Alcohol consumption in free-feeding rats: procedural, genetic and pharmacokinetic factors.

abstract：:We examined the possibility that anoxia at birth can alter behavioral sensitization to amphetamine during adulthood. Male rats born either vaginally or by Cesarean section with or without an additional 15-min period of anoxia received five once-daily injections of either d-amphetamine (2.0 mg/kg, i.p.) or vehicle or n...

journal_title：Psychopharmacology

authors： Brake WG,Boksa P,Gratton A

更新日期：1997-10-01 00:00:00

abstract：:Oxytocin plays an important role in the regulation of normal cognitive functions and behaviors, which are disturbed in schizophrenia. Several studies suggest that oxytocinergic function is abnormal in schizophrenia patients. Thus, oxytocin may be involved in the pathophysiology associated with this disorder. This stud...

journal_title：Psychopharmacology

authors： Feifel D,Reza T

更新日期：1999-01-01 00:00:00

abstract：RATIONAL:Prefrontal cortex (PFC) and dorsal striatum are part of the neural circuit critical for executive attention. The relationship between 5-HT and aspects of attention and executive control is complex depending on experimental conditions and the level of activation of different 5-HT receptors within the nuclei of ...

journal_title：Psychopharmacology

authors： Agnoli L,Carli M

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the relationship between zolpidem use and the risk of acute pancreatitis in Taiwan. METHODS:In this population-based case-control study using the database from the Taiwan National Health Insurance Program from 2000 to 2011, we selected 4535 subjects aged 20-84 years ...

journal_title：Psychopharmacology

authors： Lai SW,Lin CL,Liao KF

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVES:Previous studies have investigated the occupancy of the serotonin reuptake transporter (SERT) after clinical doses of citalopram and other selective serotonin reuptake inhibitors. In the present study, the occupancies of SERT after multiple doses of escitalopram and citalopram were compared using the radioli...

journal_title：Psychopharmacology

authors： Klein N,Sacher J,Geiss-Granadia T,Mossaheb N,Attarbaschi T,Lanzenberger R,Spindelegger C,Holik A,Asenbaum S,Dudczak R,Tauscher J,Kasper S

更新日期：2007-04-01 00:00:00

abstract：RATIONALE:A substantial body of research suggests that the neuropeptide oxytocin promotes social affiliative behaviors in a wide range of animals including humans. However, its antiaggressive action has not been unequivocally demonstrated in male laboratory rodents. OBJECTIVE:Our primary goal was to examine the putati...

journal_title：Psychopharmacology

authors： Calcagnoli F,de Boer SF,Althaus M,den Boer JA,Koolhaas JM

更新日期：2013-10-01 00:00:00

abstract：:Pigeons trained under a two-key drug discrimination procedure eventually learned to discriminate 5 mg/kg phenytoin from saline injections. When 1.25-20 mg/kg doses of phenytoin were substituted for the training dose, the percentage of responses directed to the phenytoin-appropriate key varied directly with dose. Chlor...

journal_title：Psychopharmacology

authors： Krafft K,Cleary J,Poling A

更新日期：1983-01-01 00:00:00

abstract：:Benztropine mesylate (Cogentin) and physostigmine salicylate (Antilirium), were tested for changes in tongue protrusions, retrusions, and swallowing acts in rats anesthetized with a 100 mg/kg IM injection of ketamine hydrochloride. These ketamine-induced linguopharyngeal events were monitored by means of a force displ...

journal_title：Psychopharmacology

authors： Marco LA,Joshi RS,Brown C,Aldes LD,Chronister RB

更新日期：1988-01-01 00:00:00

abstract：:The effect of electroconvulsive shock (ECS) on the responsiveness to pain (measured by the hot-plate test) and on the characteristics of L-type calcium channels (measured as [3H]nitrendipine binding sites) in the cortex and hippocampus was tested on the Wistar rat. In animals receiving a single ECS, the calcium channe...

journal_title：Psychopharmacology

authors： Antkiewicz-Michaluk L,Michaluk J,Romańska I,Vetulani J

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Recent studies have suggested that the salutary actions of clozapine in schizophrenia may be due to selective activation of M(1) muscarinic receptors by clozapine and/or its major active metabolite N-desmethylclozapine. OBJECTIVE:We systematically tested this hypothesis by screening a large number of psychoa...

journal_title：Psychopharmacology

authors： Davies MA,Compton-Toth BA,Hufeisen SJ,Meltzer HY,Roth BL

更新日期：2005-04-01 00:00:00

abstract：:On the heels of clozapine, we now have a number of newer agents (risperidone, olanzapine, quetiapine, sertindole, and ziprasidone). Are they all the same? What are the differences? How do we best understand them? In this article we review current clinical evidence to compare these issues on four measures of atypicalit...

journal_title：Psychopharmacology

authors： Remington G,Kapur S

更新日期：2000-01-01 00:00:00

abstract：:To investigate the mood response of schizophrenic subjects to psychostimulant challenge, 29 neuroleptic-treated subjects (22 with schizophrenia and 7 with schizoaffective disorder) in clinical remission received two infusions, one with methylphenidate 0.5 mg/kg and the other with normal saline, under double-blind cond...

journal_title：Psychopharmacology

authors： Robinson D,Mayerhoff D,Alvir J,Cooper T,Lieberman J

更新日期：1991-01-01 00:00:00

abstract：:Food intake of four adult male baboons (Papio c. anubis) was monitored during daily experimental sessions lasting 22 h. Food was available under a two-component operant schedule. Following completion of the first "procurement component" response requirement, access to food, i.e., a meal, became available under the sec...

journal_title：Psychopharmacology

authors： Foltin RW,Fischman MW,Byrne MF

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:Thousands of adolescents start smoking daily but information on the effects of tobacco exposure on this age group is scarce. Moreover, the available animal models rely on the effects of nicotine, neglecting other neuroactive components of tobacco. OBJECTIVES:We investigated the effects of exposure of adolesc...

journal_title：Psychopharmacology

authors： Abreu-Villaça Y,Filgueiras CC,Correa-Santos M,Cavina CC,Naiff VF,Krahe TE,Manhães AC,Ribeiro-Carvalho A

更新日期：2015-05-01 00:00:00

abstract：RATIONALE:The high prevalence of smoking and low cessation rates among individuals with schizophrenia and similar conditions are not well understood. Behavioral economics has been extensively applied to studying addictive behavior and may contribute to understanding smoking in this subpopulation. OBJECTIVES:This study...

journal_title：Psychopharmacology

authors： MacKillop J,Tidey JW

更新日期：2011-07-01 00:00:00

abstract：RATIONALE:One third of US smokers are intermittent smokers (ITS) who do not smoke daily. Unlike daily smokers (DS), whose smoking is negatively reinforced by withdrawal relief, ITS may be motivated by immediate positive reinforcement. In contrast, incentive salience theory posits hypothesis that "liking" of drug effect...

journal_title：Psychopharmacology

authors： Shiffman S,Terhorst L

更新日期：2017-10-01 00:00:00

abstract：RATIONALE:During the last few decades, alcohol use disorders (AUD) have reached an epidemic prevalence, yet social influences on alcoholism have not been fully addressed. Several factors can modulate alcohol intake. On one hand, stress can reinforce ethanol-induced behaviors and be an important component in AUD and alc...

journal_title：Psychopharmacology

authors： Bahi A,Dreyer JL

更新日期：2020-03-01 00:00:00

abstract：RATIONALE:Previous behavioral and biochemical studies suggest that allosteric coupling processes initiated by benzodiazepines, barbiturates and neuroactive steroids can be sub-categorized on the basis of their sensitivities to antagonism by increased atmospheric pressure. However, biochemical evidence supporting this h...

journal_title：Psychopharmacology

authors： Davies DL,McCauley LD,Bolger MB,Alkana RL

更新日期：2001-10-01 00:00:00

abstract：:The effects of the selective 5-HT1A agonists 8-OH-DPAT and flesinoxan and the selective 5-HT2 antagonists ritanserin and ketanserin on immobility time in rats bred for predisposition to catalepsy have been studied. Treatment with 8-OH-DPAT as well as flesinoxan caused a marked dose-dependent decrease in immobility tim...

journal_title：Psychopharmacology

authors： Kulikov AV,Kolpakov VG,Maslova GB,Kozintsev I,Popova NK

更新日期：1994-02-01 00:00:00

abstract：:A study was performed on the effect of ethanol on the basal and K+-evoked efflux of endogenous GABA from rat hypothalamic fragments. The amount of GABA present in the medium and in the tissue was measured by radioreceptor assay. In vitro addition of ethanol (50 and 100 mM) enhanced the K+-evoked efflux of GABA in a Ca...

journal_title：Psychopharmacology

authors： Seilicovich A,Duvilanski BH,Lasaga M,Debeljuk L,Díaz MC

更新日期：1988-01-01 00:00:00

abstract：:Serotonergic mechanisms mediate the expression of personality traits (such as impulsivity, aggression and anxiety) that are linked to vulnerability to psychological illnesses, and modulate the identification of emotional expressions in the face as well as learning about broader classes of appetitive and aversive signa...

journal_title：Psychopharmacology

authors： Ward R,Sreenivas S,Read J,Saunders KEA,Rogers RD

更新日期：2017-07-01 00:00:00

abstract：INTRODUCTION:Nearly 25% of American adults remain regular smokers. Current smokers may be especially likely to possess characteristics that impair their ability to quit, such as impulsivity. Impulsive individuals may be overly prone to smoke because they are particularly drawn to rewarding stimuli and related cues. The...

journal_title：Psychopharmacology

authors： Doran N,Spring B,McChargue D

更新日期：2007-10-01 00:00:00

abstract：:Pigeons were trained to acquire a new 4-response sequence in each session by pecking three keys in a predetermined order. The key color varied for each step under the chained schedule, but there was only one key color under the tandem schedule. Under the reset contingency, incorrect responses produced a reset of the 4...

journal_title：Psychopharmacology

authors： Harting J,Mcmillian DE

更新日期：1976-09-29 00:00:00

abstract：BACKGROUND:Soda manufacturers claim that caffeine is added to soda as a flavor enhancer, but many researchers have speculated that caffeine is added to increase the hedonic and reinforcing properties of the soda. Studies in adults have demonstrated that caffeine can condition flavor preferences when added to novel-flav...

journal_title：Psychopharmacology

authors： Temple JL,Ziegler AM,Graczyk A,Bendlin A,O'Leary S,Schnittker YS

更新日期：2012-09-01 00:00:00

abstract：RATIONALE:The development and validation of animal models of the cognitive impairments of schizophrenia have remained challenging subjects. OBJECTIVE:We review evidence from a series of experiments concerning an animal model that dissociates between the disruption of attentional capacities during acute illness periods...

journal_title：Psychopharmacology

authors： Sarter M,Martinez V,Kozak R

更新日期：2009-01-01 00:00:00

abstract：AIM:It is widely assumed that the upcoming therapeutics for Alzheimer's disease will require to act on more than one target to be effective. We investigated here whether a combination of the nicotinic receptor allosteric modulator/cholinesterase inhibitor galantamine can act synergistically with the type 4 serotonin re...

journal_title：Psychopharmacology

authors： Freret T,Lelong-Boulouard V,Lecouflet P,Hamidouche K,Dauphin F,Boulouard M

更新日期：2017-08-01 00:00:00

abstract：:Murine neuroblastoma cells (clone N1E-115) possess both high- and low-affinity muscarinic receptors. The low-affinity muscarinic receptor, when stimulated, initiates the formation of cyclic GMP by activating the enzyme guanylate cyclase; whereas stimulation of the high-affinity receptor inhibits prostaglanding E1-medi...

journal_title：Psychopharmacology

authors： Kanba S,Pfenning M,Richelson E

更新日期：1985-01-01 00:00:00

abstract：RATIONALE:There is evidence that events early in post-weaning life influence brain development and subsequent adult behaviour and therefore play an important role in the causation of certain psychiatric disorders in later life. Exposing rodents to stressors during the juvenile period has been suggested as a model of in...

journal_title：Psychopharmacology

authors： Peleg-Raibstein D,Feldon J

更新日期：2011-03-01 00:00:00

abstract：RATIONALE:Many previous studies have reported that alcohol and cannabis produce additive psychomotor effects in acute combination, but few have explicitly tested whether chronic exposure to cannabis, in the absence of acute administration, alters the effects of alcohol on psychomotor performance. OBJECTIVES:To test wh...

journal_title：Psychopharmacology

authors： Wright A,Terry P

更新日期：2002-03-01 00:00:00

abstract：RATIONALE:New research findings in the field of neuroactive steroids strongly suggest that to understand their role in physiopathology, it is essential to accurately measure their tissue levels. Through his broad chemical expertise and extensive knowledge of steroids, Dr. Robert H. Purdy pioneered structure-activity re...

journal_title：Psychopharmacology

authors： Vallée M

更新日期：2014-09-01 00:00:00