often facilitates sensitization in adults, yet yo...

journal_title：Psychopharmacology

authors： Wood RD,Tirelli E,Snyder KJ,Heyser CJ,LaRocca TM,Spear LP

更新日期：1998-07-01 00:00:00

abstract：:Voluntary consumption of alcohol by rats (i.e. in the absence of food or water deprivation, sweetening of the alcohol solution, etc.) that results in the attainment of behaviorally significant or pharmacologically detectable blood alcohol levels (BALs) has been difficult to demonstrate. In this study, we showed that f...

journal_title：Psychopharmacology

authors： Linseman MA

更新日期：1987-01-01 00:00:00

abstract：:Buprenorphine, a partial mu opioid agonist, is an experimental medication under development for the treatment of opioid dependence as an alternative to methadone maintenance. The present study examined the relationship between level of opioid physical dependence and response to buprenorphine administration as part of ...

journal_title：Psychopharmacology

authors： Walsh SL,June HL,Schuh KJ,Preston KL,Bigelow GE,Stitzer ML

更新日期：1995-06-01 00:00:00

abstract：RATIONALE:It is widely assumed that various forms of neural and behavioral plasticity, including sensitization, are strongly dependent on the activation of N-methyl-D-aspartate (NMDA)-receptors, but evidence also exists to suggest that not all forms of sensitization are unequivocally blocked by NMDA-receptor antagonism...

journal_title：Psychopharmacology

authors： Tzschentke TM,Schmidt WJ

更新日期：2000-08-01 00:00:00

abstract：:Evidence has been provided for impaired neurotransmitter functioning in the brain of elderly subjects. In order to assess central GABAergic transmission, the activity of the hypothalamic GABA system may be investigated by basal growth hormone (GH) response to the GABAergic drug sodium valproate (SV). For this purpose ...

journal_title：Psychopharmacology

authors： Monteleone P,Iovino M,Orio F,Steardo L

更新日期：1987-01-01 00:00:00

abstract：:Amphetamine stimulates locomotor activity, in large part by activating central dopaminergic systems. Serotonin shares on overlapping distribution with dopamine and has been shown to modulate dopaminergic function and dopamine-mediated behaviors. The present study examined whether increasing serotonergic function, via ...

journal_title：Psychopharmacology

authors： Sills TL,Greenshaw AJ,Baker GB,Fletcher PJ

更新日期：1999-02-01 00:00:00

abstract：:Rats were trained to discriminate between two compound stimulus arrays that included exteroceptive (ES) and interoceptive (IS) stimulus components. The ES components were illumination and tactile cues, and the IS components were produced by d-amphetamine (A) or Na pentobarbital (P) treatment (drug versus drug discrimi...

journal_title：Psychopharmacology

authors： Duncan PM

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Attention-deficit/hyperactivity disorder (ADHD) is thought to involve hypofunctional catecholamine systems in the striatum, nucleus accumbens, and prefrontal cortex (PFC); however, recent clinical evidence has implicated glutamate dysfunction in the pathophysiology of ADHD. Recent studies show that increased ...

journal_title：Psychopharmacology

authors： Miller EM,Pomerleau F,Huettl P,Gerhardt GA,Glaser PE

更新日期：2014-08-01 00:00:00

abstract：RATIONALE:Fluoxetine improves affect in clinical syndromes such as depression and premenstrual dysphoric disorder. Little is known about fluoxetine's influence on mood changes after quitting smoking, which often resemble sub-clinical depression. OBJECTIVES:The present study, a re-analysis of previously published data ...

journal_title：Psychopharmacology

authors： Cook JW,Spring B,McChargue DE,Borrelli B,Hitsman B,Niaura R,Keuthen NJ,Kristeller J

更新日期：2004-04-01 00:00:00

abstract：:A prospective study of response to treatment with nortriptyline was carried out in a group of 14 inpatients with mixed symptoms of depression and dementia. Platelet membrane fluidity, as reflected by the fluorescence anisotropy of DPH labeled membranes, was determined for all 14 drug-free subjects prior to treatment b...

journal_title：Psychopharmacology

authors： Zubenko GS,Reynolds CF 3rd,Perel JM,Decker C,Malinakova I

更新日期：1988-01-01 00:00:00

abstract：:Two putative predictors of placebo response were studied in three samples of psychiatric outpatients. Two groups, 73 university medical center patients and 56 college health service patients, underwent 1 week of placebo treatment. A quasi-control group of 112 patients receiving no medication waited about 1 week before...

journal_title：Psychopharmacology

authors： McNair DM,Gardos G,Haskell DS,Fisher S

更新日期：1979-06-21 00:00:00

abstract：:Oral administration of the serotonin (5-HT) precursor L-5-hydroxytryptophan (5-HTP), 200 mg, significantly increased plasma cortisol levels in man. L-5-HTP had no significant effect on the plasma prolactin levels. A borderline effect of 5-HTP on plasma ACTH levels was found. Pretreatment with the 5-HT2/5-HT1c antagoni...

journal_title：Psychopharmacology

authors： Lee MA,Nash JF,Barnes M,Meltzer HY

更新日期：1991-01-01 00:00:00